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Protein

GBC38424.1

Length

432 amino acids

Protein family membership

Cys/Met metabolism, pyridoxal phosphate-dependent enzyme (IPR000277)
- O-acetylhomoserine/O-acetylserine sulfhydrylase (IPR006235)

Domains and repeats

Domain
8 - 426
Pyridoxal phosphate-dependent transferase (IPR015424)

1 50 100 150 200 250 300 350 400 432

Detailed signature matches

IPR000277

Cys/Met metabolism, pyridoxal phosphate-dependent enzyme

cd00614 (CGS_like)

26 - 426

CDD
cd00614 (CGS_like)
PF01053 (Cys_Met_Me...)

10 - 426

Pfam
PF01053 (Cys_Met_Meta_PP)
PS00868 (CYS_MET_ME...)

203 - 217

PROSITE patterns
PS00868 (CYS_MET_METAB_PP)
PIRSF001434 (CGS)

1 - 429

PIRSF
PIRSF001434 (CGS)

IPR006235

O-acetylhomoserine/O-acetylserine sulfhydrylase

TIGR01326

8 - 426

TIGRFAMs
TIGR01326 (TIGR01326)

IPR015424

Pyridoxal phosphate-dependent transferase

SSF53383 (PLP-depen...)

8 - 426

SUPERFAMILY
SSF53383 (PLP-dependent transferases)

Residue annotation

homodimer interfac...

33A

homodimer interface
33A, 34T, 35T, 36S, 38T, 39F, 58Y, 60R, 86S, 87S, 89Q, 90A, 113Y, 118I, 121K, 210T, 218T, 220I, 267L, 278N, 280F, 281G, 361D
CDD
cd00614 (CGS_like)

34T

homodimer interface
33A, 34T, 35T, 36S, 38T, 39F, 58Y, 60R, 86S, 87S, 89Q, 90A, 113Y, 118I, 121K, 210T, 218T, 220I, 267L, 278N, 280F, 281G, 361D
CDD
cd00614 (CGS_like)

35T

homodimer interface
33A, 34T, 35T, 36S, 38T, 39F, 58Y, 60R, 86S, 87S, 89Q, 90A, 113Y, 118I, 121K, 210T, 218T, 220I, 267L, 278N, 280F, 281G, 361D
CDD
cd00614 (CGS_like)

36S

homodimer interface
33A, 34T, 35T, 36S, 38T, 39F, 58Y, 60R, 86S, 87S, 89Q, 90A, 113Y, 118I, 121K, 210T, 218T, 220I, 267L, 278N, 280F, 281G, 361D
CDD
cd00614 (CGS_like)

38T

homodimer interface
33A, 34T, 35T, 36S, 38T, 39F, 58Y, 60R, 86S, 87S, 89Q, 90A, 113Y, 118I, 121K, 210T, 218T, 220I, 267L, 278N, 280F, 281G, 361D
CDD
cd00614 (CGS_like)

39F

homodimer interface
33A, 34T, 35T, 36S, 38T, 39F, 58Y, 60R, 86S, 87S, 89Q, 90A, 113Y, 118I, 121K, 210T, 218T, 220I, 267L, 278N, 280F, 281G, 361D
CDD
cd00614 (CGS_like)

58Y

homodimer interface
33A, 34T, 35T, 36S, 38T, 39F, 58Y, 60R, 86S, 87S, 89Q, 90A, 113Y, 118I, 121K, 210T, 218T, 220I, 267L, 278N, 280F, 281G, 361D
CDD
cd00614 (CGS_like)

60R

homodimer interface
33A, 34T, 35T, 36S, 38T, 39F, 58Y, 60R, 86S, 87S, 89Q, 90A, 113Y, 118I, 121K, 210T, 218T, 220I, 267L, 278N, 280F, 281G, 361D
CDD
cd00614 (CGS_like)

86S

homodimer interface
33A, 34T, 35T, 36S, 38T, 39F, 58Y, 60R, 86S, 87S, 89Q, 90A, 113Y, 118I, 121K, 210T, 218T, 220I, 267L, 278N, 280F, 281G, 361D
CDD
cd00614 (CGS_like)

87S

homodimer interface
33A, 34T, 35T, 36S, 38T, 39F, 58Y, 60R, 86S, 87S, 89Q, 90A, 113Y, 118I, 121K, 210T, 218T, 220I, 267L, 278N, 280F, 281G, 361D
CDD
cd00614 (CGS_like)

89Q

homodimer interface
33A, 34T, 35T, 36S, 38T, 39F, 58Y, 60R, 86S, 87S, 89Q, 90A, 113Y, 118I, 121K, 210T, 218T, 220I, 267L, 278N, 280F, 281G, 361D
CDD
cd00614 (CGS_like)

90A

homodimer interface
33A, 34T, 35T, 36S, 38T, 39F, 58Y, 60R, 86S, 87S, 89Q, 90A, 113Y, 118I, 121K, 210T, 218T, 220I, 267L, 278N, 280F, 281G, 361D
CDD
cd00614 (CGS_like)

113Y

homodimer interface
33A, 34T, 35T, 36S, 38T, 39F, 58Y, 60R, 86S, 87S, 89Q, 90A, 113Y, 118I, 121K, 210T, 218T, 220I, 267L, 278N, 280F, 281G, 361D
CDD
cd00614 (CGS_like)

118I

homodimer interface
33A, 34T, 35T, 36S, 38T, 39F, 58Y, 60R, 86S, 87S, 89Q, 90A, 113Y, 118I, 121K, 210T, 218T, 220I, 267L, 278N, 280F, 281G, 361D
CDD
cd00614 (CGS_like)

121K

homodimer interface
33A, 34T, 35T, 36S, 38T, 39F, 58Y, 60R, 86S, 87S, 89Q, 90A, 113Y, 118I, 121K, 210T, 218T, 220I, 267L, 278N, 280F, 281G, 361D
CDD
cd00614 (CGS_like)

210T

homodimer interface
33A, 34T, 35T, 36S, 38T, 39F, 58Y, 60R, 86S, 87S, 89Q, 90A, 113Y, 118I, 121K, 210T, 218T, 220I, 267L, 278N, 280F, 281G, 361D
CDD
cd00614 (CGS_like)

218T

homodimer interface
33A, 34T, 35T, 36S, 38T, 39F, 58Y, 60R, 86S, 87S, 89Q, 90A, 113Y, 118I, 121K, 210T, 218T, 220I, 267L, 278N, 280F, 281G, 361D
CDD
cd00614 (CGS_like)

220I

homodimer interface
33A, 34T, 35T, 36S, 38T, 39F, 58Y, 60R, 86S, 87S, 89Q, 90A, 113Y, 118I, 121K, 210T, 218T, 220I, 267L, 278N, 280F, 281G, 361D
CDD
cd00614 (CGS_like)

267L

homodimer interface
33A, 34T, 35T, 36S, 38T, 39F, 58Y, 60R, 86S, 87S, 89Q, 90A, 113Y, 118I, 121K, 210T, 218T, 220I, 267L, 278N, 280F, 281G, 361D
CDD
cd00614 (CGS_like)

278N

homodimer interface
33A, 34T, 35T, 36S, 38T, 39F, 58Y, 60R, 86S, 87S, 89Q, 90A, 113Y, 118I, 121K, 210T, 218T, 220I, 267L, 278N, 280F, 281G, 361D
CDD
cd00614 (CGS_like)

280F

homodimer interface
33A, 34T, 35T, 36S, 38T, 39F, 58Y, 60R, 86S, 87S, 89Q, 90A, 113Y, 118I, 121K, 210T, 218T, 220I, 267L, 278N, 280F, 281G, 361D
CDD
cd00614 (CGS_like)

281G

homodimer interface
33A, 34T, 35T, 36S, 38T, 39F, 58Y, 60R, 86S, 87S, 89Q, 90A, 113Y, 118I, 121K, 210T, 218T, 220I, 267L, 278N, 280F, 281G, 361D
CDD
cd00614 (CGS_like)

361D

homodimer interface
33A, 34T, 35T, 36S, 38T, 39F, 58Y, 60R, 86S, 87S, 89Q, 90A, 113Y, 118I, 121K, 210T, 218T, 220I, 267L, 278N, 280F, 281G, 361D
CDD
cd00614 (CGS_like)
pyridoxal 5'-phosp...

87S

pyridoxal 5'-phosphate binding site
87S, 88G, 89Q, 113Y, 185D, 188F, 208S, 210T, 211K
CDD
cd00614 (CGS_like)

88G

pyridoxal 5'-phosphate binding site
87S, 88G, 89Q, 113Y, 185D, 188F, 208S, 210T, 211K
CDD
cd00614 (CGS_like)

89Q

pyridoxal 5'-phosphate binding site
87S, 88G, 89Q, 113Y, 185D, 188F, 208S, 210T, 211K
CDD
cd00614 (CGS_like)

113Y

pyridoxal 5'-phosphate binding site
87S, 88G, 89Q, 113Y, 185D, 188F, 208S, 210T, 211K
CDD
cd00614 (CGS_like)

185D

pyridoxal 5'-phosphate binding site
87S, 88G, 89Q, 113Y, 185D, 188F, 208S, 210T, 211K
CDD
cd00614 (CGS_like)

188F

pyridoxal 5'-phosphate binding site
87S, 88G, 89Q, 113Y, 185D, 188F, 208S, 210T, 211K
CDD
cd00614 (CGS_like)

208S

pyridoxal 5'-phosphate binding site
87S, 88G, 89Q, 113Y, 185D, 188F, 208S, 210T, 211K
CDD
cd00614 (CGS_like)

210T

pyridoxal 5'-phosphate binding site
87S, 88G, 89Q, 113Y, 185D, 188F, 208S, 210T, 211K
CDD
cd00614 (CGS_like)

211K

pyridoxal 5'-phosphate binding site
87S, 88G, 89Q, 113Y, 185D, 188F, 208S, 210T, 211K
CDD
cd00614 (CGS_like)
substrate-cofactor...

87S

substrate-cofactor binding pocket
87S, 88G, 89Q, 113Y, 156E, 185D, 208S, 210T, 211K, 220I
CDD
cd00614 (CGS_like)

88G

substrate-cofactor binding pocket
87S, 88G, 89Q, 113Y, 156E, 185D, 208S, 210T, 211K, 220I
CDD
cd00614 (CGS_like)

89Q

substrate-cofactor binding pocket
87S, 88G, 89Q, 113Y, 156E, 185D, 208S, 210T, 211K, 220I
CDD
cd00614 (CGS_like)

113Y

substrate-cofactor binding pocket
87S, 88G, 89Q, 113Y, 156E, 185D, 208S, 210T, 211K, 220I
CDD
cd00614 (CGS_like)

156E

substrate-cofactor binding pocket
87S, 88G, 89Q, 113Y, 156E, 185D, 208S, 210T, 211K, 220I
CDD
cd00614 (CGS_like)

185D

substrate-cofactor binding pocket
87S, 88G, 89Q, 113Y, 156E, 185D, 208S, 210T, 211K, 220I
CDD
cd00614 (CGS_like)

208S

substrate-cofactor binding pocket
87S, 88G, 89Q, 113Y, 156E, 185D, 208S, 210T, 211K, 220I
CDD
cd00614 (CGS_like)

210T

substrate-cofactor binding pocket
87S, 88G, 89Q, 113Y, 156E, 185D, 208S, 210T, 211K, 220I
CDD
cd00614 (CGS_like)

211K

substrate-cofactor binding pocket
87S, 88G, 89Q, 113Y, 156E, 185D, 208S, 210T, 211K, 220I
CDD
cd00614 (CGS_like)

220I

substrate-cofactor binding pocket
87S, 88G, 89Q, 113Y, 156E, 185D, 208S, 210T, 211K, 220I
CDD
cd00614 (CGS_like)
catalytic residue ...

211K

catalytic residue
211K
CDD
cd00614 (CGS_like)

GO term prediction

Biological Process

GO:0006520 cellular amino acid metabolic process

Molecular Function

GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0030170 pyridoxal phosphate binding

Cellular Component

None predicted.