GBC48582.1

Protein

Length

1,220 amino acids

Protein family membership

Hydroxymethylglutaryl-CoA reductase, class I/II (IPR002202)
- Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type (IPR004554)
  - Hydroxymethylglutaryl-CoA reductase, metazoan (IPR004816)

Domains and repeats

Domain
253 - 421
Sterol-sensing domain (IPR000731)
833 - 948
Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain (IPR009023)
Domain
696 - 830
Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain (IPR009029)
946 - 1,105
Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain (IPR009029)

1 200 400 600 800 1000 1220

Detailed signature matches

IPR002202

Hydroxymethylglutaryl-CoA reductase, class I/II
1. PR00071 (HMGCOARDTASE)
  
  929 - 954
  
  PRINTS
  PR00071 (HMGCOARDTASE)
  
  772 - 793
  
  PRINTS
  PR00071 (HMGCOARDTASE)
  
  799 - 819
  
  PRINTS
  PR00071 (HMGCOARDTASE)
  
  889 - 907
  
  PRINTS
  PR00071 (HMGCOARDTASE)
  
  1,034 - 1,055
  
  PRINTS
  PR00071 (HMGCOARDTASE)
  
  980 - 1,006
  
  PRINTS
  PR00071 (HMGCOARDTASE)
2. PS50065 (HMG_COA_RE...)
  
  709 - 1,115
  
  PROSITE profiles
  PS50065 (HMG_COA_REDUCTASE_4)
3. PF00368 (HMG-CoA_red)
  
  736 - 1,115
  
  Pfam
  PF00368 (HMG-CoA_red)
IPR004554

Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type
1. TIGR00533
  
  709 - 1,115
  
  TIGRFAMs
  TIGR00533 (TIGR00533)
2. cd00643 (HMG-CoA_re...)
  
  710 - 1,115
  
  CDD
  cd00643 (HMG-CoA_reductase_classI)
IPR004816

Hydroxymethylglutaryl-CoA reductase, metazoan
1. TIGR00920
  
  249 - 1,117
  
  TIGRFAMs
  TIGR00920 (TIGR00920)
IPR000731

Sterol-sensing domain
1. PS50156 (SSD)
  
  253 - 418
  
  PROSITE profiles
  PS50156 (SSD)
2. PF12349 (Sterol-sen...)
  
  282 - 421
  
  Pfam
  PF12349 (Sterol-sensing)
IPR009029

Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain
1. SSF56542 (Substrate...)
  
  946 - 1,105
  
  SUPERFAMILY
  SSF56542 (Substrate-binding domain of HMG-CoA reductase)
  
  696 - 830
  
  SUPERFAMILY
  SSF56542 (Substrate-binding domain of HMG-CoA reductase)
IPR009023

Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain
1. SSF55035 (NAD-bindi...)
  
  833 - 948
  
  SUPERFAMILY
  SSF55035 (NAD-binding domain of HMG-CoA reductase)
IPR023076

Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site
1. PS00066 (HMG_COA_RE...)
  
  891 - 905
  
  PROSITE patterns
  PS00066 (HMG_COA_REDUCTASE_1)
2. PS01192 (HMG_COA_RE...)
  
  1,100 - 1,113
  
  PROSITE patterns
  PS01192 (HMG_COA_REDUCTASE_3)
3. PS00318 (HMG_COA_RE...)
  
  1,046 - 1,053
  
  PROSITE patterns
  PS00318 (HMG_COA_REDUCTASE_2)

no IPR

Unintegrated signatures

mobidb-lite (disord...)

1,132 - 1,220

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

tetramerization in...

752T

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

753L

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

757A

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

758L

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

763Y

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

768V

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

771T

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

772C

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

773C

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

774E

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

775N

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

776V

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

777I

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

778G

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

779Y

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

780M

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

781Q

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

782I

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

783P

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

784V

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

785G

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

786V

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

798H

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

803T

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

804T

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

805E

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

806G

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

807C

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

808L

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

809V

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

810A

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

826T

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

828V

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

830T

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

841E

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

849N

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

880K

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

883L

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

885G

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

886K

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

887L

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

889F

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

926I

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

928L

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

929S

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

930G

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

931N

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

932Y

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

934T

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

936K

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

937K

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

938S

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

939A

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

940A

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

941I

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

943W

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

944I

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

945E

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

952V

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

954E

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

956I

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

975E

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

976L

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

978I

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

979S

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

980K

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

981N

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

982F

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

983I

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

984G

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

985S

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

986A

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

987M

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

993G

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

994F

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

995N

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

996A

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

999A

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

1,000N

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

1,003T

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

1,007I

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

1,008A

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

1,012D

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

1,013P

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

1,014A

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

1,016N

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

1,017V

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

1,025I

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

1,027K

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

1,036H

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

1,038T

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

1,040T

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

1,052G

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

1,057A

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

1,058Q

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

1,060S

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

1,061M

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

1,063E

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

1,064M

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

1,101L

tetramerization interface
752T, 753L, 757A, 758L, 763Y, 768V, 771T, 772C, 773C, 774E, 775N, 776V, 777I, 778G, 779Y, 780M, 781Q, 782I, 783P, 784V, 785G, 786V, 798H, 803T, 804T, 805E, 806G, 807C, 808L, 809V, 810A, 826T, 828V, 830T, 841E, 849N, 880K, 883L, 885G, 886K, 887L, 889F, 926I, 928L, 929S, 930G, 931N, 932Y, 934T, 936K, 937K, 938S, 939A, 940A, 941I, 943W, 944I, 945E, 952V, 954E, 956I, 975E, 976L, 978I, 979S, 980K, 981N, 982F, 983I, 984G, 985S, 986A, 987M, 993G, 994F, 995N, 996A, 999A, 1,000N, 1,003T, 1,007I, 1,008A, 1,012D, 1,013P, 1,014A, 1,016N, 1,017V, 1,025I, 1,027K, 1,036H, 1,038T, 1,040T, 1,052G, 1,057A, 1,058Q, 1,060S, 1,061M, 1,063E, 1,064M, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)
inhibitor binding ...

805E

inhibitor binding sites
805E, 808L, 811S, 980K, 996A, 997H, 1,000N, 1,097L, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

808L

inhibitor binding sites
805E, 808L, 811S, 980K, 996A, 997H, 1,000N, 1,097L, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

811S

inhibitor binding sites
805E, 808L, 811S, 980K, 996A, 997H, 1,000N, 1,097L, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

980K

inhibitor binding sites
805E, 808L, 811S, 980K, 996A, 997H, 1,000N, 1,097L, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

996A

inhibitor binding sites
805E, 808L, 811S, 980K, 996A, 997H, 1,000N, 1,097L, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

997H

inhibitor binding sites
805E, 808L, 811S, 980K, 996A, 997H, 1,000N, 1,097L, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

1,000N

inhibitor binding sites
805E, 808L, 811S, 980K, 996A, 997H, 1,000N, 1,097L, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

1,097L

inhibitor binding sites
805E, 808L, 811S, 980K, 996A, 997H, 1,000N, 1,097L, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)

1,101L

inhibitor binding sites
805E, 808L, 811S, 980K, 996A, 997H, 1,000N, 1,097L, 1,101L
CDD
cd00643 (HMG-CoA_reductase_classI)
catalytic residues...

805E

catalytic residues
805E, 936K, 1,012D, 1,110H
CDD
cd00643 (HMG-CoA_reductase_classI)

936K

catalytic residues
805E, 936K, 1,012D, 1,110H
CDD
cd00643 (HMG-CoA_reductase_classI)

1,012D

catalytic residues
805E, 936K, 1,012D, 1,110H
CDD
cd00643 (HMG-CoA_reductase_classI)

1,110H

catalytic residues
805E, 936K, 1,012D, 1,110H
CDD
cd00643 (HMG-CoA_reductase_classI)
substrate binding ...

805E

substrate binding pocket
805E, 807C, 808L, 810A, 811S, 813A, 814R, 817K, 967K, 997H, 1,000N, 1,096S, 1,097L, 1,100A, 1,106L, 1,109S, 1,110H, 1,113H
CDD
cd00643 (HMG-CoA_reductase_classI)

807C

substrate binding pocket
805E, 807C, 808L, 810A, 811S, 813A, 814R, 817K, 967K, 997H, 1,000N, 1,096S, 1,097L, 1,100A, 1,106L, 1,109S, 1,110H, 1,113H
CDD
cd00643 (HMG-CoA_reductase_classI)

808L

substrate binding pocket
805E, 807C, 808L, 810A, 811S, 813A, 814R, 817K, 967K, 997H, 1,000N, 1,096S, 1,097L, 1,100A, 1,106L, 1,109S, 1,110H, 1,113H
CDD
cd00643 (HMG-CoA_reductase_classI)

810A

substrate binding pocket
805E, 807C, 808L, 810A, 811S, 813A, 814R, 817K, 967K, 997H, 1,000N, 1,096S, 1,097L, 1,100A, 1,106L, 1,109S, 1,110H, 1,113H
CDD
cd00643 (HMG-CoA_reductase_classI)

811S

substrate binding pocket
805E, 807C, 808L, 810A, 811S, 813A, 814R, 817K, 967K, 997H, 1,000N, 1,096S, 1,097L, 1,100A, 1,106L, 1,109S, 1,110H, 1,113H
CDD
cd00643 (HMG-CoA_reductase_classI)

813A

substrate binding pocket
805E, 807C, 808L, 810A, 811S, 813A, 814R, 817K, 967K, 997H, 1,000N, 1,096S, 1,097L, 1,100A, 1,106L, 1,109S, 1,110H, 1,113H
CDD
cd00643 (HMG-CoA_reductase_classI)

814R

substrate binding pocket
805E, 807C, 808L, 810A, 811S, 813A, 814R, 817K, 967K, 997H, 1,000N, 1,096S, 1,097L, 1,100A, 1,106L, 1,109S, 1,110H, 1,113H
CDD
cd00643 (HMG-CoA_reductase_classI)

817K

substrate binding pocket
805E, 807C, 808L, 810A, 811S, 813A, 814R, 817K, 967K, 997H, 1,000N, 1,096S, 1,097L, 1,100A, 1,106L, 1,109S, 1,110H, 1,113H
CDD
cd00643 (HMG-CoA_reductase_classI)

967K

substrate binding pocket
805E, 807C, 808L, 810A, 811S, 813A, 814R, 817K, 967K, 997H, 1,000N, 1,096S, 1,097L, 1,100A, 1,106L, 1,109S, 1,110H, 1,113H
CDD
cd00643 (HMG-CoA_reductase_classI)

997H

substrate binding pocket
805E, 807C, 808L, 810A, 811S, 813A, 814R, 817K, 967K, 997H, 1,000N, 1,096S, 1,097L, 1,100A, 1,106L, 1,109S, 1,110H, 1,113H
CDD
cd00643 (HMG-CoA_reductase_classI)

1,000N

substrate binding pocket
805E, 807C, 808L, 810A, 811S, 813A, 814R, 817K, 967K, 997H, 1,000N, 1,096S, 1,097L, 1,100A, 1,106L, 1,109S, 1,110H, 1,113H
CDD
cd00643 (HMG-CoA_reductase_classI)

1,096S

substrate binding pocket
805E, 807C, 808L, 810A, 811S, 813A, 814R, 817K, 967K, 997H, 1,000N, 1,096S, 1,097L, 1,100A, 1,106L, 1,109S, 1,110H, 1,113H
CDD
cd00643 (HMG-CoA_reductase_classI)

1,097L

substrate binding pocket
805E, 807C, 808L, 810A, 811S, 813A, 814R, 817K, 967K, 997H, 1,000N, 1,096S, 1,097L, 1,100A, 1,106L, 1,109S, 1,110H, 1,113H
CDD
cd00643 (HMG-CoA_reductase_classI)

1,100A

substrate binding pocket
805E, 807C, 808L, 810A, 811S, 813A, 814R, 817K, 967K, 997H, 1,000N, 1,096S, 1,097L, 1,100A, 1,106L, 1,109S, 1,110H, 1,113H
CDD
cd00643 (HMG-CoA_reductase_classI)

1,106L

substrate binding pocket
805E, 807C, 808L, 810A, 811S, 813A, 814R, 817K, 967K, 997H, 1,000N, 1,096S, 1,097L, 1,100A, 1,106L, 1,109S, 1,110H, 1,113H
CDD
cd00643 (HMG-CoA_reductase_classI)

1,109S

substrate binding pocket
805E, 807C, 808L, 810A, 811S, 813A, 814R, 817K, 967K, 997H, 1,000N, 1,096S, 1,097L, 1,100A, 1,106L, 1,109S, 1,110H, 1,113H
CDD
cd00643 (HMG-CoA_reductase_classI)

1,110H

substrate binding pocket
805E, 807C, 808L, 810A, 811S, 813A, 814R, 817K, 967K, 997H, 1,000N, 1,096S, 1,097L, 1,100A, 1,106L, 1,109S, 1,110H, 1,113H
CDD
cd00643 (HMG-CoA_reductase_classI)

1,113H

substrate binding pocket
805E, 807C, 808L, 810A, 811S, 813A, 814R, 817K, 967K, 997H, 1,000N, 1,096S, 1,097L, 1,100A, 1,106L, 1,109S, 1,110H, 1,113H
CDD
cd00643 (HMG-CoA_reductase_classI)
NADP(H) binding si...

836R

NADP(H) binding site
836R, 871S, 872R, 873F, 896T, 897G, 898D, 899A, 900M, 901G, 902M, 903N, 904M, 906S, 935D, 936K, 1,012D, 1,049I, 1,050G, 1,051G
CDD
cd00643 (HMG-CoA_reductase_classI)

871S

NADP(H) binding site
836R, 871S, 872R, 873F, 896T, 897G, 898D, 899A, 900M, 901G, 902M, 903N, 904M, 906S, 935D, 936K, 1,012D, 1,049I, 1,050G, 1,051G
CDD
cd00643 (HMG-CoA_reductase_classI)

872R

NADP(H) binding site
836R, 871S, 872R, 873F, 896T, 897G, 898D, 899A, 900M, 901G, 902M, 903N, 904M, 906S, 935D, 936K, 1,012D, 1,049I, 1,050G, 1,051G
CDD
cd00643 (HMG-CoA_reductase_classI)

873F

NADP(H) binding site
836R, 871S, 872R, 873F, 896T, 897G, 898D, 899A, 900M, 901G, 902M, 903N, 904M, 906S, 935D, 936K, 1,012D, 1,049I, 1,050G, 1,051G
CDD
cd00643 (HMG-CoA_reductase_classI)

896T

NADP(H) binding site
836R, 871S, 872R, 873F, 896T, 897G, 898D, 899A, 900M, 901G, 902M, 903N, 904M, 906S, 935D, 936K, 1,012D, 1,049I, 1,050G, 1,051G
CDD
cd00643 (HMG-CoA_reductase_classI)

897G

NADP(H) binding site
836R, 871S, 872R, 873F, 896T, 897G, 898D, 899A, 900M, 901G, 902M, 903N, 904M, 906S, 935D, 936K, 1,012D, 1,049I, 1,050G, 1,051G
CDD
cd00643 (HMG-CoA_reductase_classI)

898D

NADP(H) binding site
836R, 871S, 872R, 873F, 896T, 897G, 898D, 899A, 900M, 901G, 902M, 903N, 904M, 906S, 935D, 936K, 1,012D, 1,049I, 1,050G, 1,051G
CDD
cd00643 (HMG-CoA_reductase_classI)

899A

NADP(H) binding site
836R, 871S, 872R, 873F, 896T, 897G, 898D, 899A, 900M, 901G, 902M, 903N, 904M, 906S, 935D, 936K, 1,012D, 1,049I, 1,050G, 1,051G
CDD
cd00643 (HMG-CoA_reductase_classI)

900M

NADP(H) binding site
836R, 871S, 872R, 873F, 896T, 897G, 898D, 899A, 900M, 901G, 902M, 903N, 904M, 906S, 935D, 936K, 1,012D, 1,049I, 1,050G, 1,051G
CDD
cd00643 (HMG-CoA_reductase_classI)

901G

NADP(H) binding site
836R, 871S, 872R, 873F, 896T, 897G, 898D, 899A, 900M, 901G, 902M, 903N, 904M, 906S, 935D, 936K, 1,012D, 1,049I, 1,050G, 1,051G
CDD
cd00643 (HMG-CoA_reductase_classI)

902M

NADP(H) binding site
836R, 871S, 872R, 873F, 896T, 897G, 898D, 899A, 900M, 901G, 902M, 903N, 904M, 906S, 935D, 936K, 1,012D, 1,049I, 1,050G, 1,051G
CDD
cd00643 (HMG-CoA_reductase_classI)

903N

NADP(H) binding site
836R, 871S, 872R, 873F, 896T, 897G, 898D, 899A, 900M, 901G, 902M, 903N, 904M, 906S, 935D, 936K, 1,012D, 1,049I, 1,050G, 1,051G
CDD
cd00643 (HMG-CoA_reductase_classI)

904M

NADP(H) binding site
836R, 871S, 872R, 873F, 896T, 897G, 898D, 899A, 900M, 901G, 902M, 903N, 904M, 906S, 935D, 936K, 1,012D, 1,049I, 1,050G, 1,051G
CDD
cd00643 (HMG-CoA_reductase_classI)

906S

NADP(H) binding site
836R, 871S, 872R, 873F, 896T, 897G, 898D, 899A, 900M, 901G, 902M, 903N, 904M, 906S, 935D, 936K, 1,012D, 1,049I, 1,050G, 1,051G
CDD
cd00643 (HMG-CoA_reductase_classI)

935D

NADP(H) binding site
836R, 871S, 872R, 873F, 896T, 897G, 898D, 899A, 900M, 901G, 902M, 903N, 904M, 906S, 935D, 936K, 1,012D, 1,049I, 1,050G, 1,051G
CDD
cd00643 (HMG-CoA_reductase_classI)

936K

NADP(H) binding site
836R, 871S, 872R, 873F, 896T, 897G, 898D, 899A, 900M, 901G, 902M, 903N, 904M, 906S, 935D, 936K, 1,012D, 1,049I, 1,050G, 1,051G
CDD
cd00643 (HMG-CoA_reductase_classI)

1,012D

NADP(H) binding site
836R, 871S, 872R, 873F, 896T, 897G, 898D, 899A, 900M, 901G, 902M, 903N, 904M, 906S, 935D, 936K, 1,012D, 1,049I, 1,050G, 1,051G
CDD
cd00643 (HMG-CoA_reductase_classI)

1,049I

NADP(H) binding site
836R, 871S, 872R, 873F, 896T, 897G, 898D, 899A, 900M, 901G, 902M, 903N, 904M, 906S, 935D, 936K, 1,012D, 1,049I, 1,050G, 1,051G
CDD
cd00643 (HMG-CoA_reductase_classI)

1,050G

NADP(H) binding site
836R, 871S, 872R, 873F, 896T, 897G, 898D, 899A, 900M, 901G, 902M, 903N, 904M, 906S, 935D, 936K, 1,012D, 1,049I, 1,050G, 1,051G
CDD
cd00643 (HMG-CoA_reductase_classI)

1,051G

NADP(H) binding site
836R, 871S, 872R, 873F, 896T, 897G, 898D, 899A, 900M, 901G, 902M, 903N, 904M, 906S, 935D, 936K, 1,012D, 1,049I, 1,050G, 1,051G
CDD
cd00643 (HMG-CoA_reductase_classI)

GO term prediction

Biological Process

GO:0008299 isoprenoid biosynthetic process
GO:0015936 coenzyme A metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0050661 NADP binding
GO:0050662 coenzyme binding

Cellular Component

GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features