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Entry type
Status
Per-residue features
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Protein
GBC23673.1
Length
1,908 amino acids
Protein family membership
None predicted.
Domains and repeats
-
Domain79 - 321
- Endonuclease/exonuclease/phosphatase (IPR005135)
657 - 952- Reverse transcriptase domain (IPR000477)
1,418 - 1,572- Ribonuclease H-like domain (IPR012337)
- Ribonuclease H domain (IPR002156)
1
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800
1000
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1400
1600
1800
1908
Detailed signature matches
no IPR
Unintegrated signatures
-
SSF56672 (DNA/RNA p...)599 - 954
-
cd09276 (Rnase_HI_R...)1,423 - 1,568
-
mobidb-lite (disord...)22 - 61
Residue annotation
-
active site cd092761,427D1,476E1,498D1,564D
-
RNA/DNA hybrid bin...1,427DRNA/DNA hybrid binding site
1,427D, 1,428G, 1,429S, 1,433R, 1,465S, 1,466I, 1,467T, 1,476E, 1,498D, 1,550K, 1,568K
CDD
cd09276 (Rnase_HI_RT_non_LTR)1,428GRNA/DNA hybrid binding site
1,427D, 1,428G, 1,429S, 1,433R, 1,465S, 1,466I, 1,467T, 1,476E, 1,498D, 1,550K, 1,568K
CDD
cd09276 (Rnase_HI_RT_non_LTR)1,429SRNA/DNA hybrid binding site
1,427D, 1,428G, 1,429S, 1,433R, 1,465S, 1,466I, 1,467T, 1,476E, 1,498D, 1,550K, 1,568K
CDD
cd09276 (Rnase_HI_RT_non_LTR)1,433RRNA/DNA hybrid binding site
1,427D, 1,428G, 1,429S, 1,433R, 1,465S, 1,466I, 1,467T, 1,476E, 1,498D, 1,550K, 1,568K
CDD
cd09276 (Rnase_HI_RT_non_LTR)1,465SRNA/DNA hybrid binding site
1,427D, 1,428G, 1,429S, 1,433R, 1,465S, 1,466I, 1,467T, 1,476E, 1,498D, 1,550K, 1,568K
CDD
cd09276 (Rnase_HI_RT_non_LTR)1,466IRNA/DNA hybrid binding site
1,427D, 1,428G, 1,429S, 1,433R, 1,465S, 1,466I, 1,467T, 1,476E, 1,498D, 1,550K, 1,568K
CDD
cd09276 (Rnase_HI_RT_non_LTR)1,467TRNA/DNA hybrid binding site
1,427D, 1,428G, 1,429S, 1,433R, 1,465S, 1,466I, 1,467T, 1,476E, 1,498D, 1,550K, 1,568K
CDD
cd09276 (Rnase_HI_RT_non_LTR)1,476ERNA/DNA hybrid binding site
1,427D, 1,428G, 1,429S, 1,433R, 1,465S, 1,466I, 1,467T, 1,476E, 1,498D, 1,550K, 1,568K
CDD
cd09276 (Rnase_HI_RT_non_LTR)1,498DRNA/DNA hybrid binding site
1,427D, 1,428G, 1,429S, 1,433R, 1,465S, 1,466I, 1,467T, 1,476E, 1,498D, 1,550K, 1,568K
CDD
cd09276 (Rnase_HI_RT_non_LTR)1,550KRNA/DNA hybrid binding site
1,427D, 1,428G, 1,429S, 1,433R, 1,465S, 1,466I, 1,467T, 1,476E, 1,498D, 1,550K, 1,568K
CDD
cd09276 (Rnase_HI_RT_non_LTR)1,568KRNA/DNA hybrid binding site
1,427D, 1,428G, 1,429S, 1,433R, 1,465S, 1,466I, 1,467T, 1,476E, 1,498D, 1,550K, 1,568K
CDD
cd09276 (Rnase_HI_RT_non_LTR)
GO term prediction
Biological Process
None predicted.
Molecular Function
GO:0003676 nucleic acid binding
GO:0004523 RNA-DNA hybrid ribonuclease activity
Cellular Component
None predicted.