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Entry type
Status
Per-residue features
Colour by
Protein
GBC34136.1
Length
908 amino acids
Protein family membership
- Isoleucine-tRNA ligase (IPR002301)
- Isoleucine-tRNA ligase, type 1 (IPR023585)
Domains and repeats
-
Domain
-
Domain
1
100
200
300
400
500
600
700
800
908
Detailed signature matches
Residue annotation
-
active site cd00818529Sactive site
16P, 17P, 18Y, 24H, 26G, 27H, 30N, 413R, 499W, 502S, 527E, 528G, 529S, 530D, 531Q, 533R, 535W, 558H, 559G, 560F, 561V, 562M, 566G, 567Q, 568K, 569M, 570S, 571K, 609D
CDD
cd00818 (IleRS_core)530Dactive site
16P, 17P, 18Y, 24H, 26G, 27H, 30N, 413R, 499W, 502S, 527E, 528G, 529S, 530D, 531Q, 533R, 535W, 558H, 559G, 560F, 561V, 562M, 566G, 567Q, 568K, 569M, 570S, 571K, 609D
CDD
cd00818 (IleRS_core)531Qactive site
16P, 17P, 18Y, 24H, 26G, 27H, 30N, 413R, 499W, 502S, 527E, 528G, 529S, 530D, 531Q, 533R, 535W, 558H, 559G, 560F, 561V, 562M, 566G, 567Q, 568K, 569M, 570S, 571K, 609D
CDD
cd00818 (IleRS_core)533Ractive site
16P, 17P, 18Y, 24H, 26G, 27H, 30N, 413R, 499W, 502S, 527E, 528G, 529S, 530D, 531Q, 533R, 535W, 558H, 559G, 560F, 561V, 562M, 566G, 567Q, 568K, 569M, 570S, 571K, 609D
CDD
cd00818 (IleRS_core)535Wactive site
16P, 17P, 18Y, 24H, 26G, 27H, 30N, 413R, 499W, 502S, 527E, 528G, 529S, 530D, 531Q, 533R, 535W, 558H, 559G, 560F, 561V, 562M, 566G, 567Q, 568K, 569M, 570S, 571K, 609D
CDD
cd00818 (IleRS_core)558Hactive site
16P, 17P, 18Y, 24H, 26G, 27H, 30N, 413R, 499W, 502S, 527E, 528G, 529S, 530D, 531Q, 533R, 535W, 558H, 559G, 560F, 561V, 562M, 566G, 567Q, 568K, 569M, 570S, 571K, 609D
CDD
cd00818 (IleRS_core)559Gactive site
16P, 17P, 18Y, 24H, 26G, 27H, 30N, 413R, 499W, 502S, 527E, 528G, 529S, 530D, 531Q, 533R, 535W, 558H, 559G, 560F, 561V, 562M, 566G, 567Q, 568K, 569M, 570S, 571K, 609D
CDD
cd00818 (IleRS_core)560Factive site
16P, 17P, 18Y, 24H, 26G, 27H, 30N, 413R, 499W, 502S, 527E, 528G, 529S, 530D, 531Q, 533R, 535W, 558H, 559G, 560F, 561V, 562M, 566G, 567Q, 568K, 569M, 570S, 571K, 609D
CDD
cd00818 (IleRS_core)561Vactive site
16P, 17P, 18Y, 24H, 26G, 27H, 30N, 413R, 499W, 502S, 527E, 528G, 529S, 530D, 531Q, 533R, 535W, 558H, 559G, 560F, 561V, 562M, 566G, 567Q, 568K, 569M, 570S, 571K, 609D
CDD
cd00818 (IleRS_core)562Mactive site
16P, 17P, 18Y, 24H, 26G, 27H, 30N, 413R, 499W, 502S, 527E, 528G, 529S, 530D, 531Q, 533R, 535W, 558H, 559G, 560F, 561V, 562M, 566G, 567Q, 568K, 569M, 570S, 571K, 609D
CDD
cd00818 (IleRS_core)566Gactive site
16P, 17P, 18Y, 24H, 26G, 27H, 30N, 413R, 499W, 502S, 527E, 528G, 529S, 530D, 531Q, 533R, 535W, 558H, 559G, 560F, 561V, 562M, 566G, 567Q, 568K, 569M, 570S, 571K, 609D
CDD
cd00818 (IleRS_core)567Qactive site
16P, 17P, 18Y, 24H, 26G, 27H, 30N, 413R, 499W, 502S, 527E, 528G, 529S, 530D, 531Q, 533R, 535W, 558H, 559G, 560F, 561V, 562M, 566G, 567Q, 568K, 569M, 570S, 571K, 609D
CDD
cd00818 (IleRS_core)568Kactive site
16P, 17P, 18Y, 24H, 26G, 27H, 30N, 413R, 499W, 502S, 527E, 528G, 529S, 530D, 531Q, 533R, 535W, 558H, 559G, 560F, 561V, 562M, 566G, 567Q, 568K, 569M, 570S, 571K, 609D
CDD
cd00818 (IleRS_core)569Mactive site
16P, 17P, 18Y, 24H, 26G, 27H, 30N, 413R, 499W, 502S, 527E, 528G, 529S, 530D, 531Q, 533R, 535W, 558H, 559G, 560F, 561V, 562M, 566G, 567Q, 568K, 569M, 570S, 571K, 609D
CDD
cd00818 (IleRS_core)570Sactive site
16P, 17P, 18Y, 24H, 26G, 27H, 30N, 413R, 499W, 502S, 527E, 528G, 529S, 530D, 531Q, 533R, 535W, 558H, 559G, 560F, 561V, 562M, 566G, 567Q, 568K, 569M, 570S, 571K, 609D
CDD
cd00818 (IleRS_core)571Kactive site
16P, 17P, 18Y, 24H, 26G, 27H, 30N, 413R, 499W, 502S, 527E, 528G, 529S, 530D, 531Q, 533R, 535W, 558H, 559G, 560F, 561V, 562M, 566G, 567Q, 568K, 569M, 570S, 571K, 609D
CDD
cd00818 (IleRS_core)609Dactive site
16P, 17P, 18Y, 24H, 26G, 27H, 30N, 413R, 499W, 502S, 527E, 528G, 529S, 530D, 531Q, 533R, 535W, 558H, 559G, 560F, 561V, 562M, 566G, 567Q, 568K, 569M, 570S, 571K, 609D
CDD
cd00818 (IleRS_core) -
HIGH motif cd00818
-
KMSKS motif cd00818568K569M570S571K572S
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tRNA binding surfa...615NtRNA binding surface
615N, 619Q, 622E, 626K, 629N, 632R, 633F, 680N, 683V, 684Q, 687N, 688N, 691N, 696A, 700D, 703K, 789G, 792N
CDD
cd07960 (Anticodon_Ia_Ile_BEm)619QtRNA binding surface
615N, 619Q, 622E, 626K, 629N, 632R, 633F, 680N, 683V, 684Q, 687N, 688N, 691N, 696A, 700D, 703K, 789G, 792N
CDD
cd07960 (Anticodon_Ia_Ile_BEm)622EtRNA binding surface
615N, 619Q, 622E, 626K, 629N, 632R, 633F, 680N, 683V, 684Q, 687N, 688N, 691N, 696A, 700D, 703K, 789G, 792N
CDD
cd07960 (Anticodon_Ia_Ile_BEm)626KtRNA binding surface
615N, 619Q, 622E, 626K, 629N, 632R, 633F, 680N, 683V, 684Q, 687N, 688N, 691N, 696A, 700D, 703K, 789G, 792N
CDD
cd07960 (Anticodon_Ia_Ile_BEm)629NtRNA binding surface
615N, 619Q, 622E, 626K, 629N, 632R, 633F, 680N, 683V, 684Q, 687N, 688N, 691N, 696A, 700D, 703K, 789G, 792N
CDD
cd07960 (Anticodon_Ia_Ile_BEm)632RtRNA binding surface
615N, 619Q, 622E, 626K, 629N, 632R, 633F, 680N, 683V, 684Q, 687N, 688N, 691N, 696A, 700D, 703K, 789G, 792N
CDD
cd07960 (Anticodon_Ia_Ile_BEm)633FtRNA binding surface
615N, 619Q, 622E, 626K, 629N, 632R, 633F, 680N, 683V, 684Q, 687N, 688N, 691N, 696A, 700D, 703K, 789G, 792N
CDD
cd07960 (Anticodon_Ia_Ile_BEm)680NtRNA binding surface
615N, 619Q, 622E, 626K, 629N, 632R, 633F, 680N, 683V, 684Q, 687N, 688N, 691N, 696A, 700D, 703K, 789G, 792N
CDD
cd07960 (Anticodon_Ia_Ile_BEm)683VtRNA binding surface
615N, 619Q, 622E, 626K, 629N, 632R, 633F, 680N, 683V, 684Q, 687N, 688N, 691N, 696A, 700D, 703K, 789G, 792N
CDD
cd07960 (Anticodon_Ia_Ile_BEm)684QtRNA binding surface
615N, 619Q, 622E, 626K, 629N, 632R, 633F, 680N, 683V, 684Q, 687N, 688N, 691N, 696A, 700D, 703K, 789G, 792N
CDD
cd07960 (Anticodon_Ia_Ile_BEm)687NtRNA binding surface
615N, 619Q, 622E, 626K, 629N, 632R, 633F, 680N, 683V, 684Q, 687N, 688N, 691N, 696A, 700D, 703K, 789G, 792N
CDD
cd07960 (Anticodon_Ia_Ile_BEm)688NtRNA binding surface
615N, 619Q, 622E, 626K, 629N, 632R, 633F, 680N, 683V, 684Q, 687N, 688N, 691N, 696A, 700D, 703K, 789G, 792N
CDD
cd07960 (Anticodon_Ia_Ile_BEm)691NtRNA binding surface
615N, 619Q, 622E, 626K, 629N, 632R, 633F, 680N, 683V, 684Q, 687N, 688N, 691N, 696A, 700D, 703K, 789G, 792N
CDD
cd07960 (Anticodon_Ia_Ile_BEm)696AtRNA binding surface
615N, 619Q, 622E, 626K, 629N, 632R, 633F, 680N, 683V, 684Q, 687N, 688N, 691N, 696A, 700D, 703K, 789G, 792N
CDD
cd07960 (Anticodon_Ia_Ile_BEm)700DtRNA binding surface
615N, 619Q, 622E, 626K, 629N, 632R, 633F, 680N, 683V, 684Q, 687N, 688N, 691N, 696A, 700D, 703K, 789G, 792N
CDD
cd07960 (Anticodon_Ia_Ile_BEm)703KtRNA binding surface
615N, 619Q, 622E, 626K, 629N, 632R, 633F, 680N, 683V, 684Q, 687N, 688N, 691N, 696A, 700D, 703K, 789G, 792N
CDD
cd07960 (Anticodon_Ia_Ile_BEm)789GtRNA binding surface
615N, 619Q, 622E, 626K, 629N, 632R, 633F, 680N, 683V, 684Q, 687N, 688N, 691N, 696A, 700D, 703K, 789G, 792N
CDD
cd07960 (Anticodon_Ia_Ile_BEm)792NtRNA binding surface
615N, 619Q, 622E, 626K, 629N, 632R, 633F, 680N, 683V, 684Q, 687N, 688N, 691N, 696A, 700D, 703K, 789G, 792N
CDD
cd07960 (Anticodon_Ia_Ile_BEm) -
anticodon binding ...
GO term prediction
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006428 isoleucyl-tRNA aminoacylation
Molecular Function
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0002161 aminoacyl-tRNA editing activity
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004822 isoleucine-tRNA ligase activity
GO:0005524 ATP binding
Cellular Component
GO:0005737 cytoplasm