GBC34365.1

Protein

Length

808 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
4 - 101
Aspartic peptidase domain (IPR021109)
230 - 409
Reverse transcriptase domain (IPR000477)
630 - 802
P-loop containing nucleoside triphosphate hydrolase (IPR027417)

1 100 200 300 400 500 600 700 808

Detailed signature matches

IPR021109

Aspartic peptidase domain
1. SSF50630 (Acid prot...)
  
  4 - 101
  
  SUPERFAMILY
  SSF50630 (Acid proteases)
IPR000477

Reverse transcriptase domain
1. PF00078 (RVT_1)
  
  251 - 408
  
  Pfam
  PF00078 (RVT_1)
2. PS50878 (RT_POL)
  
  230 - 409
  
  PROSITE profiles
  PS50878 (RT_POL)
IPR027417

P-loop containing nucleoside triphosphate hydrolase
1. SSF52540 (P-loop co...)
  
  630 - 802
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
IPR001969

Aspartic peptidase, active site
1. PS00141 (ASP_PROTEASE)
  
  14 - 25
  
  PROSITE patterns
  PS00141 (ASP_PROTEASE)

no IPR

Unintegrated signatures

Coil

212 - 232

COILS
Coil (Coil)

366 - 386

COILS
Coil (Coil)
PF13975 (gag-asp_pr...)

4 - 91

Pfam
PF13975 (gag-asp_proteas)
SSF56672 (DNA/RNA p...)

173 - 608

SUPERFAMILY
SSF56672 (DNA/RNA polymerases)
cd00303 (retropepsi...)

3 - 90

CDD
cd00303 (retropepsin_like)
cd01647 (RT_LTR)

235 - 409

CDD
cd01647 (RT_LTR)
cd09274 (RNase_HI_R...)

504 - 622

CDD
cd09274 (RNase_HI_RT_Ty3)

Residue annotation

Catalytic residue ...

17D

Catalytic residue
17D
CDD
cd00303 (retropepsin_like)
catalytic motif cd...

17D

catalytic motif
17D, 18T, 19G
CDD
cd00303 (retropepsin_like)

18T

catalytic motif
17D, 18T, 19G
CDD
cd00303 (retropepsin_like)

19G

catalytic motif
17D, 18T, 19G
CDD
cd00303 (retropepsin_like)
inhibitor binding ...

17D

inhibitor binding site
17D, 19G, 21A, 45C, 46T, 47I, 86I
CDD
cd00303 (retropepsin_like)

19G

inhibitor binding site
17D, 19G, 21A, 45C, 46T, 47I, 86I
CDD
cd00303 (retropepsin_like)

21A

inhibitor binding site
17D, 19G, 21A, 45C, 46T, 47I, 86I
CDD
cd00303 (retropepsin_like)

45C

inhibitor binding site
17D, 19G, 21A, 45C, 46T, 47I, 86I
CDD
cd00303 (retropepsin_like)

46T

inhibitor binding site
17D, 19G, 21A, 45C, 46T, 47I, 86I
CDD
cd00303 (retropepsin_like)

47I

inhibitor binding site
17D, 19G, 21A, 45C, 46T, 47I, 86I
CDD
cd00303 (retropepsin_like)

86I

inhibitor binding site
17D, 19G, 21A, 45C, 46T, 47I, 86I
CDD
cd00303 (retropepsin_like)
Active site flap c...

45C

Active site flap
45C, 46T, 47I, 48A, 52K, 53I, 54A, 55A
CDD
cd00303 (retropepsin_like)

46T

Active site flap
45C, 46T, 47I, 48A, 52K, 53I, 54A, 55A
CDD
cd00303 (retropepsin_like)

47I

Active site flap
45C, 46T, 47I, 48A, 52K, 53I, 54A, 55A
CDD
cd00303 (retropepsin_like)

48A

Active site flap
45C, 46T, 47I, 48A, 52K, 53I, 54A, 55A
CDD
cd00303 (retropepsin_like)

52K

Active site flap
45C, 46T, 47I, 48A, 52K, 53I, 54A, 55A
CDD
cd00303 (retropepsin_like)

53I

Active site flap
45C, 46T, 47I, 48A, 52K, 53I, 54A, 55A
CDD
cd00303 (retropepsin_like)

54A

Active site flap
45C, 46T, 47I, 48A, 52K, 53I, 54A, 55A
CDD
cd00303 (retropepsin_like)

55A

Active site flap
45C, 46T, 47I, 48A, 52K, 53I, 54A, 55A
CDD
cd00303 (retropepsin_like)
putative NTP bindi...

296D

putative NTP binding site
296D, 297L, 298A, 299A, 300G, 301F, 330F, 360D
CDD
cd01647 (RT_LTR)

297L

putative NTP binding site
296D, 297L, 298A, 299A, 300G, 301F, 330F, 360D
CDD
cd01647 (RT_LTR)

298A

putative NTP binding site
296D, 297L, 298A, 299A, 300G, 301F, 330F, 360D
CDD
cd01647 (RT_LTR)

299A

putative NTP binding site
296D, 297L, 298A, 299A, 300G, 301F, 330F, 360D
CDD
cd01647 (RT_LTR)

300G

putative NTP binding site
296D, 297L, 298A, 299A, 300G, 301F, 330F, 360D
CDD
cd01647 (RT_LTR)

301F

putative NTP binding site
296D, 297L, 298A, 299A, 300G, 301F, 330F, 360D
CDD
cd01647 (RT_LTR)

330F

putative NTP binding site
296D, 297L, 298A, 299A, 300G, 301F, 330F, 360D
CDD
cd01647 (RT_LTR)

360D

putative NTP binding site
296D, 297L, 298A, 299A, 300G, 301F, 330F, 360D
CDD
cd01647 (RT_LTR)
putative active si...

296D

putative active site
296D, 297L, 298A, 299A, 300G, 301F, 330F, 331G, 358Y, 360D, 361D, 405L, 406G
CDD
cd01647 (RT_LTR)

297L

putative active site
296D, 297L, 298A, 299A, 300G, 301F, 330F, 331G, 358Y, 360D, 361D, 405L, 406G
CDD
cd01647 (RT_LTR)

298A

putative active site
296D, 297L, 298A, 299A, 300G, 301F, 330F, 331G, 358Y, 360D, 361D, 405L, 406G
CDD
cd01647 (RT_LTR)

299A

putative active site
296D, 297L, 298A, 299A, 300G, 301F, 330F, 331G, 358Y, 360D, 361D, 405L, 406G
CDD
cd01647 (RT_LTR)

300G

putative active site
296D, 297L, 298A, 299A, 300G, 301F, 330F, 331G, 358Y, 360D, 361D, 405L, 406G
CDD
cd01647 (RT_LTR)

301F

putative active site
296D, 297L, 298A, 299A, 300G, 301F, 330F, 331G, 358Y, 360D, 361D, 405L, 406G
CDD
cd01647 (RT_LTR)

330F

putative active site
296D, 297L, 298A, 299A, 300G, 301F, 330F, 331G, 358Y, 360D, 361D, 405L, 406G
CDD
cd01647 (RT_LTR)

331G

putative active site
296D, 297L, 298A, 299A, 300G, 301F, 330F, 331G, 358Y, 360D, 361D, 405L, 406G
CDD
cd01647 (RT_LTR)

358Y

putative active site
296D, 297L, 298A, 299A, 300G, 301F, 330F, 331G, 358Y, 360D, 361D, 405L, 406G
CDD
cd01647 (RT_LTR)

360D

putative active site
296D, 297L, 298A, 299A, 300G, 301F, 330F, 331G, 358Y, 360D, 361D, 405L, 406G
CDD
cd01647 (RT_LTR)

361D

putative active site
296D, 297L, 298A, 299A, 300G, 301F, 330F, 331G, 358Y, 360D, 361D, 405L, 406G
CDD
cd01647 (RT_LTR)

405L

putative active site
296D, 297L, 298A, 299A, 300G, 301F, 330F, 331G, 358Y, 360D, 361D, 405L, 406G
CDD
cd01647 (RT_LTR)

406G

putative active site
296D, 297L, 298A, 299A, 300G, 301F, 330F, 331G, 358Y, 360D, 361D, 405L, 406G
CDD
cd01647 (RT_LTR)
putative nucleic a...

331G

putative nucleic acid binding site
331G
CDD
cd01647 (RT_LTR)
active site cd09274

507D

active site
507D, 549E, 574D, 617D
CDD
cd09274 (RNase_HI_RT_Ty3)

549E

active site
507D, 549E, 574D, 617D
CDD
cd09274 (RNase_HI_RT_Ty3)

574D

active site
507D, 549E, 574D, 617D
CDD
cd09274 (RNase_HI_RT_Ty3)

617D

active site
507D, 549E, 574D, 617D
CDD
cd09274 (RNase_HI_RT_Ty3)
RNA/DNA hybrid bin...

507D

RNA/DNA hybrid binding site
507D, 508A, 509S, 510G, 544P, 545I, 546T, 549E, 574D, 607H, 621R
CDD
cd09274 (RNase_HI_RT_Ty3)

508A

RNA/DNA hybrid binding site
507D, 508A, 509S, 510G, 544P, 545I, 546T, 549E, 574D, 607H, 621R
CDD
cd09274 (RNase_HI_RT_Ty3)

509S

RNA/DNA hybrid binding site
507D, 508A, 509S, 510G, 544P, 545I, 546T, 549E, 574D, 607H, 621R
CDD
cd09274 (RNase_HI_RT_Ty3)

510G

RNA/DNA hybrid binding site
507D, 508A, 509S, 510G, 544P, 545I, 546T, 549E, 574D, 607H, 621R
CDD
cd09274 (RNase_HI_RT_Ty3)

544P

RNA/DNA hybrid binding site
507D, 508A, 509S, 510G, 544P, 545I, 546T, 549E, 574D, 607H, 621R
CDD
cd09274 (RNase_HI_RT_Ty3)

545I

RNA/DNA hybrid binding site
507D, 508A, 509S, 510G, 544P, 545I, 546T, 549E, 574D, 607H, 621R
CDD
cd09274 (RNase_HI_RT_Ty3)

546T

RNA/DNA hybrid binding site
507D, 508A, 509S, 510G, 544P, 545I, 546T, 549E, 574D, 607H, 621R
CDD
cd09274 (RNase_HI_RT_Ty3)

549E

RNA/DNA hybrid binding site
507D, 508A, 509S, 510G, 544P, 545I, 546T, 549E, 574D, 607H, 621R
CDD
cd09274 (RNase_HI_RT_Ty3)

574D

RNA/DNA hybrid binding site
507D, 508A, 509S, 510G, 544P, 545I, 546T, 549E, 574D, 607H, 621R
CDD
cd09274 (RNase_HI_RT_Ty3)

607H

RNA/DNA hybrid binding site
507D, 508A, 509S, 510G, 544P, 545I, 546T, 549E, 574D, 607H, 621R
CDD
cd09274 (RNase_HI_RT_Ty3)

621R

RNA/DNA hybrid binding site
507D, 508A, 509S, 510G, 544P, 545I, 546T, 549E, 574D, 607H, 621R
CDD
cd09274 (RNase_HI_RT_Ty3)

GO term prediction

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0004190 aspartic-type endopeptidase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

GBC34365.1

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component