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Protein

GBC26350.1

Length

381 amino acids

Protein family membership

Adenosylhomocysteinase-like (IPR000043)

Domains and repeats

Domain
Domain

1 50 100 150 200 250 300 350 381

Detailed signature matches

IPR000043

Adenosylhomocysteinase-like

PF05221 (AdoHcyase)
SM00996 (AdoHcyase_2)
PIRSF001109 (SAHH)
cd00401 (SAHH)

IPR015878

S-adenosyl-L-homocysteine hydrolase, NAD binding domain

SM00997 (AdoHcyase_...)
PF00670 (AdoHcyase_NAD)

IPR016040

NAD(P)-binding domain

SSF51735 (NAD(P)-bi...)

IPR020082

S-adenosyl-L-homocysteine hydrolase, conserved site

PS00739 (ADOHCYASE_2)

no IPR

Unintegrated signatures

SSF52283 (Formate/g...)

Residue annotation

homotetramer inter...

358L

homotetramer interface
14W, 17Q, 21L, 24N, 25E, 111H, 114Y, 115K, 131D, 133V, 137K, 138F, 142Y, 145R, 146E, 150D, 153K, 154R, 157D, 158V, 159H, 160I, 161A, 162G, 163K, 171G, 172D, 175K, 184I, 185G, 187R, 192E, 193I, 194D, 195P, 196I, 197N, 198A, 199L, 200Q, 202A, 203V, 204E, 205G, 207K, 208V, 209T, 210T, 213D, 226A, 227N, 228R, 229D, 230I, 240K, 241D, 242D, 253V, 270I, 271K, 276R, 300T, 303P, 305F, 306V, 309N, 334M, 340D, 341E, 344A, 345T, 348L, 351L, 352G, 354K, 355L, 356T, 358L, 361V, 362Q, 365Y, 366L
CDD
cd00401 (SAHH)

361V

homotetramer interface
14W, 17Q, 21L, 24N, 25E, 111H, 114Y, 115K, 131D, 133V, 137K, 138F, 142Y, 145R, 146E, 150D, 153K, 154R, 157D, 158V, 159H, 160I, 161A, 162G, 163K, 171G, 172D, 175K, 184I, 185G, 187R, 192E, 193I, 194D, 195P, 196I, 197N, 198A, 199L, 200Q, 202A, 203V, 204E, 205G, 207K, 208V, 209T, 210T, 213D, 226A, 227N, 228R, 229D, 230I, 240K, 241D, 242D, 253V, 270I, 271K, 276R, 300T, 303P, 305F, 306V, 309N, 334M, 340D, 341E, 344A, 345T, 348L, 351L, 352G, 354K, 355L, 356T, 358L, 361V, 362Q, 365Y, 366L
CDD
cd00401 (SAHH)

362Q

homotetramer interface
14W, 17Q, 21L, 24N, 25E, 111H, 114Y, 115K, 131D, 133V, 137K, 138F, 142Y, 145R, 146E, 150D, 153K, 154R, 157D, 158V, 159H, 160I, 161A, 162G, 163K, 171G, 172D, 175K, 184I, 185G, 187R, 192E, 193I, 194D, 195P, 196I, 197N, 198A, 199L, 200Q, 202A, 203V, 204E, 205G, 207K, 208V, 209T, 210T, 213D, 226A, 227N, 228R, 229D, 230I, 240K, 241D, 242D, 253V, 270I, 271K, 276R, 300T, 303P, 305F, 306V, 309N, 334M, 340D, 341E, 344A, 345T, 348L, 351L, 352G, 354K, 355L, 356T, 358L, 361V, 362Q, 365Y, 366L
CDD
cd00401 (SAHH)

365Y

homotetramer interface
14W, 17Q, 21L, 24N, 25E, 111H, 114Y, 115K, 131D, 133V, 137K, 138F, 142Y, 145R, 146E, 150D, 153K, 154R, 157D, 158V, 159H, 160I, 161A, 162G, 163K, 171G, 172D, 175K, 184I, 185G, 187R, 192E, 193I, 194D, 195P, 196I, 197N, 198A, 199L, 200Q, 202A, 203V, 204E, 205G, 207K, 208V, 209T, 210T, 213D, 226A, 227N, 228R, 229D, 230I, 240K, 241D, 242D, 253V, 270I, 271K, 276R, 300T, 303P, 305F, 306V, 309N, 334M, 340D, 341E, 344A, 345T, 348L, 351L, 352G, 354K, 355L, 356T, 358L, 361V, 362Q, 365Y, 366L
CDD
cd00401 (SAHH)

366L

homotetramer interface
14W, 17Q, 21L, 24N, 25E, 111H, 114Y, 115K, 131D, 133V, 137K, 138F, 142Y, 145R, 146E, 150D, 153K, 154R, 157D, 158V, 159H, 160I, 161A, 162G, 163K, 171G, 172D, 175K, 184I, 185G, 187R, 192E, 193I, 194D, 195P, 196I, 197N, 198A, 199L, 200Q, 202A, 203V, 204E, 205G, 207K, 208V, 209T, 210T, 213D, 226A, 227N, 228R, 229D, 230I, 240K, 241D, 242D, 253V, 270I, 271K, 276R, 300T, 303P, 305F, 306V, 309N, 334M, 340D, 341E, 344A, 345T, 348L, 351L, 352G, 354K, 355L, 356T, 358L, 361V, 362Q, 365Y, 366L
CDD
cd00401 (SAHH)
ligand binding sit...

80D

ligand binding site
80D, 105E, 106T, 135K, 139D, 296L, 301G, 302H, 307M, 311F
CDD
cd00401 (SAHH)

105E

ligand binding site
80D, 105E, 106T, 135K, 139D, 296L, 301G, 302H, 307M, 311F
CDD
cd00401 (SAHH)

106T

ligand binding site
80D, 105E, 106T, 135K, 139D, 296L, 301G, 302H, 307M, 311F
CDD
cd00401 (SAHH)

135K

ligand binding site
80D, 105E, 106T, 135K, 139D, 296L, 301G, 302H, 307M, 311F
CDD
cd00401 (SAHH)

139D

ligand binding site
80D, 105E, 106T, 135K, 139D, 296L, 301G, 302H, 307M, 311F
CDD
cd00401 (SAHH)

296L

ligand binding site
80D, 105E, 106T, 135K, 139D, 296L, 301G, 302H, 307M, 311F
CDD
cd00401 (SAHH)

301G

ligand binding site
80D, 105E, 106T, 135K, 139D, 296L, 301G, 302H, 307M, 311F
CDD
cd00401 (SAHH)

302H

ligand binding site
80D, 105E, 106T, 135K, 139D, 296L, 301G, 302H, 307M, 311F
CDD
cd00401 (SAHH)

307M

ligand binding site
80D, 105E, 106T, 135K, 139D, 296L, 301G, 302H, 307M, 311F
CDD
cd00401 (SAHH)

311F

ligand binding site
80D, 105E, 106T, 135K, 139D, 296L, 301G, 302H, 307M, 311F
CDD
cd00401 (SAHH)
NAD binding site c...

106T

NAD binding site
106T, 107T, 108T, 140N, 144C, 169G, 171G, 172D, 173V, 191T, 192E, 193I, 194D, 197N, 224T, 225T, 226A, 227N, 230I, 248I, 249G, 250H, 293L, 295N, 302H
CDD
cd00401 (SAHH)

107T

NAD binding site
106T, 107T, 108T, 140N, 144C, 169G, 171G, 172D, 173V, 191T, 192E, 193I, 194D, 197N, 224T, 225T, 226A, 227N, 230I, 248I, 249G, 250H, 293L, 295N, 302H
CDD
cd00401 (SAHH)

108T

NAD binding site
106T, 107T, 108T, 140N, 144C, 169G, 171G, 172D, 173V, 191T, 192E, 193I, 194D, 197N, 224T, 225T, 226A, 227N, 230I, 248I, 249G, 250H, 293L, 295N, 302H
CDD
cd00401 (SAHH)

140N

NAD binding site
106T, 107T, 108T, 140N, 144C, 169G, 171G, 172D, 173V, 191T, 192E, 193I, 194D, 197N, 224T, 225T, 226A, 227N, 230I, 248I, 249G, 250H, 293L, 295N, 302H
CDD
cd00401 (SAHH)

144C

NAD binding site
106T, 107T, 108T, 140N, 144C, 169G, 171G, 172D, 173V, 191T, 192E, 193I, 194D, 197N, 224T, 225T, 226A, 227N, 230I, 248I, 249G, 250H, 293L, 295N, 302H
CDD
cd00401 (SAHH)

169G

NAD binding site
106T, 107T, 108T, 140N, 144C, 169G, 171G, 172D, 173V, 191T, 192E, 193I, 194D, 197N, 224T, 225T, 226A, 227N, 230I, 248I, 249G, 250H, 293L, 295N, 302H
CDD
cd00401 (SAHH)

171G

NAD binding site
106T, 107T, 108T, 140N, 144C, 169G, 171G, 172D, 173V, 191T, 192E, 193I, 194D, 197N, 224T, 225T, 226A, 227N, 230I, 248I, 249G, 250H, 293L, 295N, 302H
CDD
cd00401 (SAHH)

172D

NAD binding site
106T, 107T, 108T, 140N, 144C, 169G, 171G, 172D, 173V, 191T, 192E, 193I, 194D, 197N, 224T, 225T, 226A, 227N, 230I, 248I, 249G, 250H, 293L, 295N, 302H
CDD
cd00401 (SAHH)

173V

NAD binding site
106T, 107T, 108T, 140N, 144C, 169G, 171G, 172D, 173V, 191T, 192E, 193I, 194D, 197N, 224T, 225T, 226A, 227N, 230I, 248I, 249G, 250H, 293L, 295N, 302H
CDD
cd00401 (SAHH)

191T

NAD binding site
106T, 107T, 108T, 140N, 144C, 169G, 171G, 172D, 173V, 191T, 192E, 193I, 194D, 197N, 224T, 225T, 226A, 227N, 230I, 248I, 249G, 250H, 293L, 295N, 302H
CDD
cd00401 (SAHH)

192E

NAD binding site
106T, 107T, 108T, 140N, 144C, 169G, 171G, 172D, 173V, 191T, 192E, 193I, 194D, 197N, 224T, 225T, 226A, 227N, 230I, 248I, 249G, 250H, 293L, 295N, 302H
CDD
cd00401 (SAHH)

193I

NAD binding site
106T, 107T, 108T, 140N, 144C, 169G, 171G, 172D, 173V, 191T, 192E, 193I, 194D, 197N, 224T, 225T, 226A, 227N, 230I, 248I, 249G, 250H, 293L, 295N, 302H
CDD
cd00401 (SAHH)

194D

NAD binding site
106T, 107T, 108T, 140N, 144C, 169G, 171G, 172D, 173V, 191T, 192E, 193I, 194D, 197N, 224T, 225T, 226A, 227N, 230I, 248I, 249G, 250H, 293L, 295N, 302H
CDD
cd00401 (SAHH)

197N

NAD binding site
106T, 107T, 108T, 140N, 144C, 169G, 171G, 172D, 173V, 191T, 192E, 193I, 194D, 197N, 224T, 225T, 226A, 227N, 230I, 248I, 249G, 250H, 293L, 295N, 302H
CDD
cd00401 (SAHH)

224T

NAD binding site
106T, 107T, 108T, 140N, 144C, 169G, 171G, 172D, 173V, 191T, 192E, 193I, 194D, 197N, 224T, 225T, 226A, 227N, 230I, 248I, 249G, 250H, 293L, 295N, 302H
CDD
cd00401 (SAHH)

225T

NAD binding site
106T, 107T, 108T, 140N, 144C, 169G, 171G, 172D, 173V, 191T, 192E, 193I, 194D, 197N, 224T, 225T, 226A, 227N, 230I, 248I, 249G, 250H, 293L, 295N, 302H
CDD
cd00401 (SAHH)

226A

NAD binding site
106T, 107T, 108T, 140N, 144C, 169G, 171G, 172D, 173V, 191T, 192E, 193I, 194D, 197N, 224T, 225T, 226A, 227N, 230I, 248I, 249G, 250H, 293L, 295N, 302H
CDD
cd00401 (SAHH)

227N

NAD binding site
106T, 107T, 108T, 140N, 144C, 169G, 171G, 172D, 173V, 191T, 192E, 193I, 194D, 197N, 224T, 225T, 226A, 227N, 230I, 248I, 249G, 250H, 293L, 295N, 302H
CDD
cd00401 (SAHH)

230I

NAD binding site
106T, 107T, 108T, 140N, 144C, 169G, 171G, 172D, 173V, 191T, 192E, 193I, 194D, 197N, 224T, 225T, 226A, 227N, 230I, 248I, 249G, 250H, 293L, 295N, 302H
CDD
cd00401 (SAHH)

248I

NAD binding site
106T, 107T, 108T, 140N, 144C, 169G, 171G, 172D, 173V, 191T, 192E, 193I, 194D, 197N, 224T, 225T, 226A, 227N, 230I, 248I, 249G, 250H, 293L, 295N, 302H
CDD
cd00401 (SAHH)

249G

NAD binding site
106T, 107T, 108T, 140N, 144C, 169G, 171G, 172D, 173V, 191T, 192E, 193I, 194D, 197N, 224T, 225T, 226A, 227N, 230I, 248I, 249G, 250H, 293L, 295N, 302H
CDD
cd00401 (SAHH)

250H

NAD binding site
106T, 107T, 108T, 140N, 144C, 169G, 171G, 172D, 173V, 191T, 192E, 193I, 194D, 197N, 224T, 225T, 226A, 227N, 230I, 248I, 249G, 250H, 293L, 295N, 302H
CDD
cd00401 (SAHH)

293L

NAD binding site
106T, 107T, 108T, 140N, 144C, 169G, 171G, 172D, 173V, 191T, 192E, 193I, 194D, 197N, 224T, 225T, 226A, 227N, 230I, 248I, 249G, 250H, 293L, 295N, 302H
CDD
cd00401 (SAHH)

295N

NAD binding site
106T, 107T, 108T, 140N, 144C, 169G, 171G, 172D, 173V, 191T, 192E, 193I, 194D, 197N, 224T, 225T, 226A, 227N, 230I, 248I, 249G, 250H, 293L, 295N, 302H
CDD
cd00401 (SAHH)

302H

NAD binding site
106T, 107T, 108T, 140N, 144C, 169G, 171G, 172D, 173V, 191T, 192E, 193I, 194D, 197N, 224T, 225T, 226A, 227N, 230I, 248I, 249G, 250H, 293L, 295N, 302H
CDD
cd00401 (SAHH)

GO term prediction

Biological Process

GO:0006730 one-carbon metabolic process

Molecular Function

GO:0004013 adenosylhomocysteinase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

GBC26350.1

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component