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Protein

GBC30701.1

Length

739 amino acids

Protein family membership

Asparaginase/glutaminase (IPR006034)
- L-asparaginase, type I (IPR006033)

Domains and repeats

Domain
43 - 286
L-asparaginase, N-terminal (IPR027474)
487 - 664
Ankyrin repeat-containing domain (IPR020683)
Repeat
519 - 551
Ankyrin repeat (IPR002110)
552 - 584
Ankyrin repeat (IPR002110)
583 - 615
Ankyrin repeat (IPR002110)
619 - 647
Ankyrin repeat (IPR002110)

1 100 200 300 400 500 600 739

Detailed signature matches

IPR006034

Asparaginase/glutaminase

PS51732 (ASN_GLN_ASE_3)

42 - 424

PROSITE profiles
PS51732 (ASN_GLN_ASE_3)
SM00870 (Asparagina...)

43 - 417

SMART
SM00870 (Asparaginase_2)
PIRSF001220 (L-ASNa...)

108 - 429

PIRSF
PIRSF001220 (L-ASNase_gatD)
SSF53774 (Glutamina...)

140 - 432

SUPERFAMILY
SSF53774 (Glutaminase/Asparaginase)

40 - 82

SUPERFAMILY
SSF53774 (Glutaminase/Asparaginase)
PR00139 (ASNGLNASE)

355 - 373

PRINTS
PR00139 (ASNGLNASE)

44 - 55

PRINTS
PR00139 (ASNGLNASE)

176 - 194

PRINTS
PR00139 (ASNGLNASE)

IPR006033

L-asparaginase, type I

TIGR00519

145 - 430

TIGRFAMs
TIGR00519 (TIGR00519)

IPR027474

L-asparaginase, N-terminal

PF00710 (Asparaginase)

43 - 286

Pfam
PF00710 (Asparaginase)

IPR020683

Ankyrin repeat-containing domain

PF12796 (Ank_2)

510 - 580

Pfam
PF12796 (Ank_2)

594 - 664

Pfam
PF12796 (Ank_2)
PS50297 (ANK_REP_RE...)

519 - 641

PROSITE profiles
PS50297 (ANK_REP_REGION)
SSF48403 (Ankyrin r...)

487 - 664

SUPERFAMILY
SSF48403 (Ankyrin repeat)

IPR002110

Ankyrin repeat

PS50088 (ANK_REPEAT)

552 - 584

PROSITE profiles
PS50088 (ANK_REPEAT)

519 - 551

PROSITE profiles
PS50088 (ANK_REPEAT)
SM00248 (ANK_2a)

619 - 647

SMART
SM00248 (ANK_2a)

552 - 581

SMART
SM00248 (ANK_2a)

583 - 615

SMART
SM00248 (ANK_2a)

519 - 548

SMART
SM00248 (ANK_2a)

IPR027475

Asparaginase/glutaminase, active site 2

PS00917 (ASN_GLN_ASE_2)

177 - 187

PROSITE patterns
PS00917 (ASN_GLN_ASE_2)

no IPR

Unintegrated signatures

PIRSF500176 (L_ASNase)

131 - 427

PIRSF
PIRSF500176 (L_ASNase)
SFLDS00057 (Glutami...)

41 - 433

SFLD
SFLDS00057 (Glutaminase/Asparaginase)
cd00204 (ANK)

514 - 640

CDD
cd00204 (ANK)
cd08963 (L-asparagi...)

43 - 408

CDD
cd08963 (L-asparaginase_I)

Residue annotation

active site cd08963

51G

active site
51G, 52T, 153S, 154C, 183G, 184T, 185D, 210S, 256K
CDD
cd08963 (L-asparaginase_I)

52T

active site
51G, 52T, 153S, 154C, 183G, 184T, 185D, 210S, 256K
CDD
cd08963 (L-asparaginase_I)

153S

active site
51G, 52T, 153S, 154C, 183G, 184T, 185D, 210S, 256K
CDD
cd08963 (L-asparaginase_I)

154C

active site
51G, 52T, 153S, 154C, 183G, 184T, 185D, 210S, 256K
CDD
cd08963 (L-asparaginase_I)

183G

active site
51G, 52T, 153S, 154C, 183G, 184T, 185D, 210S, 256K
CDD
cd08963 (L-asparaginase_I)

184T

active site
51G, 52T, 153S, 154C, 183G, 184T, 185D, 210S, 256K
CDD
cd08963 (L-asparaginase_I)

185D

active site
51G, 52T, 153S, 154C, 183G, 184T, 185D, 210S, 256K
CDD
cd08963 (L-asparaginase_I)

210S

active site
51G, 52T, 153S, 154C, 183G, 184T, 185D, 210S, 256K
CDD
cd08963 (L-asparaginase_I)

256K

active site
51G, 52T, 153S, 154C, 183G, 184T, 185D, 210S, 256K
CDD
cd08963 (L-asparaginase_I)
SFLDS00057

52T

SFLD_Res01
52T, 208T
SFLD
SFLDS00057 (Glutaminase/Asparaginase)

208T

SFLD_Res01
52T, 208T
SFLD
SFLDS00057 (Glutaminase/Asparaginase)
homodimer interfac...

52T

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

62G

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

63Y

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

64V

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

149P

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

152D

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

153S

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

154C

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

155N

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

156I

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

157S

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

158S

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

160D

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

161W

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

185D

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

186T

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

189Y

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

211Q

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

212V

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

256K

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

257M

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

258N

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

259T

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

260V

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

261D

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

305N

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

306V

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

307G

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

308T

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

309L

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

310R

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

311L

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

312F

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

313P

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

314G

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

315I

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

317E

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

318T

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

321K

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

324L

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

325A

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

334E

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

336Y

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

337G

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

338A

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

342P

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

367Q

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

370K

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

371G

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

373V

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

374T

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

375D

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

377Y

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

396P

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

400L

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

404A

homodimer interface
52T, 62G, 63Y, 64V, 149P, 152D, 153S, 154C, 155N, 156I, 157S, 158S, 160D, 161W, 185D, 186T, 189Y, 211Q, 212V, 256K, 257M, 258N, 259T, 260V, 261D, 305N, 306V, 307G, 308T, 309L, 310R, 311L, 312F, 313P, 314G, 315I, 317E, 318T, 321K, 324L, 325A, 334E, 336Y, 337G, 338A, 342P, 367Q, 370K, 371G, 373V, 374T, 375D, 377Y, 396P, 400L, 404A
CDD
cd08963 (L-asparaginase_I)

GO term prediction

Biological Process

GO:0006520 cellular amino acid metabolic process

Molecular Function

GO:0004067 asparaginase activity
GO:0005515 protein binding

Cellular Component

None predicted.