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Protein

GBC50821.1

Length

298 amino acids

Protein family membership

NADH:cytochrome b5 reductase (CBR) (IPR001834)

Domains and repeats

Domain
50 - 160
Riboflavin synthase-like beta-barrel (IPR017938)
Ferredoxin reductase-type FAD-binding domain (IPR017927)
Oxidoreductase, FAD-binding domain (IPR008333)
Domain
108 - 115
Flavoprotein pyridine nucleotide cytochrome reductase (IPR001709)
167 - 273
Oxidoreductase FAD/NAD(P)-binding (IPR001433)
Flavoprotein pyridine nucleotide cytochrome reductase (IPR001709)

1 50 100 150 200 250 298

Detailed signature matches

IPR001834

NADH:cytochrome b5 reductase (CBR)

PR00406 (CYTB5RDTASE)

144 - 158

PRINTS
PR00406 (CYTB5RDTASE)

108 - 115

PRINTS
PR00406 (CYTB5RDTASE)

87 - 98

PRINTS
PR00406 (CYTB5RDTASE)

167 - 186

PRINTS
PR00406 (CYTB5RDTASE)

205 - 216

PRINTS
PR00406 (CYTB5RDTASE)

260 - 268

PRINTS
PR00406 (CYTB5RDTASE)

IPR017938

Riboflavin synthase-like beta-barrel

SSF63380 (Riboflavi...)

50 - 160

SUPERFAMILY
SSF63380 (Riboflavin synthase domain-like)

IPR017927

Ferredoxin reductase-type FAD-binding domain

PS51384 (FAD_FR)

56 - 159

PROSITE profiles
PS51384 (FAD_FR)

IPR008333

Oxidoreductase, FAD-binding domain

PF00970 (FAD_binding_6)

61 - 158

Pfam
PF00970 (FAD_binding_6)

IPR001433

Oxidoreductase FAD/NAD(P)-binding

PF00175 (NAD_binding_1)

168 - 273

Pfam
PF00175 (NAD_binding_1)

IPR001709

Flavoprotein pyridine nucleotide cytochrome reductase

PR00371 (FPNCR)

260 - 268

PRINTS
PR00371 (FPNCR)

167 - 186

PRINTS
PR00371 (FPNCR)

205 - 216

PRINTS
PR00371 (FPNCR)

108 - 115

PRINTS
PR00371 (FPNCR)

no IPR

Unintegrated signatures

SSF52343 (Ferredoxi...)

147 - 286

SUPERFAMILY
SSF52343 (Ferredoxin reductase-like, C-terminal NADP-linked domain)
cd06183 (cyt_b5_red...)

61 - 298

CDD
cd06183 (cyt_b5_reduct_like)

Residue annotation

FAD binding pocket...

94H

FAD binding pocket
94H, 108R, 109S, 110Y, 111T, 125V, 126V, 127K, 129Y, 131N, 132G, 133S, 134I, 135S, 173T, 176T, 177P, 298F
CDD
cd06183 (cyt_b5_reduct_like)

108R

FAD binding pocket
94H, 108R, 109S, 110Y, 111T, 125V, 126V, 127K, 129Y, 131N, 132G, 133S, 134I, 135S, 173T, 176T, 177P, 298F
CDD
cd06183 (cyt_b5_reduct_like)

109S

FAD binding pocket
94H, 108R, 109S, 110Y, 111T, 125V, 126V, 127K, 129Y, 131N, 132G, 133S, 134I, 135S, 173T, 176T, 177P, 298F
CDD
cd06183 (cyt_b5_reduct_like)

110Y

FAD binding pocket
94H, 108R, 109S, 110Y, 111T, 125V, 126V, 127K, 129Y, 131N, 132G, 133S, 134I, 135S, 173T, 176T, 177P, 298F
CDD
cd06183 (cyt_b5_reduct_like)

111T

FAD binding pocket
94H, 108R, 109S, 110Y, 111T, 125V, 126V, 127K, 129Y, 131N, 132G, 133S, 134I, 135S, 173T, 176T, 177P, 298F
CDD
cd06183 (cyt_b5_reduct_like)

125V

FAD binding pocket
94H, 108R, 109S, 110Y, 111T, 125V, 126V, 127K, 129Y, 131N, 132G, 133S, 134I, 135S, 173T, 176T, 177P, 298F
CDD
cd06183 (cyt_b5_reduct_like)

126V

FAD binding pocket
94H, 108R, 109S, 110Y, 111T, 125V, 126V, 127K, 129Y, 131N, 132G, 133S, 134I, 135S, 173T, 176T, 177P, 298F
CDD
cd06183 (cyt_b5_reduct_like)

127K

FAD binding pocket
94H, 108R, 109S, 110Y, 111T, 125V, 126V, 127K, 129Y, 131N, 132G, 133S, 134I, 135S, 173T, 176T, 177P, 298F
CDD
cd06183 (cyt_b5_reduct_like)

129Y

FAD binding pocket
94H, 108R, 109S, 110Y, 111T, 125V, 126V, 127K, 129Y, 131N, 132G, 133S, 134I, 135S, 173T, 176T, 177P, 298F
CDD
cd06183 (cyt_b5_reduct_like)

131N

FAD binding pocket
94H, 108R, 109S, 110Y, 111T, 125V, 126V, 127K, 129Y, 131N, 132G, 133S, 134I, 135S, 173T, 176T, 177P, 298F
CDD
cd06183 (cyt_b5_reduct_like)

132G

FAD binding pocket
94H, 108R, 109S, 110Y, 111T, 125V, 126V, 127K, 129Y, 131N, 132G, 133S, 134I, 135S, 173T, 176T, 177P, 298F
CDD
cd06183 (cyt_b5_reduct_like)

133S

FAD binding pocket
94H, 108R, 109S, 110Y, 111T, 125V, 126V, 127K, 129Y, 131N, 132G, 133S, 134I, 135S, 173T, 176T, 177P, 298F
CDD
cd06183 (cyt_b5_reduct_like)

134I

FAD binding pocket
94H, 108R, 109S, 110Y, 111T, 125V, 126V, 127K, 129Y, 131N, 132G, 133S, 134I, 135S, 173T, 176T, 177P, 298F
CDD
cd06183 (cyt_b5_reduct_like)

135S

FAD binding pocket
94H, 108R, 109S, 110Y, 111T, 125V, 126V, 127K, 129Y, 131N, 132G, 133S, 134I, 135S, 173T, 176T, 177P, 298F
CDD
cd06183 (cyt_b5_reduct_like)

173T

FAD binding pocket
94H, 108R, 109S, 110Y, 111T, 125V, 126V, 127K, 129Y, 131N, 132G, 133S, 134I, 135S, 173T, 176T, 177P, 298F
CDD
cd06183 (cyt_b5_reduct_like)

176T

FAD binding pocket
94H, 108R, 109S, 110Y, 111T, 125V, 126V, 127K, 129Y, 131N, 132G, 133S, 134I, 135S, 173T, 176T, 177P, 298F
CDD
cd06183 (cyt_b5_reduct_like)

177P

FAD binding pocket
94H, 108R, 109S, 110Y, 111T, 125V, 126V, 127K, 129Y, 131N, 132G, 133S, 134I, 135S, 173T, 176T, 177P, 298F
CDD
cd06183 (cyt_b5_reduct_like)

298F

FAD binding pocket
94H, 108R, 109S, 110Y, 111T, 125V, 126V, 127K, 129Y, 131N, 132G, 133S, 134I, 135S, 173T, 176T, 177P, 298F
CDD
cd06183 (cyt_b5_reduct_like)
FAD binding motif ...

108R

FAD binding motif
108R, 110Y, 111T
CDD
cd06183 (cyt_b5_reduct_like)

110Y

FAD binding motif
108R, 110Y, 111T
CDD
cd06183 (cyt_b5_reduct_like)

111T

FAD binding motif
108R, 110Y, 111T
CDD
cd06183 (cyt_b5_reduct_like)
NAD binding pocket...

127K

NAD binding pocket
127K, 129Y, 173T, 174G, 200A, 201N, 202Q, 230D, 242F, 265G, 266P, 267I, 268P, 269M
CDD
cd06183 (cyt_b5_reduct_like)

129Y

NAD binding pocket
127K, 129Y, 173T, 174G, 200A, 201N, 202Q, 230D, 242F, 265G, 266P, 267I, 268P, 269M
CDD
cd06183 (cyt_b5_reduct_like)

173T

NAD binding pocket
127K, 129Y, 173T, 174G, 200A, 201N, 202Q, 230D, 242F, 265G, 266P, 267I, 268P, 269M
CDD
cd06183 (cyt_b5_reduct_like)

174G

NAD binding pocket
127K, 129Y, 173T, 174G, 200A, 201N, 202Q, 230D, 242F, 265G, 266P, 267I, 268P, 269M
CDD
cd06183 (cyt_b5_reduct_like)

200A

NAD binding pocket
127K, 129Y, 173T, 174G, 200A, 201N, 202Q, 230D, 242F, 265G, 266P, 267I, 268P, 269M
CDD
cd06183 (cyt_b5_reduct_like)

201N

NAD binding pocket
127K, 129Y, 173T, 174G, 200A, 201N, 202Q, 230D, 242F, 265G, 266P, 267I, 268P, 269M
CDD
cd06183 (cyt_b5_reduct_like)

202Q

NAD binding pocket
127K, 129Y, 173T, 174G, 200A, 201N, 202Q, 230D, 242F, 265G, 266P, 267I, 268P, 269M
CDD
cd06183 (cyt_b5_reduct_like)

230D

NAD binding pocket
127K, 129Y, 173T, 174G, 200A, 201N, 202Q, 230D, 242F, 265G, 266P, 267I, 268P, 269M
CDD
cd06183 (cyt_b5_reduct_like)

242F

NAD binding pocket
127K, 129Y, 173T, 174G, 200A, 201N, 202Q, 230D, 242F, 265G, 266P, 267I, 268P, 269M
CDD
cd06183 (cyt_b5_reduct_like)

265G

NAD binding pocket
127K, 129Y, 173T, 174G, 200A, 201N, 202Q, 230D, 242F, 265G, 266P, 267I, 268P, 269M
CDD
cd06183 (cyt_b5_reduct_like)

266P

NAD binding pocket
127K, 129Y, 173T, 174G, 200A, 201N, 202Q, 230D, 242F, 265G, 266P, 267I, 268P, 269M
CDD
cd06183 (cyt_b5_reduct_like)

267I

NAD binding pocket
127K, 129Y, 173T, 174G, 200A, 201N, 202Q, 230D, 242F, 265G, 266P, 267I, 268P, 269M
CDD
cd06183 (cyt_b5_reduct_like)

268P

NAD binding pocket
127K, 129Y, 173T, 174G, 200A, 201N, 202Q, 230D, 242F, 265G, 266P, 267I, 268P, 269M
CDD
cd06183 (cyt_b5_reduct_like)

269M

NAD binding pocket
127K, 129Y, 173T, 174G, 200A, 201N, 202Q, 230D, 242F, 265G, 266P, 267I, 268P, 269M
CDD
cd06183 (cyt_b5_reduct_like)
phosphate binding ...

132G

phosphate binding motif
132G, 135S, 138I, 144G, 152P, 154G
CDD
cd06183 (cyt_b5_reduct_like)

135S

phosphate binding motif
132G, 135S, 138I, 144G, 152P, 154G
CDD
cd06183 (cyt_b5_reduct_like)

138I

phosphate binding motif
132G, 135S, 138I, 144G, 152P, 154G
CDD
cd06183 (cyt_b5_reduct_like)

144G

phosphate binding motif
132G, 135S, 138I, 144G, 152P, 154G
CDD
cd06183 (cyt_b5_reduct_like)

152P

phosphate binding motif
132G, 135S, 138I, 144G, 152P, 154G
CDD
cd06183 (cyt_b5_reduct_like)

154G

phosphate binding motif
132G, 135S, 138I, 144G, 152P, 154G
CDD
cd06183 (cyt_b5_reduct_like)
beta-alpha-beta st...

168M

beta-alpha-beta structure motif
168M, 172G, 173T, 174G, 175I, 177P
CDD
cd06183 (cyt_b5_reduct_like)

172G

beta-alpha-beta structure motif
168M, 172G, 173T, 174G, 175I, 177P
CDD
cd06183 (cyt_b5_reduct_like)

173T

beta-alpha-beta structure motif
168M, 172G, 173T, 174G, 175I, 177P
CDD
cd06183 (cyt_b5_reduct_like)

174G

beta-alpha-beta structure motif
168M, 172G, 173T, 174G, 175I, 177P
CDD
cd06183 (cyt_b5_reduct_like)

175I

beta-alpha-beta structure motif
168M, 172G, 173T, 174G, 175I, 177P
CDD
cd06183 (cyt_b5_reduct_like)

177P

beta-alpha-beta structure motif
168M, 172G, 173T, 174G, 175I, 177P
CDD
cd06183 (cyt_b5_reduct_like)

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

GBC50821.1

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component