632 amino acids

Protein family membership

Domains and repeats

1 100 200 300 400 500 632

Detailed signature matches

    1. PF02146 (SIR2)
    1. PF04574 (DUF592)
    1. SSF52467 (DHS-like ...)
    1. PS50305 (SIRTUIN)
Unintegrated signatures no IPR
Unintegrated signatures
  1. cd01408 (SIRT1)
  2. mobidb-lite (disord...)

Residue annotation

  1. NAD+ binding site ...
  2. substrate binding ...
  3. Zn binding site cd...

GO term prediction

Biological Process

GO:0006342 chromatin silencing
GO:0006355 regulation of transcription, DNA-templated
GO:0006476 protein deacetylation

Molecular Function

GO:0008270 zinc ion binding
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0017136 NAD-dependent histone deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

Cellular Component

None predicted.