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Protein

GBC54531.1

Length

604 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
4 - 100
Aspartic peptidase domain (IPR021109)
241 - 420
Reverse transcriptase domain (IPR000477)

1 100 200 300 400 500 604

Detailed signature matches

IPR021109

Aspartic peptidase domain

SSF50630 (Acid prot...)

4 - 100

SUPERFAMILY
SSF50630 (Acid proteases)

IPR000477

Reverse transcriptase domain

PF00078 (RVT_1)

261 - 419

Pfam
PF00078 (RVT_1)
PS50878 (RT_POL)

241 - 420

PROSITE profiles
PS50878 (RT_POL)

IPR001969

Aspartic peptidase, active site

PS00141 (ASP_PROTEASE)

14 - 25

PROSITE patterns
PS00141 (ASP_PROTEASE)

no IPR

Unintegrated signatures

Coil

223 - 243

COILS
Coil (Coil)
PF13975 (gag-asp_pr...)

4 - 93

Pfam
PF13975 (gag-asp_proteas)
SSF56672 (DNA/RNA p...)

185 - 589

SUPERFAMILY
SSF56672 (DNA/RNA polymerases)
cd00303 (retropepsi...)

4 - 93

CDD
cd00303 (retropepsin_like)
cd01647 (RT_LTR)

245 - 420

CDD
cd01647 (RT_LTR)
cd09274 (RNase_HI_R...)

483 - 603

CDD
cd09274 (RNase_HI_RT_Ty3)
mobidb-lite (disord...)

120 - 159

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

Catalytic residue ...

17D

Catalytic residue
17D
CDD
cd00303 (retropepsin_like)
catalytic motif cd...

17D

catalytic motif
17D, 18S, 19G
CDD
cd00303 (retropepsin_like)

18S

catalytic motif
17D, 18S, 19G
CDD
cd00303 (retropepsin_like)

19G

catalytic motif
17D, 18S, 19G
CDD
cd00303 (retropepsin_like)
inhibitor binding ...

17D

inhibitor binding site
17D, 19G, 21S, 45F, 46I, 47M, 86I
CDD
cd00303 (retropepsin_like)

19G

inhibitor binding site
17D, 19G, 21S, 45F, 46I, 47M, 86I
CDD
cd00303 (retropepsin_like)

21S

inhibitor binding site
17D, 19G, 21S, 45F, 46I, 47M, 86I
CDD
cd00303 (retropepsin_like)

45F

inhibitor binding site
17D, 19G, 21S, 45F, 46I, 47M, 86I
CDD
cd00303 (retropepsin_like)

46I

inhibitor binding site
17D, 19G, 21S, 45F, 46I, 47M, 86I
CDD
cd00303 (retropepsin_like)

47M

inhibitor binding site
17D, 19G, 21S, 45F, 46I, 47M, 86I
CDD
cd00303 (retropepsin_like)

86I

inhibitor binding site
17D, 19G, 21S, 45F, 46I, 47M, 86I
CDD
cd00303 (retropepsin_like)
Active site flap c...

45F

Active site flap
45F, 46I, 47M, 48A, 52R, 53V, 54A, 55S
CDD
cd00303 (retropepsin_like)

46I

Active site flap
45F, 46I, 47M, 48A, 52R, 53V, 54A, 55S
CDD
cd00303 (retropepsin_like)

47M

Active site flap
45F, 46I, 47M, 48A, 52R, 53V, 54A, 55S
CDD
cd00303 (retropepsin_like)

48A

Active site flap
45F, 46I, 47M, 48A, 52R, 53V, 54A, 55S
CDD
cd00303 (retropepsin_like)

52R

Active site flap
45F, 46I, 47M, 48A, 52R, 53V, 54A, 55S
CDD
cd00303 (retropepsin_like)

53V

Active site flap
45F, 46I, 47M, 48A, 52R, 53V, 54A, 55S
CDD
cd00303 (retropepsin_like)

54A

Active site flap
45F, 46I, 47M, 48A, 52R, 53V, 54A, 55S
CDD
cd00303 (retropepsin_like)

55S

Active site flap
45F, 46I, 47M, 48A, 52R, 53V, 54A, 55S
CDD
cd00303 (retropepsin_like)
putative NTP bindi...

307D

putative NTP binding site
307D, 308L, 309A, 310S, 311G, 312Y, 341F, 371D
CDD
cd01647 (RT_LTR)

308L

putative NTP binding site
307D, 308L, 309A, 310S, 311G, 312Y, 341F, 371D
CDD
cd01647 (RT_LTR)

309A

putative NTP binding site
307D, 308L, 309A, 310S, 311G, 312Y, 341F, 371D
CDD
cd01647 (RT_LTR)

310S

putative NTP binding site
307D, 308L, 309A, 310S, 311G, 312Y, 341F, 371D
CDD
cd01647 (RT_LTR)

311G

putative NTP binding site
307D, 308L, 309A, 310S, 311G, 312Y, 341F, 371D
CDD
cd01647 (RT_LTR)

312Y

putative NTP binding site
307D, 308L, 309A, 310S, 311G, 312Y, 341F, 371D
CDD
cd01647 (RT_LTR)

341F

putative NTP binding site
307D, 308L, 309A, 310S, 311G, 312Y, 341F, 371D
CDD
cd01647 (RT_LTR)

371D

putative NTP binding site
307D, 308L, 309A, 310S, 311G, 312Y, 341F, 371D
CDD
cd01647 (RT_LTR)
putative active si...

307D

putative active site
307D, 308L, 309A, 310S, 311G, 312Y, 341F, 342G, 369Y, 371D, 372D, 416L, 417G
CDD
cd01647 (RT_LTR)

308L

putative active site
307D, 308L, 309A, 310S, 311G, 312Y, 341F, 342G, 369Y, 371D, 372D, 416L, 417G
CDD
cd01647 (RT_LTR)

309A

putative active site
307D, 308L, 309A, 310S, 311G, 312Y, 341F, 342G, 369Y, 371D, 372D, 416L, 417G
CDD
cd01647 (RT_LTR)

310S

putative active site
307D, 308L, 309A, 310S, 311G, 312Y, 341F, 342G, 369Y, 371D, 372D, 416L, 417G
CDD
cd01647 (RT_LTR)

311G

putative active site
307D, 308L, 309A, 310S, 311G, 312Y, 341F, 342G, 369Y, 371D, 372D, 416L, 417G
CDD
cd01647 (RT_LTR)

312Y

putative active site
307D, 308L, 309A, 310S, 311G, 312Y, 341F, 342G, 369Y, 371D, 372D, 416L, 417G
CDD
cd01647 (RT_LTR)

341F

putative active site
307D, 308L, 309A, 310S, 311G, 312Y, 341F, 342G, 369Y, 371D, 372D, 416L, 417G
CDD
cd01647 (RT_LTR)

342G

putative active site
307D, 308L, 309A, 310S, 311G, 312Y, 341F, 342G, 369Y, 371D, 372D, 416L, 417G
CDD
cd01647 (RT_LTR)

369Y

putative active site
307D, 308L, 309A, 310S, 311G, 312Y, 341F, 342G, 369Y, 371D, 372D, 416L, 417G
CDD
cd01647 (RT_LTR)

371D

putative active site
307D, 308L, 309A, 310S, 311G, 312Y, 341F, 342G, 369Y, 371D, 372D, 416L, 417G
CDD
cd01647 (RT_LTR)

372D

putative active site
307D, 308L, 309A, 310S, 311G, 312Y, 341F, 342G, 369Y, 371D, 372D, 416L, 417G
CDD
cd01647 (RT_LTR)

416L

putative active site
307D, 308L, 309A, 310S, 311G, 312Y, 341F, 342G, 369Y, 371D, 372D, 416L, 417G
CDD
cd01647 (RT_LTR)

417G

putative active site
307D, 308L, 309A, 310S, 311G, 312Y, 341F, 342G, 369Y, 371D, 372D, 416L, 417G
CDD
cd01647 (RT_LTR)
putative nucleic a...

342G

putative nucleic acid binding site
342G
CDD
cd01647 (RT_LTR)
active site cd09274

487D

active site
487D, 529E, 554D, 598D
CDD
cd09274 (RNase_HI_RT_Ty3)

529E

active site
487D, 529E, 554D, 598D
CDD
cd09274 (RNase_HI_RT_Ty3)

554D

active site
487D, 529E, 554D, 598D
CDD
cd09274 (RNase_HI_RT_Ty3)

598D

active site
487D, 529E, 554D, 598D
CDD
cd09274 (RNase_HI_RT_Ty3)
RNA/DNA hybrid bin...

487D

RNA/DNA hybrid binding site
487D, 488A, 489S, 490G, 524P, 525I, 526T, 529E, 554D, 588H, 602R
CDD
cd09274 (RNase_HI_RT_Ty3)

488A

RNA/DNA hybrid binding site
487D, 488A, 489S, 490G, 524P, 525I, 526T, 529E, 554D, 588H, 602R
CDD
cd09274 (RNase_HI_RT_Ty3)

489S

RNA/DNA hybrid binding site
487D, 488A, 489S, 490G, 524P, 525I, 526T, 529E, 554D, 588H, 602R
CDD
cd09274 (RNase_HI_RT_Ty3)

490G

RNA/DNA hybrid binding site
487D, 488A, 489S, 490G, 524P, 525I, 526T, 529E, 554D, 588H, 602R
CDD
cd09274 (RNase_HI_RT_Ty3)

524P

RNA/DNA hybrid binding site
487D, 488A, 489S, 490G, 524P, 525I, 526T, 529E, 554D, 588H, 602R
CDD
cd09274 (RNase_HI_RT_Ty3)

525I

RNA/DNA hybrid binding site
487D, 488A, 489S, 490G, 524P, 525I, 526T, 529E, 554D, 588H, 602R
CDD
cd09274 (RNase_HI_RT_Ty3)

526T

RNA/DNA hybrid binding site
487D, 488A, 489S, 490G, 524P, 525I, 526T, 529E, 554D, 588H, 602R
CDD
cd09274 (RNase_HI_RT_Ty3)

529E

RNA/DNA hybrid binding site
487D, 488A, 489S, 490G, 524P, 525I, 526T, 529E, 554D, 588H, 602R
CDD
cd09274 (RNase_HI_RT_Ty3)

554D

RNA/DNA hybrid binding site
487D, 488A, 489S, 490G, 524P, 525I, 526T, 529E, 554D, 588H, 602R
CDD
cd09274 (RNase_HI_RT_Ty3)

588H

RNA/DNA hybrid binding site
487D, 488A, 489S, 490G, 524P, 525I, 526T, 529E, 554D, 588H, 602R
CDD
cd09274 (RNase_HI_RT_Ty3)

602R

RNA/DNA hybrid binding site
487D, 488A, 489S, 490G, 524P, 525I, 526T, 529E, 554D, 588H, 602R
CDD
cd09274 (RNase_HI_RT_Ty3)

GO term prediction

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0004190 aspartic-type endopeptidase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

GBC54531.1

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component