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Entry type
Status
Per-residue features
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Protein
GBC42122.1
Length
526 amino acids
Protein family membership
None predicted.
Domains and repeats
-
Domain36 - 264
- Ribonuclease H-like domain (IPR012337)
- 3'-5' exonuclease domain (IPR002562)
- Ribonuclease H-like domain (IPR012337)
1
50
100
150
200
250
300
350
400
450
500
526
Detailed signature matches
no IPR
Unintegrated signatures
-
cd06141 (WRN_exo)84 - 255
-
mobidb-lite (disord...)479 - 526
Residue annotation
-
catalytic site cd0...105D107E169D238Y242D
-
putative active si...105Dputative active site
105D, 106T, 107E, 108T, 164V, 165N, 167S, 168G, 169D, 200S, 201L, 238Y, 242D
CDD
cd06141 (WRN_exo)106Tputative active site
105D, 106T, 107E, 108T, 164V, 165N, 167S, 168G, 169D, 200S, 201L, 238Y, 242D
CDD
cd06141 (WRN_exo)107Eputative active site
105D, 106T, 107E, 108T, 164V, 165N, 167S, 168G, 169D, 200S, 201L, 238Y, 242D
CDD
cd06141 (WRN_exo)108Tputative active site
105D, 106T, 107E, 108T, 164V, 165N, 167S, 168G, 169D, 200S, 201L, 238Y, 242D
CDD
cd06141 (WRN_exo)164Vputative active site
105D, 106T, 107E, 108T, 164V, 165N, 167S, 168G, 169D, 200S, 201L, 238Y, 242D
CDD
cd06141 (WRN_exo)165Nputative active site
105D, 106T, 107E, 108T, 164V, 165N, 167S, 168G, 169D, 200S, 201L, 238Y, 242D
CDD
cd06141 (WRN_exo)167Sputative active site
105D, 106T, 107E, 108T, 164V, 165N, 167S, 168G, 169D, 200S, 201L, 238Y, 242D
CDD
cd06141 (WRN_exo)168Gputative active site
105D, 106T, 107E, 108T, 164V, 165N, 167S, 168G, 169D, 200S, 201L, 238Y, 242D
CDD
cd06141 (WRN_exo)169Dputative active site
105D, 106T, 107E, 108T, 164V, 165N, 167S, 168G, 169D, 200S, 201L, 238Y, 242D
CDD
cd06141 (WRN_exo)200Sputative active site
105D, 106T, 107E, 108T, 164V, 165N, 167S, 168G, 169D, 200S, 201L, 238Y, 242D
CDD
cd06141 (WRN_exo)201Lputative active site
105D, 106T, 107E, 108T, 164V, 165N, 167S, 168G, 169D, 200S, 201L, 238Y, 242D
CDD
cd06141 (WRN_exo)238Yputative active site
105D, 106T, 107E, 108T, 164V, 165N, 167S, 168G, 169D, 200S, 201L, 238Y, 242D
CDD
cd06141 (WRN_exo)242Dputative active site
105D, 106T, 107E, 108T, 164V, 165N, 167S, 168G, 169D, 200S, 201L, 238Y, 242D
CDD
cd06141 (WRN_exo) -
putative substrate...106Tputative substrate binding site
106T, 107E, 108T, 164V, 165N, 167S, 168G, 200S, 201L, 238Y, 242D
CDD
cd06141 (WRN_exo)107Eputative substrate binding site
106T, 107E, 108T, 164V, 165N, 167S, 168G, 200S, 201L, 238Y, 242D
CDD
cd06141 (WRN_exo)108Tputative substrate binding site
106T, 107E, 108T, 164V, 165N, 167S, 168G, 200S, 201L, 238Y, 242D
CDD
cd06141 (WRN_exo)164Vputative substrate binding site
106T, 107E, 108T, 164V, 165N, 167S, 168G, 200S, 201L, 238Y, 242D
CDD
cd06141 (WRN_exo)165Nputative substrate binding site
106T, 107E, 108T, 164V, 165N, 167S, 168G, 200S, 201L, 238Y, 242D
CDD
cd06141 (WRN_exo)167Sputative substrate binding site
106T, 107E, 108T, 164V, 165N, 167S, 168G, 200S, 201L, 238Y, 242D
CDD
cd06141 (WRN_exo)168Gputative substrate binding site
106T, 107E, 108T, 164V, 165N, 167S, 168G, 200S, 201L, 238Y, 242D
CDD
cd06141 (WRN_exo)200Sputative substrate binding site
106T, 107E, 108T, 164V, 165N, 167S, 168G, 200S, 201L, 238Y, 242D
CDD
cd06141 (WRN_exo)201Lputative substrate binding site
106T, 107E, 108T, 164V, 165N, 167S, 168G, 200S, 201L, 238Y, 242D
CDD
cd06141 (WRN_exo)238Yputative substrate binding site
106T, 107E, 108T, 164V, 165N, 167S, 168G, 200S, 201L, 238Y, 242D
CDD
cd06141 (WRN_exo)242Dputative substrate binding site
106T, 107E, 108T, 164V, 165N, 167S, 168G, 200S, 201L, 238Y, 242D
CDD
cd06141 (WRN_exo)
GO term prediction
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity
Cellular Component
None predicted.