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Entry type
Status
Per-residue features
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Protein
GBC37849.1
Length
461 amino acids
Protein family membership
- Sirtuin family (IPR003000)
Domains and repeats
-
Domain52 - 330
- DHS-like NAD/FAD-binding domain (IPR029035)
- Sirtuin family, catalytic core domain (IPR026590)
- DHS-like NAD/FAD-binding domain (IPR029035)
1
50
100
150
200
250
300
350
400
461
Detailed signature matches
no IPR
Unintegrated signatures
-
cd01408 (SIRT1)68 - 315
-
mobidb-lite (disord...)405 - 461
Residue annotation
-
NAD+ binding site ...77GNAD+ binding site
77G, 79S, 80T, 87F, 88R, 140H, 158Q, 159N, 161D, 178H, 250G, 255V, 276L, 277E, 307T
CDD
cd01408 (SIRT1)79SNAD+ binding site
77G, 79S, 80T, 87F, 88R, 140H, 158Q, 159N, 161D, 178H, 250G, 255V, 276L, 277E, 307T
CDD
cd01408 (SIRT1)80TNAD+ binding site
77G, 79S, 80T, 87F, 88R, 140H, 158Q, 159N, 161D, 178H, 250G, 255V, 276L, 277E, 307T
CDD
cd01408 (SIRT1)87FNAD+ binding site
77G, 79S, 80T, 87F, 88R, 140H, 158Q, 159N, 161D, 178H, 250G, 255V, 276L, 277E, 307T
CDD
cd01408 (SIRT1)88RNAD+ binding site
77G, 79S, 80T, 87F, 88R, 140H, 158Q, 159N, 161D, 178H, 250G, 255V, 276L, 277E, 307T
CDD
cd01408 (SIRT1)140HNAD+ binding site
77G, 79S, 80T, 87F, 88R, 140H, 158Q, 159N, 161D, 178H, 250G, 255V, 276L, 277E, 307T
CDD
cd01408 (SIRT1)158QNAD+ binding site
77G, 79S, 80T, 87F, 88R, 140H, 158Q, 159N, 161D, 178H, 250G, 255V, 276L, 277E, 307T
CDD
cd01408 (SIRT1)159NNAD+ binding site
77G, 79S, 80T, 87F, 88R, 140H, 158Q, 159N, 161D, 178H, 250G, 255V, 276L, 277E, 307T
CDD
cd01408 (SIRT1)161DNAD+ binding site
77G, 79S, 80T, 87F, 88R, 140H, 158Q, 159N, 161D, 178H, 250G, 255V, 276L, 277E, 307T
CDD
cd01408 (SIRT1)178HNAD+ binding site
77G, 79S, 80T, 87F, 88R, 140H, 158Q, 159N, 161D, 178H, 250G, 255V, 276L, 277E, 307T
CDD
cd01408 (SIRT1)250GNAD+ binding site
77G, 79S, 80T, 87F, 88R, 140H, 158Q, 159N, 161D, 178H, 250G, 255V, 276L, 277E, 307T
CDD
cd01408 (SIRT1)255VNAD+ binding site
77G, 79S, 80T, 87F, 88R, 140H, 158Q, 159N, 161D, 178H, 250G, 255V, 276L, 277E, 307T
CDD
cd01408 (SIRT1)276LNAD+ binding site
77G, 79S, 80T, 87F, 88R, 140H, 158Q, 159N, 161D, 178H, 250G, 255V, 276L, 277E, 307T
CDD
cd01408 (SIRT1)277ENAD+ binding site
77G, 79S, 80T, 87F, 88R, 140H, 158Q, 159N, 161D, 178H, 250G, 255V, 276L, 277E, 307T
CDD
cd01408 (SIRT1)307TNAD+ binding site
77G, 79S, 80T, 87F, 88R, 140H, 158Q, 159N, 161D, 178H, 250G, 255V, 276L, 277E, 307T
CDD
cd01408 (SIRT1) -
substrate binding ...160Isubstrate binding site
160I, 178H, 223T, 225F, 226G, 227E, 228A, 229M, 254Q, 255V, 256Q
CDD
cd01408 (SIRT1)178Hsubstrate binding site
160I, 178H, 223T, 225F, 226G, 227E, 228A, 229M, 254Q, 255V, 256Q
CDD
cd01408 (SIRT1)223Tsubstrate binding site
160I, 178H, 223T, 225F, 226G, 227E, 228A, 229M, 254Q, 255V, 256Q
CDD
cd01408 (SIRT1)225Fsubstrate binding site
160I, 178H, 223T, 225F, 226G, 227E, 228A, 229M, 254Q, 255V, 256Q
CDD
cd01408 (SIRT1)226Gsubstrate binding site
160I, 178H, 223T, 225F, 226G, 227E, 228A, 229M, 254Q, 255V, 256Q
CDD
cd01408 (SIRT1)227Esubstrate binding site
160I, 178H, 223T, 225F, 226G, 227E, 228A, 229M, 254Q, 255V, 256Q
CDD
cd01408 (SIRT1)228Asubstrate binding site
160I, 178H, 223T, 225F, 226G, 227E, 228A, 229M, 254Q, 255V, 256Q
CDD
cd01408 (SIRT1)229Msubstrate binding site
160I, 178H, 223T, 225F, 226G, 227E, 228A, 229M, 254Q, 255V, 256Q
CDD
cd01408 (SIRT1)254Qsubstrate binding site
160I, 178H, 223T, 225F, 226G, 227E, 228A, 229M, 254Q, 255V, 256Q
CDD
cd01408 (SIRT1)255Vsubstrate binding site
160I, 178H, 223T, 225F, 226G, 227E, 228A, 229M, 254Q, 255V, 256Q
CDD
cd01408 (SIRT1)256Qsubstrate binding site
160I, 178H, 223T, 225F, 226G, 227E, 228A, 229M, 254Q, 255V, 256Q
CDD
cd01408 (SIRT1) -
Zn binding site cd...
GO term prediction
Biological Process
None predicted.
Molecular Function
GO:0070403 NAD+ binding
Cellular Component
None predicted.