GBC42399.1

Protein

Length

1,418 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
813 - 921
Bromodomain (IPR001487)
1,171 - 1,418
Protein kinase-like domain (IPR011009)
Protein kinase domain (IPR000719)

1 200 400 600 800 1000 1200 1418

Detailed signature matches

IPR001487

Bromodomain
1. PS50014 (BROMODOMAIN_2)
  
  851 - 902
  
  PROSITE profiles
  PS50014 (BROMODOMAIN_2)
2. SM00297 (bromo_6)
  
  813 - 921
  
  SMART
  SM00297 (bromo_6)
3. SSF47370 (Bromodomain)
  
  815 - 921
  
  SUPERFAMILY
  SSF47370 (Bromodomain)
4. PF00439 (Bromodomain)
  
  827 - 906
  
  Pfam
  PF00439 (Bromodomain)
IPR011009

Protein kinase-like domain
1. SSF56112 (Protein k...)
  
  1,171 - 1,406
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
IPR000719

Protein kinase domain
1. PS50011 (PROTEIN_KI...)
  
  1,172 - 1,418
  
  PROSITE profiles
  PS50011 (PROTEIN_KINASE_DOM)
2. PF00069 (Pkinase)
  
  1,211 - 1,333
  
  Pfam
  PF00069 (Pkinase)

no IPR

Unintegrated signatures

cd00180 (PKc)

1,180 - 1,407

CDD
cd00180 (PKc)
cd04369 (Bromodomain)

837 - 915

CDD
cd04369 (Bromodomain)
mobidb-lite (disord...)

1 - 23

MobiDB Lite
mobidb-lite (disorder_prediction)

520 - 779

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

acetyllysine bindi...

844E

acetyllysine binding site
844E, 848A, 851Y, 891A, 895H, 901I
CDD
cd04369 (Bromodomain)

848A

acetyllysine binding site
844E, 848A, 851Y, 891A, 895H, 901I
CDD
cd04369 (Bromodomain)

851Y

acetyllysine binding site
844E, 848A, 851Y, 891A, 895H, 901I
CDD
cd04369 (Bromodomain)

891A

acetyllysine binding site
844E, 848A, 851Y, 891A, 895H, 901I
CDD
cd04369 (Bromodomain)

895H

acetyllysine binding site
844E, 848A, 851Y, 891A, 895H, 901I
CDD
cd04369 (Bromodomain)

901I

acetyllysine binding site
844E, 848A, 851Y, 891A, 895H, 901I
CDD
cd04369 (Bromodomain)
ATP binding site c...

1,180E

ATP binding site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D
CDD
cd00180 (PKc)

1,181G

ATP binding site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D
CDD
cd00180 (PKc)

1,182F

ATP binding site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D
CDD
cd00180 (PKc)

1,186V

ATP binding site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D
CDD
cd00180 (PKc)

1,196V

ATP binding site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D
CDD
cd00180 (PKc)

1,198Q

ATP binding site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D
CDD
cd00180 (PKc)

1,228G

ATP binding site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D
CDD
cd00180 (PKc)

1,247M

ATP binding site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D
CDD
cd00180 (PKc)

1,248E

ATP binding site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D
CDD
cd00180 (PKc)

1,249R

ATP binding site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D
CDD
cd00180 (PKc)

1,250Y

ATP binding site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D
CDD
cd00180 (PKc)

1,253T

ATP binding site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D
CDD
cd00180 (PKc)

1,293D

ATP binding site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D
CDD
cd00180 (PKc)

1,295S

ATP binding site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D
CDD
cd00180 (PKc)

1,297V

ATP binding site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D
CDD
cd00180 (PKc)

1,298N

ATP binding site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D
CDD
cd00180 (PKc)

1,300M

ATP binding site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D
CDD
cd00180 (PKc)

1,321D

ATP binding site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D
CDD
cd00180 (PKc)
active site cd00180

1,180E

active site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,255K, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D, 1,324K
CDD
cd00180 (PKc)

1,181G

active site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,255K, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D, 1,324K
CDD
cd00180 (PKc)

1,182F

active site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,255K, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D, 1,324K
CDD
cd00180 (PKc)

1,186V

active site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,255K, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D, 1,324K
CDD
cd00180 (PKc)

1,196V

active site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,255K, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D, 1,324K
CDD
cd00180 (PKc)

1,198Q

active site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,255K, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D, 1,324K
CDD
cd00180 (PKc)

1,228G

active site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,255K, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D, 1,324K
CDD
cd00180 (PKc)

1,247M

active site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,255K, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D, 1,324K
CDD
cd00180 (PKc)

1,248E

active site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,255K, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D, 1,324K
CDD
cd00180 (PKc)

1,249R

active site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,255K, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D, 1,324K
CDD
cd00180 (PKc)

1,250Y

active site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,255K, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D, 1,324K
CDD
cd00180 (PKc)

1,253T

active site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,255K, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D, 1,324K
CDD
cd00180 (PKc)

1,255K

active site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,255K, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D, 1,324K
CDD
cd00180 (PKc)

1,293D

active site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,255K, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D, 1,324K
CDD
cd00180 (PKc)

1,295S

active site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,255K, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D, 1,324K
CDD
cd00180 (PKc)

1,297V

active site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,255K, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D, 1,324K
CDD
cd00180 (PKc)

1,298N

active site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,255K, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D, 1,324K
CDD
cd00180 (PKc)

1,300M

active site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,255K, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D, 1,324K
CDD
cd00180 (PKc)

1,321D

active site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,255K, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D, 1,324K
CDD
cd00180 (PKc)

1,324K

active site
1,180E, 1,181G, 1,182F, 1,186V, 1,196V, 1,198Q, 1,228G, 1,247M, 1,248E, 1,249R, 1,250Y, 1,253T, 1,255K, 1,293D, 1,295S, 1,297V, 1,298N, 1,300M, 1,321D, 1,324K
CDD
cd00180 (PKc)
polypeptide substr...

1,182F

polypeptide substrate binding site
1,182F, 1,253T, 1,255K, 1,293D, 1,295S, 1,297V, 1,324K
CDD
cd00180 (PKc)

1,253T

polypeptide substrate binding site
1,182F, 1,253T, 1,255K, 1,293D, 1,295S, 1,297V, 1,324K
CDD
cd00180 (PKc)

1,255K

polypeptide substrate binding site
1,182F, 1,253T, 1,255K, 1,293D, 1,295S, 1,297V, 1,324K
CDD
cd00180 (PKc)

1,293D

polypeptide substrate binding site
1,182F, 1,253T, 1,255K, 1,293D, 1,295S, 1,297V, 1,324K
CDD
cd00180 (PKc)

1,295S

polypeptide substrate binding site
1,182F, 1,253T, 1,255K, 1,293D, 1,295S, 1,297V, 1,324K
CDD
cd00180 (PKc)

1,297V

polypeptide substrate binding site
1,182F, 1,253T, 1,255K, 1,293D, 1,295S, 1,297V, 1,324K
CDD
cd00180 (PKc)

1,324K

polypeptide substrate binding site
1,182F, 1,253T, 1,255K, 1,293D, 1,295S, 1,297V, 1,324K
CDD
cd00180 (PKc)
activation loop (A...

1,320I

activation loop (A-loop)
1,320I, 1,321D, 1,322F, 1,323G, 1,324K, 1,325A, 1,326E
CDD
cd00180 (PKc)

1,321D

activation loop (A-loop)
1,320I, 1,321D, 1,322F, 1,323G, 1,324K, 1,325A, 1,326E
CDD
cd00180 (PKc)

1,322F

activation loop (A-loop)
1,320I, 1,321D, 1,322F, 1,323G, 1,324K, 1,325A, 1,326E
CDD
cd00180 (PKc)

1,323G

activation loop (A-loop)
1,320I, 1,321D, 1,322F, 1,323G, 1,324K, 1,325A, 1,326E
CDD
cd00180 (PKc)

1,324K

activation loop (A-loop)
1,320I, 1,321D, 1,322F, 1,323G, 1,324K, 1,325A, 1,326E
CDD
cd00180 (PKc)

1,325A

activation loop (A-loop)
1,320I, 1,321D, 1,322F, 1,323G, 1,324K, 1,325A, 1,326E
CDD
cd00180 (PKc)

1,326E

activation loop (A-loop)
1,320I, 1,321D, 1,322F, 1,323G, 1,324K, 1,325A, 1,326E
CDD
cd00180 (PKc)

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding

Cellular Component