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Protein

GBC47133.1

Length

1,347 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
243 - 348
Retrotransposon gag domain (IPR005162)
440 - 472
Zinc finger, CCHC-type (IPR001878)
672 - 778
Aspartic peptidase domain (IPR021109)
Retroviral aspartyl protease (IPR013242)
953 - 1,132
Reverse transcriptase domain (IPR000477)

1 200 400 600 800 1000 1200 1347

Detailed signature matches

IPR005162

Retrotransposon gag domain

PF03732 (Retrotrans...)

243 - 348

Pfam
PF03732 (Retrotrans_gag)

IPR001878

Zinc finger, CCHC-type

PS50158 (ZF_CCHC)

452 - 467

PROSITE profiles
PS50158 (ZF_CCHC)
PF00098 (zf-CCHC)

451 - 467

Pfam
PF00098 (zf-CCHC)
SM00343 (c2hcfinal6)

451 - 467

SMART
SM00343 (c2hcfinal6)
SSF57756 (Retroviru...)

440 - 472

SUPERFAMILY
SSF57756 (Retrovirus zinc finger-like domains)

IPR021109

Aspartic peptidase domain

SSF50630 (Acid prot...)

672 - 771

SUPERFAMILY
SSF50630 (Acid proteases)

IPR013242

Retroviral aspartyl protease

PF08284 (RVP_2)

677 - 778

Pfam
PF08284 (RVP_2)

IPR000477

Reverse transcriptase domain

PF00078 (RVT_1)

973 - 1,131

Pfam
PF00078 (RVT_1)
PS50878 (RT_POL)

953 - 1,132

PROSITE profiles
PS50878 (RT_POL)

no IPR

Unintegrated signatures

SSF56672 (DNA/RNA p...)

897 - 1,329

SUPERFAMILY
SSF56672 (DNA/RNA polymerases)
cd00303 (retropepsi...)

677 - 764

CDD
cd00303 (retropepsin_like)
cd01647 (RT_LTR)

956 - 1,132

CDD
cd01647 (RT_LTR)
cd09274 (RNase_HI_R...)

1,227 - 1,345

CDD
cd09274 (RNase_HI_RT_Ty3)
mobidb-lite (disord...)

624 - 653

MobiDB Lite
mobidb-lite (disorder_prediction)

805 - 833

MobiDB Lite
mobidb-lite (disorder_prediction)

466 - 505

MobiDB Lite
mobidb-lite (disorder_prediction)

522 - 573

MobiDB Lite
mobidb-lite (disorder_prediction)

417 - 445

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

Catalytic residue ...

688D

Catalytic residue
688D
CDD
cd00303 (retropepsin_like)
catalytic motif cd...

688D

catalytic motif
688D, 689S, 690G
CDD
cd00303 (retropepsin_like)

689S

catalytic motif
688D, 689S, 690G
CDD
cd00303 (retropepsin_like)

690G

catalytic motif
688D, 689S, 690G
CDD
cd00303 (retropepsin_like)
inhibitor binding ...

688D

inhibitor binding site
688D, 690G, 692A, 716M, 717V, 718N, 757I
CDD
cd00303 (retropepsin_like)

690G

inhibitor binding site
688D, 690G, 692A, 716M, 717V, 718N, 757I
CDD
cd00303 (retropepsin_like)

692A

inhibitor binding site
688D, 690G, 692A, 716M, 717V, 718N, 757I
CDD
cd00303 (retropepsin_like)

716M

inhibitor binding site
688D, 690G, 692A, 716M, 717V, 718N, 757I
CDD
cd00303 (retropepsin_like)

717V

inhibitor binding site
688D, 690G, 692A, 716M, 717V, 718N, 757I
CDD
cd00303 (retropepsin_like)

718N

inhibitor binding site
688D, 690G, 692A, 716M, 717V, 718N, 757I
CDD
cd00303 (retropepsin_like)

757I

inhibitor binding site
688D, 690G, 692A, 716M, 717V, 718N, 757I
CDD
cd00303 (retropepsin_like)
Active site flap c...

716M

Active site flap
716M, 717V, 718N, 719V, 723R, 724R, 725R, 726P
CDD
cd00303 (retropepsin_like)

717V

Active site flap
716M, 717V, 718N, 719V, 723R, 724R, 725R, 726P
CDD
cd00303 (retropepsin_like)

718N

Active site flap
716M, 717V, 718N, 719V, 723R, 724R, 725R, 726P
CDD
cd00303 (retropepsin_like)

719V

Active site flap
716M, 717V, 718N, 719V, 723R, 724R, 725R, 726P
CDD
cd00303 (retropepsin_like)

723R

Active site flap
716M, 717V, 718N, 719V, 723R, 724R, 725R, 726P
CDD
cd00303 (retropepsin_like)

724R

Active site flap
716M, 717V, 718N, 719V, 723R, 724R, 725R, 726P
CDD
cd00303 (retropepsin_like)

725R

Active site flap
716M, 717V, 718N, 719V, 723R, 724R, 725R, 726P
CDD
cd00303 (retropepsin_like)

726P

Active site flap
716M, 717V, 718N, 719V, 723R, 724R, 725R, 726P
CDD
cd00303 (retropepsin_like)
putative NTP bindi...

1,019D

putative NTP binding site
1,019D, 1,020L, 1,021A, 1,022S, 1,023G, 1,024F, 1,053F, 1,083D
CDD
cd01647 (RT_LTR)

1,020L

putative NTP binding site
1,019D, 1,020L, 1,021A, 1,022S, 1,023G, 1,024F, 1,053F, 1,083D
CDD
cd01647 (RT_LTR)

1,021A

putative NTP binding site
1,019D, 1,020L, 1,021A, 1,022S, 1,023G, 1,024F, 1,053F, 1,083D
CDD
cd01647 (RT_LTR)

1,022S

putative NTP binding site
1,019D, 1,020L, 1,021A, 1,022S, 1,023G, 1,024F, 1,053F, 1,083D
CDD
cd01647 (RT_LTR)

1,023G

putative NTP binding site
1,019D, 1,020L, 1,021A, 1,022S, 1,023G, 1,024F, 1,053F, 1,083D
CDD
cd01647 (RT_LTR)

1,024F

putative NTP binding site
1,019D, 1,020L, 1,021A, 1,022S, 1,023G, 1,024F, 1,053F, 1,083D
CDD
cd01647 (RT_LTR)

1,053F

putative NTP binding site
1,019D, 1,020L, 1,021A, 1,022S, 1,023G, 1,024F, 1,053F, 1,083D
CDD
cd01647 (RT_LTR)

1,083D

putative NTP binding site
1,019D, 1,020L, 1,021A, 1,022S, 1,023G, 1,024F, 1,053F, 1,083D
CDD
cd01647 (RT_LTR)
putative active si...

1,019D

putative active site
1,019D, 1,020L, 1,021A, 1,022S, 1,023G, 1,024F, 1,053F, 1,054G, 1,081Y, 1,083D, 1,084D, 1,128L, 1,129G
CDD
cd01647 (RT_LTR)

1,020L

putative active site
1,019D, 1,020L, 1,021A, 1,022S, 1,023G, 1,024F, 1,053F, 1,054G, 1,081Y, 1,083D, 1,084D, 1,128L, 1,129G
CDD
cd01647 (RT_LTR)

1,021A

putative active site
1,019D, 1,020L, 1,021A, 1,022S, 1,023G, 1,024F, 1,053F, 1,054G, 1,081Y, 1,083D, 1,084D, 1,128L, 1,129G
CDD
cd01647 (RT_LTR)

1,022S

putative active site
1,019D, 1,020L, 1,021A, 1,022S, 1,023G, 1,024F, 1,053F, 1,054G, 1,081Y, 1,083D, 1,084D, 1,128L, 1,129G
CDD
cd01647 (RT_LTR)

1,023G

putative active site
1,019D, 1,020L, 1,021A, 1,022S, 1,023G, 1,024F, 1,053F, 1,054G, 1,081Y, 1,083D, 1,084D, 1,128L, 1,129G
CDD
cd01647 (RT_LTR)

1,024F

putative active site
1,019D, 1,020L, 1,021A, 1,022S, 1,023G, 1,024F, 1,053F, 1,054G, 1,081Y, 1,083D, 1,084D, 1,128L, 1,129G
CDD
cd01647 (RT_LTR)

1,053F

putative active site
1,019D, 1,020L, 1,021A, 1,022S, 1,023G, 1,024F, 1,053F, 1,054G, 1,081Y, 1,083D, 1,084D, 1,128L, 1,129G
CDD
cd01647 (RT_LTR)

1,054G

putative active site
1,019D, 1,020L, 1,021A, 1,022S, 1,023G, 1,024F, 1,053F, 1,054G, 1,081Y, 1,083D, 1,084D, 1,128L, 1,129G
CDD
cd01647 (RT_LTR)

1,081Y

putative active site
1,019D, 1,020L, 1,021A, 1,022S, 1,023G, 1,024F, 1,053F, 1,054G, 1,081Y, 1,083D, 1,084D, 1,128L, 1,129G
CDD
cd01647 (RT_LTR)

1,083D

putative active site
1,019D, 1,020L, 1,021A, 1,022S, 1,023G, 1,024F, 1,053F, 1,054G, 1,081Y, 1,083D, 1,084D, 1,128L, 1,129G
CDD
cd01647 (RT_LTR)

1,084D

putative active site
1,019D, 1,020L, 1,021A, 1,022S, 1,023G, 1,024F, 1,053F, 1,054G, 1,081Y, 1,083D, 1,084D, 1,128L, 1,129G
CDD
cd01647 (RT_LTR)

1,128L

putative active site
1,019D, 1,020L, 1,021A, 1,022S, 1,023G, 1,024F, 1,053F, 1,054G, 1,081Y, 1,083D, 1,084D, 1,128L, 1,129G
CDD
cd01647 (RT_LTR)

1,129G

putative active site
1,019D, 1,020L, 1,021A, 1,022S, 1,023G, 1,024F, 1,053F, 1,054G, 1,081Y, 1,083D, 1,084D, 1,128L, 1,129G
CDD
cd01647 (RT_LTR)
putative nucleic a...

1,054G

putative nucleic acid binding site
1,054G
CDD
cd01647 (RT_LTR)
active site cd09274

1,230D

active site
1,230D, 1,272E, 1,297D, 1,340D
CDD
cd09274 (RNase_HI_RT_Ty3)

1,272E

active site
1,230D, 1,272E, 1,297D, 1,340D
CDD
cd09274 (RNase_HI_RT_Ty3)

1,297D

active site
1,230D, 1,272E, 1,297D, 1,340D
CDD
cd09274 (RNase_HI_RT_Ty3)

1,340D

active site
1,230D, 1,272E, 1,297D, 1,340D
CDD
cd09274 (RNase_HI_RT_Ty3)
RNA/DNA hybrid bin...

1,230D

RNA/DNA hybrid binding site
1,230D, 1,231A, 1,232S, 1,233T, 1,267G, 1,268I, 1,269T, 1,272E, 1,297D, 1,330N, 1,344R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,231A

RNA/DNA hybrid binding site
1,230D, 1,231A, 1,232S, 1,233T, 1,267G, 1,268I, 1,269T, 1,272E, 1,297D, 1,330N, 1,344R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,232S

RNA/DNA hybrid binding site
1,230D, 1,231A, 1,232S, 1,233T, 1,267G, 1,268I, 1,269T, 1,272E, 1,297D, 1,330N, 1,344R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,233T

RNA/DNA hybrid binding site
1,230D, 1,231A, 1,232S, 1,233T, 1,267G, 1,268I, 1,269T, 1,272E, 1,297D, 1,330N, 1,344R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,267G

RNA/DNA hybrid binding site
1,230D, 1,231A, 1,232S, 1,233T, 1,267G, 1,268I, 1,269T, 1,272E, 1,297D, 1,330N, 1,344R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,268I

RNA/DNA hybrid binding site
1,230D, 1,231A, 1,232S, 1,233T, 1,267G, 1,268I, 1,269T, 1,272E, 1,297D, 1,330N, 1,344R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,269T

RNA/DNA hybrid binding site
1,230D, 1,231A, 1,232S, 1,233T, 1,267G, 1,268I, 1,269T, 1,272E, 1,297D, 1,330N, 1,344R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,272E

RNA/DNA hybrid binding site
1,230D, 1,231A, 1,232S, 1,233T, 1,267G, 1,268I, 1,269T, 1,272E, 1,297D, 1,330N, 1,344R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,297D

RNA/DNA hybrid binding site
1,230D, 1,231A, 1,232S, 1,233T, 1,267G, 1,268I, 1,269T, 1,272E, 1,297D, 1,330N, 1,344R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,330N

RNA/DNA hybrid binding site
1,230D, 1,231A, 1,232S, 1,233T, 1,267G, 1,268I, 1,269T, 1,272E, 1,297D, 1,330N, 1,344R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,344R

RNA/DNA hybrid binding site
1,230D, 1,231A, 1,232S, 1,233T, 1,267G, 1,268I, 1,269T, 1,272E, 1,297D, 1,330N, 1,344R
CDD
cd09274 (RNase_HI_RT_Ty3)

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

GBC47133.1

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component