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Protein

GBC50910.1

Length

4,058 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
110 - 332
Armadillo-type fold (IPR016024)
638 - 692
Armadillo-type fold (IPR016024)
728 - 837
Armadillo-type fold (IPR016024)
893 - 907
Armadillo-type fold (IPR016024)
956 - 1,194
Armadillo-type fold (IPR016024)
1,290 - 1,356
Armadillo-type fold (IPR016024)
1,449 - 1,484
Armadillo-type fold (IPR016024)
1,626 - 1,671
Armadillo-type fold (IPR016024)
1,792 - 1,837
Armadillo-type fold (IPR016024)
1,874 - 1,900
Armadillo-type fold (IPR016024)
1,984 - 2,003
Armadillo-type fold (IPR016024)
2,124 - 2,291
Armadillo-type fold (IPR016024)
2,439 - 2,579
Armadillo-type fold (IPR016024)
2,786 - 2,825
Armadillo-type fold (IPR016024)
2,988 - 3,073
Armadillo-type fold (IPR016024)
3,130 - 3,193
Armadillo-type fold (IPR016024)
3,258 - 3,275
Armadillo-type fold (IPR016024)
3,359 - 3,469
Armadillo-type fold (IPR016024)
3,619 - 3,998
Protein kinase-like domain (IPR011009)
Phosphatidylinositol 3-/4-kinase, catalytic domain (IPR000403)
4,026 - 4,058
FATC domain (IPR003152)
Domain
1,856 - 2,252
NUC194 (IPR012582)
2,891 - 3,479
PIK-related kinase (IPR014009)
PIK-related kinase, FAT (IPR003151)

1 500 1000 1500 2000 2500 3000 3500 4058

Detailed signature matches

IPR016024

Armadillo-type fold

SSF48371 (ARM repeat)

1,792 - 1,837

SUPERFAMILY
SSF48371 (ARM repeat)

1,626 - 1,671

SUPERFAMILY
SSF48371 (ARM repeat)

1,290 - 1,356

SUPERFAMILY
SSF48371 (ARM repeat)

1,984 - 2,003

SUPERFAMILY
SSF48371 (ARM repeat)

959 - 1,194

SUPERFAMILY
SSF48371 (ARM repeat)

2,124 - 2,291

SUPERFAMILY
SSF48371 (ARM repeat)

1,874 - 1,900

SUPERFAMILY
SSF48371 (ARM repeat)

1,449 - 1,484

SUPERFAMILY
SSF48371 (ARM repeat)

3,130 - 3,193

SUPERFAMILY
SSF48371 (ARM repeat)

3,258 - 3,275

SUPERFAMILY
SSF48371 (ARM repeat)

2,786 - 2,825

SUPERFAMILY
SSF48371 (ARM repeat)

3,359 - 3,469

SUPERFAMILY
SSF48371 (ARM repeat)

2,988 - 3,073

SUPERFAMILY
SSF48371 (ARM repeat)

2,439 - 2,579

SUPERFAMILY
SSF48371 (ARM repeat)

728 - 837

SUPERFAMILY
SSF48371 (ARM repeat)

956 - 1,161

SUPERFAMILY
SSF48371 (ARM repeat)

110 - 332

SUPERFAMILY
SSF48371 (ARM repeat)

638 - 692

SUPERFAMILY
SSF48371 (ARM repeat)

893 - 907

SUPERFAMILY
SSF48371 (ARM repeat)

IPR012582

NUC194

PF08163 (NUC194)

1,859 - 2,241

Pfam
PF08163 (NUC194)
SM01344 (NUC194_2)

1,856 - 2,252

SMART
SM01344 (NUC194_2)

IPR014009

PIK-related kinase

PS51189 (FAT)

2,891 - 3,479

PROSITE profiles
PS51189 (FAT)

IPR003151

PIK-related kinase, FAT

PF02259 (FAT)

3,082 - 3,410

Pfam
PF02259 (FAT)

IPR011009

Protein kinase-like domain

SSF56112 (Protein k...)

3,619 - 3,772

SUPERFAMILY
SSF56112 (Protein kinase-like (PK-like))

3,813 - 3,954

SUPERFAMILY
SSF56112 (Protein kinase-like (PK-like))

IPR000403

Phosphatidylinositol 3-/4-kinase, catalytic domain

SM00146 (pi3k_hr1_6)

3,696 - 3,998

SMART
SM00146 (pi3k_hr1_6)
PF00454 (PI3_PI4_ki...)

3,695 - 3,949

Pfam
PF00454 (PI3_PI4_kinase)
PS50290 (PI3_4_KINA...)

3,695 - 3,949

PROSITE profiles
PS50290 (PI3_4_KINASE_3)

IPR003152

FATC domain

SM01343 (FATC_2)

4,026 - 4,058

SMART
SM01343 (FATC_2)
PF02260 (FATC)

4,028 - 4,057

Pfam
PF02260 (FATC)
PS51190 (FATC)

4,026 - 4,058

PROSITE profiles
PS51190 (FATC)

no IPR

Unintegrated signatures

Coil

2,111 - 2,131

COILS
Coil (Coil)
cd05172 (PIKKc_DNA-PK)

3,666 - 3,949

CDD
cd05172 (PIKKc_DNA-PK)
mobidb-lite (disord...)

2,710 - 2,732

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

ATP binding site c...

3,676L

ATP binding site
3,676L, 3,678S, 3,679L, 3,680R, 3,682P, 3,698L, 3,700K, 3,703E, 3,738Y, 3,750I, 3,751E, 3,752W, 3,753I, 3,758P, 3,862N, 3,864L, 3,875I, 3,876D
CDD
cd05172 (PIKKc_DNA-PK)

3,678S

ATP binding site
3,676L, 3,678S, 3,679L, 3,680R, 3,682P, 3,698L, 3,700K, 3,703E, 3,738Y, 3,750I, 3,751E, 3,752W, 3,753I, 3,758P, 3,862N, 3,864L, 3,875I, 3,876D
CDD
cd05172 (PIKKc_DNA-PK)

3,679L

ATP binding site
3,676L, 3,678S, 3,679L, 3,680R, 3,682P, 3,698L, 3,700K, 3,703E, 3,738Y, 3,750I, 3,751E, 3,752W, 3,753I, 3,758P, 3,862N, 3,864L, 3,875I, 3,876D
CDD
cd05172 (PIKKc_DNA-PK)

3,680R

ATP binding site
3,676L, 3,678S, 3,679L, 3,680R, 3,682P, 3,698L, 3,700K, 3,703E, 3,738Y, 3,750I, 3,751E, 3,752W, 3,753I, 3,758P, 3,862N, 3,864L, 3,875I, 3,876D
CDD
cd05172 (PIKKc_DNA-PK)

3,682P

ATP binding site
3,676L, 3,678S, 3,679L, 3,680R, 3,682P, 3,698L, 3,700K, 3,703E, 3,738Y, 3,750I, 3,751E, 3,752W, 3,753I, 3,758P, 3,862N, 3,864L, 3,875I, 3,876D
CDD
cd05172 (PIKKc_DNA-PK)

3,698L

ATP binding site
3,676L, 3,678S, 3,679L, 3,680R, 3,682P, 3,698L, 3,700K, 3,703E, 3,738Y, 3,750I, 3,751E, 3,752W, 3,753I, 3,758P, 3,862N, 3,864L, 3,875I, 3,876D
CDD
cd05172 (PIKKc_DNA-PK)

3,700K

ATP binding site
3,676L, 3,678S, 3,679L, 3,680R, 3,682P, 3,698L, 3,700K, 3,703E, 3,738Y, 3,750I, 3,751E, 3,752W, 3,753I, 3,758P, 3,862N, 3,864L, 3,875I, 3,876D
CDD
cd05172 (PIKKc_DNA-PK)

3,703E

ATP binding site
3,676L, 3,678S, 3,679L, 3,680R, 3,682P, 3,698L, 3,700K, 3,703E, 3,738Y, 3,750I, 3,751E, 3,752W, 3,753I, 3,758P, 3,862N, 3,864L, 3,875I, 3,876D
CDD
cd05172 (PIKKc_DNA-PK)

3,738Y

ATP binding site
3,676L, 3,678S, 3,679L, 3,680R, 3,682P, 3,698L, 3,700K, 3,703E, 3,738Y, 3,750I, 3,751E, 3,752W, 3,753I, 3,758P, 3,862N, 3,864L, 3,875I, 3,876D
CDD
cd05172 (PIKKc_DNA-PK)

3,750I

ATP binding site
3,676L, 3,678S, 3,679L, 3,680R, 3,682P, 3,698L, 3,700K, 3,703E, 3,738Y, 3,750I, 3,751E, 3,752W, 3,753I, 3,758P, 3,862N, 3,864L, 3,875I, 3,876D
CDD
cd05172 (PIKKc_DNA-PK)

3,751E

ATP binding site
3,676L, 3,678S, 3,679L, 3,680R, 3,682P, 3,698L, 3,700K, 3,703E, 3,738Y, 3,750I, 3,751E, 3,752W, 3,753I, 3,758P, 3,862N, 3,864L, 3,875I, 3,876D
CDD
cd05172 (PIKKc_DNA-PK)

3,752W

ATP binding site
3,676L, 3,678S, 3,679L, 3,680R, 3,682P, 3,698L, 3,700K, 3,703E, 3,738Y, 3,750I, 3,751E, 3,752W, 3,753I, 3,758P, 3,862N, 3,864L, 3,875I, 3,876D
CDD
cd05172 (PIKKc_DNA-PK)

3,753I

ATP binding site
3,676L, 3,678S, 3,679L, 3,680R, 3,682P, 3,698L, 3,700K, 3,703E, 3,738Y, 3,750I, 3,751E, 3,752W, 3,753I, 3,758P, 3,862N, 3,864L, 3,875I, 3,876D
CDD
cd05172 (PIKKc_DNA-PK)

3,758P

ATP binding site
3,676L, 3,678S, 3,679L, 3,680R, 3,682P, 3,698L, 3,700K, 3,703E, 3,738Y, 3,750I, 3,751E, 3,752W, 3,753I, 3,758P, 3,862N, 3,864L, 3,875I, 3,876D
CDD
cd05172 (PIKKc_DNA-PK)

3,862N

ATP binding site
3,676L, 3,678S, 3,679L, 3,680R, 3,682P, 3,698L, 3,700K, 3,703E, 3,738Y, 3,750I, 3,751E, 3,752W, 3,753I, 3,758P, 3,862N, 3,864L, 3,875I, 3,876D
CDD
cd05172 (PIKKc_DNA-PK)

3,864L

ATP binding site
3,676L, 3,678S, 3,679L, 3,680R, 3,682P, 3,698L, 3,700K, 3,703E, 3,738Y, 3,750I, 3,751E, 3,752W, 3,753I, 3,758P, 3,862N, 3,864L, 3,875I, 3,876D
CDD
cd05172 (PIKKc_DNA-PK)

3,875I

ATP binding site
3,676L, 3,678S, 3,679L, 3,680R, 3,682P, 3,698L, 3,700K, 3,703E, 3,738Y, 3,750I, 3,751E, 3,752W, 3,753I, 3,758P, 3,862N, 3,864L, 3,875I, 3,876D
CDD
cd05172 (PIKKc_DNA-PK)

3,876D

ATP binding site
3,676L, 3,678S, 3,679L, 3,680R, 3,682P, 3,698L, 3,700K, 3,703E, 3,738Y, 3,750I, 3,751E, 3,752W, 3,753I, 3,758P, 3,862N, 3,864L, 3,875I, 3,876D
CDD
cd05172 (PIKKc_DNA-PK)
catalytic loop cd0...

3,854G

catalytic loop
3,854G, 3,855I, 3,856G, 3,857D, 3,858R, 3,859H, 3,860L, 3,861E, 3,862N
CDD
cd05172 (PIKKc_DNA-PK)

3,855I

catalytic loop
3,854G, 3,855I, 3,856G, 3,857D, 3,858R, 3,859H, 3,860L, 3,861E, 3,862N
CDD
cd05172 (PIKKc_DNA-PK)

3,856G

catalytic loop
3,854G, 3,855I, 3,856G, 3,857D, 3,858R, 3,859H, 3,860L, 3,861E, 3,862N
CDD
cd05172 (PIKKc_DNA-PK)

3,857D

catalytic loop
3,854G, 3,855I, 3,856G, 3,857D, 3,858R, 3,859H, 3,860L, 3,861E, 3,862N
CDD
cd05172 (PIKKc_DNA-PK)

3,858R

catalytic loop
3,854G, 3,855I, 3,856G, 3,857D, 3,858R, 3,859H, 3,860L, 3,861E, 3,862N
CDD
cd05172 (PIKKc_DNA-PK)

3,859H

catalytic loop
3,854G, 3,855I, 3,856G, 3,857D, 3,858R, 3,859H, 3,860L, 3,861E, 3,862N
CDD
cd05172 (PIKKc_DNA-PK)

3,860L

catalytic loop
3,854G, 3,855I, 3,856G, 3,857D, 3,858R, 3,859H, 3,860L, 3,861E, 3,862N
CDD
cd05172 (PIKKc_DNA-PK)

3,861E

catalytic loop
3,854G, 3,855I, 3,856G, 3,857D, 3,858R, 3,859H, 3,860L, 3,861E, 3,862N
CDD
cd05172 (PIKKc_DNA-PK)

3,862N

catalytic loop
3,854G, 3,855I, 3,856G, 3,857D, 3,858R, 3,859H, 3,860L, 3,861E, 3,862N
CDD
cd05172 (PIKKc_DNA-PK)
activation loop (A...

3,876D

activation loop (A-loop)
3,876D, 3,877F, 3,878G, 3,879H, 3,880A, 3,881F, 3,882G, 3,883S, 3,884A, 3,885T, 3,886E, 3,888L, 3,889E, 3,890V, 3,891P, 3,892E, 3,893L, 3,894I, 3,895P, 3,896F, 3,897R, 3,898L, 3,899T
CDD
cd05172 (PIKKc_DNA-PK)

3,877F

activation loop (A-loop)
3,876D, 3,877F, 3,878G, 3,879H, 3,880A, 3,881F, 3,882G, 3,883S, 3,884A, 3,885T, 3,886E, 3,888L, 3,889E, 3,890V, 3,891P, 3,892E, 3,893L, 3,894I, 3,895P, 3,896F, 3,897R, 3,898L, 3,899T
CDD
cd05172 (PIKKc_DNA-PK)

3,878G

activation loop (A-loop)
3,876D, 3,877F, 3,878G, 3,879H, 3,880A, 3,881F, 3,882G, 3,883S, 3,884A, 3,885T, 3,886E, 3,888L, 3,889E, 3,890V, 3,891P, 3,892E, 3,893L, 3,894I, 3,895P, 3,896F, 3,897R, 3,898L, 3,899T
CDD
cd05172 (PIKKc_DNA-PK)

3,879H

activation loop (A-loop)
3,876D, 3,877F, 3,878G, 3,879H, 3,880A, 3,881F, 3,882G, 3,883S, 3,884A, 3,885T, 3,886E, 3,888L, 3,889E, 3,890V, 3,891P, 3,892E, 3,893L, 3,894I, 3,895P, 3,896F, 3,897R, 3,898L, 3,899T
CDD
cd05172 (PIKKc_DNA-PK)

3,880A

activation loop (A-loop)
3,876D, 3,877F, 3,878G, 3,879H, 3,880A, 3,881F, 3,882G, 3,883S, 3,884A, 3,885T, 3,886E, 3,888L, 3,889E, 3,890V, 3,891P, 3,892E, 3,893L, 3,894I, 3,895P, 3,896F, 3,897R, 3,898L, 3,899T
CDD
cd05172 (PIKKc_DNA-PK)

3,881F

activation loop (A-loop)
3,876D, 3,877F, 3,878G, 3,879H, 3,880A, 3,881F, 3,882G, 3,883S, 3,884A, 3,885T, 3,886E, 3,888L, 3,889E, 3,890V, 3,891P, 3,892E, 3,893L, 3,894I, 3,895P, 3,896F, 3,897R, 3,898L, 3,899T
CDD
cd05172 (PIKKc_DNA-PK)

3,882G

activation loop (A-loop)
3,876D, 3,877F, 3,878G, 3,879H, 3,880A, 3,881F, 3,882G, 3,883S, 3,884A, 3,885T, 3,886E, 3,888L, 3,889E, 3,890V, 3,891P, 3,892E, 3,893L, 3,894I, 3,895P, 3,896F, 3,897R, 3,898L, 3,899T
CDD
cd05172 (PIKKc_DNA-PK)

3,883S

activation loop (A-loop)
3,876D, 3,877F, 3,878G, 3,879H, 3,880A, 3,881F, 3,882G, 3,883S, 3,884A, 3,885T, 3,886E, 3,888L, 3,889E, 3,890V, 3,891P, 3,892E, 3,893L, 3,894I, 3,895P, 3,896F, 3,897R, 3,898L, 3,899T
CDD
cd05172 (PIKKc_DNA-PK)

3,884A

activation loop (A-loop)
3,876D, 3,877F, 3,878G, 3,879H, 3,880A, 3,881F, 3,882G, 3,883S, 3,884A, 3,885T, 3,886E, 3,888L, 3,889E, 3,890V, 3,891P, 3,892E, 3,893L, 3,894I, 3,895P, 3,896F, 3,897R, 3,898L, 3,899T
CDD
cd05172 (PIKKc_DNA-PK)

3,885T

activation loop (A-loop)
3,876D, 3,877F, 3,878G, 3,879H, 3,880A, 3,881F, 3,882G, 3,883S, 3,884A, 3,885T, 3,886E, 3,888L, 3,889E, 3,890V, 3,891P, 3,892E, 3,893L, 3,894I, 3,895P, 3,896F, 3,897R, 3,898L, 3,899T
CDD
cd05172 (PIKKc_DNA-PK)

3,886E

activation loop (A-loop)
3,876D, 3,877F, 3,878G, 3,879H, 3,880A, 3,881F, 3,882G, 3,883S, 3,884A, 3,885T, 3,886E, 3,888L, 3,889E, 3,890V, 3,891P, 3,892E, 3,893L, 3,894I, 3,895P, 3,896F, 3,897R, 3,898L, 3,899T
CDD
cd05172 (PIKKc_DNA-PK)

3,888L

activation loop (A-loop)
3,876D, 3,877F, 3,878G, 3,879H, 3,880A, 3,881F, 3,882G, 3,883S, 3,884A, 3,885T, 3,886E, 3,888L, 3,889E, 3,890V, 3,891P, 3,892E, 3,893L, 3,894I, 3,895P, 3,896F, 3,897R, 3,898L, 3,899T
CDD
cd05172 (PIKKc_DNA-PK)

3,889E

activation loop (A-loop)
3,876D, 3,877F, 3,878G, 3,879H, 3,880A, 3,881F, 3,882G, 3,883S, 3,884A, 3,885T, 3,886E, 3,888L, 3,889E, 3,890V, 3,891P, 3,892E, 3,893L, 3,894I, 3,895P, 3,896F, 3,897R, 3,898L, 3,899T
CDD
cd05172 (PIKKc_DNA-PK)

3,890V

activation loop (A-loop)
3,876D, 3,877F, 3,878G, 3,879H, 3,880A, 3,881F, 3,882G, 3,883S, 3,884A, 3,885T, 3,886E, 3,888L, 3,889E, 3,890V, 3,891P, 3,892E, 3,893L, 3,894I, 3,895P, 3,896F, 3,897R, 3,898L, 3,899T
CDD
cd05172 (PIKKc_DNA-PK)

3,891P

activation loop (A-loop)
3,876D, 3,877F, 3,878G, 3,879H, 3,880A, 3,881F, 3,882G, 3,883S, 3,884A, 3,885T, 3,886E, 3,888L, 3,889E, 3,890V, 3,891P, 3,892E, 3,893L, 3,894I, 3,895P, 3,896F, 3,897R, 3,898L, 3,899T
CDD
cd05172 (PIKKc_DNA-PK)

3,892E

activation loop (A-loop)
3,876D, 3,877F, 3,878G, 3,879H, 3,880A, 3,881F, 3,882G, 3,883S, 3,884A, 3,885T, 3,886E, 3,888L, 3,889E, 3,890V, 3,891P, 3,892E, 3,893L, 3,894I, 3,895P, 3,896F, 3,897R, 3,898L, 3,899T
CDD
cd05172 (PIKKc_DNA-PK)

3,893L

activation loop (A-loop)
3,876D, 3,877F, 3,878G, 3,879H, 3,880A, 3,881F, 3,882G, 3,883S, 3,884A, 3,885T, 3,886E, 3,888L, 3,889E, 3,890V, 3,891P, 3,892E, 3,893L, 3,894I, 3,895P, 3,896F, 3,897R, 3,898L, 3,899T
CDD
cd05172 (PIKKc_DNA-PK)

3,894I

activation loop (A-loop)
3,876D, 3,877F, 3,878G, 3,879H, 3,880A, 3,881F, 3,882G, 3,883S, 3,884A, 3,885T, 3,886E, 3,888L, 3,889E, 3,890V, 3,891P, 3,892E, 3,893L, 3,894I, 3,895P, 3,896F, 3,897R, 3,898L, 3,899T
CDD
cd05172 (PIKKc_DNA-PK)

3,895P

activation loop (A-loop)
3,876D, 3,877F, 3,878G, 3,879H, 3,880A, 3,881F, 3,882G, 3,883S, 3,884A, 3,885T, 3,886E, 3,888L, 3,889E, 3,890V, 3,891P, 3,892E, 3,893L, 3,894I, 3,895P, 3,896F, 3,897R, 3,898L, 3,899T
CDD
cd05172 (PIKKc_DNA-PK)

3,896F

activation loop (A-loop)
3,876D, 3,877F, 3,878G, 3,879H, 3,880A, 3,881F, 3,882G, 3,883S, 3,884A, 3,885T, 3,886E, 3,888L, 3,889E, 3,890V, 3,891P, 3,892E, 3,893L, 3,894I, 3,895P, 3,896F, 3,897R, 3,898L, 3,899T
CDD
cd05172 (PIKKc_DNA-PK)

3,897R

activation loop (A-loop)
3,876D, 3,877F, 3,878G, 3,879H, 3,880A, 3,881F, 3,882G, 3,883S, 3,884A, 3,885T, 3,886E, 3,888L, 3,889E, 3,890V, 3,891P, 3,892E, 3,893L, 3,894I, 3,895P, 3,896F, 3,897R, 3,898L, 3,899T
CDD
cd05172 (PIKKc_DNA-PK)

3,898L

activation loop (A-loop)
3,876D, 3,877F, 3,878G, 3,879H, 3,880A, 3,881F, 3,882G, 3,883S, 3,884A, 3,885T, 3,886E, 3,888L, 3,889E, 3,890V, 3,891P, 3,892E, 3,893L, 3,894I, 3,895P, 3,896F, 3,897R, 3,898L, 3,899T
CDD
cd05172 (PIKKc_DNA-PK)

3,899T

activation loop (A-loop)
3,876D, 3,877F, 3,878G, 3,879H, 3,880A, 3,881F, 3,882G, 3,883S, 3,884A, 3,885T, 3,886E, 3,888L, 3,889E, 3,890V, 3,891P, 3,892E, 3,893L, 3,894I, 3,895P, 3,896F, 3,897R, 3,898L, 3,899T
CDD
cd05172 (PIKKc_DNA-PK)

GO term prediction

Biological Process

GO:0006303 double-strand break repair via nonhomologous end joining

Molecular Function

GO:0003677 DNA binding
GO:0004677 DNA-dependent protein kinase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity

Cellular Component

GO:0005634 nucleus