GBC31794.1

Protein

Length

828 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
4 - 101
Aspartic peptidase domain (IPR021109)
220 - 399
Reverse transcriptase domain (IPR000477)
619 - 822
P-loop containing nucleoside triphosphate hydrolase (IPR027417)

1 100 200 300 400 500 600 700 828

Detailed signature matches

IPR021109

Aspartic peptidase domain
1. SSF50630 (Acid prot...)
  
  4 - 101
  
  SUPERFAMILY
  SSF50630 (Acid proteases)
IPR000477

Reverse transcriptase domain
1. PF00078 (RVT_1)
  
  241 - 398
  
  Pfam
  PF00078 (RVT_1)
2. PS50878 (RT_POL)
  
  220 - 399
  
  PROSITE profiles
  PS50878 (RT_POL)
IPR027417

P-loop containing nucleoside triphosphate hydrolase
1. SSF52540 (P-loop co...)
  
  619 - 822
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
IPR001969

Aspartic peptidase, active site
1. PS00141 (ASP_PROTEASE)
  
  14 - 25
  
  PROSITE patterns
  PS00141 (ASP_PROTEASE)

no IPR

Unintegrated signatures

Coil

202 - 222

COILS
Coil (Coil)

356 - 376

COILS
Coil (Coil)
PF13975 (gag-asp_pr...)

4 - 91

Pfam
PF13975 (gag-asp_proteas)
SSF56672 (DNA/RNA p...)

163 - 598

SUPERFAMILY
SSF56672 (DNA/RNA polymerases)
cd00303 (retropepsi...)

3 - 90

CDD
cd00303 (retropepsin_like)
cd01647 (RT_LTR)

225 - 399

CDD
cd01647 (RT_LTR)
cd09274 (RNase_HI_R...)

494 - 612

CDD
cd09274 (RNase_HI_RT_Ty3)

Residue annotation

Catalytic residue ...

17D

Catalytic residue
17D
CDD
cd00303 (retropepsin_like)
catalytic motif cd...

17D

catalytic motif
17D, 18T, 19G
CDD
cd00303 (retropepsin_like)

18T

catalytic motif
17D, 18T, 19G
CDD
cd00303 (retropepsin_like)

19G

catalytic motif
17D, 18T, 19G
CDD
cd00303 (retropepsin_like)
inhibitor binding ...

17D

inhibitor binding site
17D, 19G, 21A, 45C, 46T, 47I, 86I
CDD
cd00303 (retropepsin_like)

19G

inhibitor binding site
17D, 19G, 21A, 45C, 46T, 47I, 86I
CDD
cd00303 (retropepsin_like)

21A

inhibitor binding site
17D, 19G, 21A, 45C, 46T, 47I, 86I
CDD
cd00303 (retropepsin_like)

45C

inhibitor binding site
17D, 19G, 21A, 45C, 46T, 47I, 86I
CDD
cd00303 (retropepsin_like)

46T

inhibitor binding site
17D, 19G, 21A, 45C, 46T, 47I, 86I
CDD
cd00303 (retropepsin_like)

47I

inhibitor binding site
17D, 19G, 21A, 45C, 46T, 47I, 86I
CDD
cd00303 (retropepsin_like)

86I

inhibitor binding site
17D, 19G, 21A, 45C, 46T, 47I, 86I
CDD
cd00303 (retropepsin_like)
Active site flap c...

45C

Active site flap
45C, 46T, 47I, 48A, 52K, 53I, 54A, 55A
CDD
cd00303 (retropepsin_like)

46T

Active site flap
45C, 46T, 47I, 48A, 52K, 53I, 54A, 55A
CDD
cd00303 (retropepsin_like)

47I

Active site flap
45C, 46T, 47I, 48A, 52K, 53I, 54A, 55A
CDD
cd00303 (retropepsin_like)

48A

Active site flap
45C, 46T, 47I, 48A, 52K, 53I, 54A, 55A
CDD
cd00303 (retropepsin_like)

52K

Active site flap
45C, 46T, 47I, 48A, 52K, 53I, 54A, 55A
CDD
cd00303 (retropepsin_like)

53I

Active site flap
45C, 46T, 47I, 48A, 52K, 53I, 54A, 55A
CDD
cd00303 (retropepsin_like)

54A

Active site flap
45C, 46T, 47I, 48A, 52K, 53I, 54A, 55A
CDD
cd00303 (retropepsin_like)

55A

Active site flap
45C, 46T, 47I, 48A, 52K, 53I, 54A, 55A
CDD
cd00303 (retropepsin_like)
putative NTP bindi...

286D

putative NTP binding site
286D, 287L, 288A, 289A, 290G, 291F, 320F, 350D
CDD
cd01647 (RT_LTR)

287L

putative NTP binding site
286D, 287L, 288A, 289A, 290G, 291F, 320F, 350D
CDD
cd01647 (RT_LTR)

288A

putative NTP binding site
286D, 287L, 288A, 289A, 290G, 291F, 320F, 350D
CDD
cd01647 (RT_LTR)

289A

putative NTP binding site
286D, 287L, 288A, 289A, 290G, 291F, 320F, 350D
CDD
cd01647 (RT_LTR)

290G

putative NTP binding site
286D, 287L, 288A, 289A, 290G, 291F, 320F, 350D
CDD
cd01647 (RT_LTR)

291F

putative NTP binding site
286D, 287L, 288A, 289A, 290G, 291F, 320F, 350D
CDD
cd01647 (RT_LTR)

320F

putative NTP binding site
286D, 287L, 288A, 289A, 290G, 291F, 320F, 350D
CDD
cd01647 (RT_LTR)

350D

putative NTP binding site
286D, 287L, 288A, 289A, 290G, 291F, 320F, 350D
CDD
cd01647 (RT_LTR)
putative active si...

286D

putative active site
286D, 287L, 288A, 289A, 290G, 291F, 320F, 321G, 348Y, 350D, 351D, 395L, 396G
CDD
cd01647 (RT_LTR)

287L

putative active site
286D, 287L, 288A, 289A, 290G, 291F, 320F, 321G, 348Y, 350D, 351D, 395L, 396G
CDD
cd01647 (RT_LTR)

288A

putative active site
286D, 287L, 288A, 289A, 290G, 291F, 320F, 321G, 348Y, 350D, 351D, 395L, 396G
CDD
cd01647 (RT_LTR)

289A

putative active site
286D, 287L, 288A, 289A, 290G, 291F, 320F, 321G, 348Y, 350D, 351D, 395L, 396G
CDD
cd01647 (RT_LTR)

290G

putative active site
286D, 287L, 288A, 289A, 290G, 291F, 320F, 321G, 348Y, 350D, 351D, 395L, 396G
CDD
cd01647 (RT_LTR)

291F

putative active site
286D, 287L, 288A, 289A, 290G, 291F, 320F, 321G, 348Y, 350D, 351D, 395L, 396G
CDD
cd01647 (RT_LTR)

320F

putative active site
286D, 287L, 288A, 289A, 290G, 291F, 320F, 321G, 348Y, 350D, 351D, 395L, 396G
CDD
cd01647 (RT_LTR)

321G

putative active site
286D, 287L, 288A, 289A, 290G, 291F, 320F, 321G, 348Y, 350D, 351D, 395L, 396G
CDD
cd01647 (RT_LTR)

348Y

putative active site
286D, 287L, 288A, 289A, 290G, 291F, 320F, 321G, 348Y, 350D, 351D, 395L, 396G
CDD
cd01647 (RT_LTR)

350D

putative active site
286D, 287L, 288A, 289A, 290G, 291F, 320F, 321G, 348Y, 350D, 351D, 395L, 396G
CDD
cd01647 (RT_LTR)

351D

putative active site
286D, 287L, 288A, 289A, 290G, 291F, 320F, 321G, 348Y, 350D, 351D, 395L, 396G
CDD
cd01647 (RT_LTR)

395L

putative active site
286D, 287L, 288A, 289A, 290G, 291F, 320F, 321G, 348Y, 350D, 351D, 395L, 396G
CDD
cd01647 (RT_LTR)

396G

putative active site
286D, 287L, 288A, 289A, 290G, 291F, 320F, 321G, 348Y, 350D, 351D, 395L, 396G
CDD
cd01647 (RT_LTR)
putative nucleic a...

321G

putative nucleic acid binding site
321G
CDD
cd01647 (RT_LTR)
active site cd09274

497D

active site
497D, 539E, 564D, 607D
CDD
cd09274 (RNase_HI_RT_Ty3)

539E

active site
497D, 539E, 564D, 607D
CDD
cd09274 (RNase_HI_RT_Ty3)

564D

active site
497D, 539E, 564D, 607D
CDD
cd09274 (RNase_HI_RT_Ty3)

607D

active site
497D, 539E, 564D, 607D
CDD
cd09274 (RNase_HI_RT_Ty3)
RNA/DNA hybrid bin...

497D

RNA/DNA hybrid binding site
497D, 498A, 499S, 500G, 534P, 535I, 536T, 539E, 564D, 597H, 611R
CDD
cd09274 (RNase_HI_RT_Ty3)

498A

RNA/DNA hybrid binding site
497D, 498A, 499S, 500G, 534P, 535I, 536T, 539E, 564D, 597H, 611R
CDD
cd09274 (RNase_HI_RT_Ty3)

499S

RNA/DNA hybrid binding site
497D, 498A, 499S, 500G, 534P, 535I, 536T, 539E, 564D, 597H, 611R
CDD
cd09274 (RNase_HI_RT_Ty3)

500G

RNA/DNA hybrid binding site
497D, 498A, 499S, 500G, 534P, 535I, 536T, 539E, 564D, 597H, 611R
CDD
cd09274 (RNase_HI_RT_Ty3)

534P

RNA/DNA hybrid binding site
497D, 498A, 499S, 500G, 534P, 535I, 536T, 539E, 564D, 597H, 611R
CDD
cd09274 (RNase_HI_RT_Ty3)

535I

RNA/DNA hybrid binding site
497D, 498A, 499S, 500G, 534P, 535I, 536T, 539E, 564D, 597H, 611R
CDD
cd09274 (RNase_HI_RT_Ty3)

536T

RNA/DNA hybrid binding site
497D, 498A, 499S, 500G, 534P, 535I, 536T, 539E, 564D, 597H, 611R
CDD
cd09274 (RNase_HI_RT_Ty3)

539E

RNA/DNA hybrid binding site
497D, 498A, 499S, 500G, 534P, 535I, 536T, 539E, 564D, 597H, 611R
CDD
cd09274 (RNase_HI_RT_Ty3)

564D

RNA/DNA hybrid binding site
497D, 498A, 499S, 500G, 534P, 535I, 536T, 539E, 564D, 597H, 611R
CDD
cd09274 (RNase_HI_RT_Ty3)

597H

RNA/DNA hybrid binding site
497D, 498A, 499S, 500G, 534P, 535I, 536T, 539E, 564D, 597H, 611R
CDD
cd09274 (RNase_HI_RT_Ty3)

611R

RNA/DNA hybrid binding site
497D, 498A, 499S, 500G, 534P, 535I, 536T, 539E, 564D, 597H, 611R
CDD
cd09274 (RNase_HI_RT_Ty3)

GO term prediction

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0004190 aspartic-type endopeptidase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

GBC31794.1

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component