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Protein

GBC21039.1

Length

588 amino acids

Protein family membership

AICARFT/IMPCHase bienzyme (IPR002695)

Domains and repeats

Domain
4 - 194
Methylglyoxal synthase-like domain (IPR011607)
199 - 588
Cytidine deaminase-like (IPR016193)

1 100 200 300 400 500 588

Detailed signature matches

IPR002695

AICARFT/IMPCHase bienzyme

MF_00139 (PurH)

4 - 588

HAMAP
MF_00139 (PurH)
PF01808 (AICARFT_IM...)

135 - 457

Pfam
PF01808 (AICARFT_IMPCHas)
SM00798 (aicarft_im...)

135 - 458

SMART
SM00798 (aicarft_impchas)
PIRSF000414 (PurH)

1 - 588

PIRSF
PIRSF000414 (PurH)
TIGR00355

5 - 534

TIGRFAMs
TIGR00355 (TIGR00355)

IPR011607

Methylglyoxal synthase-like domain

PF02142 (MGS)

16 - 130

Pfam
PF02142 (MGS)
SSF52335 (Methylgly...)

4 - 194

SUPERFAMILY
SSF52335 (Methylglyoxal synthase-like)
SM00851 (MGS_2a)

16 - 130

SMART
SM00851 (MGS_2a)

IPR016193

Cytidine deaminase-like

SSF53927 (Cytidine ...)

199 - 588

SUPERFAMILY
SSF53927 (Cytidine deaminase-like)

no IPR

Unintegrated signatures

cd01421 (IMPCH)

5 - 190

CDD
cd01421 (IMPCH)

Residue annotation

purine monophospha...

12Y

purine monophosphate binding site
12Y, 14K, 34S, 37T, 66K, 67T, 102N, 125D
CDD
cd01421 (IMPCH)

14K

purine monophosphate binding site
12Y, 14K, 34S, 37T, 66K, 67T, 102N, 125D
CDD
cd01421 (IMPCH)

34S

purine monophosphate binding site
12Y, 14K, 34S, 37T, 66K, 67T, 102N, 125D
CDD
cd01421 (IMPCH)

37T

purine monophosphate binding site
12Y, 14K, 34S, 37T, 66K, 67T, 102N, 125D
CDD
cd01421 (IMPCH)

66K

purine monophosphate binding site
12Y, 14K, 34S, 37T, 66K, 67T, 102N, 125D
CDD
cd01421 (IMPCH)

67T

purine monophosphate binding site
12Y, 14K, 34S, 37T, 66K, 67T, 102N, 125D
CDD
cd01421 (IMPCH)

102N

purine monophosphate binding site
12Y, 14K, 34S, 37T, 66K, 67T, 102N, 125D
CDD
cd01421 (IMPCH)

125D

purine monophosphate binding site
12Y, 14K, 34S, 37T, 66K, 67T, 102N, 125D
CDD
cd01421 (IMPCH)
dimer interface cd...

57A

dimer interface
57A, 60I, 61L, 64R, 65V, 68L, 69H, 70P, 73H, 74G, 77L, 124I, 125D, 126I, 129V, 133R, 134A, 137K, 169N, 172A, 173L, 174K, 182Y, 183D, 184E, 186I, 187S, 190F
CDD
cd01421 (IMPCH)

60I

dimer interface
57A, 60I, 61L, 64R, 65V, 68L, 69H, 70P, 73H, 74G, 77L, 124I, 125D, 126I, 129V, 133R, 134A, 137K, 169N, 172A, 173L, 174K, 182Y, 183D, 184E, 186I, 187S, 190F
CDD
cd01421 (IMPCH)

61L

dimer interface
57A, 60I, 61L, 64R, 65V, 68L, 69H, 70P, 73H, 74G, 77L, 124I, 125D, 126I, 129V, 133R, 134A, 137K, 169N, 172A, 173L, 174K, 182Y, 183D, 184E, 186I, 187S, 190F
CDD
cd01421 (IMPCH)

64R

dimer interface
57A, 60I, 61L, 64R, 65V, 68L, 69H, 70P, 73H, 74G, 77L, 124I, 125D, 126I, 129V, 133R, 134A, 137K, 169N, 172A, 173L, 174K, 182Y, 183D, 184E, 186I, 187S, 190F
CDD
cd01421 (IMPCH)

65V

dimer interface
57A, 60I, 61L, 64R, 65V, 68L, 69H, 70P, 73H, 74G, 77L, 124I, 125D, 126I, 129V, 133R, 134A, 137K, 169N, 172A, 173L, 174K, 182Y, 183D, 184E, 186I, 187S, 190F
CDD
cd01421 (IMPCH)

68L

dimer interface
57A, 60I, 61L, 64R, 65V, 68L, 69H, 70P, 73H, 74G, 77L, 124I, 125D, 126I, 129V, 133R, 134A, 137K, 169N, 172A, 173L, 174K, 182Y, 183D, 184E, 186I, 187S, 190F
CDD
cd01421 (IMPCH)

69H

dimer interface
57A, 60I, 61L, 64R, 65V, 68L, 69H, 70P, 73H, 74G, 77L, 124I, 125D, 126I, 129V, 133R, 134A, 137K, 169N, 172A, 173L, 174K, 182Y, 183D, 184E, 186I, 187S, 190F
CDD
cd01421 (IMPCH)

70P

dimer interface
57A, 60I, 61L, 64R, 65V, 68L, 69H, 70P, 73H, 74G, 77L, 124I, 125D, 126I, 129V, 133R, 134A, 137K, 169N, 172A, 173L, 174K, 182Y, 183D, 184E, 186I, 187S, 190F
CDD
cd01421 (IMPCH)

73H

dimer interface
57A, 60I, 61L, 64R, 65V, 68L, 69H, 70P, 73H, 74G, 77L, 124I, 125D, 126I, 129V, 133R, 134A, 137K, 169N, 172A, 173L, 174K, 182Y, 183D, 184E, 186I, 187S, 190F
CDD
cd01421 (IMPCH)

74G

dimer interface
57A, 60I, 61L, 64R, 65V, 68L, 69H, 70P, 73H, 74G, 77L, 124I, 125D, 126I, 129V, 133R, 134A, 137K, 169N, 172A, 173L, 174K, 182Y, 183D, 184E, 186I, 187S, 190F
CDD
cd01421 (IMPCH)

77L

dimer interface
57A, 60I, 61L, 64R, 65V, 68L, 69H, 70P, 73H, 74G, 77L, 124I, 125D, 126I, 129V, 133R, 134A, 137K, 169N, 172A, 173L, 174K, 182Y, 183D, 184E, 186I, 187S, 190F
CDD
cd01421 (IMPCH)

124I

dimer interface
57A, 60I, 61L, 64R, 65V, 68L, 69H, 70P, 73H, 74G, 77L, 124I, 125D, 126I, 129V, 133R, 134A, 137K, 169N, 172A, 173L, 174K, 182Y, 183D, 184E, 186I, 187S, 190F
CDD
cd01421 (IMPCH)

125D

dimer interface
57A, 60I, 61L, 64R, 65V, 68L, 69H, 70P, 73H, 74G, 77L, 124I, 125D, 126I, 129V, 133R, 134A, 137K, 169N, 172A, 173L, 174K, 182Y, 183D, 184E, 186I, 187S, 190F
CDD
cd01421 (IMPCH)

126I

dimer interface
57A, 60I, 61L, 64R, 65V, 68L, 69H, 70P, 73H, 74G, 77L, 124I, 125D, 126I, 129V, 133R, 134A, 137K, 169N, 172A, 173L, 174K, 182Y, 183D, 184E, 186I, 187S, 190F
CDD
cd01421 (IMPCH)

129V

dimer interface
57A, 60I, 61L, 64R, 65V, 68L, 69H, 70P, 73H, 74G, 77L, 124I, 125D, 126I, 129V, 133R, 134A, 137K, 169N, 172A, 173L, 174K, 182Y, 183D, 184E, 186I, 187S, 190F
CDD
cd01421 (IMPCH)

133R

dimer interface
57A, 60I, 61L, 64R, 65V, 68L, 69H, 70P, 73H, 74G, 77L, 124I, 125D, 126I, 129V, 133R, 134A, 137K, 169N, 172A, 173L, 174K, 182Y, 183D, 184E, 186I, 187S, 190F
CDD
cd01421 (IMPCH)

134A

dimer interface
57A, 60I, 61L, 64R, 65V, 68L, 69H, 70P, 73H, 74G, 77L, 124I, 125D, 126I, 129V, 133R, 134A, 137K, 169N, 172A, 173L, 174K, 182Y, 183D, 184E, 186I, 187S, 190F
CDD
cd01421 (IMPCH)

137K

dimer interface
57A, 60I, 61L, 64R, 65V, 68L, 69H, 70P, 73H, 74G, 77L, 124I, 125D, 126I, 129V, 133R, 134A, 137K, 169N, 172A, 173L, 174K, 182Y, 183D, 184E, 186I, 187S, 190F
CDD
cd01421 (IMPCH)

169N

dimer interface
57A, 60I, 61L, 64R, 65V, 68L, 69H, 70P, 73H, 74G, 77L, 124I, 125D, 126I, 129V, 133R, 134A, 137K, 169N, 172A, 173L, 174K, 182Y, 183D, 184E, 186I, 187S, 190F
CDD
cd01421 (IMPCH)

172A

dimer interface
57A, 60I, 61L, 64R, 65V, 68L, 69H, 70P, 73H, 74G, 77L, 124I, 125D, 126I, 129V, 133R, 134A, 137K, 169N, 172A, 173L, 174K, 182Y, 183D, 184E, 186I, 187S, 190F
CDD
cd01421 (IMPCH)

173L

dimer interface
57A, 60I, 61L, 64R, 65V, 68L, 69H, 70P, 73H, 74G, 77L, 124I, 125D, 126I, 129V, 133R, 134A, 137K, 169N, 172A, 173L, 174K, 182Y, 183D, 184E, 186I, 187S, 190F
CDD
cd01421 (IMPCH)

174K

dimer interface
57A, 60I, 61L, 64R, 65V, 68L, 69H, 70P, 73H, 74G, 77L, 124I, 125D, 126I, 129V, 133R, 134A, 137K, 169N, 172A, 173L, 174K, 182Y, 183D, 184E, 186I, 187S, 190F
CDD
cd01421 (IMPCH)

182Y

dimer interface
57A, 60I, 61L, 64R, 65V, 68L, 69H, 70P, 73H, 74G, 77L, 124I, 125D, 126I, 129V, 133R, 134A, 137K, 169N, 172A, 173L, 174K, 182Y, 183D, 184E, 186I, 187S, 190F
CDD
cd01421 (IMPCH)

183D

dimer interface
57A, 60I, 61L, 64R, 65V, 68L, 69H, 70P, 73H, 74G, 77L, 124I, 125D, 126I, 129V, 133R, 134A, 137K, 169N, 172A, 173L, 174K, 182Y, 183D, 184E, 186I, 187S, 190F
CDD
cd01421 (IMPCH)

184E

dimer interface
57A, 60I, 61L, 64R, 65V, 68L, 69H, 70P, 73H, 74G, 77L, 124I, 125D, 126I, 129V, 133R, 134A, 137K, 169N, 172A, 173L, 174K, 182Y, 183D, 184E, 186I, 187S, 190F
CDD
cd01421 (IMPCH)

186I

dimer interface
57A, 60I, 61L, 64R, 65V, 68L, 69H, 70P, 73H, 74G, 77L, 124I, 125D, 126I, 129V, 133R, 134A, 137K, 169N, 172A, 173L, 174K, 182Y, 183D, 184E, 186I, 187S, 190F
CDD
cd01421 (IMPCH)

187S

dimer interface
57A, 60I, 61L, 64R, 65V, 68L, 69H, 70P, 73H, 74G, 77L, 124I, 125D, 126I, 129V, 133R, 134A, 137K, 169N, 172A, 173L, 174K, 182Y, 183D, 184E, 186I, 187S, 190F
CDD
cd01421 (IMPCH)

190F

dimer interface
57A, 60I, 61L, 64R, 65V, 68L, 69H, 70P, 73H, 74G, 77L, 124I, 125D, 126I, 129V, 133R, 134A, 137K, 169N, 172A, 173L, 174K, 182Y, 183D, 184E, 186I, 187S, 190F
CDD
cd01421 (IMPCH)
putative catalytic...

66K

putative catalytic residues
66K, 125D
CDD
cd01421 (IMPCH)

125D

putative catalytic residues
66K, 125D
CDD
cd01421 (IMPCH)

GO term prediction

Biological Process

GO:0006164 purine nucleotide biosynthetic process

Molecular Function

GO:0003824 catalytic activity
GO:0003937 IMP cyclohydrolase activity
GO:0004643 phosphoribosylaminoimidazolecarboxamide formyltransferase activity

Cellular Component

None predicted.