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Protein

GBC35207.1

Length

703 amino acids

Protein family membership

Glucosamine-fructose-6-phosphate aminotransferase, isomerising (IPR005855)

Domains and repeats

Domain
15 - 315
Nucleophile aminohydrolases, N-terminal (IPR029055)
Glutamine amidotransferase type 2 domain (IPR017932)
381 - 520
Sugar isomerase (SIS) (IPR001347)
553 - 693
Sugar isomerase (SIS) (IPR001347)

1 100 200 300 400 500 600 703

Detailed signature matches

IPR005855

Glucosamine-fructose-6-phosphate aminotransferase, isomerising

TIGR01135

278 - 703

TIGRFAMs
TIGR01135 (TIGR01135)

IPR029055

Nucleophile aminohydrolases, N-terminal

SSF56235 (N-termina...)

15 - 218

SUPERFAMILY
SSF56235 (N-terminal nucleophile aminohydrolases (Ntn hydrolases))

271 - 315

SUPERFAMILY
SSF56235 (N-terminal nucleophile aminohydrolases (Ntn hydrolases))

IPR017932

Glutamine amidotransferase type 2 domain

PS51278 (GATASE_TYPE_2)

15 - 309

PROSITE profiles
PS51278 (GATASE_TYPE_2)

IPR001347

Sugar isomerase (SIS)

PS51464 (SIS)

553 - 693

PROSITE profiles
PS51464 (SIS)

381 - 520

PROSITE profiles
PS51464 (SIS)
PF01380 (SIS)

385 - 512

Pfam
PF01380 (SIS)

557 - 684

Pfam
PF01380 (SIS)

no IPR

Unintegrated signatures

PF13522 (GATase_6)

91 - 217

Pfam
PF13522 (GATase_6)
SSF53697 (SIS domain)

340 - 703

SUPERFAMILY
SSF53697 (SIS domain)
cd00714 (GFAT)

15 - 306

CDD
cd00714 (GFAT)
cd05008 (SIS_GlmS_G...)

390 - 515

CDD
cd05008 (SIS_GlmS_GlmD_1)
cd05009 (SIS_GlmS_G...)

547 - 701

CDD
cd05009 (SIS_GlmS_GlmD_2)

Residue annotation

glutaminase active...

15C

glutaminase active site
15C, 46R, 100R, 101W, 103T, 104H, 113H, 128N, 129G, 153D, 154T
CDD
cd00714 (GFAT)

46R

glutaminase active site
15C, 46R, 100R, 101W, 103T, 104H, 113H, 128N, 129G, 153D, 154T
CDD
cd00714 (GFAT)

100R

glutaminase active site
15C, 46R, 100R, 101W, 103T, 104H, 113H, 128N, 129G, 153D, 154T
CDD
cd00714 (GFAT)

101W

glutaminase active site
15C, 46R, 100R, 101W, 103T, 104H, 113H, 128N, 129G, 153D, 154T
CDD
cd00714 (GFAT)

103T

glutaminase active site
15C, 46R, 100R, 101W, 103T, 104H, 113H, 128N, 129G, 153D, 154T
CDD
cd00714 (GFAT)

104H

glutaminase active site
15C, 46R, 100R, 101W, 103T, 104H, 113H, 128N, 129G, 153D, 154T
CDD
cd00714 (GFAT)

113H

glutaminase active site
15C, 46R, 100R, 101W, 103T, 104H, 113H, 128N, 129G, 153D, 154T
CDD
cd00714 (GFAT)

128N

glutaminase active site
15C, 46R, 100R, 101W, 103T, 104H, 113H, 128N, 129G, 153D, 154T
CDD
cd00714 (GFAT)

129G

glutaminase active site
15C, 46R, 100R, 101W, 103T, 104H, 113H, 128N, 129G, 153D, 154T
CDD
cd00714 (GFAT)

153D

glutaminase active site
15C, 46R, 100R, 101W, 103T, 104H, 113H, 128N, 129G, 153D, 154T
CDD
cd00714 (GFAT)

154T

glutaminase active site
15C, 46R, 100R, 101W, 103T, 104H, 113H, 128N, 129G, 153D, 154T
CDD
cd00714 (GFAT)
dimer interface cd...

396C

dimer interface
396C, 397G, 407R, 408A, 411E, 412E, 419S, 421E, 425D, 428D, 450D
CDD
cd05008 (SIS_GlmS_GlmD_1)

397G

dimer interface
396C, 397G, 407R, 408A, 411E, 412E, 419S, 421E, 425D, 428D, 450D
CDD
cd05008 (SIS_GlmS_GlmD_1)

407R

dimer interface
396C, 397G, 407R, 408A, 411E, 412E, 419S, 421E, 425D, 428D, 450D
CDD
cd05008 (SIS_GlmS_GlmD_1)

408A

dimer interface
396C, 397G, 407R, 408A, 411E, 412E, 419S, 421E, 425D, 428D, 450D
CDD
cd05008 (SIS_GlmS_GlmD_1)

411E

dimer interface
396C, 397G, 407R, 408A, 411E, 412E, 419S, 421E, 425D, 428D, 450D
CDD
cd05008 (SIS_GlmS_GlmD_1)

412E

dimer interface
396C, 397G, 407R, 408A, 411E, 412E, 419S, 421E, 425D, 428D, 450D
CDD
cd05008 (SIS_GlmS_GlmD_1)

419S

dimer interface
396C, 397G, 407R, 408A, 411E, 412E, 419S, 421E, 425D, 428D, 450D
CDD
cd05008 (SIS_GlmS_GlmD_1)

421E

dimer interface
396C, 397G, 407R, 408A, 411E, 412E, 419S, 421E, 425D, 428D, 450D
CDD
cd05008 (SIS_GlmS_GlmD_1)

425D

dimer interface
396C, 397G, 407R, 408A, 411E, 412E, 419S, 421E, 425D, 428D, 450D
CDD
cd05008 (SIS_GlmS_GlmD_1)

428D

dimer interface
396C, 397G, 407R, 408A, 411E, 412E, 419S, 421E, 425D, 428D, 450D
CDD
cd05008 (SIS_GlmS_GlmD_1)

450D

dimer interface
396C, 397G, 407R, 408A, 411E, 412E, 419S, 421E, 425D, 428D, 450D
CDD
cd05008 (SIS_GlmS_GlmD_1)
active site cd05008

398T

active site
398T, 399S, 443S, 444Q, 445S
CDD
cd05008 (SIS_GlmS_GlmD_1)

399S

active site
398T, 399S, 443S, 444Q, 445S
CDD
cd05008 (SIS_GlmS_GlmD_1)

443S

active site
398T, 399S, 443S, 444Q, 445S
CDD
cd05008 (SIS_GlmS_GlmD_1)

444Q

active site
398T, 399S, 443S, 444Q, 445S
CDD
cd05008 (SIS_GlmS_GlmD_1)

445S

active site
398T, 399S, 443S, 444Q, 445S
CDD
cd05008 (SIS_GlmS_GlmD_1)
dimer interface cd...

569G

dimer interface
569G, 583K, 587Y, 589H, 591E, 593I, 597E, 599K, 600H, 601G, 603L, 604A, 605L, 606I, 623P, 624K, 628A, 630Q, 631Q, 694R, 695N, 700V
CDD
cd05009 (SIS_GlmS_GlmD_2)

583K

dimer interface
569G, 583K, 587Y, 589H, 591E, 593I, 597E, 599K, 600H, 601G, 603L, 604A, 605L, 606I, 623P, 624K, 628A, 630Q, 631Q, 694R, 695N, 700V
CDD
cd05009 (SIS_GlmS_GlmD_2)

587Y

dimer interface
569G, 583K, 587Y, 589H, 591E, 593I, 597E, 599K, 600H, 601G, 603L, 604A, 605L, 606I, 623P, 624K, 628A, 630Q, 631Q, 694R, 695N, 700V
CDD
cd05009 (SIS_GlmS_GlmD_2)

589H

dimer interface
569G, 583K, 587Y, 589H, 591E, 593I, 597E, 599K, 600H, 601G, 603L, 604A, 605L, 606I, 623P, 624K, 628A, 630Q, 631Q, 694R, 695N, 700V
CDD
cd05009 (SIS_GlmS_GlmD_2)

591E

dimer interface
569G, 583K, 587Y, 589H, 591E, 593I, 597E, 599K, 600H, 601G, 603L, 604A, 605L, 606I, 623P, 624K, 628A, 630Q, 631Q, 694R, 695N, 700V
CDD
cd05009 (SIS_GlmS_GlmD_2)

593I

dimer interface
569G, 583K, 587Y, 589H, 591E, 593I, 597E, 599K, 600H, 601G, 603L, 604A, 605L, 606I, 623P, 624K, 628A, 630Q, 631Q, 694R, 695N, 700V
CDD
cd05009 (SIS_GlmS_GlmD_2)

597E

dimer interface
569G, 583K, 587Y, 589H, 591E, 593I, 597E, 599K, 600H, 601G, 603L, 604A, 605L, 606I, 623P, 624K, 628A, 630Q, 631Q, 694R, 695N, 700V
CDD
cd05009 (SIS_GlmS_GlmD_2)

599K

dimer interface
569G, 583K, 587Y, 589H, 591E, 593I, 597E, 599K, 600H, 601G, 603L, 604A, 605L, 606I, 623P, 624K, 628A, 630Q, 631Q, 694R, 695N, 700V
CDD
cd05009 (SIS_GlmS_GlmD_2)

600H

dimer interface
569G, 583K, 587Y, 589H, 591E, 593I, 597E, 599K, 600H, 601G, 603L, 604A, 605L, 606I, 623P, 624K, 628A, 630Q, 631Q, 694R, 695N, 700V
CDD
cd05009 (SIS_GlmS_GlmD_2)

601G

dimer interface
569G, 583K, 587Y, 589H, 591E, 593I, 597E, 599K, 600H, 601G, 603L, 604A, 605L, 606I, 623P, 624K, 628A, 630Q, 631Q, 694R, 695N, 700V
CDD
cd05009 (SIS_GlmS_GlmD_2)

603L

dimer interface
569G, 583K, 587Y, 589H, 591E, 593I, 597E, 599K, 600H, 601G, 603L, 604A, 605L, 606I, 623P, 624K, 628A, 630Q, 631Q, 694R, 695N, 700V
CDD
cd05009 (SIS_GlmS_GlmD_2)

604A

dimer interface
569G, 583K, 587Y, 589H, 591E, 593I, 597E, 599K, 600H, 601G, 603L, 604A, 605L, 606I, 623P, 624K, 628A, 630Q, 631Q, 694R, 695N, 700V
CDD
cd05009 (SIS_GlmS_GlmD_2)

605L

dimer interface
569G, 583K, 587Y, 589H, 591E, 593I, 597E, 599K, 600H, 601G, 603L, 604A, 605L, 606I, 623P, 624K, 628A, 630Q, 631Q, 694R, 695N, 700V
CDD
cd05009 (SIS_GlmS_GlmD_2)

606I

dimer interface
569G, 583K, 587Y, 589H, 591E, 593I, 597E, 599K, 600H, 601G, 603L, 604A, 605L, 606I, 623P, 624K, 628A, 630Q, 631Q, 694R, 695N, 700V
CDD
cd05009 (SIS_GlmS_GlmD_2)

623P

dimer interface
569G, 583K, 587Y, 589H, 591E, 593I, 597E, 599K, 600H, 601G, 603L, 604A, 605L, 606I, 623P, 624K, 628A, 630Q, 631Q, 694R, 695N, 700V
CDD
cd05009 (SIS_GlmS_GlmD_2)

624K

dimer interface
569G, 583K, 587Y, 589H, 591E, 593I, 597E, 599K, 600H, 601G, 603L, 604A, 605L, 606I, 623P, 624K, 628A, 630Q, 631Q, 694R, 695N, 700V
CDD
cd05009 (SIS_GlmS_GlmD_2)

628A

dimer interface
569G, 583K, 587Y, 589H, 591E, 593I, 597E, 599K, 600H, 601G, 603L, 604A, 605L, 606I, 623P, 624K, 628A, 630Q, 631Q, 694R, 695N, 700V
CDD
cd05009 (SIS_GlmS_GlmD_2)

630Q

dimer interface
569G, 583K, 587Y, 589H, 591E, 593I, 597E, 599K, 600H, 601G, 603L, 604A, 605L, 606I, 623P, 624K, 628A, 630Q, 631Q, 694R, 695N, 700V
CDD
cd05009 (SIS_GlmS_GlmD_2)

631Q

dimer interface
569G, 583K, 587Y, 589H, 591E, 593I, 597E, 599K, 600H, 601G, 603L, 604A, 605L, 606I, 623P, 624K, 628A, 630Q, 631Q, 694R, 695N, 700V
CDD
cd05009 (SIS_GlmS_GlmD_2)

694R

dimer interface
569G, 583K, 587Y, 589H, 591E, 593I, 597E, 599K, 600H, 601G, 603L, 604A, 605L, 606I, 623P, 624K, 628A, 630Q, 631Q, 694R, 695N, 700V
CDD
cd05009 (SIS_GlmS_GlmD_2)

695N

dimer interface
569G, 583K, 587Y, 589H, 591E, 593I, 597E, 599K, 600H, 601G, 603L, 604A, 605L, 606I, 623P, 624K, 628A, 630Q, 631Q, 694R, 695N, 700V
CDD
cd05009 (SIS_GlmS_GlmD_2)

700V

dimer interface
569G, 583K, 587Y, 589H, 591E, 593I, 597E, 599K, 600H, 601G, 603L, 604A, 605L, 606I, 623P, 624K, 628A, 630Q, 631Q, 694R, 695N, 700V
CDD
cd05009 (SIS_GlmS_GlmD_2)
active site cd05009

581K

active site
581K, 584E
CDD
cd05009 (SIS_GlmS_GlmD_2)

584E

active site
581K, 584E
CDD
cd05009 (SIS_GlmS_GlmD_2)

GO term prediction

Biological Process

GO:1901135 carbohydrate derivative metabolic process
GO:1901137 carbohydrate derivative biosynthetic process

Molecular Function

GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GO:0097367 carbohydrate derivative binding

Cellular Component

None predicted.