Filter view on

Protein

GBC53937.1

Length

1,422 amino acids

Protein family membership

Haem peroxidase (IPR010255)
- Haem peroxidase, animal (IPR019791)

Domains and repeats

Domain
598 - 715
DOMON domain (IPR005018)
1,098 - 1,208
Riboflavin synthase-like beta-barrel (IPR017938)
Ferredoxin reductase-type FAD-binding domain (IPR017927)
Oxidoreductase, FAD-binding domain (IPR008333)
Domain
715 - 913
Cytochrome b561/ferric reductase transmembrane (IPR006593)
933 - 1,022
Cytochrome b5-like heme/steroid binding domain (IPR001199)
1,263 - 1,403
Oxidoreductase FAD/NAD(P)-binding (IPR001433)

1 200 400 600 800 1000 1200 1422

Detailed signature matches

IPR010255

Haem peroxidase

SSF48113 (Heme-depe...)

34 - 571

SUPERFAMILY
SSF48113 (Heme-dependent peroxidases)

IPR019791

Haem peroxidase, animal

PF03098 (An_peroxidase)

37 - 562

Pfam
PF03098 (An_peroxidase)
PS50292 (PEROXIDASE_3)

28 - 600

PROSITE profiles
PS50292 (PEROXIDASE_3)
PR00457 (ANPEROXIDASE)

355 - 365

PRINTS
PR00457 (ANPEROXIDASE)

306 - 332

PRINTS
PR00457 (ANPEROXIDASE)

141 - 156

PRINTS
PR00457 (ANPEROXIDASE)

471 - 491

PRINTS
PR00457 (ANPEROXIDASE)

IPR005018

DOMON domain

PF03351 (DOMON)

599 - 712

Pfam
PF03351 (DOMON)
PS50836 (DOMON)

598 - 715

PROSITE profiles
PS50836 (DOMON)
SM00664 (DOMON_3)

623 - 713

SMART
SM00664 (DOMON_3)

IPR006593

Cytochrome b561/ferric reductase transmembrane

PS50939 (CYTOCHROME...)

715 - 913

PROSITE profiles
PS50939 (CYTOCHROME_B561)
SM00665 (561_7)

752 - 877

SMART
SM00665 (561_7)

IPR001199

Cytochrome b5-like heme/steroid binding domain

PS50255 (CYTOCHROME...)

936 - 1,022

PROSITE profiles
PS50255 (CYTOCHROME_B5_2)
PF00173 (Cyt-b5)

941 - 990

Pfam
PF00173 (Cyt-b5)
SSF55856 (Cytochrom...)

933 - 991

SUPERFAMILY
SSF55856 (Cytochrome b5-like heme/steroid binding domain)

IPR017938

Riboflavin synthase-like beta-barrel

SSF63380 (Riboflavi...)

1,098 - 1,202

SUPERFAMILY
SSF63380 (Riboflavin synthase domain-like)

IPR017927

Ferredoxin reductase-type FAD-binding domain

PS51384 (FAD_FR)

1,101 - 1,208

PROSITE profiles
PS51384 (FAD_FR)

IPR008333

Oxidoreductase, FAD-binding domain

PF00970 (FAD_binding_6)

1,115 - 1,202

Pfam
PF00970 (FAD_binding_6)

IPR001433

Oxidoreductase FAD/NAD(P)-binding

PF00175 (NAD_binding_1)

1,263 - 1,403

Pfam
PF00175 (NAD_binding_1)

no IPR

Unintegrated signatures

SSF52343 (Ferredoxi...)

1,372 - 1,416

SUPERFAMILY
SSF52343 (Ferredoxin reductase-like, C-terminal NADP-linked domain)

1,261 - 1,336

SUPERFAMILY
SSF52343 (Ferredoxin reductase-like, C-terminal NADP-linked domain)
cd06183 (cyt_b5_red...)

1,106 - 1,413

CDD
cd06183 (cyt_b5_reduct_like)
cd08760 (Cyt_b561_F...)

725 - 903

CDD
cd08760 (Cyt_b561_FRRS1_like)
cd09631 (DOMON_DOH)

594 - 727

CDD
cd09631 (DOMON_DOH)

Residue annotation

putative ligand bi...

623W

putative ligand binding site
623W, 625G, 626L, 639D, 640I, 641V, 700P, 702T, 709I, 722H
CDD
cd09631 (DOMON_DOH)

625G

putative ligand binding site
623W, 625G, 626L, 639D, 640I, 641V, 700P, 702T, 709I, 722H
CDD
cd09631 (DOMON_DOH)

626L

putative ligand binding site
623W, 625G, 626L, 639D, 640I, 641V, 700P, 702T, 709I, 722H
CDD
cd09631 (DOMON_DOH)

639D

putative ligand binding site
623W, 625G, 626L, 639D, 640I, 641V, 700P, 702T, 709I, 722H
CDD
cd09631 (DOMON_DOH)

640I

putative ligand binding site
623W, 625G, 626L, 639D, 640I, 641V, 700P, 702T, 709I, 722H
CDD
cd09631 (DOMON_DOH)

641V

putative ligand binding site
623W, 625G, 626L, 639D, 640I, 641V, 700P, 702T, 709I, 722H
CDD
cd09631 (DOMON_DOH)

700P

putative ligand binding site
623W, 625G, 626L, 639D, 640I, 641V, 700P, 702T, 709I, 722H
CDD
cd09631 (DOMON_DOH)

702T

putative ligand binding site
623W, 625G, 626L, 639D, 640I, 641V, 700P, 702T, 709I, 722H
CDD
cd09631 (DOMON_DOH)

709I

putative ligand binding site
623W, 625G, 626L, 639D, 640I, 641V, 700P, 702T, 709I, 722H
CDD
cd09631 (DOMON_DOH)

722H

putative ligand binding site
623W, 625G, 626L, 639D, 640I, 641V, 700P, 702T, 709I, 722H
CDD
cd09631 (DOMON_DOH)
putative heme bind...

753H

putative heme binding sites
753H, 785H, 815H, 858H
CDD
cd08760 (Cyt_b561_FRRS1_like)

785H

putative heme binding sites
753H, 785H, 815H, 858H
CDD
cd08760 (Cyt_b561_FRRS1_like)

815H

putative heme binding sites
753H, 785H, 815H, 858H
CDD
cd08760 (Cyt_b561_FRRS1_like)

858H

putative heme binding sites
753H, 785H, 815H, 858H
CDD
cd08760 (Cyt_b561_FRRS1_like)
FAD binding pocket...

1,144Y

FAD binding pocket
1,144Y, 1,158R, 1,159S, 1,160Y, 1,161T, 1,174I, 1,175I, 1,176R, 1,178Y, 1,180E, 1,181G, 1,182L, 1,183M, 1,184S, 1,268T, 1,271T, 1,272P
CDD
cd06183 (cyt_b5_reduct_like)

1,158R

FAD binding pocket
1,144Y, 1,158R, 1,159S, 1,160Y, 1,161T, 1,174I, 1,175I, 1,176R, 1,178Y, 1,180E, 1,181G, 1,182L, 1,183M, 1,184S, 1,268T, 1,271T, 1,272P
CDD
cd06183 (cyt_b5_reduct_like)

1,159S

FAD binding pocket
1,144Y, 1,158R, 1,159S, 1,160Y, 1,161T, 1,174I, 1,175I, 1,176R, 1,178Y, 1,180E, 1,181G, 1,182L, 1,183M, 1,184S, 1,268T, 1,271T, 1,272P
CDD
cd06183 (cyt_b5_reduct_like)

1,160Y

FAD binding pocket
1,144Y, 1,158R, 1,159S, 1,160Y, 1,161T, 1,174I, 1,175I, 1,176R, 1,178Y, 1,180E, 1,181G, 1,182L, 1,183M, 1,184S, 1,268T, 1,271T, 1,272P
CDD
cd06183 (cyt_b5_reduct_like)

1,161T

FAD binding pocket
1,144Y, 1,158R, 1,159S, 1,160Y, 1,161T, 1,174I, 1,175I, 1,176R, 1,178Y, 1,180E, 1,181G, 1,182L, 1,183M, 1,184S, 1,268T, 1,271T, 1,272P
CDD
cd06183 (cyt_b5_reduct_like)

1,174I

FAD binding pocket
1,144Y, 1,158R, 1,159S, 1,160Y, 1,161T, 1,174I, 1,175I, 1,176R, 1,178Y, 1,180E, 1,181G, 1,182L, 1,183M, 1,184S, 1,268T, 1,271T, 1,272P
CDD
cd06183 (cyt_b5_reduct_like)

1,175I

FAD binding pocket
1,144Y, 1,158R, 1,159S, 1,160Y, 1,161T, 1,174I, 1,175I, 1,176R, 1,178Y, 1,180E, 1,181G, 1,182L, 1,183M, 1,184S, 1,268T, 1,271T, 1,272P
CDD
cd06183 (cyt_b5_reduct_like)

1,176R

FAD binding pocket
1,144Y, 1,158R, 1,159S, 1,160Y, 1,161T, 1,174I, 1,175I, 1,176R, 1,178Y, 1,180E, 1,181G, 1,182L, 1,183M, 1,184S, 1,268T, 1,271T, 1,272P
CDD
cd06183 (cyt_b5_reduct_like)

1,178Y

FAD binding pocket
1,144Y, 1,158R, 1,159S, 1,160Y, 1,161T, 1,174I, 1,175I, 1,176R, 1,178Y, 1,180E, 1,181G, 1,182L, 1,183M, 1,184S, 1,268T, 1,271T, 1,272P
CDD
cd06183 (cyt_b5_reduct_like)

1,180E

FAD binding pocket
1,144Y, 1,158R, 1,159S, 1,160Y, 1,161T, 1,174I, 1,175I, 1,176R, 1,178Y, 1,180E, 1,181G, 1,182L, 1,183M, 1,184S, 1,268T, 1,271T, 1,272P
CDD
cd06183 (cyt_b5_reduct_like)

1,181G

FAD binding pocket
1,144Y, 1,158R, 1,159S, 1,160Y, 1,161T, 1,174I, 1,175I, 1,176R, 1,178Y, 1,180E, 1,181G, 1,182L, 1,183M, 1,184S, 1,268T, 1,271T, 1,272P
CDD
cd06183 (cyt_b5_reduct_like)

1,182L

FAD binding pocket
1,144Y, 1,158R, 1,159S, 1,160Y, 1,161T, 1,174I, 1,175I, 1,176R, 1,178Y, 1,180E, 1,181G, 1,182L, 1,183M, 1,184S, 1,268T, 1,271T, 1,272P
CDD
cd06183 (cyt_b5_reduct_like)

1,183M

FAD binding pocket
1,144Y, 1,158R, 1,159S, 1,160Y, 1,161T, 1,174I, 1,175I, 1,176R, 1,178Y, 1,180E, 1,181G, 1,182L, 1,183M, 1,184S, 1,268T, 1,271T, 1,272P
CDD
cd06183 (cyt_b5_reduct_like)

1,184S

FAD binding pocket
1,144Y, 1,158R, 1,159S, 1,160Y, 1,161T, 1,174I, 1,175I, 1,176R, 1,178Y, 1,180E, 1,181G, 1,182L, 1,183M, 1,184S, 1,268T, 1,271T, 1,272P
CDD
cd06183 (cyt_b5_reduct_like)

1,268T

FAD binding pocket
1,144Y, 1,158R, 1,159S, 1,160Y, 1,161T, 1,174I, 1,175I, 1,176R, 1,178Y, 1,180E, 1,181G, 1,182L, 1,183M, 1,184S, 1,268T, 1,271T, 1,272P
CDD
cd06183 (cyt_b5_reduct_like)

1,271T

FAD binding pocket
1,144Y, 1,158R, 1,159S, 1,160Y, 1,161T, 1,174I, 1,175I, 1,176R, 1,178Y, 1,180E, 1,181G, 1,182L, 1,183M, 1,184S, 1,268T, 1,271T, 1,272P
CDD
cd06183 (cyt_b5_reduct_like)

1,272P

FAD binding pocket
1,144Y, 1,158R, 1,159S, 1,160Y, 1,161T, 1,174I, 1,175I, 1,176R, 1,178Y, 1,180E, 1,181G, 1,182L, 1,183M, 1,184S, 1,268T, 1,271T, 1,272P
CDD
cd06183 (cyt_b5_reduct_like)
FAD binding motif ...

1,158R

FAD binding motif
1,158R, 1,160Y, 1,161T
CDD
cd06183 (cyt_b5_reduct_like)

1,160Y

FAD binding motif
1,158R, 1,160Y, 1,161T
CDD
cd06183 (cyt_b5_reduct_like)

1,161T

FAD binding motif
1,158R, 1,160Y, 1,161T
CDD
cd06183 (cyt_b5_reduct_like)
NAD binding pocket...

1,176R

NAD binding pocket
1,176R, 1,178Y, 1,268T, 1,269G, 1,299A, 1,300N, 1,301E, 1,330T, 1,342H, 1,395G, 1,396P, 1,397P, 1,398L, 1,399M
CDD
cd06183 (cyt_b5_reduct_like)

1,178Y

NAD binding pocket
1,176R, 1,178Y, 1,268T, 1,269G, 1,299A, 1,300N, 1,301E, 1,330T, 1,342H, 1,395G, 1,396P, 1,397P, 1,398L, 1,399M
CDD
cd06183 (cyt_b5_reduct_like)

1,268T

NAD binding pocket
1,176R, 1,178Y, 1,268T, 1,269G, 1,299A, 1,300N, 1,301E, 1,330T, 1,342H, 1,395G, 1,396P, 1,397P, 1,398L, 1,399M
CDD
cd06183 (cyt_b5_reduct_like)

1,269G

NAD binding pocket
1,176R, 1,178Y, 1,268T, 1,269G, 1,299A, 1,300N, 1,301E, 1,330T, 1,342H, 1,395G, 1,396P, 1,397P, 1,398L, 1,399M
CDD
cd06183 (cyt_b5_reduct_like)

1,299A

NAD binding pocket
1,176R, 1,178Y, 1,268T, 1,269G, 1,299A, 1,300N, 1,301E, 1,330T, 1,342H, 1,395G, 1,396P, 1,397P, 1,398L, 1,399M
CDD
cd06183 (cyt_b5_reduct_like)

1,300N

NAD binding pocket
1,176R, 1,178Y, 1,268T, 1,269G, 1,299A, 1,300N, 1,301E, 1,330T, 1,342H, 1,395G, 1,396P, 1,397P, 1,398L, 1,399M
CDD
cd06183 (cyt_b5_reduct_like)

1,301E

NAD binding pocket
1,176R, 1,178Y, 1,268T, 1,269G, 1,299A, 1,300N, 1,301E, 1,330T, 1,342H, 1,395G, 1,396P, 1,397P, 1,398L, 1,399M
CDD
cd06183 (cyt_b5_reduct_like)

1,330T

NAD binding pocket
1,176R, 1,178Y, 1,268T, 1,269G, 1,299A, 1,300N, 1,301E, 1,330T, 1,342H, 1,395G, 1,396P, 1,397P, 1,398L, 1,399M
CDD
cd06183 (cyt_b5_reduct_like)

1,342H

NAD binding pocket
1,176R, 1,178Y, 1,268T, 1,269G, 1,299A, 1,300N, 1,301E, 1,330T, 1,342H, 1,395G, 1,396P, 1,397P, 1,398L, 1,399M
CDD
cd06183 (cyt_b5_reduct_like)

1,395G

NAD binding pocket
1,176R, 1,178Y, 1,268T, 1,269G, 1,299A, 1,300N, 1,301E, 1,330T, 1,342H, 1,395G, 1,396P, 1,397P, 1,398L, 1,399M
CDD
cd06183 (cyt_b5_reduct_like)

1,396P

NAD binding pocket
1,176R, 1,178Y, 1,268T, 1,269G, 1,299A, 1,300N, 1,301E, 1,330T, 1,342H, 1,395G, 1,396P, 1,397P, 1,398L, 1,399M
CDD
cd06183 (cyt_b5_reduct_like)

1,397P

NAD binding pocket
1,176R, 1,178Y, 1,268T, 1,269G, 1,299A, 1,300N, 1,301E, 1,330T, 1,342H, 1,395G, 1,396P, 1,397P, 1,398L, 1,399M
CDD
cd06183 (cyt_b5_reduct_like)

1,398L

NAD binding pocket
1,176R, 1,178Y, 1,268T, 1,269G, 1,299A, 1,300N, 1,301E, 1,330T, 1,342H, 1,395G, 1,396P, 1,397P, 1,398L, 1,399M
CDD
cd06183 (cyt_b5_reduct_like)

1,399M

NAD binding pocket
1,176R, 1,178Y, 1,268T, 1,269G, 1,299A, 1,300N, 1,301E, 1,330T, 1,342H, 1,395G, 1,396P, 1,397P, 1,398L, 1,399M
CDD
cd06183 (cyt_b5_reduct_like)
phosphate binding ...

1,181G

phosphate binding motif
1,181G, 1,184S, 1,187L, 1,193G, 1,201P, 1,230S
CDD
cd06183 (cyt_b5_reduct_like)

1,184S

phosphate binding motif
1,181G, 1,184S, 1,187L, 1,193G, 1,201P, 1,230S
CDD
cd06183 (cyt_b5_reduct_like)

1,187L

phosphate binding motif
1,181G, 1,184S, 1,187L, 1,193G, 1,201P, 1,230S
CDD
cd06183 (cyt_b5_reduct_like)

1,193G

phosphate binding motif
1,181G, 1,184S, 1,187L, 1,193G, 1,201P, 1,230S
CDD
cd06183 (cyt_b5_reduct_like)

1,201P

phosphate binding motif
1,181G, 1,184S, 1,187L, 1,193G, 1,201P, 1,230S
CDD
cd06183 (cyt_b5_reduct_like)

1,230S

phosphate binding motif
1,181G, 1,184S, 1,187L, 1,193G, 1,201P, 1,230S
CDD
cd06183 (cyt_b5_reduct_like)
beta-alpha-beta st...

1,263M

beta-alpha-beta structure motif
1,263M, 1,267G, 1,268T, 1,269G, 1,270I, 1,272P
CDD
cd06183 (cyt_b5_reduct_like)

1,267G

beta-alpha-beta structure motif
1,263M, 1,267G, 1,268T, 1,269G, 1,270I, 1,272P
CDD
cd06183 (cyt_b5_reduct_like)

1,268T

beta-alpha-beta structure motif
1,263M, 1,267G, 1,268T, 1,269G, 1,270I, 1,272P
CDD
cd06183 (cyt_b5_reduct_like)

1,269G

beta-alpha-beta structure motif
1,263M, 1,267G, 1,268T, 1,269G, 1,270I, 1,272P
CDD
cd06183 (cyt_b5_reduct_like)

1,270I

beta-alpha-beta structure motif
1,263M, 1,267G, 1,268T, 1,269G, 1,270I, 1,272P
CDD
cd06183 (cyt_b5_reduct_like)

1,272P

beta-alpha-beta structure motif
1,263M, 1,267G, 1,268T, 1,269G, 1,270I, 1,272P
CDD
cd06183 (cyt_b5_reduct_like)

GO term prediction

Biological Process

GO:0006979 response to oxidative stress
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004601 peroxidase activity
GO:0016491 oxidoreductase activity
GO:0020037 heme binding

Cellular Component

None predicted.