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Entry type
Status
Per-residue features
Colour by
Protein
GBC27404.1
Length
1,633 amino acids
Protein family membership
- eIF-2-alpha kinase Gcn2 (IPR016255)
Domains and repeats
-
Domain6 - 136
- Ubiquitin-conjugating enzyme/RWD-like (IPR016135)
- RWD domain (IPR006575)
244 - 522- Protein kinase-like domain (IPR011009)
- Protein kinase domain (IPR000719)
585 - 992- Protein kinase-like domain (IPR011009)
- Protein kinase domain (IPR000719)
1,372 - 1,629- Histidyl tRNA synthetase-related domain (IPR024435)
- Ubiquitin-conjugating enzyme/RWD-like (IPR016135)
1
200
400
600
800
1000
1200
1400
1633
Detailed signature matches
-
-
PIRSF000660 (STPK_GCN2)2 - 1,631
-
-
no IPR
Unintegrated signatures
-
157 - 209
-
PF13393 (tRNA-synt_His)1,136 - 1,344
-
SSF55681 (Class II ...)1,032 - 1,353
-
cd14012 (PK_eIF2AK_...)283 - 518
-
cd14046 (STKc_EIF2A...)586 - 969
-
mobidb-lite (disord...)722 - 766
Residue annotation
-
dimer interface cd...586Fdimer interface
586F, 587S, 588R, 591S, 592D, 641L, 642R, 645T, 646T, 648S, 649R, 651H, 657R, 658Y, 659Y, 660T, 661T, 662W, 663F, 664E, 665D, 667D, 772L, 810H, 813R, 814Q, 815G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)587Sdimer interface
586F, 587S, 588R, 591S, 592D, 641L, 642R, 645T, 646T, 648S, 649R, 651H, 657R, 658Y, 659Y, 660T, 661T, 662W, 663F, 664E, 665D, 667D, 772L, 810H, 813R, 814Q, 815G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)588Rdimer interface
586F, 587S, 588R, 591S, 592D, 641L, 642R, 645T, 646T, 648S, 649R, 651H, 657R, 658Y, 659Y, 660T, 661T, 662W, 663F, 664E, 665D, 667D, 772L, 810H, 813R, 814Q, 815G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)591Sdimer interface
586F, 587S, 588R, 591S, 592D, 641L, 642R, 645T, 646T, 648S, 649R, 651H, 657R, 658Y, 659Y, 660T, 661T, 662W, 663F, 664E, 665D, 667D, 772L, 810H, 813R, 814Q, 815G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)592Ddimer interface
586F, 587S, 588R, 591S, 592D, 641L, 642R, 645T, 646T, 648S, 649R, 651H, 657R, 658Y, 659Y, 660T, 661T, 662W, 663F, 664E, 665D, 667D, 772L, 810H, 813R, 814Q, 815G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)641Ldimer interface
586F, 587S, 588R, 591S, 592D, 641L, 642R, 645T, 646T, 648S, 649R, 651H, 657R, 658Y, 659Y, 660T, 661T, 662W, 663F, 664E, 665D, 667D, 772L, 810H, 813R, 814Q, 815G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)642Rdimer interface
586F, 587S, 588R, 591S, 592D, 641L, 642R, 645T, 646T, 648S, 649R, 651H, 657R, 658Y, 659Y, 660T, 661T, 662W, 663F, 664E, 665D, 667D, 772L, 810H, 813R, 814Q, 815G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)645Tdimer interface
586F, 587S, 588R, 591S, 592D, 641L, 642R, 645T, 646T, 648S, 649R, 651H, 657R, 658Y, 659Y, 660T, 661T, 662W, 663F, 664E, 665D, 667D, 772L, 810H, 813R, 814Q, 815G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)646Tdimer interface
586F, 587S, 588R, 591S, 592D, 641L, 642R, 645T, 646T, 648S, 649R, 651H, 657R, 658Y, 659Y, 660T, 661T, 662W, 663F, 664E, 665D, 667D, 772L, 810H, 813R, 814Q, 815G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)648Sdimer interface
586F, 587S, 588R, 591S, 592D, 641L, 642R, 645T, 646T, 648S, 649R, 651H, 657R, 658Y, 659Y, 660T, 661T, 662W, 663F, 664E, 665D, 667D, 772L, 810H, 813R, 814Q, 815G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)649Rdimer interface
586F, 587S, 588R, 591S, 592D, 641L, 642R, 645T, 646T, 648S, 649R, 651H, 657R, 658Y, 659Y, 660T, 661T, 662W, 663F, 664E, 665D, 667D, 772L, 810H, 813R, 814Q, 815G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)651Hdimer interface
586F, 587S, 588R, 591S, 592D, 641L, 642R, 645T, 646T, 648S, 649R, 651H, 657R, 658Y, 659Y, 660T, 661T, 662W, 663F, 664E, 665D, 667D, 772L, 810H, 813R, 814Q, 815G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)657Rdimer interface
586F, 587S, 588R, 591S, 592D, 641L, 642R, 645T, 646T, 648S, 649R, 651H, 657R, 658Y, 659Y, 660T, 661T, 662W, 663F, 664E, 665D, 667D, 772L, 810H, 813R, 814Q, 815G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)658Ydimer interface
586F, 587S, 588R, 591S, 592D, 641L, 642R, 645T, 646T, 648S, 649R, 651H, 657R, 658Y, 659Y, 660T, 661T, 662W, 663F, 664E, 665D, 667D, 772L, 810H, 813R, 814Q, 815G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)659Ydimer interface
586F, 587S, 588R, 591S, 592D, 641L, 642R, 645T, 646T, 648S, 649R, 651H, 657R, 658Y, 659Y, 660T, 661T, 662W, 663F, 664E, 665D, 667D, 772L, 810H, 813R, 814Q, 815G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)660Tdimer interface
586F, 587S, 588R, 591S, 592D, 641L, 642R, 645T, 646T, 648S, 649R, 651H, 657R, 658Y, 659Y, 660T, 661T, 662W, 663F, 664E, 665D, 667D, 772L, 810H, 813R, 814Q, 815G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)661Tdimer interface
586F, 587S, 588R, 591S, 592D, 641L, 642R, 645T, 646T, 648S, 649R, 651H, 657R, 658Y, 659Y, 660T, 661T, 662W, 663F, 664E, 665D, 667D, 772L, 810H, 813R, 814Q, 815G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)662Wdimer interface
586F, 587S, 588R, 591S, 592D, 641L, 642R, 645T, 646T, 648S, 649R, 651H, 657R, 658Y, 659Y, 660T, 661T, 662W, 663F, 664E, 665D, 667D, 772L, 810H, 813R, 814Q, 815G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)663Fdimer interface
586F, 587S, 588R, 591S, 592D, 641L, 642R, 645T, 646T, 648S, 649R, 651H, 657R, 658Y, 659Y, 660T, 661T, 662W, 663F, 664E, 665D, 667D, 772L, 810H, 813R, 814Q, 815G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)664Edimer interface
586F, 587S, 588R, 591S, 592D, 641L, 642R, 645T, 646T, 648S, 649R, 651H, 657R, 658Y, 659Y, 660T, 661T, 662W, 663F, 664E, 665D, 667D, 772L, 810H, 813R, 814Q, 815G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)665Ddimer interface
586F, 587S, 588R, 591S, 592D, 641L, 642R, 645T, 646T, 648S, 649R, 651H, 657R, 658Y, 659Y, 660T, 661T, 662W, 663F, 664E, 665D, 667D, 772L, 810H, 813R, 814Q, 815G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)667Ddimer interface
586F, 587S, 588R, 591S, 592D, 641L, 642R, 645T, 646T, 648S, 649R, 651H, 657R, 658Y, 659Y, 660T, 661T, 662W, 663F, 664E, 665D, 667D, 772L, 810H, 813R, 814Q, 815G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)772Ldimer interface
586F, 587S, 588R, 591S, 592D, 641L, 642R, 645T, 646T, 648S, 649R, 651H, 657R, 658Y, 659Y, 660T, 661T, 662W, 663F, 664E, 665D, 667D, 772L, 810H, 813R, 814Q, 815G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)810Hdimer interface
586F, 587S, 588R, 591S, 592D, 641L, 642R, 645T, 646T, 648S, 649R, 651H, 657R, 658Y, 659Y, 660T, 661T, 662W, 663F, 664E, 665D, 667D, 772L, 810H, 813R, 814Q, 815G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)813Rdimer interface
586F, 587S, 588R, 591S, 592D, 641L, 642R, 645T, 646T, 648S, 649R, 651H, 657R, 658Y, 659Y, 660T, 661T, 662W, 663F, 664E, 665D, 667D, 772L, 810H, 813R, 814Q, 815G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)814Qdimer interface
586F, 587S, 588R, 591S, 592D, 641L, 642R, 645T, 646T, 648S, 649R, 651H, 657R, 658Y, 659Y, 660T, 661T, 662W, 663F, 664E, 665D, 667D, 772L, 810H, 813R, 814Q, 815G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)815Gdimer interface
586F, 587S, 588R, 591S, 592D, 641L, 642R, 645T, 646T, 648S, 649R, 651H, 657R, 658Y, 659Y, 660T, 661T, 662W, 663F, 664E, 665D, 667D, 772L, 810H, 813R, 814Q, 815G
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2) -
ATP binding site c...599LATP binding site
599L, 600G, 607V, 623A, 625K, 656V, 776M, 777E, 778Y, 779C, 820D, 822K, 825N, 827F, 838D
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)600GATP binding site
599L, 600G, 607V, 623A, 625K, 656V, 776M, 777E, 778Y, 779C, 820D, 822K, 825N, 827F, 838D
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)607VATP binding site
599L, 600G, 607V, 623A, 625K, 656V, 776M, 777E, 778Y, 779C, 820D, 822K, 825N, 827F, 838D
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)623AATP binding site
599L, 600G, 607V, 623A, 625K, 656V, 776M, 777E, 778Y, 779C, 820D, 822K, 825N, 827F, 838D
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)625KATP binding site
599L, 600G, 607V, 623A, 625K, 656V, 776M, 777E, 778Y, 779C, 820D, 822K, 825N, 827F, 838D
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)656VATP binding site
599L, 600G, 607V, 623A, 625K, 656V, 776M, 777E, 778Y, 779C, 820D, 822K, 825N, 827F, 838D
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)776MATP binding site
599L, 600G, 607V, 623A, 625K, 656V, 776M, 777E, 778Y, 779C, 820D, 822K, 825N, 827F, 838D
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)777EATP binding site
599L, 600G, 607V, 623A, 625K, 656V, 776M, 777E, 778Y, 779C, 820D, 822K, 825N, 827F, 838D
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)778YATP binding site
599L, 600G, 607V, 623A, 625K, 656V, 776M, 777E, 778Y, 779C, 820D, 822K, 825N, 827F, 838D
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)779CATP binding site
599L, 600G, 607V, 623A, 625K, 656V, 776M, 777E, 778Y, 779C, 820D, 822K, 825N, 827F, 838D
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)820DATP binding site
599L, 600G, 607V, 623A, 625K, 656V, 776M, 777E, 778Y, 779C, 820D, 822K, 825N, 827F, 838D
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)822KATP binding site
599L, 600G, 607V, 623A, 625K, 656V, 776M, 777E, 778Y, 779C, 820D, 822K, 825N, 827F, 838D
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)825NATP binding site
599L, 600G, 607V, 623A, 625K, 656V, 776M, 777E, 778Y, 779C, 820D, 822K, 825N, 827F, 838D
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)827FATP binding site
599L, 600G, 607V, 623A, 625K, 656V, 776M, 777E, 778Y, 779C, 820D, 822K, 825N, 827F, 838D
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)838DATP binding site
599L, 600G, 607V, 623A, 625K, 656V, 776M, 777E, 778Y, 779C, 820D, 822K, 825N, 827F, 838D
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2) -
active site cd14046599Lactive site
599L, 600G, 605G, 607V, 623A, 625K, 776M, 777E, 778Y, 779C, 783T, 824S, 825N, 827F, 838D, 871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)600Gactive site
599L, 600G, 605G, 607V, 623A, 625K, 776M, 777E, 778Y, 779C, 783T, 824S, 825N, 827F, 838D, 871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)605Gactive site
599L, 600G, 605G, 607V, 623A, 625K, 776M, 777E, 778Y, 779C, 783T, 824S, 825N, 827F, 838D, 871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)607Vactive site
599L, 600G, 605G, 607V, 623A, 625K, 776M, 777E, 778Y, 779C, 783T, 824S, 825N, 827F, 838D, 871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)623Aactive site
599L, 600G, 605G, 607V, 623A, 625K, 776M, 777E, 778Y, 779C, 783T, 824S, 825N, 827F, 838D, 871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)625Kactive site
599L, 600G, 605G, 607V, 623A, 625K, 776M, 777E, 778Y, 779C, 783T, 824S, 825N, 827F, 838D, 871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)776Mactive site
599L, 600G, 605G, 607V, 623A, 625K, 776M, 777E, 778Y, 779C, 783T, 824S, 825N, 827F, 838D, 871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)777Eactive site
599L, 600G, 605G, 607V, 623A, 625K, 776M, 777E, 778Y, 779C, 783T, 824S, 825N, 827F, 838D, 871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)778Yactive site
599L, 600G, 605G, 607V, 623A, 625K, 776M, 777E, 778Y, 779C, 783T, 824S, 825N, 827F, 838D, 871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)779Cactive site
599L, 600G, 605G, 607V, 623A, 625K, 776M, 777E, 778Y, 779C, 783T, 824S, 825N, 827F, 838D, 871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)783Tactive site
599L, 600G, 605G, 607V, 623A, 625K, 776M, 777E, 778Y, 779C, 783T, 824S, 825N, 827F, 838D, 871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)824Sactive site
599L, 600G, 605G, 607V, 623A, 625K, 776M, 777E, 778Y, 779C, 783T, 824S, 825N, 827F, 838D, 871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)825Nactive site
599L, 600G, 605G, 607V, 623A, 625K, 776M, 777E, 778Y, 779C, 783T, 824S, 825N, 827F, 838D, 871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)827Factive site
599L, 600G, 605G, 607V, 623A, 625K, 776M, 777E, 778Y, 779C, 783T, 824S, 825N, 827F, 838D, 871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)838Dactive site
599L, 600G, 605G, 607V, 623A, 625K, 776M, 777E, 778Y, 779C, 783T, 824S, 825N, 827F, 838D, 871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)871Tactive site
599L, 600G, 605G, 607V, 623A, 625K, 776M, 777E, 778Y, 779C, 783T, 824S, 825N, 827F, 838D, 871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)872Tactive site
599L, 600G, 605G, 607V, 623A, 625K, 776M, 777E, 778Y, 779C, 783T, 824S, 825N, 827F, 838D, 871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)873Lactive site
599L, 600G, 605G, 607V, 623A, 625K, 776M, 777E, 778Y, 779C, 783T, 824S, 825N, 827F, 838D, 871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)911Kactive site
599L, 600G, 605G, 607V, 623A, 625K, 776M, 777E, 778Y, 779C, 783T, 824S, 825N, 827F, 838D, 871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)913Sactive site
599L, 600G, 605G, 607V, 623A, 625K, 776M, 777E, 778Y, 779C, 783T, 824S, 825N, 827F, 838D, 871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)914Tactive site
599L, 600G, 605G, 607V, 623A, 625K, 776M, 777E, 778Y, 779C, 783T, 824S, 825N, 827F, 838D, 871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)915Eactive site
599L, 600G, 605G, 607V, 623A, 625K, 776M, 777E, 778Y, 779C, 783T, 824S, 825N, 827F, 838D, 871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)916Mactive site
599L, 600G, 605G, 607V, 623A, 625K, 776M, 777E, 778Y, 779C, 783T, 824S, 825N, 827F, 838D, 871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)917Eactive site
599L, 600G, 605G, 607V, 623A, 625K, 776M, 777E, 778Y, 779C, 783T, 824S, 825N, 827F, 838D, 871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)918Ractive site
599L, 600G, 605G, 607V, 623A, 625K, 776M, 777E, 778Y, 779C, 783T, 824S, 825N, 827F, 838D, 871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)919Ractive site
599L, 600G, 605G, 607V, 623A, 625K, 776M, 777E, 778Y, 779C, 783T, 824S, 825N, 827F, 838D, 871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)920Vactive site
599L, 600G, 605G, 607V, 623A, 625K, 776M, 777E, 778Y, 779C, 783T, 824S, 825N, 827F, 838D, 871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2) -
activation loop (A...837Gactivation loop (A-loop)
837G, 838D, 839F, 840G, 841L, 842A, 843T, 844T, 845N, 846N, 852G, 853S, 854F, 855R, 856S, 862E, 863D, 864S, 865M, 866T, 867G, 868G, 869I, 870G, 871T, 872T, 873L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)838Dactivation loop (A-loop)
837G, 838D, 839F, 840G, 841L, 842A, 843T, 844T, 845N, 846N, 852G, 853S, 854F, 855R, 856S, 862E, 863D, 864S, 865M, 866T, 867G, 868G, 869I, 870G, 871T, 872T, 873L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)839Factivation loop (A-loop)
837G, 838D, 839F, 840G, 841L, 842A, 843T, 844T, 845N, 846N, 852G, 853S, 854F, 855R, 856S, 862E, 863D, 864S, 865M, 866T, 867G, 868G, 869I, 870G, 871T, 872T, 873L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)840Gactivation loop (A-loop)
837G, 838D, 839F, 840G, 841L, 842A, 843T, 844T, 845N, 846N, 852G, 853S, 854F, 855R, 856S, 862E, 863D, 864S, 865M, 866T, 867G, 868G, 869I, 870G, 871T, 872T, 873L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)841Lactivation loop (A-loop)
837G, 838D, 839F, 840G, 841L, 842A, 843T, 844T, 845N, 846N, 852G, 853S, 854F, 855R, 856S, 862E, 863D, 864S, 865M, 866T, 867G, 868G, 869I, 870G, 871T, 872T, 873L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)842Aactivation loop (A-loop)
837G, 838D, 839F, 840G, 841L, 842A, 843T, 844T, 845N, 846N, 852G, 853S, 854F, 855R, 856S, 862E, 863D, 864S, 865M, 866T, 867G, 868G, 869I, 870G, 871T, 872T, 873L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)843Tactivation loop (A-loop)
837G, 838D, 839F, 840G, 841L, 842A, 843T, 844T, 845N, 846N, 852G, 853S, 854F, 855R, 856S, 862E, 863D, 864S, 865M, 866T, 867G, 868G, 869I, 870G, 871T, 872T, 873L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)844Tactivation loop (A-loop)
837G, 838D, 839F, 840G, 841L, 842A, 843T, 844T, 845N, 846N, 852G, 853S, 854F, 855R, 856S, 862E, 863D, 864S, 865M, 866T, 867G, 868G, 869I, 870G, 871T, 872T, 873L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)845Nactivation loop (A-loop)
837G, 838D, 839F, 840G, 841L, 842A, 843T, 844T, 845N, 846N, 852G, 853S, 854F, 855R, 856S, 862E, 863D, 864S, 865M, 866T, 867G, 868G, 869I, 870G, 871T, 872T, 873L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)846Nactivation loop (A-loop)
837G, 838D, 839F, 840G, 841L, 842A, 843T, 844T, 845N, 846N, 852G, 853S, 854F, 855R, 856S, 862E, 863D, 864S, 865M, 866T, 867G, 868G, 869I, 870G, 871T, 872T, 873L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)852Gactivation loop (A-loop)
837G, 838D, 839F, 840G, 841L, 842A, 843T, 844T, 845N, 846N, 852G, 853S, 854F, 855R, 856S, 862E, 863D, 864S, 865M, 866T, 867G, 868G, 869I, 870G, 871T, 872T, 873L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)853Sactivation loop (A-loop)
837G, 838D, 839F, 840G, 841L, 842A, 843T, 844T, 845N, 846N, 852G, 853S, 854F, 855R, 856S, 862E, 863D, 864S, 865M, 866T, 867G, 868G, 869I, 870G, 871T, 872T, 873L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)854Factivation loop (A-loop)
837G, 838D, 839F, 840G, 841L, 842A, 843T, 844T, 845N, 846N, 852G, 853S, 854F, 855R, 856S, 862E, 863D, 864S, 865M, 866T, 867G, 868G, 869I, 870G, 871T, 872T, 873L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)855Ractivation loop (A-loop)
837G, 838D, 839F, 840G, 841L, 842A, 843T, 844T, 845N, 846N, 852G, 853S, 854F, 855R, 856S, 862E, 863D, 864S, 865M, 866T, 867G, 868G, 869I, 870G, 871T, 872T, 873L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)856Sactivation loop (A-loop)
837G, 838D, 839F, 840G, 841L, 842A, 843T, 844T, 845N, 846N, 852G, 853S, 854F, 855R, 856S, 862E, 863D, 864S, 865M, 866T, 867G, 868G, 869I, 870G, 871T, 872T, 873L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)862Eactivation loop (A-loop)
837G, 838D, 839F, 840G, 841L, 842A, 843T, 844T, 845N, 846N, 852G, 853S, 854F, 855R, 856S, 862E, 863D, 864S, 865M, 866T, 867G, 868G, 869I, 870G, 871T, 872T, 873L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)863Dactivation loop (A-loop)
837G, 838D, 839F, 840G, 841L, 842A, 843T, 844T, 845N, 846N, 852G, 853S, 854F, 855R, 856S, 862E, 863D, 864S, 865M, 866T, 867G, 868G, 869I, 870G, 871T, 872T, 873L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)864Sactivation loop (A-loop)
837G, 838D, 839F, 840G, 841L, 842A, 843T, 844T, 845N, 846N, 852G, 853S, 854F, 855R, 856S, 862E, 863D, 864S, 865M, 866T, 867G, 868G, 869I, 870G, 871T, 872T, 873L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)865Mactivation loop (A-loop)
837G, 838D, 839F, 840G, 841L, 842A, 843T, 844T, 845N, 846N, 852G, 853S, 854F, 855R, 856S, 862E, 863D, 864S, 865M, 866T, 867G, 868G, 869I, 870G, 871T, 872T, 873L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)866Tactivation loop (A-loop)
837G, 838D, 839F, 840G, 841L, 842A, 843T, 844T, 845N, 846N, 852G, 853S, 854F, 855R, 856S, 862E, 863D, 864S, 865M, 866T, 867G, 868G, 869I, 870G, 871T, 872T, 873L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)867Gactivation loop (A-loop)
837G, 838D, 839F, 840G, 841L, 842A, 843T, 844T, 845N, 846N, 852G, 853S, 854F, 855R, 856S, 862E, 863D, 864S, 865M, 866T, 867G, 868G, 869I, 870G, 871T, 872T, 873L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)868Gactivation loop (A-loop)
837G, 838D, 839F, 840G, 841L, 842A, 843T, 844T, 845N, 846N, 852G, 853S, 854F, 855R, 856S, 862E, 863D, 864S, 865M, 866T, 867G, 868G, 869I, 870G, 871T, 872T, 873L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)869Iactivation loop (A-loop)
837G, 838D, 839F, 840G, 841L, 842A, 843T, 844T, 845N, 846N, 852G, 853S, 854F, 855R, 856S, 862E, 863D, 864S, 865M, 866T, 867G, 868G, 869I, 870G, 871T, 872T, 873L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)870Gactivation loop (A-loop)
837G, 838D, 839F, 840G, 841L, 842A, 843T, 844T, 845N, 846N, 852G, 853S, 854F, 855R, 856S, 862E, 863D, 864S, 865M, 866T, 867G, 868G, 869I, 870G, 871T, 872T, 873L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)871Tactivation loop (A-loop)
837G, 838D, 839F, 840G, 841L, 842A, 843T, 844T, 845N, 846N, 852G, 853S, 854F, 855R, 856S, 862E, 863D, 864S, 865M, 866T, 867G, 868G, 869I, 870G, 871T, 872T, 873L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)872Tactivation loop (A-loop)
837G, 838D, 839F, 840G, 841L, 842A, 843T, 844T, 845N, 846N, 852G, 853S, 854F, 855R, 856S, 862E, 863D, 864S, 865M, 866T, 867G, 868G, 869I, 870G, 871T, 872T, 873L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)873Lactivation loop (A-loop)
837G, 838D, 839F, 840G, 841L, 842A, 843T, 844T, 845N, 846N, 852G, 853S, 854F, 855R, 856S, 862E, 863D, 864S, 865M, 866T, 867G, 868G, 869I, 870G, 871T, 872T, 873L
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2) -
eIF2alpha (substra...871TeIF2alpha (substrate) binding site
871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)872TeIF2alpha (substrate) binding site
871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)873LeIF2alpha (substrate) binding site
871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)911KeIF2alpha (substrate) binding site
871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)913SeIF2alpha (substrate) binding site
871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)914TeIF2alpha (substrate) binding site
871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)915EeIF2alpha (substrate) binding site
871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)916MeIF2alpha (substrate) binding site
871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)917EeIF2alpha (substrate) binding site
871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)918ReIF2alpha (substrate) binding site
871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)919ReIF2alpha (substrate) binding site
871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)920VeIF2alpha (substrate) binding site
871T, 872T, 873L, 911K, 913S, 914T, 915E, 916M, 917E, 918R, 919R, 920V
CDD
cd14046 (STKc_EIF2AK4_GCN2_rpt2)
GO term prediction
Biological Process
GO:0000077 DNA damage checkpoint
GO:0006468 protein phosphorylation
GO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation
Molecular Function
GO:0004672 protein kinase activity
GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
Cellular Component
None predicted.