GBC43157.1

Protein

Length

2,645 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
1,221 - 1,562
Rho GTPase activation protein (IPR008936)
Ras GTPase-activating protein (IPR001936)
1,608 - 1,767
CRAL-TRIO lipid binding domain (IPR001251)
1,886 - 1,921
Armadillo-type fold (IPR016024)
2,040 - 2,167
Armadillo-type fold (IPR016024)
2,225 - 2,359
Armadillo-type fold (IPR016024)

1 500 1000 1500 2000 2645

Detailed signature matches

IPR008936

Rho GTPase activation protein
1. SSF48350 (GTPase ac...)
  
  1,238 - 1,538
  
  SUPERFAMILY
  SSF48350 (GTPase activation domain, GAP)
IPR001936

Ras GTPase-activating protein
1. PF00616 (RasGAP)
  
  1,286 - 1,352
  
  Pfam
  PF00616 (RasGAP)
  
  1,359 - 1,458
  
  Pfam
  PF00616 (RasGAP)
2. PS50018 (RAS_GTPASE...)
  
  1,265 - 1,458
  
  PROSITE profiles
  PS50018 (RAS_GTPASE_ACTIV_2)
3. SM00323 (RasGAP_2)
  
  1,221 - 1,562
  
  SMART
  SM00323 (RasGAP_2)
IPR001251

CRAL-TRIO lipid binding domain
1. SSF52087 (CRAL/TRIO...)
  
  1,613 - 1,749
  
  SUPERFAMILY
  SSF52087 (CRAL/TRIO domain)
2. cd00170 (SEC14)
  
  1,618 - 1,749
  
  CDD
  cd00170 (SEC14)
3. PF13716 (CRAL_TRIO_2)
  
  1,631 - 1,763
  
  Pfam
  PF13716 (CRAL_TRIO_2)
4. PS50191 (CRAL_TRIO)
  
  1,608 - 1,767
  
  PROSITE profiles
  PS50191 (CRAL_TRIO)
IPR016024

Armadillo-type fold
1. SSF48371 (ARM repeat)
  
  2,225 - 2,359
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  2,040 - 2,167
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  1,886 - 1,921
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
IPR023152

Ras GTPase-activating protein, conserved site
1. PS00509 (RAS_GTPASE...)
  
  1,414 - 1,428
  
  PROSITE patterns
  PS00509 (RAS_GTPASE_ACTIV_1)

no IPR

Unintegrated signatures

Coil

131 - 151

COILS
Coil (Coil)
cd05392 (RasGAP_Neu...)

1,236 - 1,536

CDD
cd05392 (RasGAP_Neurofibromin_like)
mobidb-lite (disord...)

202 - 229

MobiDB Lite
mobidb-lite (disorder_prediction)

153 - 177

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative RAS inter...

1,266I

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,302S

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,304L

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,306R

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,307R

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,309C

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,312T

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,316A

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,410V

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,418L

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,419R

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,422N

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,423P

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,426V

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,447L

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,450T

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,451K

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,454Q

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,458N

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,460V

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,465K

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)

1,466E

putative RAS interface
1,266I, 1,302S, 1,304L, 1,306R, 1,307R, 1,309C, 1,312T, 1,316A, 1,410V, 1,418L, 1,419R, 1,422N, 1,423P, 1,426V, 1,447L, 1,450T, 1,451K, 1,454Q, 1,458N, 1,460V, 1,465K, 1,466E
CDD
cd05392 (RasGAP_Neurofibromin_like)
phospholipid bindi...

1,632R

phospholipid binding pocket
1,632R, 1,634F, 1,636L, 1,662Y, 1,671V, 1,673V, 1,687A, 1,691M, 1,695P, 1,702L, 1,705L, 1,707F, 1,714F, 1,724A, 1,736I
CDD
cd00170 (SEC14)

1,634F

phospholipid binding pocket
1,632R, 1,634F, 1,636L, 1,662Y, 1,671V, 1,673V, 1,687A, 1,691M, 1,695P, 1,702L, 1,705L, 1,707F, 1,714F, 1,724A, 1,736I
CDD
cd00170 (SEC14)

1,636L

phospholipid binding pocket
1,632R, 1,634F, 1,636L, 1,662Y, 1,671V, 1,673V, 1,687A, 1,691M, 1,695P, 1,702L, 1,705L, 1,707F, 1,714F, 1,724A, 1,736I
CDD
cd00170 (SEC14)

1,662Y

phospholipid binding pocket
1,632R, 1,634F, 1,636L, 1,662Y, 1,671V, 1,673V, 1,687A, 1,691M, 1,695P, 1,702L, 1,705L, 1,707F, 1,714F, 1,724A, 1,736I
CDD
cd00170 (SEC14)

1,671V

phospholipid binding pocket
1,632R, 1,634F, 1,636L, 1,662Y, 1,671V, 1,673V, 1,687A, 1,691M, 1,695P, 1,702L, 1,705L, 1,707F, 1,714F, 1,724A, 1,736I
CDD
cd00170 (SEC14)

1,673V

phospholipid binding pocket
1,632R, 1,634F, 1,636L, 1,662Y, 1,671V, 1,673V, 1,687A, 1,691M, 1,695P, 1,702L, 1,705L, 1,707F, 1,714F, 1,724A, 1,736I
CDD
cd00170 (SEC14)

1,687A

phospholipid binding pocket
1,632R, 1,634F, 1,636L, 1,662Y, 1,671V, 1,673V, 1,687A, 1,691M, 1,695P, 1,702L, 1,705L, 1,707F, 1,714F, 1,724A, 1,736I
CDD
cd00170 (SEC14)

1,691M

phospholipid binding pocket
1,632R, 1,634F, 1,636L, 1,662Y, 1,671V, 1,673V, 1,687A, 1,691M, 1,695P, 1,702L, 1,705L, 1,707F, 1,714F, 1,724A, 1,736I
CDD
cd00170 (SEC14)

1,695P

phospholipid binding pocket
1,632R, 1,634F, 1,636L, 1,662Y, 1,671V, 1,673V, 1,687A, 1,691M, 1,695P, 1,702L, 1,705L, 1,707F, 1,714F, 1,724A, 1,736I
CDD
cd00170 (SEC14)

1,702L

phospholipid binding pocket
1,632R, 1,634F, 1,636L, 1,662Y, 1,671V, 1,673V, 1,687A, 1,691M, 1,695P, 1,702L, 1,705L, 1,707F, 1,714F, 1,724A, 1,736I
CDD
cd00170 (SEC14)

1,705L

phospholipid binding pocket
1,632R, 1,634F, 1,636L, 1,662Y, 1,671V, 1,673V, 1,687A, 1,691M, 1,695P, 1,702L, 1,705L, 1,707F, 1,714F, 1,724A, 1,736I
CDD
cd00170 (SEC14)

1,707F

phospholipid binding pocket
1,632R, 1,634F, 1,636L, 1,662Y, 1,671V, 1,673V, 1,687A, 1,691M, 1,695P, 1,702L, 1,705L, 1,707F, 1,714F, 1,724A, 1,736I
CDD
cd00170 (SEC14)

1,714F

phospholipid binding pocket
1,632R, 1,634F, 1,636L, 1,662Y, 1,671V, 1,673V, 1,687A, 1,691M, 1,695P, 1,702L, 1,705L, 1,707F, 1,714F, 1,724A, 1,736I
CDD
cd00170 (SEC14)

1,724A

phospholipid binding pocket
1,632R, 1,634F, 1,636L, 1,662Y, 1,671V, 1,673V, 1,687A, 1,691M, 1,695P, 1,702L, 1,705L, 1,707F, 1,714F, 1,724A, 1,736I
CDD
cd00170 (SEC14)

1,736I

phospholipid binding pocket
1,632R, 1,634F, 1,636L, 1,662Y, 1,671V, 1,673V, 1,687A, 1,691M, 1,695P, 1,702L, 1,705L, 1,707F, 1,714F, 1,724A, 1,736I
CDD
cd00170 (SEC14)
salt bridge cd00170

1,700E

salt bridge
1,700E, 1,735T
CDD
cd00170 (SEC14)

1,735T

salt bridge
1,700E, 1,735T
CDD
cd00170 (SEC14)

GO term prediction

Biological Process

GO:0007165 signal transduction
GO:0043087 regulation of GTPase activity

Molecular Function

GO:0005488 binding

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

GBC43157.1

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component