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Protein

GBC34940.1

Length

312 amino acids

Protein family membership

Peptidase M17, leucine aminopeptidase/peptidase B (IPR011356)

Domains and repeats

Domain
1 - 301
Peptidase M17, leucyl aminopeptidase, C-terminal (IPR000819)

1 50 100 150 200 250 312

Detailed signature matches

IPR011356

Peptidase M17, leucine aminopeptidase/peptidase B

PR00481 (LAMNOPPTDASE)

32 - 49

PRINTS
PR00481 (LAMNOPPTDASE)

54 - 75

PRINTS
PR00481 (LAMNOPPTDASE)

113 - 133

PRINTS
PR00481 (LAMNOPPTDASE)

91 - 112

PRINTS
PR00481 (LAMNOPPTDASE)

142 - 157

PRINTS
PR00481 (LAMNOPPTDASE)
cd00433 (Peptidase_M17)

1 - 303

CDD
cd00433 (Peptidase_M17)

IPR000819

Peptidase M17, leucyl aminopeptidase, C-terminal

PF00883 (Peptidase_M17)

1 - 301

Pfam
PF00883 (Peptidase_M17)

no IPR

Unintegrated signatures

SSF53187 (Zn-depend...)

1 - 230

SUPERFAMILY
SSF53187 (Zn-dependent exopeptidases)

268 - 306

SUPERFAMILY
SSF53187 (Zn-dependent exopeptidases)

Residue annotation

interface (dimer o...

10G

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

12N

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

41F

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

47S

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

52K

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

55S

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

58K

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

59I

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

91E

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

93L

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

94L

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

95S

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

96G

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

98A

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

100K

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

101P

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

102G

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

103D

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

104V

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

110G

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

112S

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

116D

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

153M

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

154A

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

155G

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

156L

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

157G

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

161Y

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

187W

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

188R

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

190P

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

195Y

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

197K

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

198A

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

204V

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

206D

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

216G

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

217D

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

219C

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)

291K

interface (dimer of trimers)
10G, 12N, 41F, 47S, 52K, 55S, 58K, 59I, 91E, 93L, 94L, 95S, 96G, 98A, 100K, 101P, 102G, 103D, 104V, 110G, 112S, 116D, 153M, 154A, 155G, 156L, 157G, 161Y, 187W, 188R, 190P, 195Y, 197K, 198A, 204V, 206D, 216G, 217D, 219C, 291K
CDD
cd00433 (Peptidase_M17)
Zn-binding sites c...

37K

Zn-binding sites
37K, 42D, 60D, 119D, 121E
CDD
cd00433 (Peptidase_M17)

42D

Zn-binding sites
37K, 42D, 60D, 119D, 121E
CDD
cd00433 (Peptidase_M17)

60D

Zn-binding sites
37K, 42D, 60D, 119D, 121E
CDD
cd00433 (Peptidase_M17)

119D

Zn-binding sites
37K, 42D, 60D, 119D, 121E
CDD
cd00433 (Peptidase_M17)

121E

Zn-binding sites
37K, 42D, 60D, 119D, 121E
CDD
cd00433 (Peptidase_M17)
Substrate-binding/...

37K

Substrate-binding/catalytic site
37K, 42D, 49K, 60D, 119D, 121E, 123R, 148L
CDD
cd00433 (Peptidase_M17)

42D

Substrate-binding/catalytic site
37K, 42D, 49K, 60D, 119D, 121E, 123R, 148L
CDD
cd00433 (Peptidase_M17)

49K

Substrate-binding/catalytic site
37K, 42D, 49K, 60D, 119D, 121E, 123R, 148L
CDD
cd00433 (Peptidase_M17)

60D

Substrate-binding/catalytic site
37K, 42D, 49K, 60D, 119D, 121E, 123R, 148L
CDD
cd00433 (Peptidase_M17)

119D

Substrate-binding/catalytic site
37K, 42D, 49K, 60D, 119D, 121E, 123R, 148L
CDD
cd00433 (Peptidase_M17)

121E

Substrate-binding/catalytic site
37K, 42D, 49K, 60D, 119D, 121E, 123R, 148L
CDD
cd00433 (Peptidase_M17)

123R

Substrate-binding/catalytic site
37K, 42D, 49K, 60D, 119D, 121E, 123R, 148L
CDD
cd00433 (Peptidase_M17)

148L

Substrate-binding/catalytic site
37K, 42D, 49K, 60D, 119D, 121E, 123R, 148L
CDD
cd00433 (Peptidase_M17)

GO term prediction

Biological Process

GO:0006508 proteolysis
GO:0019538 protein metabolic process

Molecular Function

GO:0004177 aminopeptidase activity
GO:0008235 metalloexopeptidase activity
GO:0030145 manganese ion binding

Cellular Component

GO:0005622 intracellular
GO:0005737 cytoplasm