GBC54329.1

Protein

Length

220 amino acids

Protein family membership

GrpE nucleotide exchange factor (IPR000740)

Domains and repeats

Domain
164 - 218
GrpE nucleotide exchange factor, head (IPR009012)

1 50 100 150 220

Detailed signature matches

IPR000740

GrpE nucleotide exchange factor
1. MF_01151 (GrpE)
  
  41 - 219
  
  HAMAP
  MF_01151 (GrpE)
2. PS01071 (GRPE)
  
  174 - 217
  
  PROSITE patterns
  PS01071 (GRPE)
3. PR00773 (GRPEPROTEIN)
  
  81 - 97
  
  PRINTS
  PR00773 (GRPEPROTEIN)
  
  171 - 186
  
  PRINTS
  PR00773 (GRPEPROTEIN)
  
  198 - 217
  
  PRINTS
  PR00773 (GRPEPROTEIN)
  
  109 - 124
  
  PRINTS
  PR00773 (GRPEPROTEIN)
4. cd00446 (GrpE)
  
  74 - 217
  
  CDD
  cd00446 (GrpE)
5. PF01025 (GrpE)
  
  49 - 218
  
  Pfam
  PF01025 (GrpE)
IPR009012

GrpE nucleotide exchange factor, head
1. SSF51064 (Head doma...)
  
  164 - 218
  
  SUPERFAMILY
  SSF51064 (Head domain of nucleotide exchange factor GrpE)

no IPR

Unintegrated signatures

Coil

73 - 93

COILS
Coil (Coil)
SSF58014 (Coiled-co...)

67 - 163

SUPERFAMILY
SSF58014 (Coiled-coil domain of nucleotide exchange factor GrpE)
mobidb-lite (disord...)

38 - 63

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

dimer interface cd...

76L

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

79S

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

80Y

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

83C

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

84L

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

86D

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

87M

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

90L

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

91R

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

92E

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

94T

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

97E

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

98V

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

101T

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

102A

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

105A

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

106I

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

108K

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

109F

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

112D

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

113L

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

114L

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

116T

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

117V

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

118D

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

119I

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

120L

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

122L

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

123A

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

147G

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

148V

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

150L

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

151T

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

152E

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

155L

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

161R

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)

162H

dimer interface
76L, 79S, 80Y, 83C, 84L, 86D, 87M, 90L, 91R, 92E, 94T, 97E, 98V, 101T, 102A, 105A, 106I, 108K, 109F, 112D, 113L, 114L, 116T, 117V, 118D, 119I, 120L, 122L, 123A, 147G, 148V, 150L, 151T, 152E, 155L, 161R, 162H
CDD
cd00446 (GrpE)
Hsp70 (ATPase doma...

92E

Hsp70 (ATPase domain) interactions
92E, 100S, 122L, 125S, 174F, 176P, 177N, 179H, 180E, 181A, 182I, 183Y, 199Q, 208R, 212P, 214Q, 217V
CDD
cd00446 (GrpE)

100S

Hsp70 (ATPase domain) interactions
92E, 100S, 122L, 125S, 174F, 176P, 177N, 179H, 180E, 181A, 182I, 183Y, 199Q, 208R, 212P, 214Q, 217V
CDD
cd00446 (GrpE)

122L

Hsp70 (ATPase domain) interactions
92E, 100S, 122L, 125S, 174F, 176P, 177N, 179H, 180E, 181A, 182I, 183Y, 199Q, 208R, 212P, 214Q, 217V
CDD
cd00446 (GrpE)

125S

Hsp70 (ATPase domain) interactions
92E, 100S, 122L, 125S, 174F, 176P, 177N, 179H, 180E, 181A, 182I, 183Y, 199Q, 208R, 212P, 214Q, 217V
CDD
cd00446 (GrpE)

174F

Hsp70 (ATPase domain) interactions
92E, 100S, 122L, 125S, 174F, 176P, 177N, 179H, 180E, 181A, 182I, 183Y, 199Q, 208R, 212P, 214Q, 217V
CDD
cd00446 (GrpE)

176P

Hsp70 (ATPase domain) interactions
92E, 100S, 122L, 125S, 174F, 176P, 177N, 179H, 180E, 181A, 182I, 183Y, 199Q, 208R, 212P, 214Q, 217V
CDD
cd00446 (GrpE)

177N

Hsp70 (ATPase domain) interactions
92E, 100S, 122L, 125S, 174F, 176P, 177N, 179H, 180E, 181A, 182I, 183Y, 199Q, 208R, 212P, 214Q, 217V
CDD
cd00446 (GrpE)

179H

Hsp70 (ATPase domain) interactions
92E, 100S, 122L, 125S, 174F, 176P, 177N, 179H, 180E, 181A, 182I, 183Y, 199Q, 208R, 212P, 214Q, 217V
CDD
cd00446 (GrpE)

180E

Hsp70 (ATPase domain) interactions
92E, 100S, 122L, 125S, 174F, 176P, 177N, 179H, 180E, 181A, 182I, 183Y, 199Q, 208R, 212P, 214Q, 217V
CDD
cd00446 (GrpE)

181A

Hsp70 (ATPase domain) interactions
92E, 100S, 122L, 125S, 174F, 176P, 177N, 179H, 180E, 181A, 182I, 183Y, 199Q, 208R, 212P, 214Q, 217V
CDD
cd00446 (GrpE)

182I

Hsp70 (ATPase domain) interactions
92E, 100S, 122L, 125S, 174F, 176P, 177N, 179H, 180E, 181A, 182I, 183Y, 199Q, 208R, 212P, 214Q, 217V
CDD
cd00446 (GrpE)

183Y

Hsp70 (ATPase domain) interactions
92E, 100S, 122L, 125S, 174F, 176P, 177N, 179H, 180E, 181A, 182I, 183Y, 199Q, 208R, 212P, 214Q, 217V
CDD
cd00446 (GrpE)

199Q

Hsp70 (ATPase domain) interactions
92E, 100S, 122L, 125S, 174F, 176P, 177N, 179H, 180E, 181A, 182I, 183Y, 199Q, 208R, 212P, 214Q, 217V
CDD
cd00446 (GrpE)

208R

Hsp70 (ATPase domain) interactions
92E, 100S, 122L, 125S, 174F, 176P, 177N, 179H, 180E, 181A, 182I, 183Y, 199Q, 208R, 212P, 214Q, 217V
CDD
cd00446 (GrpE)

212P

Hsp70 (ATPase domain) interactions
92E, 100S, 122L, 125S, 174F, 176P, 177N, 179H, 180E, 181A, 182I, 183Y, 199Q, 208R, 212P, 214Q, 217V
CDD
cd00446 (GrpE)

214Q

Hsp70 (ATPase domain) interactions
92E, 100S, 122L, 125S, 174F, 176P, 177N, 179H, 180E, 181A, 182I, 183Y, 199Q, 208R, 212P, 214Q, 217V
CDD
cd00446 (GrpE)

217V

Hsp70 (ATPase domain) interactions
92E, 100S, 122L, 125S, 174F, 176P, 177N, 179H, 180E, 181A, 182I, 183Y, 199Q, 208R, 212P, 214Q, 217V
CDD
cd00446 (GrpE)

GO term prediction

Biological Process

GO:0006457 protein folding

Molecular Function

GO:0000774 adenyl-nucleotide exchange factor activity
GO:0042803 protein homodimerization activity
GO:0051087 chaperone binding

Cellular Component

None predicted.

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Entry type

Status

Per-residue features