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Protein

GBC42609.1

Length

1,870 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain

1 200 400 600 800 1000 1200 1400 1600 1870

Detailed signature matches

Domain

Endonuclease/exonuclease/phosphatase

PF03372 (Exo_endo_phos)
SSF56219 (DNase I-like)

Domain

Reverse transcriptase domain

PF00078 (RVT_1)
PS50878 (RT_POL)

619 - 896

PROSITE profiles
PS50878 (RT_POL)

Domain

Ribonuclease H-like domain

SSF53098 (Ribonucle...)

1,382 - 1,533

SUPERFAMILY
SSF53098 (Ribonuclease H-like)

Domain

Ribonuclease H domain

PF00075 (RNase_H)

1,384 - 1,531

Pfam
PF00075 (RNase_H)
PS50879 (RNASE_H)

1,380 - 1,534

PROSITE profiles
PS50879 (RNASE_H)

Unintegrated signatures

no IPR

Unintegrated signatures

SSF56672 (DNA/RNA p...)

560 - 916

SUPERFAMILY
SSF56672 (DNA/RNA polymerases)
cd09276 (Rnase_HI_R...)

1,385 - 1,530

CDD
cd09276 (Rnase_HI_RT_non_LTR)
mobidb-lite (disord...)

23 - 61

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

active site cd09276

1,389D

active site
1,389D, 1,438E, 1,460D, 1,526D
CDD
cd09276 (Rnase_HI_RT_non_LTR)

1,438E

active site
1,389D, 1,438E, 1,460D, 1,526D
CDD
cd09276 (Rnase_HI_RT_non_LTR)

1,460D

active site
1,389D, 1,438E, 1,460D, 1,526D
CDD
cd09276 (Rnase_HI_RT_non_LTR)

1,526D

active site
1,389D, 1,438E, 1,460D, 1,526D
CDD
cd09276 (Rnase_HI_RT_non_LTR)
RNA/DNA hybrid bin...

1,389D

RNA/DNA hybrid binding site
1,389D, 1,390G, 1,391S, 1,395R, 1,427S, 1,428I, 1,429T, 1,438E, 1,460D, 1,512K, 1,530K
CDD
cd09276 (Rnase_HI_RT_non_LTR)

1,390G

RNA/DNA hybrid binding site
1,389D, 1,390G, 1,391S, 1,395R, 1,427S, 1,428I, 1,429T, 1,438E, 1,460D, 1,512K, 1,530K
CDD
cd09276 (Rnase_HI_RT_non_LTR)

1,391S

RNA/DNA hybrid binding site
1,389D, 1,390G, 1,391S, 1,395R, 1,427S, 1,428I, 1,429T, 1,438E, 1,460D, 1,512K, 1,530K
CDD
cd09276 (Rnase_HI_RT_non_LTR)

1,395R

RNA/DNA hybrid binding site
1,389D, 1,390G, 1,391S, 1,395R, 1,427S, 1,428I, 1,429T, 1,438E, 1,460D, 1,512K, 1,530K
CDD
cd09276 (Rnase_HI_RT_non_LTR)

1,427S

RNA/DNA hybrid binding site
1,389D, 1,390G, 1,391S, 1,395R, 1,427S, 1,428I, 1,429T, 1,438E, 1,460D, 1,512K, 1,530K
CDD
cd09276 (Rnase_HI_RT_non_LTR)

1,428I

RNA/DNA hybrid binding site
1,389D, 1,390G, 1,391S, 1,395R, 1,427S, 1,428I, 1,429T, 1,438E, 1,460D, 1,512K, 1,530K
CDD
cd09276 (Rnase_HI_RT_non_LTR)

1,429T

RNA/DNA hybrid binding site
1,389D, 1,390G, 1,391S, 1,395R, 1,427S, 1,428I, 1,429T, 1,438E, 1,460D, 1,512K, 1,530K
CDD
cd09276 (Rnase_HI_RT_non_LTR)

1,438E

RNA/DNA hybrid binding site
1,389D, 1,390G, 1,391S, 1,395R, 1,427S, 1,428I, 1,429T, 1,438E, 1,460D, 1,512K, 1,530K
CDD
cd09276 (Rnase_HI_RT_non_LTR)

1,460D

RNA/DNA hybrid binding site
1,389D, 1,390G, 1,391S, 1,395R, 1,427S, 1,428I, 1,429T, 1,438E, 1,460D, 1,512K, 1,530K
CDD
cd09276 (Rnase_HI_RT_non_LTR)

1,512K

RNA/DNA hybrid binding site
1,389D, 1,390G, 1,391S, 1,395R, 1,427S, 1,428I, 1,429T, 1,438E, 1,460D, 1,512K, 1,530K
CDD
cd09276 (Rnase_HI_RT_non_LTR)

1,530K

RNA/DNA hybrid binding site
1,389D, 1,390G, 1,391S, 1,395R, 1,427S, 1,428I, 1,429T, 1,438E, 1,460D, 1,512K, 1,530K
CDD
cd09276 (Rnase_HI_RT_non_LTR)

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003676 nucleic acid binding
GO:0004523 RNA-DNA hybrid ribonuclease activity

Cellular Component

None predicted.