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Protein

GBC38366.1

Length

456 amino acids

Protein family membership

Cys/Met metabolism, pyridoxal phosphate-dependent enzyme (IPR000277)
- O-acetylhomoserine/O-acetylserine sulfhydrylase (IPR006235)

Domains and repeats

Domain
32 - 448
Pyridoxal phosphate-dependent transferase (IPR015424)

1 50 100 150 200 250 300 350 400 456

Detailed signature matches

IPR000277

Cys/Met metabolism, pyridoxal phosphate-dependent enzyme

cd00614 (CGS_like)

50 - 450

CDD
cd00614 (CGS_like)
PF01053 (Cys_Met_Me...)

34 - 450

Pfam
PF01053 (Cys_Met_Meta_PP)
PS00868 (CYS_MET_ME...)

227 - 241

PROSITE patterns
PS00868 (CYS_MET_METAB_PP)
PIRSF001434 (CGS)

19 - 453

PIRSF
PIRSF001434 (CGS)

IPR006235

O-acetylhomoserine/O-acetylserine sulfhydrylase

TIGR01326

32 - 450

TIGRFAMs
TIGR01326 (TIGR01326)

IPR015424

Pyridoxal phosphate-dependent transferase

SSF53383 (PLP-depen...)

32 - 448

SUPERFAMILY
SSF53383 (PLP-dependent transferases)

no IPR

Unintegrated signatures

mobidb-lite (disord...)

1 - 26

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

homodimer interfac...

57A

homodimer interface
57A, 58T, 59T, 60S, 62T, 63F, 82Y, 84R, 110S, 111S, 113Q, 114A, 137Y, 142I, 145K, 234T, 293I, 302N, 304F, 305G, 385D
CDD
cd00614 (CGS_like)

58T

homodimer interface
57A, 58T, 59T, 60S, 62T, 63F, 82Y, 84R, 110S, 111S, 113Q, 114A, 137Y, 142I, 145K, 234T, 293I, 302N, 304F, 305G, 385D
CDD
cd00614 (CGS_like)

59T

homodimer interface
57A, 58T, 59T, 60S, 62T, 63F, 82Y, 84R, 110S, 111S, 113Q, 114A, 137Y, 142I, 145K, 234T, 293I, 302N, 304F, 305G, 385D
CDD
cd00614 (CGS_like)

60S

homodimer interface
57A, 58T, 59T, 60S, 62T, 63F, 82Y, 84R, 110S, 111S, 113Q, 114A, 137Y, 142I, 145K, 234T, 293I, 302N, 304F, 305G, 385D
CDD
cd00614 (CGS_like)

62T

homodimer interface
57A, 58T, 59T, 60S, 62T, 63F, 82Y, 84R, 110S, 111S, 113Q, 114A, 137Y, 142I, 145K, 234T, 293I, 302N, 304F, 305G, 385D
CDD
cd00614 (CGS_like)

63F

homodimer interface
57A, 58T, 59T, 60S, 62T, 63F, 82Y, 84R, 110S, 111S, 113Q, 114A, 137Y, 142I, 145K, 234T, 293I, 302N, 304F, 305G, 385D
CDD
cd00614 (CGS_like)

82Y

homodimer interface
57A, 58T, 59T, 60S, 62T, 63F, 82Y, 84R, 110S, 111S, 113Q, 114A, 137Y, 142I, 145K, 234T, 293I, 302N, 304F, 305G, 385D
CDD
cd00614 (CGS_like)

84R

homodimer interface
57A, 58T, 59T, 60S, 62T, 63F, 82Y, 84R, 110S, 111S, 113Q, 114A, 137Y, 142I, 145K, 234T, 293I, 302N, 304F, 305G, 385D
CDD
cd00614 (CGS_like)

110S

homodimer interface
57A, 58T, 59T, 60S, 62T, 63F, 82Y, 84R, 110S, 111S, 113Q, 114A, 137Y, 142I, 145K, 234T, 293I, 302N, 304F, 305G, 385D
CDD
cd00614 (CGS_like)

111S

homodimer interface
57A, 58T, 59T, 60S, 62T, 63F, 82Y, 84R, 110S, 111S, 113Q, 114A, 137Y, 142I, 145K, 234T, 293I, 302N, 304F, 305G, 385D
CDD
cd00614 (CGS_like)

113Q

homodimer interface
57A, 58T, 59T, 60S, 62T, 63F, 82Y, 84R, 110S, 111S, 113Q, 114A, 137Y, 142I, 145K, 234T, 293I, 302N, 304F, 305G, 385D
CDD
cd00614 (CGS_like)

114A

homodimer interface
57A, 58T, 59T, 60S, 62T, 63F, 82Y, 84R, 110S, 111S, 113Q, 114A, 137Y, 142I, 145K, 234T, 293I, 302N, 304F, 305G, 385D
CDD
cd00614 (CGS_like)

137Y

homodimer interface
57A, 58T, 59T, 60S, 62T, 63F, 82Y, 84R, 110S, 111S, 113Q, 114A, 137Y, 142I, 145K, 234T, 293I, 302N, 304F, 305G, 385D
CDD
cd00614 (CGS_like)

142I

homodimer interface
57A, 58T, 59T, 60S, 62T, 63F, 82Y, 84R, 110S, 111S, 113Q, 114A, 137Y, 142I, 145K, 234T, 293I, 302N, 304F, 305G, 385D
CDD
cd00614 (CGS_like)

145K

homodimer interface
57A, 58T, 59T, 60S, 62T, 63F, 82Y, 84R, 110S, 111S, 113Q, 114A, 137Y, 142I, 145K, 234T, 293I, 302N, 304F, 305G, 385D
CDD
cd00614 (CGS_like)

234T

homodimer interface
57A, 58T, 59T, 60S, 62T, 63F, 82Y, 84R, 110S, 111S, 113Q, 114A, 137Y, 142I, 145K, 234T, 293I, 302N, 304F, 305G, 385D
CDD
cd00614 (CGS_like)

293I

homodimer interface
57A, 58T, 59T, 60S, 62T, 63F, 82Y, 84R, 110S, 111S, 113Q, 114A, 137Y, 142I, 145K, 234T, 293I, 302N, 304F, 305G, 385D
CDD
cd00614 (CGS_like)

302N

homodimer interface
57A, 58T, 59T, 60S, 62T, 63F, 82Y, 84R, 110S, 111S, 113Q, 114A, 137Y, 142I, 145K, 234T, 293I, 302N, 304F, 305G, 385D
CDD
cd00614 (CGS_like)

304F

homodimer interface
57A, 58T, 59T, 60S, 62T, 63F, 82Y, 84R, 110S, 111S, 113Q, 114A, 137Y, 142I, 145K, 234T, 293I, 302N, 304F, 305G, 385D
CDD
cd00614 (CGS_like)

305G

homodimer interface
57A, 58T, 59T, 60S, 62T, 63F, 82Y, 84R, 110S, 111S, 113Q, 114A, 137Y, 142I, 145K, 234T, 293I, 302N, 304F, 305G, 385D
CDD
cd00614 (CGS_like)

385D

homodimer interface
57A, 58T, 59T, 60S, 62T, 63F, 82Y, 84R, 110S, 111S, 113Q, 114A, 137Y, 142I, 145K, 234T, 293I, 302N, 304F, 305G, 385D
CDD
cd00614 (CGS_like)
pyridoxal 5'-phosp...

111S

pyridoxal 5'-phosphate binding site
111S, 112G, 113Q, 137Y, 209D, 212F, 232S, 234T, 235K
CDD
cd00614 (CGS_like)

112G

pyridoxal 5'-phosphate binding site
111S, 112G, 113Q, 137Y, 209D, 212F, 232S, 234T, 235K
CDD
cd00614 (CGS_like)

113Q

pyridoxal 5'-phosphate binding site
111S, 112G, 113Q, 137Y, 209D, 212F, 232S, 234T, 235K
CDD
cd00614 (CGS_like)

137Y

pyridoxal 5'-phosphate binding site
111S, 112G, 113Q, 137Y, 209D, 212F, 232S, 234T, 235K
CDD
cd00614 (CGS_like)

209D

pyridoxal 5'-phosphate binding site
111S, 112G, 113Q, 137Y, 209D, 212F, 232S, 234T, 235K
CDD
cd00614 (CGS_like)

212F

pyridoxal 5'-phosphate binding site
111S, 112G, 113Q, 137Y, 209D, 212F, 232S, 234T, 235K
CDD
cd00614 (CGS_like)

232S

pyridoxal 5'-phosphate binding site
111S, 112G, 113Q, 137Y, 209D, 212F, 232S, 234T, 235K
CDD
cd00614 (CGS_like)

234T

pyridoxal 5'-phosphate binding site
111S, 112G, 113Q, 137Y, 209D, 212F, 232S, 234T, 235K
CDD
cd00614 (CGS_like)

235K

pyridoxal 5'-phosphate binding site
111S, 112G, 113Q, 137Y, 209D, 212F, 232S, 234T, 235K
CDD
cd00614 (CGS_like)
substrate-cofactor...

111S

substrate-cofactor binding pocket
111S, 112G, 113Q, 137Y, 180E, 209D, 232S, 234T, 235K
CDD
cd00614 (CGS_like)

112G

substrate-cofactor binding pocket
111S, 112G, 113Q, 137Y, 180E, 209D, 232S, 234T, 235K
CDD
cd00614 (CGS_like)

113Q

substrate-cofactor binding pocket
111S, 112G, 113Q, 137Y, 180E, 209D, 232S, 234T, 235K
CDD
cd00614 (CGS_like)

137Y

substrate-cofactor binding pocket
111S, 112G, 113Q, 137Y, 180E, 209D, 232S, 234T, 235K
CDD
cd00614 (CGS_like)

180E

substrate-cofactor binding pocket
111S, 112G, 113Q, 137Y, 180E, 209D, 232S, 234T, 235K
CDD
cd00614 (CGS_like)

209D

substrate-cofactor binding pocket
111S, 112G, 113Q, 137Y, 180E, 209D, 232S, 234T, 235K
CDD
cd00614 (CGS_like)

232S

substrate-cofactor binding pocket
111S, 112G, 113Q, 137Y, 180E, 209D, 232S, 234T, 235K
CDD
cd00614 (CGS_like)

234T

substrate-cofactor binding pocket
111S, 112G, 113Q, 137Y, 180E, 209D, 232S, 234T, 235K
CDD
cd00614 (CGS_like)

235K

substrate-cofactor binding pocket
111S, 112G, 113Q, 137Y, 180E, 209D, 232S, 234T, 235K
CDD
cd00614 (CGS_like)
catalytic residue ...

235K

catalytic residue
235K
CDD
cd00614 (CGS_like)

GO term prediction

Biological Process

GO:0006520 cellular amino acid metabolic process

Molecular Function

GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0030170 pyridoxal phosphate binding

Cellular Component

None predicted.