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Protein

GBC34329.1

Length

1,849 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
79 - 250
Endonuclease/exonuclease/phosphatase (IPR005135)
586 - 881
Reverse transcriptase domain (IPR000477)
1,347 - 1,501
Ribonuclease H-like domain (IPR012337)
Ribonuclease H domain (IPR002156)

1 200 400 600 800 1000 1200 1400 1600 1849

Detailed signature matches

Domain

Endonuclease/exonuclease/phosphatase

SSF56219 (DNase I-like)

79 - 250

SUPERFAMILY
SSF56219 (DNase I-like)

Domain

Reverse transcriptase domain

PF00078 (RVT_1)

615 - 881

Pfam
PF00078 (RVT_1)
PS50878 (RT_POL)

586 - 863

PROSITE profiles
PS50878 (RT_POL)

Domain

Ribonuclease H-like domain

SSF53098 (Ribonucle...)

1,349 - 1,500

SUPERFAMILY
SSF53098 (Ribonuclease H-like)

Domain

Ribonuclease H domain

PF00075 (RNase_H)

1,351 - 1,498

Pfam
PF00075 (RNase_H)
PS50879 (RNASE_H)

1,347 - 1,501

PROSITE profiles
PS50879 (RNASE_H)

Unintegrated signatures

no IPR

Unintegrated signatures

SSF56672 (DNA/RNA p...)

527 - 883

SUPERFAMILY
SSF56672 (DNA/RNA polymerases)
cd09276 (Rnase_HI_R...)

1,352 - 1,497

CDD
cd09276 (Rnase_HI_RT_non_LTR)
mobidb-lite (disord...)

22 - 68

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

active site cd09276

1,356D

active site
1,356D, 1,405E, 1,427D, 1,493D
CDD
cd09276 (Rnase_HI_RT_non_LTR)

1,405E

active site
1,356D, 1,405E, 1,427D, 1,493D
CDD
cd09276 (Rnase_HI_RT_non_LTR)

1,427D

active site
1,356D, 1,405E, 1,427D, 1,493D
CDD
cd09276 (Rnase_HI_RT_non_LTR)

1,493D

active site
1,356D, 1,405E, 1,427D, 1,493D
CDD
cd09276 (Rnase_HI_RT_non_LTR)
RNA/DNA hybrid bin...

1,356D

RNA/DNA hybrid binding site
1,356D, 1,357G, 1,358S, 1,362R, 1,394S, 1,395I, 1,396T, 1,405E, 1,427D, 1,479K, 1,497K
CDD
cd09276 (Rnase_HI_RT_non_LTR)

1,357G

RNA/DNA hybrid binding site
1,356D, 1,357G, 1,358S, 1,362R, 1,394S, 1,395I, 1,396T, 1,405E, 1,427D, 1,479K, 1,497K
CDD
cd09276 (Rnase_HI_RT_non_LTR)

1,358S

RNA/DNA hybrid binding site
1,356D, 1,357G, 1,358S, 1,362R, 1,394S, 1,395I, 1,396T, 1,405E, 1,427D, 1,479K, 1,497K
CDD
cd09276 (Rnase_HI_RT_non_LTR)

1,362R

RNA/DNA hybrid binding site
1,356D, 1,357G, 1,358S, 1,362R, 1,394S, 1,395I, 1,396T, 1,405E, 1,427D, 1,479K, 1,497K
CDD
cd09276 (Rnase_HI_RT_non_LTR)

1,394S

RNA/DNA hybrid binding site
1,356D, 1,357G, 1,358S, 1,362R, 1,394S, 1,395I, 1,396T, 1,405E, 1,427D, 1,479K, 1,497K
CDD
cd09276 (Rnase_HI_RT_non_LTR)

1,395I

RNA/DNA hybrid binding site
1,356D, 1,357G, 1,358S, 1,362R, 1,394S, 1,395I, 1,396T, 1,405E, 1,427D, 1,479K, 1,497K
CDD
cd09276 (Rnase_HI_RT_non_LTR)

1,396T

RNA/DNA hybrid binding site
1,356D, 1,357G, 1,358S, 1,362R, 1,394S, 1,395I, 1,396T, 1,405E, 1,427D, 1,479K, 1,497K
CDD
cd09276 (Rnase_HI_RT_non_LTR)

1,405E

RNA/DNA hybrid binding site
1,356D, 1,357G, 1,358S, 1,362R, 1,394S, 1,395I, 1,396T, 1,405E, 1,427D, 1,479K, 1,497K
CDD
cd09276 (Rnase_HI_RT_non_LTR)

1,427D

RNA/DNA hybrid binding site
1,356D, 1,357G, 1,358S, 1,362R, 1,394S, 1,395I, 1,396T, 1,405E, 1,427D, 1,479K, 1,497K
CDD
cd09276 (Rnase_HI_RT_non_LTR)

1,479K

RNA/DNA hybrid binding site
1,356D, 1,357G, 1,358S, 1,362R, 1,394S, 1,395I, 1,396T, 1,405E, 1,427D, 1,479K, 1,497K
CDD
cd09276 (Rnase_HI_RT_non_LTR)

1,497K

RNA/DNA hybrid binding site
1,356D, 1,357G, 1,358S, 1,362R, 1,394S, 1,395I, 1,396T, 1,405E, 1,427D, 1,479K, 1,497K
CDD
cd09276 (Rnase_HI_RT_non_LTR)

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003676 nucleic acid binding
GO:0004523 RNA-DNA hybrid ribonuclease activity

Cellular Component

None predicted.