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Protein

GBC43157.1

Length

2,645 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
1,221 - 1,562
Rho GTPase activation protein (IPR008936)
Ras GTPase-activating protein (IPR001936)
1,608 - 1,767
CRAL-TRIO lipid binding domain (IPR001251)
1,886 - 1,921
Armadillo-type fold (IPR016024)
2,040 - 2,167
Armadillo-type fold (IPR016024)
2,225 - 2,359
Armadillo-type fold (IPR016024)

1 500 1000 1500 2000 2645

Detailed signature matches

IPR008936

Rho GTPase activation protein

SSF48350 (GTPase ac...)

1,238 - 1,538

SUPERFAMILY
SSF48350 (GTPase activation domain, GAP)

IPR001936

Ras GTPase-activating protein

PF00616 (RasGAP)

1,286 - 1,352

Pfam
PF00616 (RasGAP)

1,359 - 1,458

Pfam
PF00616 (RasGAP)
PS50018 (RAS_GTPASE...)

1,265 - 1,458

PROSITE profiles
PS50018 (RAS_GTPASE_ACTIV_2)
SM00323 (RasGAP_2)

1,221 - 1,562

SMART
SM00323 (RasGAP_2)

IPR001251

CRAL-TRIO lipid binding domain

SSF52087 (CRAL/TRIO...)

1,613 - 1,749

SUPERFAMILY
SSF52087 (CRAL/TRIO domain)
cd00170 (SEC14)

1,618 - 1,749

CDD
cd00170 (SEC14)
PF13716 (CRAL_TRIO_2)

1,631 - 1,763

Pfam
PF13716 (CRAL_TRIO_2)
PS50191 (CRAL_TRIO)

1,608 - 1,767

PROSITE profiles
PS50191 (CRAL_TRIO)

IPR016024

Armadillo-type fold

SSF48371 (ARM repeat)

2,225 - 2,359

SUPERFAMILY
SSF48371 (ARM repeat)

2,040 - 2,167

SUPERFAMILY
SSF48371 (ARM repeat)

1,886 - 1,921

SUPERFAMILY
SSF48371 (ARM repeat)

IPR023152

Ras GTPase-activating protein, conserved site

PS00509 (RAS_GTPASE...)

1,414 - 1,428

PROSITE patterns
PS00509 (RAS_GTPASE_ACTIV_1)

no IPR

Unintegrated signatures

Coil

131 - 151

COILS
Coil (Coil)
cd05392 (RasGAP_Neu...)

1,236 - 1,536

CDD
cd05392 (RasGAP_Neurofibromin_like)
mobidb-lite (disord...)

202 - 229

MobiDB Lite
mobidb-lite (disorder_prediction)

153 - 177

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative RAS inter...

1,266I

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,302S

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,304L

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,306R

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,307R

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,309C

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,312T

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,316A

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,410V

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,418L

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,419R

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,422N

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,423P

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,426V

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,447L

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,450T

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,451K

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,454Q

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,458N

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,460V

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,465K

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,466E

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)
phospholipid bindi...

1,632R

phospholipid binding pocket
1,632R, 1,634F, 1,636L, 1,662Y, 1,671V, 1,673V, 1,687A, 1,691M, 1,695P, 1,702L, 1,705L, 1,707F, 1,714F, 1,724A, 1,736I
CDD
cd00170 (SEC14)

1,634F

phospholipid binding pocket
1,632R, 1,634F, 1,636L, 1,662Y, 1,671V, 1,673V, 1,687A, 1,691M, 1,695P, 1,702L, 1,705L, 1,707F, 1,714F, 1,724A, 1,736I
CDD
cd00170 (SEC14)

1,636L

phospholipid binding pocket
1,632R, 1,634F, 1,636L, 1,662Y, 1,671V, 1,673V, 1,687A, 1,691M, 1,695P, 1,702L, 1,705L, 1,707F, 1,714F, 1,724A, 1,736I
CDD
cd00170 (SEC14)

1,662Y

phospholipid binding pocket
1,632R, 1,634F, 1,636L, 1,662Y, 1,671V, 1,673V, 1,687A, 1,691M, 1,695P, 1,702L, 1,705L, 1,707F, 1,714F, 1,724A, 1,736I
CDD
cd00170 (SEC14)

1,671V

phospholipid binding pocket
1,632R, 1,634F, 1,636L, 1,662Y, 1,671V, 1,673V, 1,687A, 1,691M, 1,695P, 1,702L, 1,705L, 1,707F, 1,714F, 1,724A, 1,736I
CDD
cd00170 (SEC14)

1,673V

phospholipid binding pocket
1,632R, 1,634F, 1,636L, 1,662Y, 1,671V, 1,673V, 1,687A, 1,691M, 1,695P, 1,702L, 1,705L, 1,707F, 1,714F, 1,724A, 1,736I
CDD
cd00170 (SEC14)

1,687A

phospholipid binding pocket
1,632R, 1,634F, 1,636L, 1,662Y, 1,671V, 1,673V, 1,687A, 1,691M, 1,695P, 1,702L, 1,705L, 1,707F, 1,714F, 1,724A, 1,736I
CDD
cd00170 (SEC14)

1,691M

phospholipid binding pocket
1,632R, 1,634F, 1,636L, 1,662Y, 1,671V, 1,673V, 1,687A, 1,691M, 1,695P, 1,702L, 1,705L, 1,707F, 1,714F, 1,724A, 1,736I
CDD
cd00170 (SEC14)

1,695P

phospholipid binding pocket
1,632R, 1,634F, 1,636L, 1,662Y, 1,671V, 1,673V, 1,687A, 1,691M, 1,695P, 1,702L, 1,705L, 1,707F, 1,714F, 1,724A, 1,736I
CDD
cd00170 (SEC14)

1,702L

phospholipid binding pocket
1,632R, 1,634F, 1,636L, 1,662Y, 1,671V, 1,673V, 1,687A, 1,691M, 1,695P, 1,702L, 1,705L, 1,707F, 1,714F, 1,724A, 1,736I
CDD
cd00170 (SEC14)

1,705L

phospholipid binding pocket
1,632R, 1,634F, 1,636L, 1,662Y, 1,671V, 1,673V, 1,687A, 1,691M, 1,695P, 1,702L, 1,705L, 1,707F, 1,714F, 1,724A, 1,736I
CDD
cd00170 (SEC14)

1,707F

phospholipid binding pocket
1,632R, 1,634F, 1,636L, 1,662Y, 1,671V, 1,673V, 1,687A, 1,691M, 1,695P, 1,702L, 1,705L, 1,707F, 1,714F, 1,724A, 1,736I
CDD
cd00170 (SEC14)

1,714F

phospholipid binding pocket
1,632R, 1,634F, 1,636L, 1,662Y, 1,671V, 1,673V, 1,687A, 1,691M, 1,695P, 1,702L, 1,705L, 1,707F, 1,714F, 1,724A, 1,736I
CDD
cd00170 (SEC14)

1,724A

phospholipid binding pocket
1,632R, 1,634F, 1,636L, 1,662Y, 1,671V, 1,673V, 1,687A, 1,691M, 1,695P, 1,702L, 1,705L, 1,707F, 1,714F, 1,724A, 1,736I
CDD
cd00170 (SEC14)

1,736I

phospholipid binding pocket
1,632R, 1,634F, 1,636L, 1,662Y, 1,671V, 1,673V, 1,687A, 1,691M, 1,695P, 1,702L, 1,705L, 1,707F, 1,714F, 1,724A, 1,736I
CDD
cd00170 (SEC14)
salt bridge cd00170

1,700E

salt bridge
1,700E, 1,735T
CDD
cd00170 (SEC14)

1,735T

salt bridge
1,700E, 1,735T
CDD
cd00170 (SEC14)

GO term prediction

Biological Process

GO:0007165 signal transduction
GO:0043087 regulation of GTPase activity

Molecular Function

GO:0005488 binding

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

GBC43157.1

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component