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Protein

GBC37720.1

Length

198 amino acids

Protein family membership

Imidazoleglycerol-phosphate dehydratase (IPR000807)

Domains and repeats

Domain
5 - 89
Ribosomal protein S5 domain 2-type fold (IPR020568)
92 - 184
Ribosomal protein S5 domain 2-type fold (IPR020568)

1 20 40 60 80 100 120 140 160 180 198

Detailed signature matches

IPR000807

Imidazoleglycerol-phosphate dehydratase

PF00475 (IGPD)

37 - 179

Pfam
PF00475 (IGPD)
cd07914 (IGPD)

7 - 198

CDD
cd07914 (IGPD)
MF_00076 (HisB)

5 - 198

HAMAP
MF_00076 (HisB)

IPR020568

Ribosomal protein S5 domain 2-type fold

SSF54211 (Ribosomal...)

5 - 89

SUPERFAMILY
SSF54211 (Ribosomal protein S5 domain 2-like)

92 - 184

SUPERFAMILY
SSF54211 (Ribosomal protein S5 domain 2-like)

IPR020565

Imidazoleglycerol-phosphate dehydratase, conserved site

PS00955 (IGP_DEHYDR...)

161 - 173

PROSITE patterns
PS00955 (IGP_DEHYDRATASE_2)
PS00954 (IGP_DEHYDR...)

66 - 79

PROSITE patterns
PS00954 (IGP_DEHYDRATASE_1)

Residue annotation

putative active si...

15E

putative active site pocket
15E, 43H, 47A, 50K, 51H, 69H, 70H, 73E, 95R, 103L, 104D, 117R, 141H, 165H, 166H, 169E
CDD
cd07914 (IGPD)

43H

putative active site pocket
15E, 43H, 47A, 50K, 51H, 69H, 70H, 73E, 95R, 103L, 104D, 117R, 141H, 165H, 166H, 169E
CDD
cd07914 (IGPD)

47A

putative active site pocket
15E, 43H, 47A, 50K, 51H, 69H, 70H, 73E, 95R, 103L, 104D, 117R, 141H, 165H, 166H, 169E
CDD
cd07914 (IGPD)

50K

putative active site pocket
15E, 43H, 47A, 50K, 51H, 69H, 70H, 73E, 95R, 103L, 104D, 117R, 141H, 165H, 166H, 169E
CDD
cd07914 (IGPD)

51H

putative active site pocket
15E, 43H, 47A, 50K, 51H, 69H, 70H, 73E, 95R, 103L, 104D, 117R, 141H, 165H, 166H, 169E
CDD
cd07914 (IGPD)

69H

putative active site pocket
15E, 43H, 47A, 50K, 51H, 69H, 70H, 73E, 95R, 103L, 104D, 117R, 141H, 165H, 166H, 169E
CDD
cd07914 (IGPD)

70H

putative active site pocket
15E, 43H, 47A, 50K, 51H, 69H, 70H, 73E, 95R, 103L, 104D, 117R, 141H, 165H, 166H, 169E
CDD
cd07914 (IGPD)

73E

putative active site pocket
15E, 43H, 47A, 50K, 51H, 69H, 70H, 73E, 95R, 103L, 104D, 117R, 141H, 165H, 166H, 169E
CDD
cd07914 (IGPD)

95R

putative active site pocket
15E, 43H, 47A, 50K, 51H, 69H, 70H, 73E, 95R, 103L, 104D, 117R, 141H, 165H, 166H, 169E
CDD
cd07914 (IGPD)

103L

putative active site pocket
15E, 43H, 47A, 50K, 51H, 69H, 70H, 73E, 95R, 103L, 104D, 117R, 141H, 165H, 166H, 169E
CDD
cd07914 (IGPD)

104D

putative active site pocket
15E, 43H, 47A, 50K, 51H, 69H, 70H, 73E, 95R, 103L, 104D, 117R, 141H, 165H, 166H, 169E
CDD
cd07914 (IGPD)

117R

putative active site pocket
15E, 43H, 47A, 50K, 51H, 69H, 70H, 73E, 95R, 103L, 104D, 117R, 141H, 165H, 166H, 169E
CDD
cd07914 (IGPD)

141H

putative active site pocket
15E, 43H, 47A, 50K, 51H, 69H, 70H, 73E, 95R, 103L, 104D, 117R, 141H, 165H, 166H, 169E
CDD
cd07914 (IGPD)

165H

putative active site pocket
15E, 43H, 47A, 50K, 51H, 69H, 70H, 73E, 95R, 103L, 104D, 117R, 141H, 165H, 166H, 169E
CDD
cd07914 (IGPD)

166H

putative active site pocket
15E, 43H, 47A, 50K, 51H, 69H, 70H, 73E, 95R, 103L, 104D, 117R, 141H, 165H, 166H, 169E
CDD
cd07914 (IGPD)

169E

putative active site pocket
15E, 43H, 47A, 50K, 51H, 69H, 70H, 73E, 95R, 103L, 104D, 117R, 141H, 165H, 166H, 169E
CDD
cd07914 (IGPD)
4-fold oligomeriza...

39G

4-fold oligomerization interface
39G, 40F, 43H, 65H, 66I, 67D, 69H, 70H, 128R, 129E, 130K, 131I, 132G, 135S, 137E, 140P, 141H, 162K, 163N, 164D, 165H, 166H
CDD
cd07914 (IGPD)

40F

4-fold oligomerization interface
39G, 40F, 43H, 65H, 66I, 67D, 69H, 70H, 128R, 129E, 130K, 131I, 132G, 135S, 137E, 140P, 141H, 162K, 163N, 164D, 165H, 166H
CDD
cd07914 (IGPD)

43H

4-fold oligomerization interface
39G, 40F, 43H, 65H, 66I, 67D, 69H, 70H, 128R, 129E, 130K, 131I, 132G, 135S, 137E, 140P, 141H, 162K, 163N, 164D, 165H, 166H
CDD
cd07914 (IGPD)

65H

4-fold oligomerization interface
39G, 40F, 43H, 65H, 66I, 67D, 69H, 70H, 128R, 129E, 130K, 131I, 132G, 135S, 137E, 140P, 141H, 162K, 163N, 164D, 165H, 166H
CDD
cd07914 (IGPD)

66I

4-fold oligomerization interface
39G, 40F, 43H, 65H, 66I, 67D, 69H, 70H, 128R, 129E, 130K, 131I, 132G, 135S, 137E, 140P, 141H, 162K, 163N, 164D, 165H, 166H
CDD
cd07914 (IGPD)

67D

4-fold oligomerization interface
39G, 40F, 43H, 65H, 66I, 67D, 69H, 70H, 128R, 129E, 130K, 131I, 132G, 135S, 137E, 140P, 141H, 162K, 163N, 164D, 165H, 166H
CDD
cd07914 (IGPD)

69H

4-fold oligomerization interface
39G, 40F, 43H, 65H, 66I, 67D, 69H, 70H, 128R, 129E, 130K, 131I, 132G, 135S, 137E, 140P, 141H, 162K, 163N, 164D, 165H, 166H
CDD
cd07914 (IGPD)

70H

4-fold oligomerization interface
39G, 40F, 43H, 65H, 66I, 67D, 69H, 70H, 128R, 129E, 130K, 131I, 132G, 135S, 137E, 140P, 141H, 162K, 163N, 164D, 165H, 166H
CDD
cd07914 (IGPD)

128R

4-fold oligomerization interface
39G, 40F, 43H, 65H, 66I, 67D, 69H, 70H, 128R, 129E, 130K, 131I, 132G, 135S, 137E, 140P, 141H, 162K, 163N, 164D, 165H, 166H
CDD
cd07914 (IGPD)

129E

4-fold oligomerization interface
39G, 40F, 43H, 65H, 66I, 67D, 69H, 70H, 128R, 129E, 130K, 131I, 132G, 135S, 137E, 140P, 141H, 162K, 163N, 164D, 165H, 166H
CDD
cd07914 (IGPD)

130K

4-fold oligomerization interface
39G, 40F, 43H, 65H, 66I, 67D, 69H, 70H, 128R, 129E, 130K, 131I, 132G, 135S, 137E, 140P, 141H, 162K, 163N, 164D, 165H, 166H
CDD
cd07914 (IGPD)

131I

4-fold oligomerization interface
39G, 40F, 43H, 65H, 66I, 67D, 69H, 70H, 128R, 129E, 130K, 131I, 132G, 135S, 137E, 140P, 141H, 162K, 163N, 164D, 165H, 166H
CDD
cd07914 (IGPD)

132G

4-fold oligomerization interface
39G, 40F, 43H, 65H, 66I, 67D, 69H, 70H, 128R, 129E, 130K, 131I, 132G, 135S, 137E, 140P, 141H, 162K, 163N, 164D, 165H, 166H
CDD
cd07914 (IGPD)

135S

4-fold oligomerization interface
39G, 40F, 43H, 65H, 66I, 67D, 69H, 70H, 128R, 129E, 130K, 131I, 132G, 135S, 137E, 140P, 141H, 162K, 163N, 164D, 165H, 166H
CDD
cd07914 (IGPD)

137E

4-fold oligomerization interface
39G, 40F, 43H, 65H, 66I, 67D, 69H, 70H, 128R, 129E, 130K, 131I, 132G, 135S, 137E, 140P, 141H, 162K, 163N, 164D, 165H, 166H
CDD
cd07914 (IGPD)

140P

4-fold oligomerization interface
39G, 40F, 43H, 65H, 66I, 67D, 69H, 70H, 128R, 129E, 130K, 131I, 132G, 135S, 137E, 140P, 141H, 162K, 163N, 164D, 165H, 166H
CDD
cd07914 (IGPD)

141H

4-fold oligomerization interface
39G, 40F, 43H, 65H, 66I, 67D, 69H, 70H, 128R, 129E, 130K, 131I, 132G, 135S, 137E, 140P, 141H, 162K, 163N, 164D, 165H, 166H
CDD
cd07914 (IGPD)

162K

4-fold oligomerization interface
39G, 40F, 43H, 65H, 66I, 67D, 69H, 70H, 128R, 129E, 130K, 131I, 132G, 135S, 137E, 140P, 141H, 162K, 163N, 164D, 165H, 166H
CDD
cd07914 (IGPD)

163N

4-fold oligomerization interface
39G, 40F, 43H, 65H, 66I, 67D, 69H, 70H, 128R, 129E, 130K, 131I, 132G, 135S, 137E, 140P, 141H, 162K, 163N, 164D, 165H, 166H
CDD
cd07914 (IGPD)

164D

4-fold oligomerization interface
39G, 40F, 43H, 65H, 66I, 67D, 69H, 70H, 128R, 129E, 130K, 131I, 132G, 135S, 137E, 140P, 141H, 162K, 163N, 164D, 165H, 166H
CDD
cd07914 (IGPD)

165H

4-fold oligomerization interface
39G, 40F, 43H, 65H, 66I, 67D, 69H, 70H, 128R, 129E, 130K, 131I, 132G, 135S, 137E, 140P, 141H, 162K, 163N, 164D, 165H, 166H
CDD
cd07914 (IGPD)

166H

4-fold oligomerization interface
39G, 40F, 43H, 65H, 66I, 67D, 69H, 70H, 128R, 129E, 130K, 131I, 132G, 135S, 137E, 140P, 141H, 162K, 163N, 164D, 165H, 166H
CDD
cd07914 (IGPD)
metal binding resi...

43H

metal binding residues
43H, 69H, 70H, 73E, 141H, 165H, 166H, 169E
CDD
cd07914 (IGPD)

69H

metal binding residues
43H, 69H, 70H, 73E, 141H, 165H, 166H, 169E
CDD
cd07914 (IGPD)

70H

metal binding residues
43H, 69H, 70H, 73E, 141H, 165H, 166H, 169E
CDD
cd07914 (IGPD)

73E

metal binding residues
43H, 69H, 70H, 73E, 141H, 165H, 166H, 169E
CDD
cd07914 (IGPD)

141H

metal binding residues
43H, 69H, 70H, 73E, 141H, 165H, 166H, 169E
CDD
cd07914 (IGPD)

165H

metal binding residues
43H, 69H, 70H, 73E, 141H, 165H, 166H, 169E
CDD
cd07914 (IGPD)

166H

metal binding residues
43H, 69H, 70H, 73E, 141H, 165H, 166H, 169E
CDD
cd07914 (IGPD)

169E

metal binding residues
43H, 69H, 70H, 73E, 141H, 165H, 166H, 169E
CDD
cd07914 (IGPD)
3-fold/trimer inte...

94K

3-fold/trimer interface
94K, 96F, 98Y, 99A, 100Y, 102P, 103L, 104D, 106A, 107L, 111V, 112V, 113D, 117R, 119F, 153T, 155H, 157D, 159L, 177V, 180R, 186T
CDD
cd07914 (IGPD)

96F

3-fold/trimer interface
94K, 96F, 98Y, 99A, 100Y, 102P, 103L, 104D, 106A, 107L, 111V, 112V, 113D, 117R, 119F, 153T, 155H, 157D, 159L, 177V, 180R, 186T
CDD
cd07914 (IGPD)

98Y

3-fold/trimer interface
94K, 96F, 98Y, 99A, 100Y, 102P, 103L, 104D, 106A, 107L, 111V, 112V, 113D, 117R, 119F, 153T, 155H, 157D, 159L, 177V, 180R, 186T
CDD
cd07914 (IGPD)

99A

3-fold/trimer interface
94K, 96F, 98Y, 99A, 100Y, 102P, 103L, 104D, 106A, 107L, 111V, 112V, 113D, 117R, 119F, 153T, 155H, 157D, 159L, 177V, 180R, 186T
CDD
cd07914 (IGPD)

100Y

3-fold/trimer interface
94K, 96F, 98Y, 99A, 100Y, 102P, 103L, 104D, 106A, 107L, 111V, 112V, 113D, 117R, 119F, 153T, 155H, 157D, 159L, 177V, 180R, 186T
CDD
cd07914 (IGPD)

102P

3-fold/trimer interface
94K, 96F, 98Y, 99A, 100Y, 102P, 103L, 104D, 106A, 107L, 111V, 112V, 113D, 117R, 119F, 153T, 155H, 157D, 159L, 177V, 180R, 186T
CDD
cd07914 (IGPD)

103L

3-fold/trimer interface
94K, 96F, 98Y, 99A, 100Y, 102P, 103L, 104D, 106A, 107L, 111V, 112V, 113D, 117R, 119F, 153T, 155H, 157D, 159L, 177V, 180R, 186T
CDD
cd07914 (IGPD)

104D

3-fold/trimer interface
94K, 96F, 98Y, 99A, 100Y, 102P, 103L, 104D, 106A, 107L, 111V, 112V, 113D, 117R, 119F, 153T, 155H, 157D, 159L, 177V, 180R, 186T
CDD
cd07914 (IGPD)

106A

3-fold/trimer interface
94K, 96F, 98Y, 99A, 100Y, 102P, 103L, 104D, 106A, 107L, 111V, 112V, 113D, 117R, 119F, 153T, 155H, 157D, 159L, 177V, 180R, 186T
CDD
cd07914 (IGPD)

107L

3-fold/trimer interface
94K, 96F, 98Y, 99A, 100Y, 102P, 103L, 104D, 106A, 107L, 111V, 112V, 113D, 117R, 119F, 153T, 155H, 157D, 159L, 177V, 180R, 186T
CDD
cd07914 (IGPD)

111V

3-fold/trimer interface
94K, 96F, 98Y, 99A, 100Y, 102P, 103L, 104D, 106A, 107L, 111V, 112V, 113D, 117R, 119F, 153T, 155H, 157D, 159L, 177V, 180R, 186T
CDD
cd07914 (IGPD)

112V

3-fold/trimer interface
94K, 96F, 98Y, 99A, 100Y, 102P, 103L, 104D, 106A, 107L, 111V, 112V, 113D, 117R, 119F, 153T, 155H, 157D, 159L, 177V, 180R, 186T
CDD
cd07914 (IGPD)

113D

3-fold/trimer interface
94K, 96F, 98Y, 99A, 100Y, 102P, 103L, 104D, 106A, 107L, 111V, 112V, 113D, 117R, 119F, 153T, 155H, 157D, 159L, 177V, 180R, 186T
CDD
cd07914 (IGPD)

117R

3-fold/trimer interface
94K, 96F, 98Y, 99A, 100Y, 102P, 103L, 104D, 106A, 107L, 111V, 112V, 113D, 117R, 119F, 153T, 155H, 157D, 159L, 177V, 180R, 186T
CDD
cd07914 (IGPD)

119F

3-fold/trimer interface
94K, 96F, 98Y, 99A, 100Y, 102P, 103L, 104D, 106A, 107L, 111V, 112V, 113D, 117R, 119F, 153T, 155H, 157D, 159L, 177V, 180R, 186T
CDD
cd07914 (IGPD)

153T

3-fold/trimer interface
94K, 96F, 98Y, 99A, 100Y, 102P, 103L, 104D, 106A, 107L, 111V, 112V, 113D, 117R, 119F, 153T, 155H, 157D, 159L, 177V, 180R, 186T
CDD
cd07914 (IGPD)

155H

3-fold/trimer interface
94K, 96F, 98Y, 99A, 100Y, 102P, 103L, 104D, 106A, 107L, 111V, 112V, 113D, 117R, 119F, 153T, 155H, 157D, 159L, 177V, 180R, 186T
CDD
cd07914 (IGPD)

157D

3-fold/trimer interface
94K, 96F, 98Y, 99A, 100Y, 102P, 103L, 104D, 106A, 107L, 111V, 112V, 113D, 117R, 119F, 153T, 155H, 157D, 159L, 177V, 180R, 186T
CDD
cd07914 (IGPD)

159L

3-fold/trimer interface
94K, 96F, 98Y, 99A, 100Y, 102P, 103L, 104D, 106A, 107L, 111V, 112V, 113D, 117R, 119F, 153T, 155H, 157D, 159L, 177V, 180R, 186T
CDD
cd07914 (IGPD)

177V

3-fold/trimer interface
94K, 96F, 98Y, 99A, 100Y, 102P, 103L, 104D, 106A, 107L, 111V, 112V, 113D, 117R, 119F, 153T, 155H, 157D, 159L, 177V, 180R, 186T
CDD
cd07914 (IGPD)

180R

3-fold/trimer interface
94K, 96F, 98Y, 99A, 100Y, 102P, 103L, 104D, 106A, 107L, 111V, 112V, 113D, 117R, 119F, 153T, 155H, 157D, 159L, 177V, 180R, 186T
CDD
cd07914 (IGPD)

186T

3-fold/trimer interface
94K, 96F, 98Y, 99A, 100Y, 102P, 103L, 104D, 106A, 107L, 111V, 112V, 113D, 117R, 119F, 153T, 155H, 157D, 159L, 177V, 180R, 186T
CDD
cd07914 (IGPD)

GO term prediction

Biological Process

GO:0000105 histidine biosynthetic process

Molecular Function

GO:0004424 imidazoleglycerol-phosphate dehydratase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

GBC37720.1

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component