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Protein

GBC40934.1

Length

1,372 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
266 - 371
Retrotransposon gag domain (IPR005162)
458 - 494
Zinc finger, CCHC-type (IPR001878)
691 - 801
Aspartic peptidase domain (IPR021109)
Retroviral aspartyl protease (IPR013242)
978 - 1,157
Reverse transcriptase domain (IPR000477)

1 200 400 600 800 1000 1200 1372

Detailed signature matches

IPR005162

Retrotransposon gag domain

PF03732 (Retrotrans...)

266 - 371

Pfam
PF03732 (Retrotrans_gag)

IPR001878

Zinc finger, CCHC-type

PS50158 (ZF_CCHC)

474 - 489

PROSITE profiles
PS50158 (ZF_CCHC)
PF00098 (zf-CCHC)

473 - 489

Pfam
PF00098 (zf-CCHC)
SM00343 (c2hcfinal6)

473 - 489

SMART
SM00343 (c2hcfinal6)
SSF57756 (Retroviru...)

458 - 494

SUPERFAMILY
SSF57756 (Retrovirus zinc finger-like domains)

IPR021109

Aspartic peptidase domain

SSF50630 (Acid prot...)

691 - 792

SUPERFAMILY
SSF50630 (Acid proteases)

IPR013242

Retroviral aspartyl protease

PF08284 (RVP_2)

705 - 801

Pfam
PF08284 (RVP_2)

IPR000477

Reverse transcriptase domain

PF00078 (RVT_1)

998 - 1,156

Pfam
PF00078 (RVT_1)
PS50878 (RT_POL)

978 - 1,157

PROSITE profiles
PS50878 (RT_POL)

no IPR

Unintegrated signatures

Coil

844 - 864

COILS
Coil (Coil)
SSF56672 (DNA/RNA p...)

923 - 1,354

SUPERFAMILY
SSF56672 (DNA/RNA polymerases)
cd00303 (retropepsi...)

708 - 785

CDD
cd00303 (retropepsin_like)
cd01647 (RT_LTR)

981 - 1,157

CDD
cd01647 (RT_LTR)
cd09274 (RNase_HI_R...)

1,251 - 1,370

CDD
cd09274 (RNase_HI_RT_Ty3)
mobidb-lite (disord...)

488 - 513

MobiDB Lite
mobidb-lite (disorder_prediction)

134 - 153

MobiDB Lite
mobidb-lite (disorder_prediction)

828 - 862

MobiDB Lite
mobidb-lite (disorder_prediction)

644 - 670

MobiDB Lite
mobidb-lite (disorder_prediction)

532 - 562

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

Catalytic residue ...

709D

Catalytic residue
709D
CDD
cd00303 (retropepsin_like)
catalytic motif cd...

709D

catalytic motif
709D, 710S, 711G
CDD
cd00303 (retropepsin_like)

710S

catalytic motif
709D, 710S, 711G
CDD
cd00303 (retropepsin_like)

711G

catalytic motif
709D, 710S, 711G
CDD
cd00303 (retropepsin_like)
inhibitor binding ...

709D

inhibitor binding site
709D, 711G, 713A, 737M, 738V, 739N, 778I
CDD
cd00303 (retropepsin_like)

711G

inhibitor binding site
709D, 711G, 713A, 737M, 738V, 739N, 778I
CDD
cd00303 (retropepsin_like)

713A

inhibitor binding site
709D, 711G, 713A, 737M, 738V, 739N, 778I
CDD
cd00303 (retropepsin_like)

737M

inhibitor binding site
709D, 711G, 713A, 737M, 738V, 739N, 778I
CDD
cd00303 (retropepsin_like)

738V

inhibitor binding site
709D, 711G, 713A, 737M, 738V, 739N, 778I
CDD
cd00303 (retropepsin_like)

739N

inhibitor binding site
709D, 711G, 713A, 737M, 738V, 739N, 778I
CDD
cd00303 (retropepsin_like)

778I

inhibitor binding site
709D, 711G, 713A, 737M, 738V, 739N, 778I
CDD
cd00303 (retropepsin_like)
Active site flap c...

737M

Active site flap
737M, 738V, 739N, 740V, 744R, 745R, 746R, 747P
CDD
cd00303 (retropepsin_like)

738V

Active site flap
737M, 738V, 739N, 740V, 744R, 745R, 746R, 747P
CDD
cd00303 (retropepsin_like)

739N

Active site flap
737M, 738V, 739N, 740V, 744R, 745R, 746R, 747P
CDD
cd00303 (retropepsin_like)

740V

Active site flap
737M, 738V, 739N, 740V, 744R, 745R, 746R, 747P
CDD
cd00303 (retropepsin_like)

744R

Active site flap
737M, 738V, 739N, 740V, 744R, 745R, 746R, 747P
CDD
cd00303 (retropepsin_like)

745R

Active site flap
737M, 738V, 739N, 740V, 744R, 745R, 746R, 747P
CDD
cd00303 (retropepsin_like)

746R

Active site flap
737M, 738V, 739N, 740V, 744R, 745R, 746R, 747P
CDD
cd00303 (retropepsin_like)

747P

Active site flap
737M, 738V, 739N, 740V, 744R, 745R, 746R, 747P
CDD
cd00303 (retropepsin_like)
putative NTP bindi...

1,044D

putative NTP binding site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,108D
CDD
cd01647 (RT_LTR)

1,045L

putative NTP binding site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,108D
CDD
cd01647 (RT_LTR)

1,046A

putative NTP binding site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,108D
CDD
cd01647 (RT_LTR)

1,047S

putative NTP binding site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,108D
CDD
cd01647 (RT_LTR)

1,048G

putative NTP binding site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,108D
CDD
cd01647 (RT_LTR)

1,049F

putative NTP binding site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,108D
CDD
cd01647 (RT_LTR)

1,078F

putative NTP binding site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,108D
CDD
cd01647 (RT_LTR)

1,108D

putative NTP binding site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,108D
CDD
cd01647 (RT_LTR)
putative active si...

1,044D

putative active site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,079G, 1,106Y, 1,108D, 1,109D, 1,153L, 1,154G
CDD
cd01647 (RT_LTR)

1,045L

putative active site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,079G, 1,106Y, 1,108D, 1,109D, 1,153L, 1,154G
CDD
cd01647 (RT_LTR)

1,046A

putative active site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,079G, 1,106Y, 1,108D, 1,109D, 1,153L, 1,154G
CDD
cd01647 (RT_LTR)

1,047S

putative active site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,079G, 1,106Y, 1,108D, 1,109D, 1,153L, 1,154G
CDD
cd01647 (RT_LTR)

1,048G

putative active site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,079G, 1,106Y, 1,108D, 1,109D, 1,153L, 1,154G
CDD
cd01647 (RT_LTR)

1,049F

putative active site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,079G, 1,106Y, 1,108D, 1,109D, 1,153L, 1,154G
CDD
cd01647 (RT_LTR)

1,078F

putative active site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,079G, 1,106Y, 1,108D, 1,109D, 1,153L, 1,154G
CDD
cd01647 (RT_LTR)

1,079G

putative active site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,079G, 1,106Y, 1,108D, 1,109D, 1,153L, 1,154G
CDD
cd01647 (RT_LTR)

1,106Y

putative active site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,079G, 1,106Y, 1,108D, 1,109D, 1,153L, 1,154G
CDD
cd01647 (RT_LTR)

1,108D

putative active site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,079G, 1,106Y, 1,108D, 1,109D, 1,153L, 1,154G
CDD
cd01647 (RT_LTR)

1,109D

putative active site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,079G, 1,106Y, 1,108D, 1,109D, 1,153L, 1,154G
CDD
cd01647 (RT_LTR)

1,153L

putative active site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,079G, 1,106Y, 1,108D, 1,109D, 1,153L, 1,154G
CDD
cd01647 (RT_LTR)

1,154G

putative active site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,079G, 1,106Y, 1,108D, 1,109D, 1,153L, 1,154G
CDD
cd01647 (RT_LTR)
putative nucleic a...

1,079G

putative nucleic acid binding site
1,079G
CDD
cd01647 (RT_LTR)
active site cd09274

1,255D

active site
1,255D, 1,297E, 1,322D, 1,365D
CDD
cd09274 (RNase_HI_RT_Ty3)

1,297E

active site
1,255D, 1,297E, 1,322D, 1,365D
CDD
cd09274 (RNase_HI_RT_Ty3)

1,322D

active site
1,255D, 1,297E, 1,322D, 1,365D
CDD
cd09274 (RNase_HI_RT_Ty3)

1,365D

active site
1,255D, 1,297E, 1,322D, 1,365D
CDD
cd09274 (RNase_HI_RT_Ty3)
RNA/DNA hybrid bin...

1,255D

RNA/DNA hybrid binding site
1,255D, 1,256A, 1,257S, 1,258T, 1,292S, 1,293I, 1,294T, 1,297E, 1,322D, 1,355N, 1,369R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,256A

RNA/DNA hybrid binding site
1,255D, 1,256A, 1,257S, 1,258T, 1,292S, 1,293I, 1,294T, 1,297E, 1,322D, 1,355N, 1,369R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,257S

RNA/DNA hybrid binding site
1,255D, 1,256A, 1,257S, 1,258T, 1,292S, 1,293I, 1,294T, 1,297E, 1,322D, 1,355N, 1,369R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,258T

RNA/DNA hybrid binding site
1,255D, 1,256A, 1,257S, 1,258T, 1,292S, 1,293I, 1,294T, 1,297E, 1,322D, 1,355N, 1,369R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,292S

RNA/DNA hybrid binding site
1,255D, 1,256A, 1,257S, 1,258T, 1,292S, 1,293I, 1,294T, 1,297E, 1,322D, 1,355N, 1,369R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,293I

RNA/DNA hybrid binding site
1,255D, 1,256A, 1,257S, 1,258T, 1,292S, 1,293I, 1,294T, 1,297E, 1,322D, 1,355N, 1,369R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,294T

RNA/DNA hybrid binding site
1,255D, 1,256A, 1,257S, 1,258T, 1,292S, 1,293I, 1,294T, 1,297E, 1,322D, 1,355N, 1,369R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,297E

RNA/DNA hybrid binding site
1,255D, 1,256A, 1,257S, 1,258T, 1,292S, 1,293I, 1,294T, 1,297E, 1,322D, 1,355N, 1,369R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,322D

RNA/DNA hybrid binding site
1,255D, 1,256A, 1,257S, 1,258T, 1,292S, 1,293I, 1,294T, 1,297E, 1,322D, 1,355N, 1,369R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,355N

RNA/DNA hybrid binding site
1,255D, 1,256A, 1,257S, 1,258T, 1,292S, 1,293I, 1,294T, 1,297E, 1,322D, 1,355N, 1,369R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,369R

RNA/DNA hybrid binding site
1,255D, 1,256A, 1,257S, 1,258T, 1,292S, 1,293I, 1,294T, 1,297E, 1,322D, 1,355N, 1,369R
CDD
cd09274 (RNase_HI_RT_Ty3)

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

GBC40934.1

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component