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Entry type
Status
Per-residue features
Colour by
Protein
GBC40153.1
Length
377 amino acids
Protein family membership
None predicted.
Domains and repeats
-
Domain48 - 251
- Thiamin diphosphate-binding fold (IPR029061)
-
Domain
1
50
100
150
200
250
300
350
377
Detailed signature matches
no IPR
Residue annotation
-
alpha subunit inte...66Ealpha subunit interface
66E, 68V, 74E, 96R, 99D, 101P, 102I, 103T, 104E, 105A, 106G, 109G, 110L, 112V, 113G, 114A, 133Q, 136D, 137H, 146L, 147Y, 169V, 172Q, 187L, 188K, 209P, 210N
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)68Valpha subunit interface
66E, 68V, 74E, 96R, 99D, 101P, 102I, 103T, 104E, 105A, 106G, 109G, 110L, 112V, 113G, 114A, 133Q, 136D, 137H, 146L, 147Y, 169V, 172Q, 187L, 188K, 209P, 210N
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)74Ealpha subunit interface
66E, 68V, 74E, 96R, 99D, 101P, 102I, 103T, 104E, 105A, 106G, 109G, 110L, 112V, 113G, 114A, 133Q, 136D, 137H, 146L, 147Y, 169V, 172Q, 187L, 188K, 209P, 210N
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)96Ralpha subunit interface
66E, 68V, 74E, 96R, 99D, 101P, 102I, 103T, 104E, 105A, 106G, 109G, 110L, 112V, 113G, 114A, 133Q, 136D, 137H, 146L, 147Y, 169V, 172Q, 187L, 188K, 209P, 210N
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)99Dalpha subunit interface
66E, 68V, 74E, 96R, 99D, 101P, 102I, 103T, 104E, 105A, 106G, 109G, 110L, 112V, 113G, 114A, 133Q, 136D, 137H, 146L, 147Y, 169V, 172Q, 187L, 188K, 209P, 210N
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)101Palpha subunit interface
66E, 68V, 74E, 96R, 99D, 101P, 102I, 103T, 104E, 105A, 106G, 109G, 110L, 112V, 113G, 114A, 133Q, 136D, 137H, 146L, 147Y, 169V, 172Q, 187L, 188K, 209P, 210N
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)102Ialpha subunit interface
66E, 68V, 74E, 96R, 99D, 101P, 102I, 103T, 104E, 105A, 106G, 109G, 110L, 112V, 113G, 114A, 133Q, 136D, 137H, 146L, 147Y, 169V, 172Q, 187L, 188K, 209P, 210N
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)103Talpha subunit interface
66E, 68V, 74E, 96R, 99D, 101P, 102I, 103T, 104E, 105A, 106G, 109G, 110L, 112V, 113G, 114A, 133Q, 136D, 137H, 146L, 147Y, 169V, 172Q, 187L, 188K, 209P, 210N
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)104Ealpha subunit interface
66E, 68V, 74E, 96R, 99D, 101P, 102I, 103T, 104E, 105A, 106G, 109G, 110L, 112V, 113G, 114A, 133Q, 136D, 137H, 146L, 147Y, 169V, 172Q, 187L, 188K, 209P, 210N
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)105Aalpha subunit interface
66E, 68V, 74E, 96R, 99D, 101P, 102I, 103T, 104E, 105A, 106G, 109G, 110L, 112V, 113G, 114A, 133Q, 136D, 137H, 146L, 147Y, 169V, 172Q, 187L, 188K, 209P, 210N
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)106Galpha subunit interface
66E, 68V, 74E, 96R, 99D, 101P, 102I, 103T, 104E, 105A, 106G, 109G, 110L, 112V, 113G, 114A, 133Q, 136D, 137H, 146L, 147Y, 169V, 172Q, 187L, 188K, 209P, 210N
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)109Galpha subunit interface
66E, 68V, 74E, 96R, 99D, 101P, 102I, 103T, 104E, 105A, 106G, 109G, 110L, 112V, 113G, 114A, 133Q, 136D, 137H, 146L, 147Y, 169V, 172Q, 187L, 188K, 209P, 210N
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)110Lalpha subunit interface
66E, 68V, 74E, 96R, 99D, 101P, 102I, 103T, 104E, 105A, 106G, 109G, 110L, 112V, 113G, 114A, 133Q, 136D, 137H, 146L, 147Y, 169V, 172Q, 187L, 188K, 209P, 210N
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)112Valpha subunit interface
66E, 68V, 74E, 96R, 99D, 101P, 102I, 103T, 104E, 105A, 106G, 109G, 110L, 112V, 113G, 114A, 133Q, 136D, 137H, 146L, 147Y, 169V, 172Q, 187L, 188K, 209P, 210N
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)113Galpha subunit interface
66E, 68V, 74E, 96R, 99D, 101P, 102I, 103T, 104E, 105A, 106G, 109G, 110L, 112V, 113G, 114A, 133Q, 136D, 137H, 146L, 147Y, 169V, 172Q, 187L, 188K, 209P, 210N
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)114Aalpha subunit interface
66E, 68V, 74E, 96R, 99D, 101P, 102I, 103T, 104E, 105A, 106G, 109G, 110L, 112V, 113G, 114A, 133Q, 136D, 137H, 146L, 147Y, 169V, 172Q, 187L, 188K, 209P, 210N
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)133Qalpha subunit interface
66E, 68V, 74E, 96R, 99D, 101P, 102I, 103T, 104E, 105A, 106G, 109G, 110L, 112V, 113G, 114A, 133Q, 136D, 137H, 146L, 147Y, 169V, 172Q, 187L, 188K, 209P, 210N
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)136Dalpha subunit interface
66E, 68V, 74E, 96R, 99D, 101P, 102I, 103T, 104E, 105A, 106G, 109G, 110L, 112V, 113G, 114A, 133Q, 136D, 137H, 146L, 147Y, 169V, 172Q, 187L, 188K, 209P, 210N
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)137Halpha subunit interface
66E, 68V, 74E, 96R, 99D, 101P, 102I, 103T, 104E, 105A, 106G, 109G, 110L, 112V, 113G, 114A, 133Q, 136D, 137H, 146L, 147Y, 169V, 172Q, 187L, 188K, 209P, 210N
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)146Lalpha subunit interface
66E, 68V, 74E, 96R, 99D, 101P, 102I, 103T, 104E, 105A, 106G, 109G, 110L, 112V, 113G, 114A, 133Q, 136D, 137H, 146L, 147Y, 169V, 172Q, 187L, 188K, 209P, 210N
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)147Yalpha subunit interface
66E, 68V, 74E, 96R, 99D, 101P, 102I, 103T, 104E, 105A, 106G, 109G, 110L, 112V, 113G, 114A, 133Q, 136D, 137H, 146L, 147Y, 169V, 172Q, 187L, 188K, 209P, 210N
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)169Valpha subunit interface
66E, 68V, 74E, 96R, 99D, 101P, 102I, 103T, 104E, 105A, 106G, 109G, 110L, 112V, 113G, 114A, 133Q, 136D, 137H, 146L, 147Y, 169V, 172Q, 187L, 188K, 209P, 210N
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)172Qalpha subunit interface
66E, 68V, 74E, 96R, 99D, 101P, 102I, 103T, 104E, 105A, 106G, 109G, 110L, 112V, 113G, 114A, 133Q, 136D, 137H, 146L, 147Y, 169V, 172Q, 187L, 188K, 209P, 210N
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)187Lalpha subunit interface
66E, 68V, 74E, 96R, 99D, 101P, 102I, 103T, 104E, 105A, 106G, 109G, 110L, 112V, 113G, 114A, 133Q, 136D, 137H, 146L, 147Y, 169V, 172Q, 187L, 188K, 209P, 210N
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)188Kalpha subunit interface
66E, 68V, 74E, 96R, 99D, 101P, 102I, 103T, 104E, 105A, 106G, 109G, 110L, 112V, 113G, 114A, 133Q, 136D, 137H, 146L, 147Y, 169V, 172Q, 187L, 188K, 209P, 210N
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)209Palpha subunit interface
66E, 68V, 74E, 96R, 99D, 101P, 102I, 103T, 104E, 105A, 106G, 109G, 110L, 112V, 113G, 114A, 133Q, 136D, 137H, 146L, 147Y, 169V, 172Q, 187L, 188K, 209P, 210N
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)210Nalpha subunit interface
66E, 68V, 74E, 96R, 99D, 101P, 102I, 103T, 104E, 105A, 106G, 109G, 110L, 112V, 113G, 114A, 133Q, 136D, 137H, 146L, 147Y, 169V, 172Q, 187L, 188K, 209P, 210N
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like) -
TPP binding site c...73E102I104E130F133Q
-
heterodimer interf...74Eheterodimer interface
74E, 99D, 101P, 102I, 103T, 104E, 132M, 133Q, 135I, 140N, 144K, 147Y, 169V, 171A, 172Q, 180W, 182G, 183A, 185P
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)99Dheterodimer interface
74E, 99D, 101P, 102I, 103T, 104E, 132M, 133Q, 135I, 140N, 144K, 147Y, 169V, 171A, 172Q, 180W, 182G, 183A, 185P
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)101Pheterodimer interface
74E, 99D, 101P, 102I, 103T, 104E, 132M, 133Q, 135I, 140N, 144K, 147Y, 169V, 171A, 172Q, 180W, 182G, 183A, 185P
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)102Iheterodimer interface
74E, 99D, 101P, 102I, 103T, 104E, 132M, 133Q, 135I, 140N, 144K, 147Y, 169V, 171A, 172Q, 180W, 182G, 183A, 185P
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)103Theterodimer interface
74E, 99D, 101P, 102I, 103T, 104E, 132M, 133Q, 135I, 140N, 144K, 147Y, 169V, 171A, 172Q, 180W, 182G, 183A, 185P
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)104Eheterodimer interface
74E, 99D, 101P, 102I, 103T, 104E, 132M, 133Q, 135I, 140N, 144K, 147Y, 169V, 171A, 172Q, 180W, 182G, 183A, 185P
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)132Mheterodimer interface
74E, 99D, 101P, 102I, 103T, 104E, 132M, 133Q, 135I, 140N, 144K, 147Y, 169V, 171A, 172Q, 180W, 182G, 183A, 185P
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)133Qheterodimer interface
74E, 99D, 101P, 102I, 103T, 104E, 132M, 133Q, 135I, 140N, 144K, 147Y, 169V, 171A, 172Q, 180W, 182G, 183A, 185P
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)135Iheterodimer interface
74E, 99D, 101P, 102I, 103T, 104E, 132M, 133Q, 135I, 140N, 144K, 147Y, 169V, 171A, 172Q, 180W, 182G, 183A, 185P
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)140Nheterodimer interface
74E, 99D, 101P, 102I, 103T, 104E, 132M, 133Q, 135I, 140N, 144K, 147Y, 169V, 171A, 172Q, 180W, 182G, 183A, 185P
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)144Kheterodimer interface
74E, 99D, 101P, 102I, 103T, 104E, 132M, 133Q, 135I, 140N, 144K, 147Y, 169V, 171A, 172Q, 180W, 182G, 183A, 185P
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)147Yheterodimer interface
74E, 99D, 101P, 102I, 103T, 104E, 132M, 133Q, 135I, 140N, 144K, 147Y, 169V, 171A, 172Q, 180W, 182G, 183A, 185P
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)169Vheterodimer interface
74E, 99D, 101P, 102I, 103T, 104E, 132M, 133Q, 135I, 140N, 144K, 147Y, 169V, 171A, 172Q, 180W, 182G, 183A, 185P
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)171Aheterodimer interface
74E, 99D, 101P, 102I, 103T, 104E, 132M, 133Q, 135I, 140N, 144K, 147Y, 169V, 171A, 172Q, 180W, 182G, 183A, 185P
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)172Qheterodimer interface
74E, 99D, 101P, 102I, 103T, 104E, 132M, 133Q, 135I, 140N, 144K, 147Y, 169V, 171A, 172Q, 180W, 182G, 183A, 185P
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)180Wheterodimer interface
74E, 99D, 101P, 102I, 103T, 104E, 132M, 133Q, 135I, 140N, 144K, 147Y, 169V, 171A, 172Q, 180W, 182G, 183A, 185P
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)182Gheterodimer interface
74E, 99D, 101P, 102I, 103T, 104E, 132M, 133Q, 135I, 140N, 144K, 147Y, 169V, 171A, 172Q, 180W, 182G, 183A, 185P
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)183Aheterodimer interface
74E, 99D, 101P, 102I, 103T, 104E, 132M, 133Q, 135I, 140N, 144K, 147Y, 169V, 171A, 172Q, 180W, 182G, 183A, 185P
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)185Pheterodimer interface
74E, 99D, 101P, 102I, 103T, 104E, 132M, 133Q, 135I, 140N, 144K, 147Y, 169V, 171A, 172Q, 180W, 182G, 183A, 185P
CDD
cd07036 (TPP_PYR_E1-PDHc-beta_like)
GO term prediction
Biological Process
GO:0008152 metabolic process
Molecular Function
GO:0003824 catalytic activity
Cellular Component
None predicted.