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Entry type
Status
Per-residue features
Colour by
Protein
GBC30092.1
Length
253 amino acids
Protein family membership
- Proteasome, subunit alpha/beta (IPR001353)
- Proteasome alpha-type subunit (IPR023332)
Domains and repeats
-
Domain4 - 236
- Nucleophile aminohydrolases, N-terminal (IPR029055)
-
Domain5 - 27
- Proteasome alpha-subunit, N-terminal domain (IPR000426)
1
50
100
150
200
253
Detailed signature matches
no IPR
Residue annotation
-
alpha subunit inte...7Ralpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)8Aalpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)9Lalpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)10Talpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)12Falpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)13Salpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)15Dalpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)16Galpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)20Qalpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)23Yalpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)26Ealpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)27Aalpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)30Kalpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)38Ralpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)53Lalpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)55Lalpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)56Qalpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)79Salpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)80Aalpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)81Dalpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)83Ralpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)84Valpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)115Galpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)118Qalpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)121Talpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)122Qalpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)125Galpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)126Valpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)127Ralpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)128Palpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)129Falpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)148Yalpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)153Salpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)154Galpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)156Yalpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)158Aalpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)159Walpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7)161Aalpha subunit interaction site
7R, 8A, 9L, 10T, 12F, 13S, 15D, 16G, 20Q, 23Y, 26E, 27A, 30K, 38R, 53L, 55L, 56Q, 79S, 80A, 81D, 83R, 84V, 115G, 118Q, 121T, 122Q, 125G, 126V, 127R, 128P, 129F, 148Y, 153S, 154G, 156Y, 158A, 159W, 161A
CDD
cd03755 (proteasome_alpha_type_7) -
active site cd0375532T48E50K63K166R
GO term prediction
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0051603 proteolysis involved in cellular protein catabolic process
Molecular Function
GO:0004175 endopeptidase activity
GO:0004298 threonine-type endopeptidase activity
Cellular Component
GO:0005839 proteasome core complex
GO:0019773 proteasome core complex, alpha-subunit complex