GBC53863.1

Protein

Length

1,760 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
5 - 457
DNA topoisomerase, type IA, core domain (IPR023405)
Domain
7 - 103
DNA topoisomerase, type IA, domain 2 (IPR003601)
740 - 1,061
Armadillo-type fold (IPR016024)
1,091 - 1,389
Armadillo-type fold (IPR016024)
1,392 - 1,720
Armadillo-type fold (IPR016024)
Domain
31 - 457
DNA topoisomerase, type IA, central (IPR013497)
829 - 944
Exportin-1/Importin-beta-like (IPR013598)
Domain
151 - 407
DNA topoisomerase, type IA, DNA-binding domain (IPR003602)
751 - 817
Importin-beta, N-terminal domain (IPR001494)
1,392 - 1,716
CRM1 C-terminal domain (IPR014877)

1 200 400 600 800 1000 1200 1400 1600 1760

Detailed signature matches

IPR023405

DNA topoisomerase, type IA, core domain
1. SSF56712 (Prokaryot...)
  
  5 - 457
  
  SUPERFAMILY
  SSF56712 (Prokaryotic type I DNA topoisomerase)
IPR003601

DNA topoisomerase, type IA, domain 2
1. SM00436 (topIban2)
  
  7 - 103
  
  SMART
  SM00436 (topIban2)
IPR013497

DNA topoisomerase, type IA, central
1. PR00417 (PRTPISMRASEI)
  
  268 - 284
  
  PRINTS
  PR00417 (PRTPISMRASEI)
  
  366 - 380
  
  PRINTS
  PR00417 (PRTPISMRASEI)
  
  73 - 91
  
  PRINTS
  PR00417 (PRTPISMRASEI)
  
  193 - 202
  
  PRINTS
  PR00417 (PRTPISMRASEI)
2. cd00186 (TOP1Ac)
  
  33 - 457
  
  CDD
  cd00186 (TOP1Ac)
3. PF01131 (Topoisom_bac)
  
  31 - 446
  
  Pfam
  PF01131 (Topoisom_bac)
IPR003602

DNA topoisomerase, type IA, DNA-binding domain
1. SM00437 (topIaneu2)
  
  151 - 407
  
  SMART
  SM00437 (topIaneu2)
IPR016024

Armadillo-type fold
1. SSF48371 (ARM repeat)
  
  1,452 - 1,720
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  740 - 1,061
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  1,091 - 1,389
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  1,392 - 1,716
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
IPR001494

Importin-beta, N-terminal domain
1. SM00913 (IBN_N_2)
  
  751 - 817
  
  SMART
  SM00913 (IBN_N_2)
2. PS50166 (IMPORTIN_B_NT)
  
  751 - 817
  
  PROSITE profiles
  PS50166 (IMPORTIN_B_NT)
3. PF03810 (IBN_N)
  
  751 - 816
  
  Pfam
  PF03810 (IBN_N)
IPR013598

Exportin-1/Importin-beta-like
1. PF08389 (Xpo1)
  
  829 - 944
  
  Pfam
  PF08389 (Xpo1)
IPR014877

CRM1 C-terminal domain
1. SM01102 (CRM1_C_2)
  
  1,392 - 1,716
  
  SMART
  SM01102 (CRM1_C_2)
2. PF08767 (CRM1_C)
  
  1,392 - 1,716
  
  Pfam
  PF08767 (CRM1_C)

no IPR

Unintegrated signatures

mobidb-lite (disord...)

590 - 692

MobiDB Lite
mobidb-lite (disorder_prediction)

1,729 - 1,760

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

domain I cd00186

33M

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

34N

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

35Q

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

36A

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

37E

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

38A

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

39V

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

40N

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

41T

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

42R

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

43M

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

44E

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

45L

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

46D

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

47L

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

48R

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

49I

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

50G

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

51Y

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

52A

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

53F

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

54T

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

55R

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

56Y

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

57Q

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

58T

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

59L

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

60G

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

73L

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

74S

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

75Y

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

76G

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

77S

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

78C

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

79Q

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

80F

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

81P

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

82T

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

83L

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

84G

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

85F

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

86V

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

87V

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

88E

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

89R

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

90Y

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

91K

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

92A

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)

93V

domain I
33M, 34N, 35Q, 36A, 37E, 38A, 39V, 40N, 41T, 42R, 43M, 44E, 45L, 46D, 47L, 48R, 49I, 50G, 51Y, 52A, 53F, 54T, 55R, 56Y, 57Q, 58T, 59L, 60G, 73L, 74S, 75Y, 76G, 77S, 78C, 79Q, 80F, 81P, 82T, 83L, 84G, 85F, 86V, 87V, 88E, 89R, 90Y, 91K, 92A, 93V
CDD
cd00186 (TOP1Ac)
DNA binding groove...

42R

DNA binding groove
42R, 43M, 46D, 50G, 54T, 188E, 192N, 200R, 371A, 372T, 375E, 376H, 378K, 382D, 383R
CDD
cd00186 (TOP1Ac)

43M

DNA binding groove
42R, 43M, 46D, 50G, 54T, 188E, 192N, 200R, 371A, 372T, 375E, 376H, 378K, 382D, 383R
CDD
cd00186 (TOP1Ac)

46D

DNA binding groove
42R, 43M, 46D, 50G, 54T, 188E, 192N, 200R, 371A, 372T, 375E, 376H, 378K, 382D, 383R
CDD
cd00186 (TOP1Ac)

50G

DNA binding groove
42R, 43M, 46D, 50G, 54T, 188E, 192N, 200R, 371A, 372T, 375E, 376H, 378K, 382D, 383R
CDD
cd00186 (TOP1Ac)

54T

DNA binding groove
42R, 43M, 46D, 50G, 54T, 188E, 192N, 200R, 371A, 372T, 375E, 376H, 378K, 382D, 383R
CDD
cd00186 (TOP1Ac)

188E

DNA binding groove
42R, 43M, 46D, 50G, 54T, 188E, 192N, 200R, 371A, 372T, 375E, 376H, 378K, 382D, 383R
CDD
cd00186 (TOP1Ac)

192N

DNA binding groove
42R, 43M, 46D, 50G, 54T, 188E, 192N, 200R, 371A, 372T, 375E, 376H, 378K, 382D, 383R
CDD
cd00186 (TOP1Ac)

200R

DNA binding groove
42R, 43M, 46D, 50G, 54T, 188E, 192N, 200R, 371A, 372T, 375E, 376H, 378K, 382D, 383R
CDD
cd00186 (TOP1Ac)

371A

DNA binding groove
42R, 43M, 46D, 50G, 54T, 188E, 192N, 200R, 371A, 372T, 375E, 376H, 378K, 382D, 383R
CDD
cd00186 (TOP1Ac)

372T

DNA binding groove
42R, 43M, 46D, 50G, 54T, 188E, 192N, 200R, 371A, 372T, 375E, 376H, 378K, 382D, 383R
CDD
cd00186 (TOP1Ac)

375E

DNA binding groove
42R, 43M, 46D, 50G, 54T, 188E, 192N, 200R, 371A, 372T, 375E, 376H, 378K, 382D, 383R
CDD
cd00186 (TOP1Ac)

376H

DNA binding groove
42R, 43M, 46D, 50G, 54T, 188E, 192N, 200R, 371A, 372T, 375E, 376H, 378K, 382D, 383R
CDD
cd00186 (TOP1Ac)

378K

DNA binding groove
42R, 43M, 46D, 50G, 54T, 188E, 192N, 200R, 371A, 372T, 375E, 376H, 378K, 382D, 383R
CDD
cd00186 (TOP1Ac)

382D

DNA binding groove
42R, 43M, 46D, 50G, 54T, 188E, 192N, 200R, 371A, 372T, 375E, 376H, 378K, 382D, 383R
CDD
cd00186 (TOP1Ac)

383R

DNA binding groove
42R, 43M, 46D, 50G, 54T, 188E, 192N, 200R, 371A, 372T, 375E, 376H, 378K, 382D, 383R
CDD
cd00186 (TOP1Ac)
phosphate binding ...

84G

phosphate binding site
84G, 88E, 411D
CDD
cd00186 (TOP1Ac)

88E

phosphate binding site
84G, 88E, 411D
CDD
cd00186 (TOP1Ac)

411D

phosphate binding site
84G, 88E, 411D
CDD
cd00186 (TOP1Ac)
domain II cd00186

98K

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

99E

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

100K

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

101F

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

102W

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

103K

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

104I

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

105H

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

106V

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

145A

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

146T

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

147V

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

148V

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

149E

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

150V

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

151V

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

152T

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

153K

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

154E

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

155T

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

156R

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

157K

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

158Y

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

282D

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

283D

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

284A

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

285K

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

286G

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

287N

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

288E

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

289T

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

290T

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

291V

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

292K

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

293I

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

294K

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

295I

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

296K

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

298E

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

299Y

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

300F

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

301T

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

302A

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

303K

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

304G

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

305L

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

306V

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

307I

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

308T

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

309E

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

310N

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

311N

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

312Y

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

313L

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

314D

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

315V

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

316Y

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

338K

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

339E

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

340C

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

341T

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

342M

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

343E

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

344E

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

345G

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

346E

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

347T

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)

348T

domain II
98K, 99E, 100K, 101F, 102W, 103K, 104I, 105H, 106V, 145A, 146T, 147V, 148V, 149E, 150V, 151V, 152T, 153K, 154E, 155T, 156R, 157K, 158Y, 282D, 283D, 284A, 285K, 286G, 287N, 288E, 289T, 290T, 291V, 292K, 293I, 294K, 295I, 296K, 298E, 299Y, 300F, 301T, 302A, 303K, 304G, 305L, 306V, 307I, 308T, 309E, 310N, 311N, 312Y, 313L, 314D, 315V, 316Y, 338K, 339E, 340C, 341T, 342M, 343E, 344E, 345G, 346E, 347T, 348T
CDD
cd00186 (TOP1Ac)
domain III cd00186

159K

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

160P

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

161F

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

162P

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

163L

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

164T

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

165T

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

167E

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

168L

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

169Q

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

170K

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

171A

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

172G

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

173C

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

174R

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

175F

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

176L

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

177H

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

178I

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

179S

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

180S

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

181A

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

182E

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

183I

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

184M

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

185K

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

186I

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

187A

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

188E

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

189D

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

190L

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

191Y

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

192N

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

193K

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

194G

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

195F

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

196I

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

197S

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

198Y

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

199P

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

200R

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

201T

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

202E

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

203T

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

204D

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

205Q

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

206F

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

207D

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

208H

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

209Q

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

210F

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

211N

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

212F

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

213K

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

214D

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

215L

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

216I

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

217Q

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

218A

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

219Q

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

220S

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

221Q

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

222D

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

248A

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

249H

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

250P

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

251P

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

252I

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

253H

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

254P

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

255V

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

261L

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

262T

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

263G

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

264K

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

265E

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

266K

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

267T

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

268V

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

269Y

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

270E

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

271F

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

272V

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

273V

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

274R

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

275R

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

276F

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

277L

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

278A

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

279C

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

280C

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)

281S

domain III
159K, 160P, 161F, 162P, 163L, 164T, 165T, 167E, 168L, 169Q, 170K, 171A, 172G, 173C, 174R, 175F, 176L, 177H, 178I, 179S, 180S, 181A, 182E, 183I, 184M, 185K, 186I, 187A, 188E, 189D, 190L, 191Y, 192N, 193K, 194G, 195F, 196I, 197S, 198Y, 199P, 200R, 201T, 202E, 203T, 204D, 205Q, 206F, 207D, 208H, 209Q, 210F, 211N, 212F, 213K, 214D, 215L, 216I, 217Q, 218A, 219Q, 220S, 221Q, 222D, 248A, 249H, 250P, 251P, 252I, 253H, 254P, 255V, 261L, 262T, 263G, 264K, 265E, 266K, 267T, 268V, 269Y, 270E, 271F, 272V, 273V, 274R, 275R, 276F, 277L, 278A, 279C, 280C, 281S
CDD
cd00186 (TOP1Ac)
nucleotide binding...

170K

nucleotide binding site
170K, 174R, 175F, 176L, 249H, 267T, 270E, 274R, 369T, 371A, 397L
CDD
cd00186 (TOP1Ac)

174R

nucleotide binding site
170K, 174R, 175F, 176L, 249H, 267T, 270E, 274R, 369T, 371A, 397L
CDD
cd00186 (TOP1Ac)

175F

nucleotide binding site
170K, 174R, 175F, 176L, 249H, 267T, 270E, 274R, 369T, 371A, 397L
CDD
cd00186 (TOP1Ac)

176L

nucleotide binding site
170K, 174R, 175F, 176L, 249H, 267T, 270E, 274R, 369T, 371A, 397L
CDD
cd00186 (TOP1Ac)

249H

nucleotide binding site
170K, 174R, 175F, 176L, 249H, 267T, 270E, 274R, 369T, 371A, 397L
CDD
cd00186 (TOP1Ac)

267T

nucleotide binding site
170K, 174R, 175F, 176L, 249H, 267T, 270E, 274R, 369T, 371A, 397L
CDD
cd00186 (TOP1Ac)

270E

nucleotide binding site
170K, 174R, 175F, 176L, 249H, 267T, 270E, 274R, 369T, 371A, 397L
CDD
cd00186 (TOP1Ac)

274R

nucleotide binding site
170K, 174R, 175F, 176L, 249H, 267T, 270E, 274R, 369T, 371A, 397L
CDD
cd00186 (TOP1Ac)

369T

nucleotide binding site
170K, 174R, 175F, 176L, 249H, 267T, 270E, 274R, 369T, 371A, 397L
CDD
cd00186 (TOP1Ac)

371A

nucleotide binding site
170K, 174R, 175F, 176L, 249H, 267T, 270E, 274R, 369T, 371A, 397L
CDD
cd00186 (TOP1Ac)

397L

nucleotide binding site
170K, 174R, 175F, 176L, 249H, 267T, 270E, 274R, 369T, 371A, 397L
CDD
cd00186 (TOP1Ac)
catalytic site cd0...

198Y

catalytic site
198Y, 200R, 249H
CDD
cd00186 (TOP1Ac)

200R

catalytic site
198Y, 200R, 249H
CDD
cd00186 (TOP1Ac)

249H

catalytic site
198Y, 200R, 249H
CDD
cd00186 (TOP1Ac)
domain IV cd00186

349P

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

350P

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

351E

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

352Y

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

353L

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

354T

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

355E

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

356A

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

357E

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

358L

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

359I

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

360N

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

361T

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

362M

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

363D

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

364K

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

365N

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

366G

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

367I

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

368G

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

369T

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

370D

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

371A

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

372T

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

373I

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

374H

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

375E

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

376H

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

377I

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

378K

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

379K

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

380I

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

381I

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

382D

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

383R

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

384E

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

385Y

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

386V

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

387E

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

388K

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

393N

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

397L

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

398I

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

399P

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

400S

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

401N

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

402L

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

403G

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

404L

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

405A

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

406I

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

407V

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

408E

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

409G

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

410Y

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

411D

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

419L

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

420T

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

421K

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

422P

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

423L

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

424L

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

425R

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

426A

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

427K

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

428M

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

429E

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

430Q

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

431N

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

432L

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

433K

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

434E

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

435I

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

436C

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

437E

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

438G

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

439T

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

440R

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

441E

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

442K

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

443N

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

444D

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

445V

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

446L

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

447T

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

448E

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

449N

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

450V

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

451N

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

452K

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

453Y

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

454R

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

455D

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

456M

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

457F

domain IV
349P, 350P, 351E, 352Y, 353L, 354T, 355E, 356A, 357E, 358L, 359I, 360N, 361T, 362M, 363D, 364K, 365N, 366G, 367I, 368G, 369T, 370D, 371A, 372T, 373I, 374H, 375E, 376H, 377I, 378K, 379K, 380I, 381I, 382D, 383R, 384E, 385Y, 386V, 387E, 388K, 393N, 397L, 398I, 399P, 400S, 401N, 402L, 403G, 404L, 405A, 406I, 407V, 408E, 409G, 410Y, 411D, 419L, 420T, 421K, 422P, 423L, 424L, 425R, 426A, 427K, 428M, 429E, 430Q, 431N, 432L, 433K, 434E, 435I, 436C, 437E, 438G, 439T, 440R, 441E, 442K, 443N, 444D, 445V, 446L, 447T, 448E, 449N, 450V, 451N, 452K, 453Y, 454R, 455D, 456M, 457F
CDD
cd00186 (TOP1Ac)

GO term prediction

Biological Process

GO:0006265 DNA topological change
GO:0006886 intracellular protein transport

Molecular Function

GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0005488 binding
GO:0008536 Ran GTPase binding

Cellular Component