GBC51074.1

Protein

Length

1,159 amino acids

Protein family membership

Phosphatidylinositol 4-kinase, Pik1, fungi (IPR021601)

Domains and repeats

Domain
1 - 117
Armadillo-type fold (IPR016024)
Phosphoinositide 3-kinase, accessory (PIK) domain (IPR001263)
406 - 497
Protein kinase-like domain (IPR011009)
883 - 1,158
Protein kinase-like domain (IPR011009)
Phosphatidylinositol 3-/4-kinase, catalytic domain (IPR000403)

1 200 400 600 800 1000 1159

Detailed signature matches

IPR021601

Phosphatidylinositol 4-kinase, Pik1, fungi
1. PF11522 (Pik1)
  
  104 - 163
  
  Pfam
  PF11522 (Pik1)
IPR016024

Armadillo-type fold
1. SSF48371 (ARM repeat)
  
  4 - 93
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
IPR001263

Phosphoinositide 3-kinase, accessory (PIK) domain
1. PS51545 (PIK_HELICAL)
  
  1 - 117
  
  PROSITE profiles
  PS51545 (PIK_HELICAL)
IPR011009

Protein kinase-like domain
1. SSF56112 (Protein k...)
  
  883 - 1,153
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
  
  406 - 497
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
IPR000403

Phosphatidylinositol 3-/4-kinase, catalytic domain
1. SM00146 (pi3k_hr1_6)
  
  892 - 1,157
  
  SMART
  SM00146 (pi3k_hr1_6)
2. PF00454 (PI3_PI4_ki...)
  
  892 - 1,099
  
  Pfam
  PF00454 (PI3_PI4_kinase)
3. PS50290 (PI3_4_KINA...)
  
  891 - 1,158
  
  PROSITE profiles
  PS50290 (PI3_4_KINASE_3)
IPR018936

Phosphatidylinositol 3/4-kinase, conserved site
1. PS00916 (PI3_4_KINA...)
  
  998 - 1,018
  
  PROSITE patterns
  PS00916 (PI3_4_KINASE_2)
2. PS00915 (PI3_4_KINA...)
  
  895 - 909
  
  PROSITE patterns
  PS00915 (PI3_4_KINASE_1)

no IPR

Unintegrated signatures

Coil

798 - 818

COILS
Coil (Coil)
cd05168 (PI4Kc_III_...)

861 - 1,159

CDD
cd05168 (PI4Kc_III_beta)
mobidb-lite (disord...)

185 - 236

MobiDB Lite
mobidb-lite (disorder_prediction)

326 - 372

MobiDB Lite
mobidb-lite (disorder_prediction)

513 - 638

MobiDB Lite
mobidb-lite (disorder_prediction)

718 - 745

MobiDB Lite
mobidb-lite (disorder_prediction)

272 - 314

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

ATP binding site c...

874E

ATP binding site
874E, 876I, 877R, 879A, 881P, 894I, 896K, 899A, 930Y, 942I, 943E, 944T, 945I, 950S, 953S, 1,018N, 1,020L, 1,030I, 1,031D
CDD
cd05168 (PI4Kc_III_beta)

876I

ATP binding site
874E, 876I, 877R, 879A, 881P, 894I, 896K, 899A, 930Y, 942I, 943E, 944T, 945I, 950S, 953S, 1,018N, 1,020L, 1,030I, 1,031D
CDD
cd05168 (PI4Kc_III_beta)

877R

ATP binding site
874E, 876I, 877R, 879A, 881P, 894I, 896K, 899A, 930Y, 942I, 943E, 944T, 945I, 950S, 953S, 1,018N, 1,020L, 1,030I, 1,031D
CDD
cd05168 (PI4Kc_III_beta)

879A

ATP binding site
874E, 876I, 877R, 879A, 881P, 894I, 896K, 899A, 930Y, 942I, 943E, 944T, 945I, 950S, 953S, 1,018N, 1,020L, 1,030I, 1,031D
CDD
cd05168 (PI4Kc_III_beta)

881P

ATP binding site
874E, 876I, 877R, 879A, 881P, 894I, 896K, 899A, 930Y, 942I, 943E, 944T, 945I, 950S, 953S, 1,018N, 1,020L, 1,030I, 1,031D
CDD
cd05168 (PI4Kc_III_beta)

894I

ATP binding site
874E, 876I, 877R, 879A, 881P, 894I, 896K, 899A, 930Y, 942I, 943E, 944T, 945I, 950S, 953S, 1,018N, 1,020L, 1,030I, 1,031D
CDD
cd05168 (PI4Kc_III_beta)

896K

ATP binding site
874E, 876I, 877R, 879A, 881P, 894I, 896K, 899A, 930Y, 942I, 943E, 944T, 945I, 950S, 953S, 1,018N, 1,020L, 1,030I, 1,031D
CDD
cd05168 (PI4Kc_III_beta)

899A

ATP binding site
874E, 876I, 877R, 879A, 881P, 894I, 896K, 899A, 930Y, 942I, 943E, 944T, 945I, 950S, 953S, 1,018N, 1,020L, 1,030I, 1,031D
CDD
cd05168 (PI4Kc_III_beta)

930Y

ATP binding site
874E, 876I, 877R, 879A, 881P, 894I, 896K, 899A, 930Y, 942I, 943E, 944T, 945I, 950S, 953S, 1,018N, 1,020L, 1,030I, 1,031D
CDD
cd05168 (PI4Kc_III_beta)

942I

ATP binding site
874E, 876I, 877R, 879A, 881P, 894I, 896K, 899A, 930Y, 942I, 943E, 944T, 945I, 950S, 953S, 1,018N, 1,020L, 1,030I, 1,031D
CDD
cd05168 (PI4Kc_III_beta)

943E

ATP binding site
874E, 876I, 877R, 879A, 881P, 894I, 896K, 899A, 930Y, 942I, 943E, 944T, 945I, 950S, 953S, 1,018N, 1,020L, 1,030I, 1,031D
CDD
cd05168 (PI4Kc_III_beta)

944T

ATP binding site
874E, 876I, 877R, 879A, 881P, 894I, 896K, 899A, 930Y, 942I, 943E, 944T, 945I, 950S, 953S, 1,018N, 1,020L, 1,030I, 1,031D
CDD
cd05168 (PI4Kc_III_beta)

945I

ATP binding site
874E, 876I, 877R, 879A, 881P, 894I, 896K, 899A, 930Y, 942I, 943E, 944T, 945I, 950S, 953S, 1,018N, 1,020L, 1,030I, 1,031D
CDD
cd05168 (PI4Kc_III_beta)

950S

ATP binding site
874E, 876I, 877R, 879A, 881P, 894I, 896K, 899A, 930Y, 942I, 943E, 944T, 945I, 950S, 953S, 1,018N, 1,020L, 1,030I, 1,031D
CDD
cd05168 (PI4Kc_III_beta)

953S

ATP binding site
874E, 876I, 877R, 879A, 881P, 894I, 896K, 899A, 930Y, 942I, 943E, 944T, 945I, 950S, 953S, 1,018N, 1,020L, 1,030I, 1,031D
CDD
cd05168 (PI4Kc_III_beta)

1,018N

ATP binding site
874E, 876I, 877R, 879A, 881P, 894I, 896K, 899A, 930Y, 942I, 943E, 944T, 945I, 950S, 953S, 1,018N, 1,020L, 1,030I, 1,031D
CDD
cd05168 (PI4Kc_III_beta)

1,020L

ATP binding site
874E, 876I, 877R, 879A, 881P, 894I, 896K, 899A, 930Y, 942I, 943E, 944T, 945I, 950S, 953S, 1,018N, 1,020L, 1,030I, 1,031D
CDD
cd05168 (PI4Kc_III_beta)

1,030I

ATP binding site
874E, 876I, 877R, 879A, 881P, 894I, 896K, 899A, 930Y, 942I, 943E, 944T, 945I, 950S, 953S, 1,018N, 1,020L, 1,030I, 1,031D
CDD
cd05168 (PI4Kc_III_beta)

1,031D

ATP binding site
874E, 876I, 877R, 879A, 881P, 894I, 896K, 899A, 930Y, 942I, 943E, 944T, 945I, 950S, 953S, 1,018N, 1,020L, 1,030I, 1,031D
CDD
cd05168 (PI4Kc_III_beta)
catalytic loop cd0...

1,010Q

catalytic loop
1,010Q, 1,011V, 1,012K, 1,013D, 1,014R, 1,015H, 1,016N, 1,017G, 1,018N
CDD
cd05168 (PI4Kc_III_beta)

1,011V

catalytic loop
1,010Q, 1,011V, 1,012K, 1,013D, 1,014R, 1,015H, 1,016N, 1,017G, 1,018N
CDD
cd05168 (PI4Kc_III_beta)

1,012K

catalytic loop
1,010Q, 1,011V, 1,012K, 1,013D, 1,014R, 1,015H, 1,016N, 1,017G, 1,018N
CDD
cd05168 (PI4Kc_III_beta)

1,013D

catalytic loop
1,010Q, 1,011V, 1,012K, 1,013D, 1,014R, 1,015H, 1,016N, 1,017G, 1,018N
CDD
cd05168 (PI4Kc_III_beta)

1,014R

catalytic loop
1,010Q, 1,011V, 1,012K, 1,013D, 1,014R, 1,015H, 1,016N, 1,017G, 1,018N
CDD
cd05168 (PI4Kc_III_beta)

1,015H

catalytic loop
1,010Q, 1,011V, 1,012K, 1,013D, 1,014R, 1,015H, 1,016N, 1,017G, 1,018N
CDD
cd05168 (PI4Kc_III_beta)

1,016N

catalytic loop
1,010Q, 1,011V, 1,012K, 1,013D, 1,014R, 1,015H, 1,016N, 1,017G, 1,018N
CDD
cd05168 (PI4Kc_III_beta)

1,017G

catalytic loop
1,010Q, 1,011V, 1,012K, 1,013D, 1,014R, 1,015H, 1,016N, 1,017G, 1,018N
CDD
cd05168 (PI4Kc_III_beta)

1,018N

catalytic loop
1,010Q, 1,011V, 1,012K, 1,013D, 1,014R, 1,015H, 1,016N, 1,017G, 1,018N
CDD
cd05168 (PI4Kc_III_beta)
activation loop (A...

1,031D

activation loop (A-loop)
1,031D, 1,032F, 1,033G, 1,034F, 1,035M, 1,036L, 1,037S, 1,038N, 1,039S, 1,040P, 1,041G, 1,042S, 1,043V, 1,044G, 1,045F, 1,046E, 1,048A, 1,049P, 1,050F, 1,051K, 1,052L, 1,053S
CDD
cd05168 (PI4Kc_III_beta)

1,032F

activation loop (A-loop)
1,031D, 1,032F, 1,033G, 1,034F, 1,035M, 1,036L, 1,037S, 1,038N, 1,039S, 1,040P, 1,041G, 1,042S, 1,043V, 1,044G, 1,045F, 1,046E, 1,048A, 1,049P, 1,050F, 1,051K, 1,052L, 1,053S
CDD
cd05168 (PI4Kc_III_beta)

1,033G

activation loop (A-loop)
1,031D, 1,032F, 1,033G, 1,034F, 1,035M, 1,036L, 1,037S, 1,038N, 1,039S, 1,040P, 1,041G, 1,042S, 1,043V, 1,044G, 1,045F, 1,046E, 1,048A, 1,049P, 1,050F, 1,051K, 1,052L, 1,053S
CDD
cd05168 (PI4Kc_III_beta)

1,034F

activation loop (A-loop)
1,031D, 1,032F, 1,033G, 1,034F, 1,035M, 1,036L, 1,037S, 1,038N, 1,039S, 1,040P, 1,041G, 1,042S, 1,043V, 1,044G, 1,045F, 1,046E, 1,048A, 1,049P, 1,050F, 1,051K, 1,052L, 1,053S
CDD
cd05168 (PI4Kc_III_beta)

1,035M

activation loop (A-loop)
1,031D, 1,032F, 1,033G, 1,034F, 1,035M, 1,036L, 1,037S, 1,038N, 1,039S, 1,040P, 1,041G, 1,042S, 1,043V, 1,044G, 1,045F, 1,046E, 1,048A, 1,049P, 1,050F, 1,051K, 1,052L, 1,053S
CDD
cd05168 (PI4Kc_III_beta)

1,036L

activation loop (A-loop)
1,031D, 1,032F, 1,033G, 1,034F, 1,035M, 1,036L, 1,037S, 1,038N, 1,039S, 1,040P, 1,041G, 1,042S, 1,043V, 1,044G, 1,045F, 1,046E, 1,048A, 1,049P, 1,050F, 1,051K, 1,052L, 1,053S
CDD
cd05168 (PI4Kc_III_beta)

1,037S

activation loop (A-loop)
1,031D, 1,032F, 1,033G, 1,034F, 1,035M, 1,036L, 1,037S, 1,038N, 1,039S, 1,040P, 1,041G, 1,042S, 1,043V, 1,044G, 1,045F, 1,046E, 1,048A, 1,049P, 1,050F, 1,051K, 1,052L, 1,053S
CDD
cd05168 (PI4Kc_III_beta)

1,038N

activation loop (A-loop)
1,031D, 1,032F, 1,033G, 1,034F, 1,035M, 1,036L, 1,037S, 1,038N, 1,039S, 1,040P, 1,041G, 1,042S, 1,043V, 1,044G, 1,045F, 1,046E, 1,048A, 1,049P, 1,050F, 1,051K, 1,052L, 1,053S
CDD
cd05168 (PI4Kc_III_beta)

1,039S

activation loop (A-loop)
1,031D, 1,032F, 1,033G, 1,034F, 1,035M, 1,036L, 1,037S, 1,038N, 1,039S, 1,040P, 1,041G, 1,042S, 1,043V, 1,044G, 1,045F, 1,046E, 1,048A, 1,049P, 1,050F, 1,051K, 1,052L, 1,053S
CDD
cd05168 (PI4Kc_III_beta)

1,040P

activation loop (A-loop)
1,031D, 1,032F, 1,033G, 1,034F, 1,035M, 1,036L, 1,037S, 1,038N, 1,039S, 1,040P, 1,041G, 1,042S, 1,043V, 1,044G, 1,045F, 1,046E, 1,048A, 1,049P, 1,050F, 1,051K, 1,052L, 1,053S
CDD
cd05168 (PI4Kc_III_beta)

1,041G

activation loop (A-loop)
1,031D, 1,032F, 1,033G, 1,034F, 1,035M, 1,036L, 1,037S, 1,038N, 1,039S, 1,040P, 1,041G, 1,042S, 1,043V, 1,044G, 1,045F, 1,046E, 1,048A, 1,049P, 1,050F, 1,051K, 1,052L, 1,053S
CDD
cd05168 (PI4Kc_III_beta)

1,042S

activation loop (A-loop)
1,031D, 1,032F, 1,033G, 1,034F, 1,035M, 1,036L, 1,037S, 1,038N, 1,039S, 1,040P, 1,041G, 1,042S, 1,043V, 1,044G, 1,045F, 1,046E, 1,048A, 1,049P, 1,050F, 1,051K, 1,052L, 1,053S
CDD
cd05168 (PI4Kc_III_beta)

1,043V

activation loop (A-loop)
1,031D, 1,032F, 1,033G, 1,034F, 1,035M, 1,036L, 1,037S, 1,038N, 1,039S, 1,040P, 1,041G, 1,042S, 1,043V, 1,044G, 1,045F, 1,046E, 1,048A, 1,049P, 1,050F, 1,051K, 1,052L, 1,053S
CDD
cd05168 (PI4Kc_III_beta)

1,044G

activation loop (A-loop)
1,031D, 1,032F, 1,033G, 1,034F, 1,035M, 1,036L, 1,037S, 1,038N, 1,039S, 1,040P, 1,041G, 1,042S, 1,043V, 1,044G, 1,045F, 1,046E, 1,048A, 1,049P, 1,050F, 1,051K, 1,052L, 1,053S
CDD
cd05168 (PI4Kc_III_beta)

1,045F

activation loop (A-loop)
1,031D, 1,032F, 1,033G, 1,034F, 1,035M, 1,036L, 1,037S, 1,038N, 1,039S, 1,040P, 1,041G, 1,042S, 1,043V, 1,044G, 1,045F, 1,046E, 1,048A, 1,049P, 1,050F, 1,051K, 1,052L, 1,053S
CDD
cd05168 (PI4Kc_III_beta)

1,046E

activation loop (A-loop)
1,031D, 1,032F, 1,033G, 1,034F, 1,035M, 1,036L, 1,037S, 1,038N, 1,039S, 1,040P, 1,041G, 1,042S, 1,043V, 1,044G, 1,045F, 1,046E, 1,048A, 1,049P, 1,050F, 1,051K, 1,052L, 1,053S
CDD
cd05168 (PI4Kc_III_beta)

1,048A

activation loop (A-loop)
1,031D, 1,032F, 1,033G, 1,034F, 1,035M, 1,036L, 1,037S, 1,038N, 1,039S, 1,040P, 1,041G, 1,042S, 1,043V, 1,044G, 1,045F, 1,046E, 1,048A, 1,049P, 1,050F, 1,051K, 1,052L, 1,053S
CDD
cd05168 (PI4Kc_III_beta)

1,049P

activation loop (A-loop)
1,031D, 1,032F, 1,033G, 1,034F, 1,035M, 1,036L, 1,037S, 1,038N, 1,039S, 1,040P, 1,041G, 1,042S, 1,043V, 1,044G, 1,045F, 1,046E, 1,048A, 1,049P, 1,050F, 1,051K, 1,052L, 1,053S
CDD
cd05168 (PI4Kc_III_beta)

1,050F

activation loop (A-loop)
1,031D, 1,032F, 1,033G, 1,034F, 1,035M, 1,036L, 1,037S, 1,038N, 1,039S, 1,040P, 1,041G, 1,042S, 1,043V, 1,044G, 1,045F, 1,046E, 1,048A, 1,049P, 1,050F, 1,051K, 1,052L, 1,053S
CDD
cd05168 (PI4Kc_III_beta)

1,051K

activation loop (A-loop)
1,031D, 1,032F, 1,033G, 1,034F, 1,035M, 1,036L, 1,037S, 1,038N, 1,039S, 1,040P, 1,041G, 1,042S, 1,043V, 1,044G, 1,045F, 1,046E, 1,048A, 1,049P, 1,050F, 1,051K, 1,052L, 1,053S
CDD
cd05168 (PI4Kc_III_beta)

1,052L

activation loop (A-loop)
1,031D, 1,032F, 1,033G, 1,034F, 1,035M, 1,036L, 1,037S, 1,038N, 1,039S, 1,040P, 1,041G, 1,042S, 1,043V, 1,044G, 1,045F, 1,046E, 1,048A, 1,049P, 1,050F, 1,051K, 1,052L, 1,053S
CDD
cd05168 (PI4Kc_III_beta)

1,053S

activation loop (A-loop)
1,031D, 1,032F, 1,033G, 1,034F, 1,035M, 1,036L, 1,037S, 1,038N, 1,039S, 1,040P, 1,041G, 1,042S, 1,043V, 1,044G, 1,045F, 1,046E, 1,048A, 1,049P, 1,050F, 1,051K, 1,052L, 1,053S
CDD
cd05168 (PI4Kc_III_beta)

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0005488 binding
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor

Cellular Component