GBC30059.1

Protein

Length

364 amino acids

Protein family membership

GDP-mannose 4,6-dehydratase (IPR006368)

Domains and repeats

Domain
18 - 354
NAD(P)-binding domain (IPR016040)

1 50 100 150 200 250 300 364

Detailed signature matches

IPR006368

GDP-mannose 4,6-dehydratase
1. TIGR01472
  
  18 - 356
  
  TIGRFAMs
  TIGR01472 (TIGR01472)
2. MF_00955 (GDP_Man_d...)
  
  18 - 360
  
  HAMAP
  MF_00955 (GDP_Man_dehydratase)
IPR016040

NAD(P)-binding domain
1. PF16363 (GDP_Man_Dehyd)
  
  21 - 350
  
  Pfam
  PF16363 (GDP_Man_Dehyd)
2. SSF51735 (NAD(P)-bi...)
  
  18 - 354
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)

no IPR

Unintegrated signatures

cd05260 (GDP_MD_SDR_e)

19 - 356

CDD
cd05260 (GDP_MD_SDR_e)

Residue annotation

NADP-binding site ...

24G

NADP-binding site
24G, 25I, 26T, 27G, 28Q, 29D, 49R, 50R, 51S, 77G, 78D, 79L, 100L, 101G, 102A, 104S, 119V, 145A, 146S, 147T, 171Y, 175K, 198L, 199F, 200N, 201H, 202E
CDD
cd05260 (GDP_MD_SDR_e)

25I

NADP-binding site
24G, 25I, 26T, 27G, 28Q, 29D, 49R, 50R, 51S, 77G, 78D, 79L, 100L, 101G, 102A, 104S, 119V, 145A, 146S, 147T, 171Y, 175K, 198L, 199F, 200N, 201H, 202E
CDD
cd05260 (GDP_MD_SDR_e)

26T

NADP-binding site
24G, 25I, 26T, 27G, 28Q, 29D, 49R, 50R, 51S, 77G, 78D, 79L, 100L, 101G, 102A, 104S, 119V, 145A, 146S, 147T, 171Y, 175K, 198L, 199F, 200N, 201H, 202E
CDD
cd05260 (GDP_MD_SDR_e)

27G

NADP-binding site
24G, 25I, 26T, 27G, 28Q, 29D, 49R, 50R, 51S, 77G, 78D, 79L, 100L, 101G, 102A, 104S, 119V, 145A, 146S, 147T, 171Y, 175K, 198L, 199F, 200N, 201H, 202E
CDD
cd05260 (GDP_MD_SDR_e)

28Q

NADP-binding site
24G, 25I, 26T, 27G, 28Q, 29D, 49R, 50R, 51S, 77G, 78D, 79L, 100L, 101G, 102A, 104S, 119V, 145A, 146S, 147T, 171Y, 175K, 198L, 199F, 200N, 201H, 202E
CDD
cd05260 (GDP_MD_SDR_e)

29D

NADP-binding site
24G, 25I, 26T, 27G, 28Q, 29D, 49R, 50R, 51S, 77G, 78D, 79L, 100L, 101G, 102A, 104S, 119V, 145A, 146S, 147T, 171Y, 175K, 198L, 199F, 200N, 201H, 202E
CDD
cd05260 (GDP_MD_SDR_e)

49R

NADP-binding site
24G, 25I, 26T, 27G, 28Q, 29D, 49R, 50R, 51S, 77G, 78D, 79L, 100L, 101G, 102A, 104S, 119V, 145A, 146S, 147T, 171Y, 175K, 198L, 199F, 200N, 201H, 202E
CDD
cd05260 (GDP_MD_SDR_e)

50R

NADP-binding site
24G, 25I, 26T, 27G, 28Q, 29D, 49R, 50R, 51S, 77G, 78D, 79L, 100L, 101G, 102A, 104S, 119V, 145A, 146S, 147T, 171Y, 175K, 198L, 199F, 200N, 201H, 202E
CDD
cd05260 (GDP_MD_SDR_e)

51S

NADP-binding site
24G, 25I, 26T, 27G, 28Q, 29D, 49R, 50R, 51S, 77G, 78D, 79L, 100L, 101G, 102A, 104S, 119V, 145A, 146S, 147T, 171Y, 175K, 198L, 199F, 200N, 201H, 202E
CDD
cd05260 (GDP_MD_SDR_e)

77G

NADP-binding site
24G, 25I, 26T, 27G, 28Q, 29D, 49R, 50R, 51S, 77G, 78D, 79L, 100L, 101G, 102A, 104S, 119V, 145A, 146S, 147T, 171Y, 175K, 198L, 199F, 200N, 201H, 202E
CDD
cd05260 (GDP_MD_SDR_e)

78D

NADP-binding site
24G, 25I, 26T, 27G, 28Q, 29D, 49R, 50R, 51S, 77G, 78D, 79L, 100L, 101G, 102A, 104S, 119V, 145A, 146S, 147T, 171Y, 175K, 198L, 199F, 200N, 201H, 202E
CDD
cd05260 (GDP_MD_SDR_e)

79L

NADP-binding site
24G, 25I, 26T, 27G, 28Q, 29D, 49R, 50R, 51S, 77G, 78D, 79L, 100L, 101G, 102A, 104S, 119V, 145A, 146S, 147T, 171Y, 175K, 198L, 199F, 200N, 201H, 202E
CDD
cd05260 (GDP_MD_SDR_e)

100L

NADP-binding site
24G, 25I, 26T, 27G, 28Q, 29D, 49R, 50R, 51S, 77G, 78D, 79L, 100L, 101G, 102A, 104S, 119V, 145A, 146S, 147T, 171Y, 175K, 198L, 199F, 200N, 201H, 202E
CDD
cd05260 (GDP_MD_SDR_e)

101G

NADP-binding site
24G, 25I, 26T, 27G, 28Q, 29D, 49R, 50R, 51S, 77G, 78D, 79L, 100L, 101G, 102A, 104S, 119V, 145A, 146S, 147T, 171Y, 175K, 198L, 199F, 200N, 201H, 202E
CDD
cd05260 (GDP_MD_SDR_e)

102A

NADP-binding site
24G, 25I, 26T, 27G, 28Q, 29D, 49R, 50R, 51S, 77G, 78D, 79L, 100L, 101G, 102A, 104S, 119V, 145A, 146S, 147T, 171Y, 175K, 198L, 199F, 200N, 201H, 202E
CDD
cd05260 (GDP_MD_SDR_e)

104S

NADP-binding site
24G, 25I, 26T, 27G, 28Q, 29D, 49R, 50R, 51S, 77G, 78D, 79L, 100L, 101G, 102A, 104S, 119V, 145A, 146S, 147T, 171Y, 175K, 198L, 199F, 200N, 201H, 202E
CDD
cd05260 (GDP_MD_SDR_e)

119V

NADP-binding site
24G, 25I, 26T, 27G, 28Q, 29D, 49R, 50R, 51S, 77G, 78D, 79L, 100L, 101G, 102A, 104S, 119V, 145A, 146S, 147T, 171Y, 175K, 198L, 199F, 200N, 201H, 202E
CDD
cd05260 (GDP_MD_SDR_e)

145A

NADP-binding site
24G, 25I, 26T, 27G, 28Q, 29D, 49R, 50R, 51S, 77G, 78D, 79L, 100L, 101G, 102A, 104S, 119V, 145A, 146S, 147T, 171Y, 175K, 198L, 199F, 200N, 201H, 202E
CDD
cd05260 (GDP_MD_SDR_e)

146S

NADP-binding site
24G, 25I, 26T, 27G, 28Q, 29D, 49R, 50R, 51S, 77G, 78D, 79L, 100L, 101G, 102A, 104S, 119V, 145A, 146S, 147T, 171Y, 175K, 198L, 199F, 200N, 201H, 202E
CDD
cd05260 (GDP_MD_SDR_e)

147T

NADP-binding site
24G, 25I, 26T, 27G, 28Q, 29D, 49R, 50R, 51S, 77G, 78D, 79L, 100L, 101G, 102A, 104S, 119V, 145A, 146S, 147T, 171Y, 175K, 198L, 199F, 200N, 201H, 202E
CDD
cd05260 (GDP_MD_SDR_e)

171Y

NADP-binding site
24G, 25I, 26T, 27G, 28Q, 29D, 49R, 50R, 51S, 77G, 78D, 79L, 100L, 101G, 102A, 104S, 119V, 145A, 146S, 147T, 171Y, 175K, 198L, 199F, 200N, 201H, 202E
CDD
cd05260 (GDP_MD_SDR_e)

175K

NADP-binding site
24G, 25I, 26T, 27G, 28Q, 29D, 49R, 50R, 51S, 77G, 78D, 79L, 100L, 101G, 102A, 104S, 119V, 145A, 146S, 147T, 171Y, 175K, 198L, 199F, 200N, 201H, 202E
CDD
cd05260 (GDP_MD_SDR_e)

198L

NADP-binding site
24G, 25I, 26T, 27G, 28Q, 29D, 49R, 50R, 51S, 77G, 78D, 79L, 100L, 101G, 102A, 104S, 119V, 145A, 146S, 147T, 171Y, 175K, 198L, 199F, 200N, 201H, 202E
CDD
cd05260 (GDP_MD_SDR_e)

199F

NADP-binding site
24G, 25I, 26T, 27G, 28Q, 29D, 49R, 50R, 51S, 77G, 78D, 79L, 100L, 101G, 102A, 104S, 119V, 145A, 146S, 147T, 171Y, 175K, 198L, 199F, 200N, 201H, 202E
CDD
cd05260 (GDP_MD_SDR_e)

200N

NADP-binding site
24G, 25I, 26T, 27G, 28Q, 29D, 49R, 50R, 51S, 77G, 78D, 79L, 100L, 101G, 102A, 104S, 119V, 145A, 146S, 147T, 171Y, 175K, 198L, 199F, 200N, 201H, 202E
CDD
cd05260 (GDP_MD_SDR_e)

201H

NADP-binding site
24G, 25I, 26T, 27G, 28Q, 29D, 49R, 50R, 51S, 77G, 78D, 79L, 100L, 101G, 102A, 104S, 119V, 145A, 146S, 147T, 171Y, 175K, 198L, 199F, 200N, 201H, 202E
CDD
cd05260 (GDP_MD_SDR_e)

202E

NADP-binding site
24G, 25I, 26T, 27G, 28Q, 29D, 49R, 50R, 51S, 77G, 78D, 79L, 100L, 101G, 102A, 104S, 119V, 145A, 146S, 147T, 171Y, 175K, 198L, 199F, 200N, 201H, 202E
CDD
cd05260 (GDP_MD_SDR_e)
homotetramer inter...

26T

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

27G

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

49R

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

50R

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

51S

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

52S

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

53S

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

54F

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

57G

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

58R

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

76Y

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

77G

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

78D

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

80T

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

81D

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

82S

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

83T

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

84N

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

86V

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

87H

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

88I

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

90S

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

102A

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

103Q

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

104S

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

105H

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

108V

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

110F

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

111D

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

112M

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

113A

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

117G

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

118D

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

122L

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

125L

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

126R

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

129D

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

132R

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

133T

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

164P

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

165F

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

166Y

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

167P

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

169S

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

170P

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

173V

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

174A

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

176L

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

177Y

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

180W

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

181I

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

183T

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

184N

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

185Y

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

187E

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

188A

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

189Y

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

209T

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

210F

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

318P

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

319T

homotetramer interface
26T, 27G, 49R, 50R, 51S, 52S, 53S, 54F, 57G, 58R, 76Y, 77G, 78D, 80T, 81D, 82S, 83T, 84N, 86V, 87H, 88I, 90S, 102A, 103Q, 104S, 105H, 108V, 110F, 111D, 112M, 113A, 117G, 118D, 122L, 125L, 126R, 129D, 132R, 133T, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 209T, 210F, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)
substrate binding ...

104S

substrate binding site
104S, 105H, 106V, 147T, 148S, 149E, 171Y, 200N, 209T, 210F, 211V, 214K, 231W, 232L, 233G, 234N, 237A, 239R, 273V, 315Y, 317R, 320E, 321V
CDD
cd05260 (GDP_MD_SDR_e)

105H

substrate binding site
104S, 105H, 106V, 147T, 148S, 149E, 171Y, 200N, 209T, 210F, 211V, 214K, 231W, 232L, 233G, 234N, 237A, 239R, 273V, 315Y, 317R, 320E, 321V
CDD
cd05260 (GDP_MD_SDR_e)

106V

substrate binding site
104S, 105H, 106V, 147T, 148S, 149E, 171Y, 200N, 209T, 210F, 211V, 214K, 231W, 232L, 233G, 234N, 237A, 239R, 273V, 315Y, 317R, 320E, 321V
CDD
cd05260 (GDP_MD_SDR_e)

147T

substrate binding site
104S, 105H, 106V, 147T, 148S, 149E, 171Y, 200N, 209T, 210F, 211V, 214K, 231W, 232L, 233G, 234N, 237A, 239R, 273V, 315Y, 317R, 320E, 321V
CDD
cd05260 (GDP_MD_SDR_e)

148S

substrate binding site
104S, 105H, 106V, 147T, 148S, 149E, 171Y, 200N, 209T, 210F, 211V, 214K, 231W, 232L, 233G, 234N, 237A, 239R, 273V, 315Y, 317R, 320E, 321V
CDD
cd05260 (GDP_MD_SDR_e)

149E

substrate binding site
104S, 105H, 106V, 147T, 148S, 149E, 171Y, 200N, 209T, 210F, 211V, 214K, 231W, 232L, 233G, 234N, 237A, 239R, 273V, 315Y, 317R, 320E, 321V
CDD
cd05260 (GDP_MD_SDR_e)

171Y

substrate binding site
104S, 105H, 106V, 147T, 148S, 149E, 171Y, 200N, 209T, 210F, 211V, 214K, 231W, 232L, 233G, 234N, 237A, 239R, 273V, 315Y, 317R, 320E, 321V
CDD
cd05260 (GDP_MD_SDR_e)

200N

substrate binding site
104S, 105H, 106V, 147T, 148S, 149E, 171Y, 200N, 209T, 210F, 211V, 214K, 231W, 232L, 233G, 234N, 237A, 239R, 273V, 315Y, 317R, 320E, 321V
CDD
cd05260 (GDP_MD_SDR_e)

209T

substrate binding site
104S, 105H, 106V, 147T, 148S, 149E, 171Y, 200N, 209T, 210F, 211V, 214K, 231W, 232L, 233G, 234N, 237A, 239R, 273V, 315Y, 317R, 320E, 321V
CDD
cd05260 (GDP_MD_SDR_e)

210F

substrate binding site
104S, 105H, 106V, 147T, 148S, 149E, 171Y, 200N, 209T, 210F, 211V, 214K, 231W, 232L, 233G, 234N, 237A, 239R, 273V, 315Y, 317R, 320E, 321V
CDD
cd05260 (GDP_MD_SDR_e)

211V

substrate binding site
104S, 105H, 106V, 147T, 148S, 149E, 171Y, 200N, 209T, 210F, 211V, 214K, 231W, 232L, 233G, 234N, 237A, 239R, 273V, 315Y, 317R, 320E, 321V
CDD
cd05260 (GDP_MD_SDR_e)

214K

substrate binding site
104S, 105H, 106V, 147T, 148S, 149E, 171Y, 200N, 209T, 210F, 211V, 214K, 231W, 232L, 233G, 234N, 237A, 239R, 273V, 315Y, 317R, 320E, 321V
CDD
cd05260 (GDP_MD_SDR_e)

231W

substrate binding site
104S, 105H, 106V, 147T, 148S, 149E, 171Y, 200N, 209T, 210F, 211V, 214K, 231W, 232L, 233G, 234N, 237A, 239R, 273V, 315Y, 317R, 320E, 321V
CDD
cd05260 (GDP_MD_SDR_e)

232L

substrate binding site
104S, 105H, 106V, 147T, 148S, 149E, 171Y, 200N, 209T, 210F, 211V, 214K, 231W, 232L, 233G, 234N, 237A, 239R, 273V, 315Y, 317R, 320E, 321V
CDD
cd05260 (GDP_MD_SDR_e)

233G

substrate binding site
104S, 105H, 106V, 147T, 148S, 149E, 171Y, 200N, 209T, 210F, 211V, 214K, 231W, 232L, 233G, 234N, 237A, 239R, 273V, 315Y, 317R, 320E, 321V
CDD
cd05260 (GDP_MD_SDR_e)

234N

substrate binding site
104S, 105H, 106V, 147T, 148S, 149E, 171Y, 200N, 209T, 210F, 211V, 214K, 231W, 232L, 233G, 234N, 237A, 239R, 273V, 315Y, 317R, 320E, 321V
CDD
cd05260 (GDP_MD_SDR_e)

237A

substrate binding site
104S, 105H, 106V, 147T, 148S, 149E, 171Y, 200N, 209T, 210F, 211V, 214K, 231W, 232L, 233G, 234N, 237A, 239R, 273V, 315Y, 317R, 320E, 321V
CDD
cd05260 (GDP_MD_SDR_e)

239R

substrate binding site
104S, 105H, 106V, 147T, 148S, 149E, 171Y, 200N, 209T, 210F, 211V, 214K, 231W, 232L, 233G, 234N, 237A, 239R, 273V, 315Y, 317R, 320E, 321V
CDD
cd05260 (GDP_MD_SDR_e)

273V

substrate binding site
104S, 105H, 106V, 147T, 148S, 149E, 171Y, 200N, 209T, 210F, 211V, 214K, 231W, 232L, 233G, 234N, 237A, 239R, 273V, 315Y, 317R, 320E, 321V
CDD
cd05260 (GDP_MD_SDR_e)

315Y

substrate binding site
104S, 105H, 106V, 147T, 148S, 149E, 171Y, 200N, 209T, 210F, 211V, 214K, 231W, 232L, 233G, 234N, 237A, 239R, 273V, 315Y, 317R, 320E, 321V
CDD
cd05260 (GDP_MD_SDR_e)

317R

substrate binding site
104S, 105H, 106V, 147T, 148S, 149E, 171Y, 200N, 209T, 210F, 211V, 214K, 231W, 232L, 233G, 234N, 237A, 239R, 273V, 315Y, 317R, 320E, 321V
CDD
cd05260 (GDP_MD_SDR_e)

320E

substrate binding site
104S, 105H, 106V, 147T, 148S, 149E, 171Y, 200N, 209T, 210F, 211V, 214K, 231W, 232L, 233G, 234N, 237A, 239R, 273V, 315Y, 317R, 320E, 321V
CDD
cd05260 (GDP_MD_SDR_e)

321V

substrate binding site
104S, 105H, 106V, 147T, 148S, 149E, 171Y, 200N, 209T, 210F, 211V, 214K, 231W, 232L, 233G, 234N, 237A, 239R, 273V, 315Y, 317R, 320E, 321V
CDD
cd05260 (GDP_MD_SDR_e)
homodimer interfac...

110F

homodimer interface
110F, 113A, 117G, 118D, 121G, 122L, 125L, 126R, 129D, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

113A

homodimer interface
110F, 113A, 117G, 118D, 121G, 122L, 125L, 126R, 129D, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

117G

homodimer interface
110F, 113A, 117G, 118D, 121G, 122L, 125L, 126R, 129D, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

118D

homodimer interface
110F, 113A, 117G, 118D, 121G, 122L, 125L, 126R, 129D, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

121G

homodimer interface
110F, 113A, 117G, 118D, 121G, 122L, 125L, 126R, 129D, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

122L

homodimer interface
110F, 113A, 117G, 118D, 121G, 122L, 125L, 126R, 129D, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

125L

homodimer interface
110F, 113A, 117G, 118D, 121G, 122L, 125L, 126R, 129D, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

126R

homodimer interface
110F, 113A, 117G, 118D, 121G, 122L, 125L, 126R, 129D, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

129D

homodimer interface
110F, 113A, 117G, 118D, 121G, 122L, 125L, 126R, 129D, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

164P

homodimer interface
110F, 113A, 117G, 118D, 121G, 122L, 125L, 126R, 129D, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

165F

homodimer interface
110F, 113A, 117G, 118D, 121G, 122L, 125L, 126R, 129D, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

166Y

homodimer interface
110F, 113A, 117G, 118D, 121G, 122L, 125L, 126R, 129D, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

167P

homodimer interface
110F, 113A, 117G, 118D, 121G, 122L, 125L, 126R, 129D, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

169S

homodimer interface
110F, 113A, 117G, 118D, 121G, 122L, 125L, 126R, 129D, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

170P

homodimer interface
110F, 113A, 117G, 118D, 121G, 122L, 125L, 126R, 129D, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

173V

homodimer interface
110F, 113A, 117G, 118D, 121G, 122L, 125L, 126R, 129D, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

174A

homodimer interface
110F, 113A, 117G, 118D, 121G, 122L, 125L, 126R, 129D, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

176L

homodimer interface
110F, 113A, 117G, 118D, 121G, 122L, 125L, 126R, 129D, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

177Y

homodimer interface
110F, 113A, 117G, 118D, 121G, 122L, 125L, 126R, 129D, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

180W

homodimer interface
110F, 113A, 117G, 118D, 121G, 122L, 125L, 126R, 129D, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

181I

homodimer interface
110F, 113A, 117G, 118D, 121G, 122L, 125L, 126R, 129D, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

183T

homodimer interface
110F, 113A, 117G, 118D, 121G, 122L, 125L, 126R, 129D, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

184N

homodimer interface
110F, 113A, 117G, 118D, 121G, 122L, 125L, 126R, 129D, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

185Y

homodimer interface
110F, 113A, 117G, 118D, 121G, 122L, 125L, 126R, 129D, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

187E

homodimer interface
110F, 113A, 117G, 118D, 121G, 122L, 125L, 126R, 129D, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

188A

homodimer interface
110F, 113A, 117G, 118D, 121G, 122L, 125L, 126R, 129D, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

189Y

homodimer interface
110F, 113A, 117G, 118D, 121G, 122L, 125L, 126R, 129D, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

318P

homodimer interface
110F, 113A, 117G, 118D, 121G, 122L, 125L, 126R, 129D, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)

319T

homodimer interface
110F, 113A, 117G, 118D, 121G, 122L, 125L, 126R, 129D, 164P, 165F, 166Y, 167P, 169S, 170P, 173V, 174A, 176L, 177Y, 180W, 181I, 183T, 184N, 185Y, 187E, 188A, 189Y, 318P, 319T
CDD
cd05260 (GDP_MD_SDR_e)
active site cd05260

120D

active site
120D, 147T, 171Y, 175K
CDD
cd05260 (GDP_MD_SDR_e)

147T

active site
120D, 147T, 171Y, 175K
CDD
cd05260 (GDP_MD_SDR_e)

171Y

active site
120D, 147T, 171Y, 175K
CDD
cd05260 (GDP_MD_SDR_e)

175K

active site
120D, 147T, 171Y, 175K
CDD
cd05260 (GDP_MD_SDR_e)

GO term prediction

Biological Process

GO:0019673 GDP-mannose metabolic process

Molecular Function

GO:0008446 GDP-mannose 4,6-dehydratase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

GBC30059.1

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component