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Entry type
Status
Per-residue features
Colour by
Protein
GBC27405.1
Length
1,630 amino acids
Protein family membership
- eIF-2-alpha kinase Gcn2 (IPR016255)
Domains and repeats
-
Domain6 - 136
- Ubiquitin-conjugating enzyme/RWD-like (IPR016135)
- RWD domain (IPR006575)
244 - 522- Protein kinase-like domain (IPR011009)
- Protein kinase domain (IPR000719)
585 - 989- Protein kinase-like domain (IPR011009)
- Protein kinase domain (IPR000719)
1,369 - 1,626- Histidyl tRNA synthetase-related domain (IPR024435)
- Ubiquitin-conjugating enzyme/RWD-like (IPR016135)
1
200
400
600
800
1000
1200
1400
1630
Detailed signature matches
-
-
PIRSF000660 (STPK_GCN2)2 - 1,628
-
-
no IPR
Unintegrated signatures
-
157 - 209
-
PF13393 (tRNA-synt_His)1,133 - 1,341
-
SSF55681 (Class II ...)1,029 - 1,350
-
cd14012 (PK_eIF2AK_...)283 - 518
-
cd14046 (STKc_EIF2A...)586 - 966
-
mobidb-lite (disord...)719 - 763
Residue annotation
-
dimer interface cd...586Fdimer interface
586F, 587S, 588R, 591S, 592D, 638L, 639R, 642T, 643T, 645S, 646R, 648H, 654R, 655Y, 656Y, 657T, 658T, 659W, 660F, 661E, 662D, 664D, 769L, 807H, 810R, 811Q, 812G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)587Sdimer interface
586F, 587S, 588R, 591S, 592D, 638L, 639R, 642T, 643T, 645S, 646R, 648H, 654R, 655Y, 656Y, 657T, 658T, 659W, 660F, 661E, 662D, 664D, 769L, 807H, 810R, 811Q, 812G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)588Rdimer interface
586F, 587S, 588R, 591S, 592D, 638L, 639R, 642T, 643T, 645S, 646R, 648H, 654R, 655Y, 656Y, 657T, 658T, 659W, 660F, 661E, 662D, 664D, 769L, 807H, 810R, 811Q, 812G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)591Sdimer interface
586F, 587S, 588R, 591S, 592D, 638L, 639R, 642T, 643T, 645S, 646R, 648H, 654R, 655Y, 656Y, 657T, 658T, 659W, 660F, 661E, 662D, 664D, 769L, 807H, 810R, 811Q, 812G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)592Ddimer interface
586F, 587S, 588R, 591S, 592D, 638L, 639R, 642T, 643T, 645S, 646R, 648H, 654R, 655Y, 656Y, 657T, 658T, 659W, 660F, 661E, 662D, 664D, 769L, 807H, 810R, 811Q, 812G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)638Ldimer interface
586F, 587S, 588R, 591S, 592D, 638L, 639R, 642T, 643T, 645S, 646R, 648H, 654R, 655Y, 656Y, 657T, 658T, 659W, 660F, 661E, 662D, 664D, 769L, 807H, 810R, 811Q, 812G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)639Rdimer interface
586F, 587S, 588R, 591S, 592D, 638L, 639R, 642T, 643T, 645S, 646R, 648H, 654R, 655Y, 656Y, 657T, 658T, 659W, 660F, 661E, 662D, 664D, 769L, 807H, 810R, 811Q, 812G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)642Tdimer interface
586F, 587S, 588R, 591S, 592D, 638L, 639R, 642T, 643T, 645S, 646R, 648H, 654R, 655Y, 656Y, 657T, 658T, 659W, 660F, 661E, 662D, 664D, 769L, 807H, 810R, 811Q, 812G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)643Tdimer interface
586F, 587S, 588R, 591S, 592D, 638L, 639R, 642T, 643T, 645S, 646R, 648H, 654R, 655Y, 656Y, 657T, 658T, 659W, 660F, 661E, 662D, 664D, 769L, 807H, 810R, 811Q, 812G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)645Sdimer interface
586F, 587S, 588R, 591S, 592D, 638L, 639R, 642T, 643T, 645S, 646R, 648H, 654R, 655Y, 656Y, 657T, 658T, 659W, 660F, 661E, 662D, 664D, 769L, 807H, 810R, 811Q, 812G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)646Rdimer interface
586F, 587S, 588R, 591S, 592D, 638L, 639R, 642T, 643T, 645S, 646R, 648H, 654R, 655Y, 656Y, 657T, 658T, 659W, 660F, 661E, 662D, 664D, 769L, 807H, 810R, 811Q, 812G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)648Hdimer interface
586F, 587S, 588R, 591S, 592D, 638L, 639R, 642T, 643T, 645S, 646R, 648H, 654R, 655Y, 656Y, 657T, 658T, 659W, 660F, 661E, 662D, 664D, 769L, 807H, 810R, 811Q, 812G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)654Rdimer interface
586F, 587S, 588R, 591S, 592D, 638L, 639R, 642T, 643T, 645S, 646R, 648H, 654R, 655Y, 656Y, 657T, 658T, 659W, 660F, 661E, 662D, 664D, 769L, 807H, 810R, 811Q, 812G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)655Ydimer interface
586F, 587S, 588R, 591S, 592D, 638L, 639R, 642T, 643T, 645S, 646R, 648H, 654R, 655Y, 656Y, 657T, 658T, 659W, 660F, 661E, 662D, 664D, 769L, 807H, 810R, 811Q, 812G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)656Ydimer interface
586F, 587S, 588R, 591S, 592D, 638L, 639R, 642T, 643T, 645S, 646R, 648H, 654R, 655Y, 656Y, 657T, 658T, 659W, 660F, 661E, 662D, 664D, 769L, 807H, 810R, 811Q, 812G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)657Tdimer interface
586F, 587S, 588R, 591S, 592D, 638L, 639R, 642T, 643T, 645S, 646R, 648H, 654R, 655Y, 656Y, 657T, 658T, 659W, 660F, 661E, 662D, 664D, 769L, 807H, 810R, 811Q, 812G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)658Tdimer interface
586F, 587S, 588R, 591S, 592D, 638L, 639R, 642T, 643T, 645S, 646R, 648H, 654R, 655Y, 656Y, 657T, 658T, 659W, 660F, 661E, 662D, 664D, 769L, 807H, 810R, 811Q, 812G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)659Wdimer interface
586F, 587S, 588R, 591S, 592D, 638L, 639R, 642T, 643T, 645S, 646R, 648H, 654R, 655Y, 656Y, 657T, 658T, 659W, 660F, 661E, 662D, 664D, 769L, 807H, 810R, 811Q, 812G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)660Fdimer interface
586F, 587S, 588R, 591S, 592D, 638L, 639R, 642T, 643T, 645S, 646R, 648H, 654R, 655Y, 656Y, 657T, 658T, 659W, 660F, 661E, 662D, 664D, 769L, 807H, 810R, 811Q, 812G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)661Edimer interface
586F, 587S, 588R, 591S, 592D, 638L, 639R, 642T, 643T, 645S, 646R, 648H, 654R, 655Y, 656Y, 657T, 658T, 659W, 660F, 661E, 662D, 664D, 769L, 807H, 810R, 811Q, 812G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)662Ddimer interface
586F, 587S, 588R, 591S, 592D, 638L, 639R, 642T, 643T, 645S, 646R, 648H, 654R, 655Y, 656Y, 657T, 658T, 659W, 660F, 661E, 662D, 664D, 769L, 807H, 810R, 811Q, 812G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)664Ddimer interface
586F, 587S, 588R, 591S, 592D, 638L, 639R, 642T, 643T, 645S, 646R, 648H, 654R, 655Y, 656Y, 657T, 658T, 659W, 660F, 661E, 662D, 664D, 769L, 807H, 810R, 811Q, 812G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)769Ldimer interface
586F, 587S, 588R, 591S, 592D, 638L, 639R, 642T, 643T, 645S, 646R, 648H, 654R, 655Y, 656Y, 657T, 658T, 659W, 660F, 661E, 662D, 664D, 769L, 807H, 810R, 811Q, 812G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)807Hdimer interface
586F, 587S, 588R, 591S, 592D, 638L, 639R, 642T, 643T, 645S, 646R, 648H, 654R, 655Y, 656Y, 657T, 658T, 659W, 660F, 661E, 662D, 664D, 769L, 807H, 810R, 811Q, 812G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)810Rdimer interface
586F, 587S, 588R, 591S, 592D, 638L, 639R, 642T, 643T, 645S, 646R, 648H, 654R, 655Y, 656Y, 657T, 658T, 659W, 660F, 661E, 662D, 664D, 769L, 807H, 810R, 811Q, 812G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)811Qdimer interface
586F, 587S, 588R, 591S, 592D, 638L, 639R, 642T, 643T, 645S, 646R, 648H, 654R, 655Y, 656Y, 657T, 658T, 659W, 660F, 661E, 662D, 664D, 769L, 807H, 810R, 811Q, 812G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)812Gdimer interface
586F, 587S, 588R, 591S, 592D, 638L, 639R, 642T, 643T, 645S, 646R, 648H, 654R, 655Y, 656Y, 657T, 658T, 659W, 660F, 661E, 662D, 664D, 769L, 807H, 810R, 811Q, 812G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2) -
ATP binding site c...599LATP binding site
599L, 600G, 607V, 620A, 622K, 653V, 773M, 774E, 775Y, 776C, 817D, 819K, 822N, 824F, 835D
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)600GATP binding site
599L, 600G, 607V, 620A, 622K, 653V, 773M, 774E, 775Y, 776C, 817D, 819K, 822N, 824F, 835D
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)607VATP binding site
599L, 600G, 607V, 620A, 622K, 653V, 773M, 774E, 775Y, 776C, 817D, 819K, 822N, 824F, 835D
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)620AATP binding site
599L, 600G, 607V, 620A, 622K, 653V, 773M, 774E, 775Y, 776C, 817D, 819K, 822N, 824F, 835D
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)622KATP binding site
599L, 600G, 607V, 620A, 622K, 653V, 773M, 774E, 775Y, 776C, 817D, 819K, 822N, 824F, 835D
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)653VATP binding site
599L, 600G, 607V, 620A, 622K, 653V, 773M, 774E, 775Y, 776C, 817D, 819K, 822N, 824F, 835D
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)773MATP binding site
599L, 600G, 607V, 620A, 622K, 653V, 773M, 774E, 775Y, 776C, 817D, 819K, 822N, 824F, 835D
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)774EATP binding site
599L, 600G, 607V, 620A, 622K, 653V, 773M, 774E, 775Y, 776C, 817D, 819K, 822N, 824F, 835D
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)775YATP binding site
599L, 600G, 607V, 620A, 622K, 653V, 773M, 774E, 775Y, 776C, 817D, 819K, 822N, 824F, 835D
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)776CATP binding site
599L, 600G, 607V, 620A, 622K, 653V, 773M, 774E, 775Y, 776C, 817D, 819K, 822N, 824F, 835D
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)817DATP binding site
599L, 600G, 607V, 620A, 622K, 653V, 773M, 774E, 775Y, 776C, 817D, 819K, 822N, 824F, 835D
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)819KATP binding site
599L, 600G, 607V, 620A, 622K, 653V, 773M, 774E, 775Y, 776C, 817D, 819K, 822N, 824F, 835D
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)822NATP binding site
599L, 600G, 607V, 620A, 622K, 653V, 773M, 774E, 775Y, 776C, 817D, 819K, 822N, 824F, 835D
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)824FATP binding site
599L, 600G, 607V, 620A, 622K, 653V, 773M, 774E, 775Y, 776C, 817D, 819K, 822N, 824F, 835D
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)835DATP binding site
599L, 600G, 607V, 620A, 622K, 653V, 773M, 774E, 775Y, 776C, 817D, 819K, 822N, 824F, 835D
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2) -
active site cd14046599Lactive site
599L, 600G, 605G, 607V, 620A, 622K, 773M, 774E, 775Y, 776C, 780T, 821S, 822N, 824F, 835D, 868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)600Gactive site
599L, 600G, 605G, 607V, 620A, 622K, 773M, 774E, 775Y, 776C, 780T, 821S, 822N, 824F, 835D, 868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)605Gactive site
599L, 600G, 605G, 607V, 620A, 622K, 773M, 774E, 775Y, 776C, 780T, 821S, 822N, 824F, 835D, 868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)607Vactive site
599L, 600G, 605G, 607V, 620A, 622K, 773M, 774E, 775Y, 776C, 780T, 821S, 822N, 824F, 835D, 868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)620Aactive site
599L, 600G, 605G, 607V, 620A, 622K, 773M, 774E, 775Y, 776C, 780T, 821S, 822N, 824F, 835D, 868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)622Kactive site
599L, 600G, 605G, 607V, 620A, 622K, 773M, 774E, 775Y, 776C, 780T, 821S, 822N, 824F, 835D, 868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)773Mactive site
599L, 600G, 605G, 607V, 620A, 622K, 773M, 774E, 775Y, 776C, 780T, 821S, 822N, 824F, 835D, 868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)774Eactive site
599L, 600G, 605G, 607V, 620A, 622K, 773M, 774E, 775Y, 776C, 780T, 821S, 822N, 824F, 835D, 868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)775Yactive site
599L, 600G, 605G, 607V, 620A, 622K, 773M, 774E, 775Y, 776C, 780T, 821S, 822N, 824F, 835D, 868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)776Cactive site
599L, 600G, 605G, 607V, 620A, 622K, 773M, 774E, 775Y, 776C, 780T, 821S, 822N, 824F, 835D, 868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)780Tactive site
599L, 600G, 605G, 607V, 620A, 622K, 773M, 774E, 775Y, 776C, 780T, 821S, 822N, 824F, 835D, 868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)821Sactive site
599L, 600G, 605G, 607V, 620A, 622K, 773M, 774E, 775Y, 776C, 780T, 821S, 822N, 824F, 835D, 868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)822Nactive site
599L, 600G, 605G, 607V, 620A, 622K, 773M, 774E, 775Y, 776C, 780T, 821S, 822N, 824F, 835D, 868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)824Factive site
599L, 600G, 605G, 607V, 620A, 622K, 773M, 774E, 775Y, 776C, 780T, 821S, 822N, 824F, 835D, 868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)835Dactive site
599L, 600G, 605G, 607V, 620A, 622K, 773M, 774E, 775Y, 776C, 780T, 821S, 822N, 824F, 835D, 868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)868Tactive site
599L, 600G, 605G, 607V, 620A, 622K, 773M, 774E, 775Y, 776C, 780T, 821S, 822N, 824F, 835D, 868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)869Tactive site
599L, 600G, 605G, 607V, 620A, 622K, 773M, 774E, 775Y, 776C, 780T, 821S, 822N, 824F, 835D, 868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)870Lactive site
599L, 600G, 605G, 607V, 620A, 622K, 773M, 774E, 775Y, 776C, 780T, 821S, 822N, 824F, 835D, 868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)908Kactive site
599L, 600G, 605G, 607V, 620A, 622K, 773M, 774E, 775Y, 776C, 780T, 821S, 822N, 824F, 835D, 868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)910Sactive site
599L, 600G, 605G, 607V, 620A, 622K, 773M, 774E, 775Y, 776C, 780T, 821S, 822N, 824F, 835D, 868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)911Tactive site
599L, 600G, 605G, 607V, 620A, 622K, 773M, 774E, 775Y, 776C, 780T, 821S, 822N, 824F, 835D, 868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)912Eactive site
599L, 600G, 605G, 607V, 620A, 622K, 773M, 774E, 775Y, 776C, 780T, 821S, 822N, 824F, 835D, 868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)913Mactive site
599L, 600G, 605G, 607V, 620A, 622K, 773M, 774E, 775Y, 776C, 780T, 821S, 822N, 824F, 835D, 868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)914Eactive site
599L, 600G, 605G, 607V, 620A, 622K, 773M, 774E, 775Y, 776C, 780T, 821S, 822N, 824F, 835D, 868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)915Ractive site
599L, 600G, 605G, 607V, 620A, 622K, 773M, 774E, 775Y, 776C, 780T, 821S, 822N, 824F, 835D, 868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)916Ractive site
599L, 600G, 605G, 607V, 620A, 622K, 773M, 774E, 775Y, 776C, 780T, 821S, 822N, 824F, 835D, 868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)917Vactive site
599L, 600G, 605G, 607V, 620A, 622K, 773M, 774E, 775Y, 776C, 780T, 821S, 822N, 824F, 835D, 868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2) -
activation loop (A...834Gactivation loop (A-loop)
834G, 835D, 836F, 837G, 838L, 839A, 840T, 841T, 842N, 843N, 849G, 850S, 851F, 852R, 853S, 859E, 860D, 861S, 862M, 863T, 864G, 865G, 866I, 867G, 868T, 869T, 870L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)835Dactivation loop (A-loop)
834G, 835D, 836F, 837G, 838L, 839A, 840T, 841T, 842N, 843N, 849G, 850S, 851F, 852R, 853S, 859E, 860D, 861S, 862M, 863T, 864G, 865G, 866I, 867G, 868T, 869T, 870L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)836Factivation loop (A-loop)
834G, 835D, 836F, 837G, 838L, 839A, 840T, 841T, 842N, 843N, 849G, 850S, 851F, 852R, 853S, 859E, 860D, 861S, 862M, 863T, 864G, 865G, 866I, 867G, 868T, 869T, 870L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)837Gactivation loop (A-loop)
834G, 835D, 836F, 837G, 838L, 839A, 840T, 841T, 842N, 843N, 849G, 850S, 851F, 852R, 853S, 859E, 860D, 861S, 862M, 863T, 864G, 865G, 866I, 867G, 868T, 869T, 870L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)838Lactivation loop (A-loop)
834G, 835D, 836F, 837G, 838L, 839A, 840T, 841T, 842N, 843N, 849G, 850S, 851F, 852R, 853S, 859E, 860D, 861S, 862M, 863T, 864G, 865G, 866I, 867G, 868T, 869T, 870L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)839Aactivation loop (A-loop)
834G, 835D, 836F, 837G, 838L, 839A, 840T, 841T, 842N, 843N, 849G, 850S, 851F, 852R, 853S, 859E, 860D, 861S, 862M, 863T, 864G, 865G, 866I, 867G, 868T, 869T, 870L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)840Tactivation loop (A-loop)
834G, 835D, 836F, 837G, 838L, 839A, 840T, 841T, 842N, 843N, 849G, 850S, 851F, 852R, 853S, 859E, 860D, 861S, 862M, 863T, 864G, 865G, 866I, 867G, 868T, 869T, 870L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)841Tactivation loop (A-loop)
834G, 835D, 836F, 837G, 838L, 839A, 840T, 841T, 842N, 843N, 849G, 850S, 851F, 852R, 853S, 859E, 860D, 861S, 862M, 863T, 864G, 865G, 866I, 867G, 868T, 869T, 870L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)842Nactivation loop (A-loop)
834G, 835D, 836F, 837G, 838L, 839A, 840T, 841T, 842N, 843N, 849G, 850S, 851F, 852R, 853S, 859E, 860D, 861S, 862M, 863T, 864G, 865G, 866I, 867G, 868T, 869T, 870L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)843Nactivation loop (A-loop)
834G, 835D, 836F, 837G, 838L, 839A, 840T, 841T, 842N, 843N, 849G, 850S, 851F, 852R, 853S, 859E, 860D, 861S, 862M, 863T, 864G, 865G, 866I, 867G, 868T, 869T, 870L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)849Gactivation loop (A-loop)
834G, 835D, 836F, 837G, 838L, 839A, 840T, 841T, 842N, 843N, 849G, 850S, 851F, 852R, 853S, 859E, 860D, 861S, 862M, 863T, 864G, 865G, 866I, 867G, 868T, 869T, 870L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)850Sactivation loop (A-loop)
834G, 835D, 836F, 837G, 838L, 839A, 840T, 841T, 842N, 843N, 849G, 850S, 851F, 852R, 853S, 859E, 860D, 861S, 862M, 863T, 864G, 865G, 866I, 867G, 868T, 869T, 870L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)851Factivation loop (A-loop)
834G, 835D, 836F, 837G, 838L, 839A, 840T, 841T, 842N, 843N, 849G, 850S, 851F, 852R, 853S, 859E, 860D, 861S, 862M, 863T, 864G, 865G, 866I, 867G, 868T, 869T, 870L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)852Ractivation loop (A-loop)
834G, 835D, 836F, 837G, 838L, 839A, 840T, 841T, 842N, 843N, 849G, 850S, 851F, 852R, 853S, 859E, 860D, 861S, 862M, 863T, 864G, 865G, 866I, 867G, 868T, 869T, 870L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)853Sactivation loop (A-loop)
834G, 835D, 836F, 837G, 838L, 839A, 840T, 841T, 842N, 843N, 849G, 850S, 851F, 852R, 853S, 859E, 860D, 861S, 862M, 863T, 864G, 865G, 866I, 867G, 868T, 869T, 870L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)859Eactivation loop (A-loop)
834G, 835D, 836F, 837G, 838L, 839A, 840T, 841T, 842N, 843N, 849G, 850S, 851F, 852R, 853S, 859E, 860D, 861S, 862M, 863T, 864G, 865G, 866I, 867G, 868T, 869T, 870L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)860Dactivation loop (A-loop)
834G, 835D, 836F, 837G, 838L, 839A, 840T, 841T, 842N, 843N, 849G, 850S, 851F, 852R, 853S, 859E, 860D, 861S, 862M, 863T, 864G, 865G, 866I, 867G, 868T, 869T, 870L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)861Sactivation loop (A-loop)
834G, 835D, 836F, 837G, 838L, 839A, 840T, 841T, 842N, 843N, 849G, 850S, 851F, 852R, 853S, 859E, 860D, 861S, 862M, 863T, 864G, 865G, 866I, 867G, 868T, 869T, 870L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)862Mactivation loop (A-loop)
834G, 835D, 836F, 837G, 838L, 839A, 840T, 841T, 842N, 843N, 849G, 850S, 851F, 852R, 853S, 859E, 860D, 861S, 862M, 863T, 864G, 865G, 866I, 867G, 868T, 869T, 870L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)863Tactivation loop (A-loop)
834G, 835D, 836F, 837G, 838L, 839A, 840T, 841T, 842N, 843N, 849G, 850S, 851F, 852R, 853S, 859E, 860D, 861S, 862M, 863T, 864G, 865G, 866I, 867G, 868T, 869T, 870L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)864Gactivation loop (A-loop)
834G, 835D, 836F, 837G, 838L, 839A, 840T, 841T, 842N, 843N, 849G, 850S, 851F, 852R, 853S, 859E, 860D, 861S, 862M, 863T, 864G, 865G, 866I, 867G, 868T, 869T, 870L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)865Gactivation loop (A-loop)
834G, 835D, 836F, 837G, 838L, 839A, 840T, 841T, 842N, 843N, 849G, 850S, 851F, 852R, 853S, 859E, 860D, 861S, 862M, 863T, 864G, 865G, 866I, 867G, 868T, 869T, 870L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)866Iactivation loop (A-loop)
834G, 835D, 836F, 837G, 838L, 839A, 840T, 841T, 842N, 843N, 849G, 850S, 851F, 852R, 853S, 859E, 860D, 861S, 862M, 863T, 864G, 865G, 866I, 867G, 868T, 869T, 870L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)867Gactivation loop (A-loop)
834G, 835D, 836F, 837G, 838L, 839A, 840T, 841T, 842N, 843N, 849G, 850S, 851F, 852R, 853S, 859E, 860D, 861S, 862M, 863T, 864G, 865G, 866I, 867G, 868T, 869T, 870L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)868Tactivation loop (A-loop)
834G, 835D, 836F, 837G, 838L, 839A, 840T, 841T, 842N, 843N, 849G, 850S, 851F, 852R, 853S, 859E, 860D, 861S, 862M, 863T, 864G, 865G, 866I, 867G, 868T, 869T, 870L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)869Tactivation loop (A-loop)
834G, 835D, 836F, 837G, 838L, 839A, 840T, 841T, 842N, 843N, 849G, 850S, 851F, 852R, 853S, 859E, 860D, 861S, 862M, 863T, 864G, 865G, 866I, 867G, 868T, 869T, 870L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)870Lactivation loop (A-loop)
834G, 835D, 836F, 837G, 838L, 839A, 840T, 841T, 842N, 843N, 849G, 850S, 851F, 852R, 853S, 859E, 860D, 861S, 862M, 863T, 864G, 865G, 866I, 867G, 868T, 869T, 870L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2) -
eIF2alpha (substra...868TeIF2alpha (substrate) binding site
868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)869TeIF2alpha (substrate) binding site
868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)870LeIF2alpha (substrate) binding site
868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)908KeIF2alpha (substrate) binding site
868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)910SeIF2alpha (substrate) binding site
868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)911TeIF2alpha (substrate) binding site
868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)912EeIF2alpha (substrate) binding site
868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)913MeIF2alpha (substrate) binding site
868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)914EeIF2alpha (substrate) binding site
868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)915ReIF2alpha (substrate) binding site
868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)916ReIF2alpha (substrate) binding site
868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)917VeIF2alpha (substrate) binding site
868T, 869T, 870L, 908K, 910S, 911T, 912E, 913M, 914E, 915R, 916R, 917V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)
GO term prediction
Biological Process
GO:0000077 DNA damage checkpoint
GO:0006468 protein phosphorylation
GO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation
Molecular Function
GO:0004672 protein kinase activity
GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
Cellular Component
None predicted.