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Entry type
Status
Per-residue features
Colour by
Protein
GBC30307.1
Length
248 amino acids
Protein family membership
- Thiamin pyrophosphokinase (IPR006282)
- Thiamin pyrophosphokinase, eukaryotic (IPR016966)
Domains and repeats
-
Domain21 - 244
- Thiamin pyrophosphokinase, catalytic domain (IPR007371)
-
Domain165 - 246
1
50
100
150
200
248
Detailed signature matches
-
-
PIRSF031057 (TPK1)1 - 248
-
Residue annotation
-
active site cd0799530Lactive site
30L, 31N, 32Q, 54A, 55D, 56G, 77D, 79D, 80S, 102Q, 103E, 104S, 105T, 106D, 107F, 134A, 136G, 137G, 138R, 141H, 145N, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)31Nactive site
30L, 31N, 32Q, 54A, 55D, 56G, 77D, 79D, 80S, 102Q, 103E, 104S, 105T, 106D, 107F, 134A, 136G, 137G, 138R, 141H, 145N, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)32Qactive site
30L, 31N, 32Q, 54A, 55D, 56G, 77D, 79D, 80S, 102Q, 103E, 104S, 105T, 106D, 107F, 134A, 136G, 137G, 138R, 141H, 145N, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)54Aactive site
30L, 31N, 32Q, 54A, 55D, 56G, 77D, 79D, 80S, 102Q, 103E, 104S, 105T, 106D, 107F, 134A, 136G, 137G, 138R, 141H, 145N, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)55Dactive site
30L, 31N, 32Q, 54A, 55D, 56G, 77D, 79D, 80S, 102Q, 103E, 104S, 105T, 106D, 107F, 134A, 136G, 137G, 138R, 141H, 145N, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)56Gactive site
30L, 31N, 32Q, 54A, 55D, 56G, 77D, 79D, 80S, 102Q, 103E, 104S, 105T, 106D, 107F, 134A, 136G, 137G, 138R, 141H, 145N, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)77Dactive site
30L, 31N, 32Q, 54A, 55D, 56G, 77D, 79D, 80S, 102Q, 103E, 104S, 105T, 106D, 107F, 134A, 136G, 137G, 138R, 141H, 145N, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)79Dactive site
30L, 31N, 32Q, 54A, 55D, 56G, 77D, 79D, 80S, 102Q, 103E, 104S, 105T, 106D, 107F, 134A, 136G, 137G, 138R, 141H, 145N, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)80Sactive site
30L, 31N, 32Q, 54A, 55D, 56G, 77D, 79D, 80S, 102Q, 103E, 104S, 105T, 106D, 107F, 134A, 136G, 137G, 138R, 141H, 145N, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)102Qactive site
30L, 31N, 32Q, 54A, 55D, 56G, 77D, 79D, 80S, 102Q, 103E, 104S, 105T, 106D, 107F, 134A, 136G, 137G, 138R, 141H, 145N, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)103Eactive site
30L, 31N, 32Q, 54A, 55D, 56G, 77D, 79D, 80S, 102Q, 103E, 104S, 105T, 106D, 107F, 134A, 136G, 137G, 138R, 141H, 145N, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)104Sactive site
30L, 31N, 32Q, 54A, 55D, 56G, 77D, 79D, 80S, 102Q, 103E, 104S, 105T, 106D, 107F, 134A, 136G, 137G, 138R, 141H, 145N, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)105Tactive site
30L, 31N, 32Q, 54A, 55D, 56G, 77D, 79D, 80S, 102Q, 103E, 104S, 105T, 106D, 107F, 134A, 136G, 137G, 138R, 141H, 145N, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)106Dactive site
30L, 31N, 32Q, 54A, 55D, 56G, 77D, 79D, 80S, 102Q, 103E, 104S, 105T, 106D, 107F, 134A, 136G, 137G, 138R, 141H, 145N, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)107Factive site
30L, 31N, 32Q, 54A, 55D, 56G, 77D, 79D, 80S, 102Q, 103E, 104S, 105T, 106D, 107F, 134A, 136G, 137G, 138R, 141H, 145N, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)134Aactive site
30L, 31N, 32Q, 54A, 55D, 56G, 77D, 79D, 80S, 102Q, 103E, 104S, 105T, 106D, 107F, 134A, 136G, 137G, 138R, 141H, 145N, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)136Gactive site
30L, 31N, 32Q, 54A, 55D, 56G, 77D, 79D, 80S, 102Q, 103E, 104S, 105T, 106D, 107F, 134A, 136G, 137G, 138R, 141H, 145N, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)137Gactive site
30L, 31N, 32Q, 54A, 55D, 56G, 77D, 79D, 80S, 102Q, 103E, 104S, 105T, 106D, 107F, 134A, 136G, 137G, 138R, 141H, 145N, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)138Ractive site
30L, 31N, 32Q, 54A, 55D, 56G, 77D, 79D, 80S, 102Q, 103E, 104S, 105T, 106D, 107F, 134A, 136G, 137G, 138R, 141H, 145N, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)141Hactive site
30L, 31N, 32Q, 54A, 55D, 56G, 77D, 79D, 80S, 102Q, 103E, 104S, 105T, 106D, 107F, 134A, 136G, 137G, 138R, 141H, 145N, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)145Nactive site
30L, 31N, 32Q, 54A, 55D, 56G, 77D, 79D, 80S, 102Q, 103E, 104S, 105T, 106D, 107F, 134A, 136G, 137G, 138R, 141H, 145N, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)207Wactive site
30L, 31N, 32Q, 54A, 55D, 56G, 77D, 79D, 80S, 102Q, 103E, 104S, 105T, 106D, 107F, 134A, 136G, 137G, 138R, 141H, 145N, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)209Iactive site
30L, 31N, 32Q, 54A, 55D, 56G, 77D, 79D, 80S, 102Q, 103E, 104S, 105T, 106D, 107F, 134A, 136G, 137G, 138R, 141H, 145N, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)221Sactive site
30L, 31N, 32Q, 54A, 55D, 56G, 77D, 79D, 80S, 102Q, 103E, 104S, 105T, 106D, 107F, 134A, 136G, 137G, 138R, 141H, 145N, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)222Tactive site
30L, 31N, 32Q, 54A, 55D, 56G, 77D, 79D, 80S, 102Q, 103E, 104S, 105T, 106D, 107F, 134A, 136G, 137G, 138R, 141H, 145N, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)223Sactive site
30L, 31N, 32Q, 54A, 55D, 56G, 77D, 79D, 80S, 102Q, 103E, 104S, 105T, 106D, 107F, 134A, 136G, 137G, 138R, 141H, 145N, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)224Nactive site
30L, 31N, 32Q, 54A, 55D, 56G, 77D, 79D, 80S, 102Q, 103E, 104S, 105T, 106D, 107F, 134A, 136G, 137G, 138R, 141H, 145N, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK) -
dimerization inter...56Gdimerization interface
56G, 60H, 63D, 102Q, 103E, 104S, 108M, 135S, 137G, 138R, 139F, 140D, 141H, 142I, 143M, 144S, 146I, 147H, 165N, 167I, 187T, 189G, 191L, 193I, 194G, 220I, 222T, 223S, 243V
CDD
cd07995 (TPK)60Hdimerization interface
56G, 60H, 63D, 102Q, 103E, 104S, 108M, 135S, 137G, 138R, 139F, 140D, 141H, 142I, 143M, 144S, 146I, 147H, 165N, 167I, 187T, 189G, 191L, 193I, 194G, 220I, 222T, 223S, 243V
CDD
cd07995 (TPK)63Ddimerization interface
56G, 60H, 63D, 102Q, 103E, 104S, 108M, 135S, 137G, 138R, 139F, 140D, 141H, 142I, 143M, 144S, 146I, 147H, 165N, 167I, 187T, 189G, 191L, 193I, 194G, 220I, 222T, 223S, 243V
CDD
cd07995 (TPK)102Qdimerization interface
56G, 60H, 63D, 102Q, 103E, 104S, 108M, 135S, 137G, 138R, 139F, 140D, 141H, 142I, 143M, 144S, 146I, 147H, 165N, 167I, 187T, 189G, 191L, 193I, 194G, 220I, 222T, 223S, 243V
CDD
cd07995 (TPK)103Edimerization interface
56G, 60H, 63D, 102Q, 103E, 104S, 108M, 135S, 137G, 138R, 139F, 140D, 141H, 142I, 143M, 144S, 146I, 147H, 165N, 167I, 187T, 189G, 191L, 193I, 194G, 220I, 222T, 223S, 243V
CDD
cd07995 (TPK)104Sdimerization interface
56G, 60H, 63D, 102Q, 103E, 104S, 108M, 135S, 137G, 138R, 139F, 140D, 141H, 142I, 143M, 144S, 146I, 147H, 165N, 167I, 187T, 189G, 191L, 193I, 194G, 220I, 222T, 223S, 243V
CDD
cd07995 (TPK)108Mdimerization interface
56G, 60H, 63D, 102Q, 103E, 104S, 108M, 135S, 137G, 138R, 139F, 140D, 141H, 142I, 143M, 144S, 146I, 147H, 165N, 167I, 187T, 189G, 191L, 193I, 194G, 220I, 222T, 223S, 243V
CDD
cd07995 (TPK)135Sdimerization interface
56G, 60H, 63D, 102Q, 103E, 104S, 108M, 135S, 137G, 138R, 139F, 140D, 141H, 142I, 143M, 144S, 146I, 147H, 165N, 167I, 187T, 189G, 191L, 193I, 194G, 220I, 222T, 223S, 243V
CDD
cd07995 (TPK)137Gdimerization interface
56G, 60H, 63D, 102Q, 103E, 104S, 108M, 135S, 137G, 138R, 139F, 140D, 141H, 142I, 143M, 144S, 146I, 147H, 165N, 167I, 187T, 189G, 191L, 193I, 194G, 220I, 222T, 223S, 243V
CDD
cd07995 (TPK)138Rdimerization interface
56G, 60H, 63D, 102Q, 103E, 104S, 108M, 135S, 137G, 138R, 139F, 140D, 141H, 142I, 143M, 144S, 146I, 147H, 165N, 167I, 187T, 189G, 191L, 193I, 194G, 220I, 222T, 223S, 243V
CDD
cd07995 (TPK)139Fdimerization interface
56G, 60H, 63D, 102Q, 103E, 104S, 108M, 135S, 137G, 138R, 139F, 140D, 141H, 142I, 143M, 144S, 146I, 147H, 165N, 167I, 187T, 189G, 191L, 193I, 194G, 220I, 222T, 223S, 243V
CDD
cd07995 (TPK)140Ddimerization interface
56G, 60H, 63D, 102Q, 103E, 104S, 108M, 135S, 137G, 138R, 139F, 140D, 141H, 142I, 143M, 144S, 146I, 147H, 165N, 167I, 187T, 189G, 191L, 193I, 194G, 220I, 222T, 223S, 243V
CDD
cd07995 (TPK)141Hdimerization interface
56G, 60H, 63D, 102Q, 103E, 104S, 108M, 135S, 137G, 138R, 139F, 140D, 141H, 142I, 143M, 144S, 146I, 147H, 165N, 167I, 187T, 189G, 191L, 193I, 194G, 220I, 222T, 223S, 243V
CDD
cd07995 (TPK)142Idimerization interface
56G, 60H, 63D, 102Q, 103E, 104S, 108M, 135S, 137G, 138R, 139F, 140D, 141H, 142I, 143M, 144S, 146I, 147H, 165N, 167I, 187T, 189G, 191L, 193I, 194G, 220I, 222T, 223S, 243V
CDD
cd07995 (TPK)143Mdimerization interface
56G, 60H, 63D, 102Q, 103E, 104S, 108M, 135S, 137G, 138R, 139F, 140D, 141H, 142I, 143M, 144S, 146I, 147H, 165N, 167I, 187T, 189G, 191L, 193I, 194G, 220I, 222T, 223S, 243V
CDD
cd07995 (TPK)144Sdimerization interface
56G, 60H, 63D, 102Q, 103E, 104S, 108M, 135S, 137G, 138R, 139F, 140D, 141H, 142I, 143M, 144S, 146I, 147H, 165N, 167I, 187T, 189G, 191L, 193I, 194G, 220I, 222T, 223S, 243V
CDD
cd07995 (TPK)146Idimerization interface
56G, 60H, 63D, 102Q, 103E, 104S, 108M, 135S, 137G, 138R, 139F, 140D, 141H, 142I, 143M, 144S, 146I, 147H, 165N, 167I, 187T, 189G, 191L, 193I, 194G, 220I, 222T, 223S, 243V
CDD
cd07995 (TPK)147Hdimerization interface
56G, 60H, 63D, 102Q, 103E, 104S, 108M, 135S, 137G, 138R, 139F, 140D, 141H, 142I, 143M, 144S, 146I, 147H, 165N, 167I, 187T, 189G, 191L, 193I, 194G, 220I, 222T, 223S, 243V
CDD
cd07995 (TPK)165Ndimerization interface
56G, 60H, 63D, 102Q, 103E, 104S, 108M, 135S, 137G, 138R, 139F, 140D, 141H, 142I, 143M, 144S, 146I, 147H, 165N, 167I, 187T, 189G, 191L, 193I, 194G, 220I, 222T, 223S, 243V
CDD
cd07995 (TPK)167Idimerization interface
56G, 60H, 63D, 102Q, 103E, 104S, 108M, 135S, 137G, 138R, 139F, 140D, 141H, 142I, 143M, 144S, 146I, 147H, 165N, 167I, 187T, 189G, 191L, 193I, 194G, 220I, 222T, 223S, 243V
CDD
cd07995 (TPK)187Tdimerization interface
56G, 60H, 63D, 102Q, 103E, 104S, 108M, 135S, 137G, 138R, 139F, 140D, 141H, 142I, 143M, 144S, 146I, 147H, 165N, 167I, 187T, 189G, 191L, 193I, 194G, 220I, 222T, 223S, 243V
CDD
cd07995 (TPK)189Gdimerization interface
56G, 60H, 63D, 102Q, 103E, 104S, 108M, 135S, 137G, 138R, 139F, 140D, 141H, 142I, 143M, 144S, 146I, 147H, 165N, 167I, 187T, 189G, 191L, 193I, 194G, 220I, 222T, 223S, 243V
CDD
cd07995 (TPK)191Ldimerization interface
56G, 60H, 63D, 102Q, 103E, 104S, 108M, 135S, 137G, 138R, 139F, 140D, 141H, 142I, 143M, 144S, 146I, 147H, 165N, 167I, 187T, 189G, 191L, 193I, 194G, 220I, 222T, 223S, 243V
CDD
cd07995 (TPK)193Idimerization interface
56G, 60H, 63D, 102Q, 103E, 104S, 108M, 135S, 137G, 138R, 139F, 140D, 141H, 142I, 143M, 144S, 146I, 147H, 165N, 167I, 187T, 189G, 191L, 193I, 194G, 220I, 222T, 223S, 243V
CDD
cd07995 (TPK)194Gdimerization interface
56G, 60H, 63D, 102Q, 103E, 104S, 108M, 135S, 137G, 138R, 139F, 140D, 141H, 142I, 143M, 144S, 146I, 147H, 165N, 167I, 187T, 189G, 191L, 193I, 194G, 220I, 222T, 223S, 243V
CDD
cd07995 (TPK)220Idimerization interface
56G, 60H, 63D, 102Q, 103E, 104S, 108M, 135S, 137G, 138R, 139F, 140D, 141H, 142I, 143M, 144S, 146I, 147H, 165N, 167I, 187T, 189G, 191L, 193I, 194G, 220I, 222T, 223S, 243V
CDD
cd07995 (TPK)222Tdimerization interface
56G, 60H, 63D, 102Q, 103E, 104S, 108M, 135S, 137G, 138R, 139F, 140D, 141H, 142I, 143M, 144S, 146I, 147H, 165N, 167I, 187T, 189G, 191L, 193I, 194G, 220I, 222T, 223S, 243V
CDD
cd07995 (TPK)223Sdimerization interface
56G, 60H, 63D, 102Q, 103E, 104S, 108M, 135S, 137G, 138R, 139F, 140D, 141H, 142I, 143M, 144S, 146I, 147H, 165N, 167I, 187T, 189G, 191L, 193I, 194G, 220I, 222T, 223S, 243V
CDD
cd07995 (TPK)243Vdimerization interface
56G, 60H, 63D, 102Q, 103E, 104S, 108M, 135S, 137G, 138R, 139F, 140D, 141H, 142I, 143M, 144S, 146I, 147H, 165N, 167I, 187T, 189G, 191L, 193I, 194G, 220I, 222T, 223S, 243V
CDD
cd07995 (TPK) -
thiamine binding s...77Dthiamine binding site
77D, 102Q, 103E, 104S, 105T, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)102Qthiamine binding site
77D, 102Q, 103E, 104S, 105T, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)103Ethiamine binding site
77D, 102Q, 103E, 104S, 105T, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)104Sthiamine binding site
77D, 102Q, 103E, 104S, 105T, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)105Tthiamine binding site
77D, 102Q, 103E, 104S, 105T, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)207Wthiamine binding site
77D, 102Q, 103E, 104S, 105T, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)209Ithiamine binding site
77D, 102Q, 103E, 104S, 105T, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)221Sthiamine binding site
77D, 102Q, 103E, 104S, 105T, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)222Tthiamine binding site
77D, 102Q, 103E, 104S, 105T, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)223Sthiamine binding site
77D, 102Q, 103E, 104S, 105T, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)224Nthiamine binding site
77D, 102Q, 103E, 104S, 105T, 207W, 209I, 221S, 222T, 223S, 224N
CDD
cd07995 (TPK)
GO term prediction
Biological Process
GO:0006772 thiamine metabolic process
GO:0009229 thiamine diphosphate biosynthetic process
Molecular Function
GO:0004788 thiamine diphosphokinase activity
GO:0005524 ATP binding
GO:0030975 thiamine binding
Cellular Component
None predicted.