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Protein

GBC29922.1

Length

500 amino acids

Protein family membership

Cystathionine beta-synthase (IPR005857)

Domains and repeats

Domain
23 - 348
Tryptophan synthase beta subunit-like PLP-dependent enzyme (IPR001926)
372 - 431
CBS domain (IPR000644)
440 - 500
CBS domain (IPR000644)

1 50 100 150 200 250 300 350 400 450 500 500

Detailed signature matches

IPR005857

Cystathionine beta-synthase

TIGR01137

34 - 497

TIGRFAMs
TIGR01137 (TIGR01137)

IPR001926

Tryptophan synthase beta subunit-like PLP-dependent enzyme

PF00291 (PALP)

38 - 328

Pfam
PF00291 (PALP)
SSF53686 (Tryptopha...)

23 - 348

SUPERFAMILY
SSF53686 (Tryptophan synthase beta subunit-like PLP-dependent enzymes)

IPR000644

CBS domain

PS51371 (CBS)

374 - 431

PROSITE profiles
PS51371 (CBS)

440 - 500

PROSITE profiles
PS51371 (CBS)
PF00571 (CBS)

448 - 498

Pfam
PF00571 (CBS)

372 - 426

Pfam
PF00571 (CBS)
SM00116 (cbs_1)

448 - 498

SMART
SM00116 (cbs_1)

377 - 426

SMART
SM00116 (cbs_1)

IPR001216

Cysteine synthase/cystathionine beta-synthase, pyridoxal-phosphate attachment site

PS00901 (CYS_SYNTHASE)

65 - 83

PROSITE patterns
PS00901 (CYS_SYNTHASE)

no IPR

Unintegrated signatures

SSF54631 (CBS-domai...)

362 - 499

SUPERFAMILY
SSF54631 (CBS-domain pair)
cd01561 (CBS_like)

42 - 336

CDD
cd01561 (CBS_like)
mobidb-lite (disord...)

1 - 27

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

dimer interface cd...

46L

dimer interface
46L, 47V, 48R, 63L, 69F, 71A, 113L, 116A, 132Q, 133E, 136D, 137V, 140A, 141L, 199S, 200S, 292I, 293R, 294E, 296G, 297I, 298L, 322R, 332R, 335M
CDD
cd01561 (CBS_like)

47V

dimer interface
46L, 47V, 48R, 63L, 69F, 71A, 113L, 116A, 132Q, 133E, 136D, 137V, 140A, 141L, 199S, 200S, 292I, 293R, 294E, 296G, 297I, 298L, 322R, 332R, 335M
CDD
cd01561 (CBS_like)

48R

dimer interface
46L, 47V, 48R, 63L, 69F, 71A, 113L, 116A, 132Q, 133E, 136D, 137V, 140A, 141L, 199S, 200S, 292I, 293R, 294E, 296G, 297I, 298L, 322R, 332R, 335M
CDD
cd01561 (CBS_like)

63L

dimer interface
46L, 47V, 48R, 63L, 69F, 71A, 113L, 116A, 132Q, 133E, 136D, 137V, 140A, 141L, 199S, 200S, 292I, 293R, 294E, 296G, 297I, 298L, 322R, 332R, 335M
CDD
cd01561 (CBS_like)

69F

dimer interface
46L, 47V, 48R, 63L, 69F, 71A, 113L, 116A, 132Q, 133E, 136D, 137V, 140A, 141L, 199S, 200S, 292I, 293R, 294E, 296G, 297I, 298L, 322R, 332R, 335M
CDD
cd01561 (CBS_like)

71A

dimer interface
46L, 47V, 48R, 63L, 69F, 71A, 113L, 116A, 132Q, 133E, 136D, 137V, 140A, 141L, 199S, 200S, 292I, 293R, 294E, 296G, 297I, 298L, 322R, 332R, 335M
CDD
cd01561 (CBS_like)

113L

dimer interface
46L, 47V, 48R, 63L, 69F, 71A, 113L, 116A, 132Q, 133E, 136D, 137V, 140A, 141L, 199S, 200S, 292I, 293R, 294E, 296G, 297I, 298L, 322R, 332R, 335M
CDD
cd01561 (CBS_like)

116A

dimer interface
46L, 47V, 48R, 63L, 69F, 71A, 113L, 116A, 132Q, 133E, 136D, 137V, 140A, 141L, 199S, 200S, 292I, 293R, 294E, 296G, 297I, 298L, 322R, 332R, 335M
CDD
cd01561 (CBS_like)

132Q

dimer interface
46L, 47V, 48R, 63L, 69F, 71A, 113L, 116A, 132Q, 133E, 136D, 137V, 140A, 141L, 199S, 200S, 292I, 293R, 294E, 296G, 297I, 298L, 322R, 332R, 335M
CDD
cd01561 (CBS_like)

133E

dimer interface
46L, 47V, 48R, 63L, 69F, 71A, 113L, 116A, 132Q, 133E, 136D, 137V, 140A, 141L, 199S, 200S, 292I, 293R, 294E, 296G, 297I, 298L, 322R, 332R, 335M
CDD
cd01561 (CBS_like)

136D

dimer interface
46L, 47V, 48R, 63L, 69F, 71A, 113L, 116A, 132Q, 133E, 136D, 137V, 140A, 141L, 199S, 200S, 292I, 293R, 294E, 296G, 297I, 298L, 322R, 332R, 335M
CDD
cd01561 (CBS_like)

137V

dimer interface
46L, 47V, 48R, 63L, 69F, 71A, 113L, 116A, 132Q, 133E, 136D, 137V, 140A, 141L, 199S, 200S, 292I, 293R, 294E, 296G, 297I, 298L, 322R, 332R, 335M
CDD
cd01561 (CBS_like)

140A

dimer interface
46L, 47V, 48R, 63L, 69F, 71A, 113L, 116A, 132Q, 133E, 136D, 137V, 140A, 141L, 199S, 200S, 292I, 293R, 294E, 296G, 297I, 298L, 322R, 332R, 335M
CDD
cd01561 (CBS_like)

141L

dimer interface
46L, 47V, 48R, 63L, 69F, 71A, 113L, 116A, 132Q, 133E, 136D, 137V, 140A, 141L, 199S, 200S, 292I, 293R, 294E, 296G, 297I, 298L, 322R, 332R, 335M
CDD
cd01561 (CBS_like)

199S

dimer interface
46L, 47V, 48R, 63L, 69F, 71A, 113L, 116A, 132Q, 133E, 136D, 137V, 140A, 141L, 199S, 200S, 292I, 293R, 294E, 296G, 297I, 298L, 322R, 332R, 335M
CDD
cd01561 (CBS_like)

200S

dimer interface
46L, 47V, 48R, 63L, 69F, 71A, 113L, 116A, 132Q, 133E, 136D, 137V, 140A, 141L, 199S, 200S, 292I, 293R, 294E, 296G, 297I, 298L, 322R, 332R, 335M
CDD
cd01561 (CBS_like)

292I

dimer interface
46L, 47V, 48R, 63L, 69F, 71A, 113L, 116A, 132Q, 133E, 136D, 137V, 140A, 141L, 199S, 200S, 292I, 293R, 294E, 296G, 297I, 298L, 322R, 332R, 335M
CDD
cd01561 (CBS_like)

293R

dimer interface
46L, 47V, 48R, 63L, 69F, 71A, 113L, 116A, 132Q, 133E, 136D, 137V, 140A, 141L, 199S, 200S, 292I, 293R, 294E, 296G, 297I, 298L, 322R, 332R, 335M
CDD
cd01561 (CBS_like)

294E

dimer interface
46L, 47V, 48R, 63L, 69F, 71A, 113L, 116A, 132Q, 133E, 136D, 137V, 140A, 141L, 199S, 200S, 292I, 293R, 294E, 296G, 297I, 298L, 322R, 332R, 335M
CDD
cd01561 (CBS_like)

296G

dimer interface
46L, 47V, 48R, 63L, 69F, 71A, 113L, 116A, 132Q, 133E, 136D, 137V, 140A, 141L, 199S, 200S, 292I, 293R, 294E, 296G, 297I, 298L, 322R, 332R, 335M
CDD
cd01561 (CBS_like)

297I

dimer interface
46L, 47V, 48R, 63L, 69F, 71A, 113L, 116A, 132Q, 133E, 136D, 137V, 140A, 141L, 199S, 200S, 292I, 293R, 294E, 296G, 297I, 298L, 322R, 332R, 335M
CDD
cd01561 (CBS_like)

298L

dimer interface
46L, 47V, 48R, 63L, 69F, 71A, 113L, 116A, 132Q, 133E, 136D, 137V, 140A, 141L, 199S, 200S, 292I, 293R, 294E, 296G, 297I, 298L, 322R, 332R, 335M
CDD
cd01561 (CBS_like)

322R

dimer interface
46L, 47V, 48R, 63L, 69F, 71A, 113L, 116A, 132Q, 133E, 136D, 137V, 140A, 141L, 199S, 200S, 292I, 293R, 294E, 296G, 297I, 298L, 322R, 332R, 335M
CDD
cd01561 (CBS_like)

332R

dimer interface
46L, 47V, 48R, 63L, 69F, 71A, 113L, 116A, 132Q, 133E, 136D, 137V, 140A, 141L, 199S, 200S, 292I, 293R, 294E, 296G, 297I, 298L, 322R, 332R, 335M
CDD
cd01561 (CBS_like)

335M

dimer interface
46L, 47V, 48R, 63L, 69F, 71A, 113L, 116A, 132Q, 133E, 136D, 137V, 140A, 141L, 199S, 200S, 292I, 293R, 294E, 296G, 297I, 298L, 322R, 332R, 335M
CDD
cd01561 (CBS_like)
catalytic residue ...

76K

catalytic residue
76K
CDD
cd01561 (CBS_like)
pyridoxal 5'-phosp...

76K

pyridoxal 5'-phosphate binding site
76K, 106N, 212A, 213G, 214T, 215G, 216G, 217T, 258G, 302S, 328A, 329D
CDD
cd01561 (CBS_like)

106N

pyridoxal 5'-phosphate binding site
76K, 106N, 212A, 213G, 214T, 215G, 216G, 217T, 258G, 302S, 328A, 329D
CDD
cd01561 (CBS_like)

212A

pyridoxal 5'-phosphate binding site
76K, 106N, 212A, 213G, 214T, 215G, 216G, 217T, 258G, 302S, 328A, 329D
CDD
cd01561 (CBS_like)

213G

pyridoxal 5'-phosphate binding site
76K, 106N, 212A, 213G, 214T, 215G, 216G, 217T, 258G, 302S, 328A, 329D
CDD
cd01561 (CBS_like)

214T

pyridoxal 5'-phosphate binding site
76K, 106N, 212A, 213G, 214T, 215G, 216G, 217T, 258G, 302S, 328A, 329D
CDD
cd01561 (CBS_like)

215G

pyridoxal 5'-phosphate binding site
76K, 106N, 212A, 213G, 214T, 215G, 216G, 217T, 258G, 302S, 328A, 329D
CDD
cd01561 (CBS_like)

216G

pyridoxal 5'-phosphate binding site
76K, 106N, 212A, 213G, 214T, 215G, 216G, 217T, 258G, 302S, 328A, 329D
CDD
cd01561 (CBS_like)

217T

pyridoxal 5'-phosphate binding site
76K, 106N, 212A, 213G, 214T, 215G, 216G, 217T, 258G, 302S, 328A, 329D
CDD
cd01561 (CBS_like)

258G

pyridoxal 5'-phosphate binding site
76K, 106N, 212A, 213G, 214T, 215G, 216G, 217T, 258G, 302S, 328A, 329D
CDD
cd01561 (CBS_like)

302S

pyridoxal 5'-phosphate binding site
76K, 106N, 212A, 213G, 214T, 215G, 216G, 217T, 258G, 302S, 328A, 329D
CDD
cd01561 (CBS_like)

328A

pyridoxal 5'-phosphate binding site
76K, 106N, 212A, 213G, 214T, 215G, 216G, 217T, 258G, 302S, 328A, 329D
CDD
cd01561 (CBS_like)

329D

pyridoxal 5'-phosphate binding site
76K, 106N, 212A, 213G, 214T, 215G, 216G, 217T, 258G, 302S, 328A, 329D
CDD
cd01561 (CBS_like)

GO term prediction

Biological Process

GO:0006535 cysteine biosynthetic process from serine
GO:0019343 cysteine biosynthetic process via cystathionine

Molecular Function

GO:0004122 cystathionine beta-synthase activity

Cellular Component

GO:0005737 cytoplasm