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Protein

GBC47538.1

Length

225 amino acids

Protein family membership

Proteasome, subunit alpha/beta (IPR001353)

Domains and repeats

Domain
30 - 219
Nucleophile aminohydrolases, N-terminal (IPR029055)

1 50 100 150 200 225

Detailed signature matches

IPR001353

Proteasome, subunit alpha/beta

PF00227 (Proteasome)

34 - 118

Pfam
PF00227 (Proteasome)

125 - 195

Pfam
PF00227 (Proteasome)

IPR016295

Proteasome endopeptidase complex, beta subunit

cd03760 (proteasome...)

35 - 207

CDD
cd03760 (proteasome_beta_type_4)

IPR029055

Nucleophile aminohydrolases, N-terminal

SSF56235 (N-termina...)

30 - 219

SUPERFAMILY
SSF56235 (N-terminal nucleophile aminohydrolases (Ntn hydrolases))

IPR016050

Proteasome beta-type subunit, conserved site

PS00854 (PROTEASOME...)

40 - 87

PROSITE patterns
PS00854 (PROTEASOME_BETA_1)

Residue annotation

active site cd03760

37T

active site
37T, 53D, 55L, 69R, 145F, 185D, 188S, 189F
CDD
cd03760 (proteasome_beta_type_4)

53D

active site
37T, 53D, 55L, 69R, 145F, 185D, 188S, 189F
CDD
cd03760 (proteasome_beta_type_4)

55L

active site
37T, 53D, 55L, 69R, 145F, 185D, 188S, 189F
CDD
cd03760 (proteasome_beta_type_4)

69R

active site
37T, 53D, 55L, 69R, 145F, 185D, 188S, 189F
CDD
cd03760 (proteasome_beta_type_4)

145F

active site
37T, 53D, 55L, 69R, 145F, 185D, 188S, 189F
CDD
cd03760 (proteasome_beta_type_4)

185D

active site
37T, 53D, 55L, 69R, 145F, 185D, 188S, 189F
CDD
cd03760 (proteasome_beta_type_4)

188S

active site
37T, 53D, 55L, 69R, 145F, 185D, 188S, 189F
CDD
cd03760 (proteasome_beta_type_4)

189F

active site
37T, 53D, 55L, 69R, 145F, 185D, 188S, 189F
CDD
cd03760 (proteasome_beta_type_4)
beta subunit inter...

55L

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

58Y

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

60S

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

61L

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

62A

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

63R

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

64F

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

65T

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

85I

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

87D

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

102E

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

115N

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

118E

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

119Y

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

121S

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

122R

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

130D

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

132L

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

134T

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

135T

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

136Y

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

137Q

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

140T

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

148Y

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

149L

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

151Q

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

152P

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

155R

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

156K

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

157A

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

176S

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

183Y

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

184R

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

185D

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

186A

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

189F

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

190N

beta subunit interaction site
55L, 58Y, 60S, 61L, 62A, 63R, 64F, 65T, 85I, 87D, 102E, 115N, 118E, 119Y, 121S, 122R, 130D, 132L, 134T, 135T, 136Y, 137Q, 140T, 148Y, 149L, 151Q, 152P, 155R, 156K, 157A, 176S, 183Y, 184R, 185D, 186A, 189F, 190N
CDD
cd03760 (proteasome_beta_type_4)

GO term prediction

Biological Process

GO:0051603 proteolysis involved in cellular protein catabolic process

Molecular Function

GO:0004175 endopeptidase activity
GO:0004298 threonine-type endopeptidase activity

Cellular Component

GO:0005839 proteasome core complex