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Protein

GBC54119.1

Length

1,960 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
133 - 173
Armadillo-type fold (IPR016024)
287 - 453
Armadillo-type fold (IPR016024)
1,390 - 1,586
Armadillo-type fold (IPR016024)
Phosphoinositide 3-kinase, accessory (PIK) domain (IPR001263)
Domain
1,583 - 1,667
Protein kinase-like domain (IPR011009)
1,698 - 1,958
Protein kinase-like domain (IPR011009)
Phosphatidylinositol 3-/4-kinase, catalytic domain (IPR000403)

1 200 400 600 800 1000 1200 1400 1600 1800 1960

Detailed signature matches

IPR016024

Armadillo-type fold

SSF48371 (ARM repeat)

1,390 - 1,561

SUPERFAMILY
SSF48371 (ARM repeat)

287 - 453

SUPERFAMILY
SSF48371 (ARM repeat)

133 - 173

SUPERFAMILY
SSF48371 (ARM repeat)

65 - 94

SUPERFAMILY
SSF48371 (ARM repeat)

IPR001263

Phosphoinositide 3-kinase, accessory (PIK) domain

PS51545 (PIK_HELICAL)

1,396 - 1,572

PROSITE profiles
PS51545 (PIK_HELICAL)
PF00613 (PI3Ka)

1,455 - 1,578

Pfam
PF00613 (PI3Ka)
SM00145 (pi3k_hr2_4)

1,397 - 1,586

SMART
SM00145 (pi3k_hr2_4)

IPR011009

Protein kinase-like domain

SSF56112 (Protein k...)

1,698 - 1,953

SUPERFAMILY
SSF56112 (Protein kinase-like (PK-like))

1,583 - 1,667

SUPERFAMILY
SSF56112 (Protein kinase-like (PK-like))

IPR000403

Phosphatidylinositol 3-/4-kinase, catalytic domain

SM00146 (pi3k_hr1_6)

1,704 - 1,957

SMART
SM00146 (pi3k_hr1_6)
PF00454 (PI3_PI4_ki...)

1,704 - 1,908

Pfam
PF00454 (PI3_PI4_kinase)
PS50290 (PI3_4_KINA...)

1,703 - 1,958

PROSITE profiles
PS50290 (PI3_4_KINASE_3)

IPR018936

Phosphatidylinositol 3/4-kinase, conserved site

PS00916 (PI3_4_KINA...)

1,800 - 1,820

PROSITE patterns
PS00916 (PI3_4_KINASE_2)
PS00915 (PI3_4_KINA...)

1,707 - 1,721

PROSITE patterns
PS00915 (PI3_4_KINASE_1)

no IPR

Unintegrated signatures

cd05167 (PI4Kc_III_...)

1,640 - 1,959

CDD
cd05167 (PI4Kc_III_alpha)

Residue annotation

ATP binding site c...

1,651L

ATP binding site
1,651L, 1,653S, 1,654H, 1,656K, 1,658P, 1,706I, 1,708K, 1,711D, 1,742Y, 1,754I, 1,755D, 1,756V, 1,757I, 1,762S, 1,765Q, 1,820N, 1,822M, 1,832I, 1,833D
CDD
cd05167 (PI4Kc_III_alpha)

1,653S

ATP binding site
1,651L, 1,653S, 1,654H, 1,656K, 1,658P, 1,706I, 1,708K, 1,711D, 1,742Y, 1,754I, 1,755D, 1,756V, 1,757I, 1,762S, 1,765Q, 1,820N, 1,822M, 1,832I, 1,833D
CDD
cd05167 (PI4Kc_III_alpha)

1,654H

ATP binding site
1,651L, 1,653S, 1,654H, 1,656K, 1,658P, 1,706I, 1,708K, 1,711D, 1,742Y, 1,754I, 1,755D, 1,756V, 1,757I, 1,762S, 1,765Q, 1,820N, 1,822M, 1,832I, 1,833D
CDD
cd05167 (PI4Kc_III_alpha)

1,656K

ATP binding site
1,651L, 1,653S, 1,654H, 1,656K, 1,658P, 1,706I, 1,708K, 1,711D, 1,742Y, 1,754I, 1,755D, 1,756V, 1,757I, 1,762S, 1,765Q, 1,820N, 1,822M, 1,832I, 1,833D
CDD
cd05167 (PI4Kc_III_alpha)

1,658P

ATP binding site
1,651L, 1,653S, 1,654H, 1,656K, 1,658P, 1,706I, 1,708K, 1,711D, 1,742Y, 1,754I, 1,755D, 1,756V, 1,757I, 1,762S, 1,765Q, 1,820N, 1,822M, 1,832I, 1,833D
CDD
cd05167 (PI4Kc_III_alpha)

1,706I

ATP binding site
1,651L, 1,653S, 1,654H, 1,656K, 1,658P, 1,706I, 1,708K, 1,711D, 1,742Y, 1,754I, 1,755D, 1,756V, 1,757I, 1,762S, 1,765Q, 1,820N, 1,822M, 1,832I, 1,833D
CDD
cd05167 (PI4Kc_III_alpha)

1,708K

ATP binding site
1,651L, 1,653S, 1,654H, 1,656K, 1,658P, 1,706I, 1,708K, 1,711D, 1,742Y, 1,754I, 1,755D, 1,756V, 1,757I, 1,762S, 1,765Q, 1,820N, 1,822M, 1,832I, 1,833D
CDD
cd05167 (PI4Kc_III_alpha)

1,711D

ATP binding site
1,651L, 1,653S, 1,654H, 1,656K, 1,658P, 1,706I, 1,708K, 1,711D, 1,742Y, 1,754I, 1,755D, 1,756V, 1,757I, 1,762S, 1,765Q, 1,820N, 1,822M, 1,832I, 1,833D
CDD
cd05167 (PI4Kc_III_alpha)

1,742Y

ATP binding site
1,651L, 1,653S, 1,654H, 1,656K, 1,658P, 1,706I, 1,708K, 1,711D, 1,742Y, 1,754I, 1,755D, 1,756V, 1,757I, 1,762S, 1,765Q, 1,820N, 1,822M, 1,832I, 1,833D
CDD
cd05167 (PI4Kc_III_alpha)

1,754I

ATP binding site
1,651L, 1,653S, 1,654H, 1,656K, 1,658P, 1,706I, 1,708K, 1,711D, 1,742Y, 1,754I, 1,755D, 1,756V, 1,757I, 1,762S, 1,765Q, 1,820N, 1,822M, 1,832I, 1,833D
CDD
cd05167 (PI4Kc_III_alpha)

1,755D

ATP binding site
1,651L, 1,653S, 1,654H, 1,656K, 1,658P, 1,706I, 1,708K, 1,711D, 1,742Y, 1,754I, 1,755D, 1,756V, 1,757I, 1,762S, 1,765Q, 1,820N, 1,822M, 1,832I, 1,833D
CDD
cd05167 (PI4Kc_III_alpha)

1,756V

ATP binding site
1,651L, 1,653S, 1,654H, 1,656K, 1,658P, 1,706I, 1,708K, 1,711D, 1,742Y, 1,754I, 1,755D, 1,756V, 1,757I, 1,762S, 1,765Q, 1,820N, 1,822M, 1,832I, 1,833D
CDD
cd05167 (PI4Kc_III_alpha)

1,757I

ATP binding site
1,651L, 1,653S, 1,654H, 1,656K, 1,658P, 1,706I, 1,708K, 1,711D, 1,742Y, 1,754I, 1,755D, 1,756V, 1,757I, 1,762S, 1,765Q, 1,820N, 1,822M, 1,832I, 1,833D
CDD
cd05167 (PI4Kc_III_alpha)

1,762S

ATP binding site
1,651L, 1,653S, 1,654H, 1,656K, 1,658P, 1,706I, 1,708K, 1,711D, 1,742Y, 1,754I, 1,755D, 1,756V, 1,757I, 1,762S, 1,765Q, 1,820N, 1,822M, 1,832I, 1,833D
CDD
cd05167 (PI4Kc_III_alpha)

1,765Q

ATP binding site
1,651L, 1,653S, 1,654H, 1,656K, 1,658P, 1,706I, 1,708K, 1,711D, 1,742Y, 1,754I, 1,755D, 1,756V, 1,757I, 1,762S, 1,765Q, 1,820N, 1,822M, 1,832I, 1,833D
CDD
cd05167 (PI4Kc_III_alpha)

1,820N

ATP binding site
1,651L, 1,653S, 1,654H, 1,656K, 1,658P, 1,706I, 1,708K, 1,711D, 1,742Y, 1,754I, 1,755D, 1,756V, 1,757I, 1,762S, 1,765Q, 1,820N, 1,822M, 1,832I, 1,833D
CDD
cd05167 (PI4Kc_III_alpha)

1,822M

ATP binding site
1,651L, 1,653S, 1,654H, 1,656K, 1,658P, 1,706I, 1,708K, 1,711D, 1,742Y, 1,754I, 1,755D, 1,756V, 1,757I, 1,762S, 1,765Q, 1,820N, 1,822M, 1,832I, 1,833D
CDD
cd05167 (PI4Kc_III_alpha)

1,832I

ATP binding site
1,651L, 1,653S, 1,654H, 1,656K, 1,658P, 1,706I, 1,708K, 1,711D, 1,742Y, 1,754I, 1,755D, 1,756V, 1,757I, 1,762S, 1,765Q, 1,820N, 1,822M, 1,832I, 1,833D
CDD
cd05167 (PI4Kc_III_alpha)

1,833D

ATP binding site
1,651L, 1,653S, 1,654H, 1,656K, 1,658P, 1,706I, 1,708K, 1,711D, 1,742Y, 1,754I, 1,755D, 1,756V, 1,757I, 1,762S, 1,765Q, 1,820N, 1,822M, 1,832I, 1,833D
CDD
cd05167 (PI4Kc_III_alpha)
catalytic loop cd0...

1,812Q

catalytic loop
1,812Q, 1,813I, 1,814K, 1,815D, 1,816R, 1,817H, 1,818N, 1,819G, 1,820N
CDD
cd05167 (PI4Kc_III_alpha)

1,813I

catalytic loop
1,812Q, 1,813I, 1,814K, 1,815D, 1,816R, 1,817H, 1,818N, 1,819G, 1,820N
CDD
cd05167 (PI4Kc_III_alpha)

1,814K

catalytic loop
1,812Q, 1,813I, 1,814K, 1,815D, 1,816R, 1,817H, 1,818N, 1,819G, 1,820N
CDD
cd05167 (PI4Kc_III_alpha)

1,815D

catalytic loop
1,812Q, 1,813I, 1,814K, 1,815D, 1,816R, 1,817H, 1,818N, 1,819G, 1,820N
CDD
cd05167 (PI4Kc_III_alpha)

1,816R

catalytic loop
1,812Q, 1,813I, 1,814K, 1,815D, 1,816R, 1,817H, 1,818N, 1,819G, 1,820N
CDD
cd05167 (PI4Kc_III_alpha)

1,817H

catalytic loop
1,812Q, 1,813I, 1,814K, 1,815D, 1,816R, 1,817H, 1,818N, 1,819G, 1,820N
CDD
cd05167 (PI4Kc_III_alpha)

1,818N

catalytic loop
1,812Q, 1,813I, 1,814K, 1,815D, 1,816R, 1,817H, 1,818N, 1,819G, 1,820N
CDD
cd05167 (PI4Kc_III_alpha)

1,819G

catalytic loop
1,812Q, 1,813I, 1,814K, 1,815D, 1,816R, 1,817H, 1,818N, 1,819G, 1,820N
CDD
cd05167 (PI4Kc_III_alpha)

1,820N

catalytic loop
1,812Q, 1,813I, 1,814K, 1,815D, 1,816R, 1,817H, 1,818N, 1,819G, 1,820N
CDD
cd05167 (PI4Kc_III_alpha)
activation loop (A...

1,833D

activation loop (A-loop)
1,833D, 1,834F, 1,835G, 1,836F, 1,837I, 1,838L, 1,839D, 1,840I, 1,841A, 1,842P, 1,843G, 1,845I, 1,846T, 1,847F, 1,848E, 1,850S, 1,851P, 1,852F, 1,853K, 1,854L, 1,855T
CDD
cd05167 (PI4Kc_III_alpha)

1,834F

activation loop (A-loop)
1,833D, 1,834F, 1,835G, 1,836F, 1,837I, 1,838L, 1,839D, 1,840I, 1,841A, 1,842P, 1,843G, 1,845I, 1,846T, 1,847F, 1,848E, 1,850S, 1,851P, 1,852F, 1,853K, 1,854L, 1,855T
CDD
cd05167 (PI4Kc_III_alpha)

1,835G

activation loop (A-loop)
1,833D, 1,834F, 1,835G, 1,836F, 1,837I, 1,838L, 1,839D, 1,840I, 1,841A, 1,842P, 1,843G, 1,845I, 1,846T, 1,847F, 1,848E, 1,850S, 1,851P, 1,852F, 1,853K, 1,854L, 1,855T
CDD
cd05167 (PI4Kc_III_alpha)

1,836F

activation loop (A-loop)
1,833D, 1,834F, 1,835G, 1,836F, 1,837I, 1,838L, 1,839D, 1,840I, 1,841A, 1,842P, 1,843G, 1,845I, 1,846T, 1,847F, 1,848E, 1,850S, 1,851P, 1,852F, 1,853K, 1,854L, 1,855T
CDD
cd05167 (PI4Kc_III_alpha)

1,837I

activation loop (A-loop)
1,833D, 1,834F, 1,835G, 1,836F, 1,837I, 1,838L, 1,839D, 1,840I, 1,841A, 1,842P, 1,843G, 1,845I, 1,846T, 1,847F, 1,848E, 1,850S, 1,851P, 1,852F, 1,853K, 1,854L, 1,855T
CDD
cd05167 (PI4Kc_III_alpha)

1,838L

activation loop (A-loop)
1,833D, 1,834F, 1,835G, 1,836F, 1,837I, 1,838L, 1,839D, 1,840I, 1,841A, 1,842P, 1,843G, 1,845I, 1,846T, 1,847F, 1,848E, 1,850S, 1,851P, 1,852F, 1,853K, 1,854L, 1,855T
CDD
cd05167 (PI4Kc_III_alpha)

1,839D

activation loop (A-loop)
1,833D, 1,834F, 1,835G, 1,836F, 1,837I, 1,838L, 1,839D, 1,840I, 1,841A, 1,842P, 1,843G, 1,845I, 1,846T, 1,847F, 1,848E, 1,850S, 1,851P, 1,852F, 1,853K, 1,854L, 1,855T
CDD
cd05167 (PI4Kc_III_alpha)

1,840I

activation loop (A-loop)
1,833D, 1,834F, 1,835G, 1,836F, 1,837I, 1,838L, 1,839D, 1,840I, 1,841A, 1,842P, 1,843G, 1,845I, 1,846T, 1,847F, 1,848E, 1,850S, 1,851P, 1,852F, 1,853K, 1,854L, 1,855T
CDD
cd05167 (PI4Kc_III_alpha)

1,841A

activation loop (A-loop)
1,833D, 1,834F, 1,835G, 1,836F, 1,837I, 1,838L, 1,839D, 1,840I, 1,841A, 1,842P, 1,843G, 1,845I, 1,846T, 1,847F, 1,848E, 1,850S, 1,851P, 1,852F, 1,853K, 1,854L, 1,855T
CDD
cd05167 (PI4Kc_III_alpha)

1,842P

activation loop (A-loop)
1,833D, 1,834F, 1,835G, 1,836F, 1,837I, 1,838L, 1,839D, 1,840I, 1,841A, 1,842P, 1,843G, 1,845I, 1,846T, 1,847F, 1,848E, 1,850S, 1,851P, 1,852F, 1,853K, 1,854L, 1,855T
CDD
cd05167 (PI4Kc_III_alpha)

1,843G

activation loop (A-loop)
1,833D, 1,834F, 1,835G, 1,836F, 1,837I, 1,838L, 1,839D, 1,840I, 1,841A, 1,842P, 1,843G, 1,845I, 1,846T, 1,847F, 1,848E, 1,850S, 1,851P, 1,852F, 1,853K, 1,854L, 1,855T
CDD
cd05167 (PI4Kc_III_alpha)

1,845I

activation loop (A-loop)
1,833D, 1,834F, 1,835G, 1,836F, 1,837I, 1,838L, 1,839D, 1,840I, 1,841A, 1,842P, 1,843G, 1,845I, 1,846T, 1,847F, 1,848E, 1,850S, 1,851P, 1,852F, 1,853K, 1,854L, 1,855T
CDD
cd05167 (PI4Kc_III_alpha)

1,846T

activation loop (A-loop)
1,833D, 1,834F, 1,835G, 1,836F, 1,837I, 1,838L, 1,839D, 1,840I, 1,841A, 1,842P, 1,843G, 1,845I, 1,846T, 1,847F, 1,848E, 1,850S, 1,851P, 1,852F, 1,853K, 1,854L, 1,855T
CDD
cd05167 (PI4Kc_III_alpha)

1,847F

activation loop (A-loop)
1,833D, 1,834F, 1,835G, 1,836F, 1,837I, 1,838L, 1,839D, 1,840I, 1,841A, 1,842P, 1,843G, 1,845I, 1,846T, 1,847F, 1,848E, 1,850S, 1,851P, 1,852F, 1,853K, 1,854L, 1,855T
CDD
cd05167 (PI4Kc_III_alpha)

1,848E

activation loop (A-loop)
1,833D, 1,834F, 1,835G, 1,836F, 1,837I, 1,838L, 1,839D, 1,840I, 1,841A, 1,842P, 1,843G, 1,845I, 1,846T, 1,847F, 1,848E, 1,850S, 1,851P, 1,852F, 1,853K, 1,854L, 1,855T
CDD
cd05167 (PI4Kc_III_alpha)

1,850S

activation loop (A-loop)
1,833D, 1,834F, 1,835G, 1,836F, 1,837I, 1,838L, 1,839D, 1,840I, 1,841A, 1,842P, 1,843G, 1,845I, 1,846T, 1,847F, 1,848E, 1,850S, 1,851P, 1,852F, 1,853K, 1,854L, 1,855T
CDD
cd05167 (PI4Kc_III_alpha)

1,851P

activation loop (A-loop)
1,833D, 1,834F, 1,835G, 1,836F, 1,837I, 1,838L, 1,839D, 1,840I, 1,841A, 1,842P, 1,843G, 1,845I, 1,846T, 1,847F, 1,848E, 1,850S, 1,851P, 1,852F, 1,853K, 1,854L, 1,855T
CDD
cd05167 (PI4Kc_III_alpha)

1,852F

activation loop (A-loop)
1,833D, 1,834F, 1,835G, 1,836F, 1,837I, 1,838L, 1,839D, 1,840I, 1,841A, 1,842P, 1,843G, 1,845I, 1,846T, 1,847F, 1,848E, 1,850S, 1,851P, 1,852F, 1,853K, 1,854L, 1,855T
CDD
cd05167 (PI4Kc_III_alpha)

1,853K

activation loop (A-loop)
1,833D, 1,834F, 1,835G, 1,836F, 1,837I, 1,838L, 1,839D, 1,840I, 1,841A, 1,842P, 1,843G, 1,845I, 1,846T, 1,847F, 1,848E, 1,850S, 1,851P, 1,852F, 1,853K, 1,854L, 1,855T
CDD
cd05167 (PI4Kc_III_alpha)

1,854L

activation loop (A-loop)
1,833D, 1,834F, 1,835G, 1,836F, 1,837I, 1,838L, 1,839D, 1,840I, 1,841A, 1,842P, 1,843G, 1,845I, 1,846T, 1,847F, 1,848E, 1,850S, 1,851P, 1,852F, 1,853K, 1,854L, 1,855T
CDD
cd05167 (PI4Kc_III_alpha)

1,855T

activation loop (A-loop)
1,833D, 1,834F, 1,835G, 1,836F, 1,837I, 1,838L, 1,839D, 1,840I, 1,841A, 1,842P, 1,843G, 1,845I, 1,846T, 1,847F, 1,848E, 1,850S, 1,851P, 1,852F, 1,853K, 1,854L, 1,855T
CDD
cd05167 (PI4Kc_III_alpha)

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0005488 binding
GO:0016301 kinase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

GBC54119.1

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component