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Entry type
Status
Per-residue features
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Protein
GBC45928.1
Length
350 amino acids
Protein family membership
- Dihydroorotase homodimeric type (IPR004721)
Domains and repeats
-
Domain5 - 347
- Metal-dependent hydrolase (IPR032466)
- Amidohydrolase-related (IPR006680)
- Metal-dependent hydrolase (IPR032466)
1
50
100
150
200
250
300
350
350
Detailed signature matches
-
-
cd01294 (DHOase)6 - 345
-
8 - 347
-
SFLDF00074 (dihydro...)2 - 348
-
PIRSF001237 (Dihydr...)2 - 350
-
Residue annotation
-
active site cd0129415H17H98K135H175H245D
-
SFLDF0007415H17H98K135H175H245D
-
substrate binding ...19R216C217K247A249H261A262G
-
dimer interface cd...148Vdimer interface
148V, 149M, 150N, 151A, 205V, 206D, 215F, 222F, 257A, 258Q, 259S
CDD
cd01294 (DHOase)149Mdimer interface
148V, 149M, 150N, 151A, 205V, 206D, 215F, 222F, 257A, 258Q, 259S
CDD
cd01294 (DHOase)150Ndimer interface
148V, 149M, 150N, 151A, 205V, 206D, 215F, 222F, 257A, 258Q, 259S
CDD
cd01294 (DHOase)151Adimer interface
148V, 149M, 150N, 151A, 205V, 206D, 215F, 222F, 257A, 258Q, 259S
CDD
cd01294 (DHOase)205Vdimer interface
148V, 149M, 150N, 151A, 205V, 206D, 215F, 222F, 257A, 258Q, 259S
CDD
cd01294 (DHOase)206Ddimer interface
148V, 149M, 150N, 151A, 205V, 206D, 215F, 222F, 257A, 258Q, 259S
CDD
cd01294 (DHOase)215Fdimer interface
148V, 149M, 150N, 151A, 205V, 206D, 215F, 222F, 257A, 258Q, 259S
CDD
cd01294 (DHOase)222Fdimer interface
148V, 149M, 150N, 151A, 205V, 206D, 215F, 222F, 257A, 258Q, 259S
CDD
cd01294 (DHOase)257Adimer interface
148V, 149M, 150N, 151A, 205V, 206D, 215F, 222F, 257A, 258Q, 259S
CDD
cd01294 (DHOase)258Qdimer interface
148V, 149M, 150N, 151A, 205V, 206D, 215F, 222F, 257A, 258Q, 259S
CDD
cd01294 (DHOase)259Sdimer interface
148V, 149M, 150N, 151A, 205V, 206D, 215F, 222F, 257A, 258Q, 259S
CDD
cd01294 (DHOase)
GO term prediction
Biological Process
GO:0019856 pyrimidine nucleobase biosynthetic process
Molecular Function
GO:0004151 dihydroorotase activity
GO:0016787 hydrolase activity
GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Cellular Component
None predicted.