GBC48604.1

Protein

Length

414 amino acids

Protein family membership

Aminotransferase class IV (IPR001544)
- Branched-chain aminotransferase (IPR033939)
  - Branched-chain amino acid aminotransferase II (IPR005786)

Domains and repeats

None predicted.

Detailed signature matches

IPR001544

Aminotransferase class IV
1. SSF56752 (D-aminoac...)
  
  59 - 412
  
  SUPERFAMILY
  SSF56752 (D-aminoacid aminotransferase-like PLP-dependent enzymes)
2. PF01063 (Aminotran_4)
  
  118 - 366
  
  Pfam
  PF01063 (Aminotran_4)
IPR033939

Branched-chain aminotransferase
1. cd01557 (BCAT_beta_...)
  
  104 - 403
  
  CDD
  cd01557 (BCAT_beta_family)
IPR005786

Branched-chain amino acid aminotransferase II
1. PIRSF006468 (BCAT1)
  
  49 - 414
  
  PIRSF
  PIRSF006468 (BCAT1)
2. TIGR01123
  
  92 - 411
  
  TIGRFAMs
  TIGR01123 (TIGR01123)
IPR018300

Aminotransferase, class IV, conserved site
1. PS00770 (AA_TRANSFE...)
  
  280 - 314
  
  PROSITE patterns
  PS00770 (AA_TRANSFER_CLASS_4)

Residue annotation

homodimer interfac...

104S

homodimer interface
104S, 105L, 106E, 107P, 108S, 111V, 112F, 113H, 114Y, 115S, 117E, 119F, 150R, 187R, 189A, 195E, 196S, 197L, 201A, 208F, 247G, 252P, 254V, 258I, 272F
CDD
cd01557 (BCAT_beta_family)

105L

homodimer interface
104S, 105L, 106E, 107P, 108S, 111V, 112F, 113H, 114Y, 115S, 117E, 119F, 150R, 187R, 189A, 195E, 196S, 197L, 201A, 208F, 247G, 252P, 254V, 258I, 272F
CDD
cd01557 (BCAT_beta_family)

106E

homodimer interface
104S, 105L, 106E, 107P, 108S, 111V, 112F, 113H, 114Y, 115S, 117E, 119F, 150R, 187R, 189A, 195E, 196S, 197L, 201A, 208F, 247G, 252P, 254V, 258I, 272F
CDD
cd01557 (BCAT_beta_family)

107P

homodimer interface
104S, 105L, 106E, 107P, 108S, 111V, 112F, 113H, 114Y, 115S, 117E, 119F, 150R, 187R, 189A, 195E, 196S, 197L, 201A, 208F, 247G, 252P, 254V, 258I, 272F
CDD
cd01557 (BCAT_beta_family)

108S

homodimer interface
104S, 105L, 106E, 107P, 108S, 111V, 112F, 113H, 114Y, 115S, 117E, 119F, 150R, 187R, 189A, 195E, 196S, 197L, 201A, 208F, 247G, 252P, 254V, 258I, 272F
CDD
cd01557 (BCAT_beta_family)

111V

homodimer interface
104S, 105L, 106E, 107P, 108S, 111V, 112F, 113H, 114Y, 115S, 117E, 119F, 150R, 187R, 189A, 195E, 196S, 197L, 201A, 208F, 247G, 252P, 254V, 258I, 272F
CDD
cd01557 (BCAT_beta_family)

112F

homodimer interface
104S, 105L, 106E, 107P, 108S, 111V, 112F, 113H, 114Y, 115S, 117E, 119F, 150R, 187R, 189A, 195E, 196S, 197L, 201A, 208F, 247G, 252P, 254V, 258I, 272F
CDD
cd01557 (BCAT_beta_family)

113H

homodimer interface
104S, 105L, 106E, 107P, 108S, 111V, 112F, 113H, 114Y, 115S, 117E, 119F, 150R, 187R, 189A, 195E, 196S, 197L, 201A, 208F, 247G, 252P, 254V, 258I, 272F
CDD
cd01557 (BCAT_beta_family)

114Y

homodimer interface
104S, 105L, 106E, 107P, 108S, 111V, 112F, 113H, 114Y, 115S, 117E, 119F, 150R, 187R, 189A, 195E, 196S, 197L, 201A, 208F, 247G, 252P, 254V, 258I, 272F
CDD
cd01557 (BCAT_beta_family)

115S

homodimer interface
104S, 105L, 106E, 107P, 108S, 111V, 112F, 113H, 114Y, 115S, 117E, 119F, 150R, 187R, 189A, 195E, 196S, 197L, 201A, 208F, 247G, 252P, 254V, 258I, 272F
CDD
cd01557 (BCAT_beta_family)

117E

homodimer interface
104S, 105L, 106E, 107P, 108S, 111V, 112F, 113H, 114Y, 115S, 117E, 119F, 150R, 187R, 189A, 195E, 196S, 197L, 201A, 208F, 247G, 252P, 254V, 258I, 272F
CDD
cd01557 (BCAT_beta_family)

119F

homodimer interface
104S, 105L, 106E, 107P, 108S, 111V, 112F, 113H, 114Y, 115S, 117E, 119F, 150R, 187R, 189A, 195E, 196S, 197L, 201A, 208F, 247G, 252P, 254V, 258I, 272F
CDD
cd01557 (BCAT_beta_family)

150R

homodimer interface
104S, 105L, 106E, 107P, 108S, 111V, 112F, 113H, 114Y, 115S, 117E, 119F, 150R, 187R, 189A, 195E, 196S, 197L, 201A, 208F, 247G, 252P, 254V, 258I, 272F
CDD
cd01557 (BCAT_beta_family)

187R

homodimer interface
104S, 105L, 106E, 107P, 108S, 111V, 112F, 113H, 114Y, 115S, 117E, 119F, 150R, 187R, 189A, 195E, 196S, 197L, 201A, 208F, 247G, 252P, 254V, 258I, 272F
CDD
cd01557 (BCAT_beta_family)

189A

homodimer interface
104S, 105L, 106E, 107P, 108S, 111V, 112F, 113H, 114Y, 115S, 117E, 119F, 150R, 187R, 189A, 195E, 196S, 197L, 201A, 208F, 247G, 252P, 254V, 258I, 272F
CDD
cd01557 (BCAT_beta_family)

195E

homodimer interface
104S, 105L, 106E, 107P, 108S, 111V, 112F, 113H, 114Y, 115S, 117E, 119F, 150R, 187R, 189A, 195E, 196S, 197L, 201A, 208F, 247G, 252P, 254V, 258I, 272F
CDD
cd01557 (BCAT_beta_family)

196S

homodimer interface
104S, 105L, 106E, 107P, 108S, 111V, 112F, 113H, 114Y, 115S, 117E, 119F, 150R, 187R, 189A, 195E, 196S, 197L, 201A, 208F, 247G, 252P, 254V, 258I, 272F
CDD
cd01557 (BCAT_beta_family)

197L

homodimer interface
104S, 105L, 106E, 107P, 108S, 111V, 112F, 113H, 114Y, 115S, 117E, 119F, 150R, 187R, 189A, 195E, 196S, 197L, 201A, 208F, 247G, 252P, 254V, 258I, 272F
CDD
cd01557 (BCAT_beta_family)

201A

homodimer interface
104S, 105L, 106E, 107P, 108S, 111V, 112F, 113H, 114Y, 115S, 117E, 119F, 150R, 187R, 189A, 195E, 196S, 197L, 201A, 208F, 247G, 252P, 254V, 258I, 272F
CDD
cd01557 (BCAT_beta_family)

208F

homodimer interface
104S, 105L, 106E, 107P, 108S, 111V, 112F, 113H, 114Y, 115S, 117E, 119F, 150R, 187R, 189A, 195E, 196S, 197L, 201A, 208F, 247G, 252P, 254V, 258I, 272F
CDD
cd01557 (BCAT_beta_family)

247G

homodimer interface
104S, 105L, 106E, 107P, 108S, 111V, 112F, 113H, 114Y, 115S, 117E, 119F, 150R, 187R, 189A, 195E, 196S, 197L, 201A, 208F, 247G, 252P, 254V, 258I, 272F
CDD
cd01557 (BCAT_beta_family)

252P

homodimer interface
104S, 105L, 106E, 107P, 108S, 111V, 112F, 113H, 114Y, 115S, 117E, 119F, 150R, 187R, 189A, 195E, 196S, 197L, 201A, 208F, 247G, 252P, 254V, 258I, 272F
CDD
cd01557 (BCAT_beta_family)

254V

homodimer interface
104S, 105L, 106E, 107P, 108S, 111V, 112F, 113H, 114Y, 115S, 117E, 119F, 150R, 187R, 189A, 195E, 196S, 197L, 201A, 208F, 247G, 252P, 254V, 258I, 272F
CDD
cd01557 (BCAT_beta_family)

258I

homodimer interface
104S, 105L, 106E, 107P, 108S, 111V, 112F, 113H, 114Y, 115S, 117E, 119F, 150R, 187R, 189A, 195E, 196S, 197L, 201A, 208F, 247G, 252P, 254V, 258I, 272F
CDD
cd01557 (BCAT_beta_family)

272F

homodimer interface
104S, 105L, 106E, 107P, 108S, 111V, 112F, 113H, 114Y, 115S, 117E, 119F, 150R, 187R, 189A, 195E, 196S, 197L, 201A, 208F, 247G, 252P, 254V, 258I, 272F
CDD
cd01557 (BCAT_beta_family)
substrate-cofactor...

114Y

substrate-cofactor binding pocket
114Y, 119F, 143R, 199V, 245K, 250Y, 280E, 312V, 313T, 356T
CDD
cd01557 (BCAT_beta_family)

119F

substrate-cofactor binding pocket
114Y, 119F, 143R, 199V, 245K, 250Y, 280E, 312V, 313T, 356T
CDD
cd01557 (BCAT_beta_family)

143R

substrate-cofactor binding pocket
114Y, 119F, 143R, 199V, 245K, 250Y, 280E, 312V, 313T, 356T
CDD
cd01557 (BCAT_beta_family)

199V

substrate-cofactor binding pocket
114Y, 119F, 143R, 199V, 245K, 250Y, 280E, 312V, 313T, 356T
CDD
cd01557 (BCAT_beta_family)

245K

substrate-cofactor binding pocket
114Y, 119F, 143R, 199V, 245K, 250Y, 280E, 312V, 313T, 356T
CDD
cd01557 (BCAT_beta_family)

250Y

substrate-cofactor binding pocket
114Y, 119F, 143R, 199V, 245K, 250Y, 280E, 312V, 313T, 356T
CDD
cd01557 (BCAT_beta_family)

280E

substrate-cofactor binding pocket
114Y, 119F, 143R, 199V, 245K, 250Y, 280E, 312V, 313T, 356T
CDD
cd01557 (BCAT_beta_family)

312V

substrate-cofactor binding pocket
114Y, 119F, 143R, 199V, 245K, 250Y, 280E, 312V, 313T, 356T
CDD
cd01557 (BCAT_beta_family)

313T

substrate-cofactor binding pocket
114Y, 119F, 143R, 199V, 245K, 250Y, 280E, 312V, 313T, 356T
CDD
cd01557 (BCAT_beta_family)

356T

substrate-cofactor binding pocket
114Y, 119F, 143R, 199V, 245K, 250Y, 280E, 312V, 313T, 356T
CDD
cd01557 (BCAT_beta_family)
catalytic residue ...

245K

catalytic residue
245K
CDD
cd01557 (BCAT_beta_family)

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0009081 branched-chain amino acid metabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0004084 branched-chain-amino-acid transaminase activity

Cellular Component