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Protein

GBC20949.1

Length

324 amino acids

Protein family membership

Geranylgeranyl transferase type-2 subunit beta (IPR026873)

Domains and repeats

Domain
8 - 315
Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid (IPR008930)
Repeat
60 - 98
PFTB repeat (IPR001330)
107 - 149
PFTB repeat (IPR001330)
155 - 197
PFTB repeat (IPR001330)
205 - 246
PFTB repeat (IPR001330)
251 - 295
PFTB repeat (IPR001330)

1 50 100 150 200 250 324

Detailed signature matches

IPR026873

Geranylgeranyl transferase type-2 subunit beta

cd02894 (GGTase-II)

10 - 294

CDD
cd02894 (GGTase-II)

IPR008930

Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid

SSF48239 (Terpenoid...)

8 - 315

SUPERFAMILY
SSF48239 (Terpenoid cyclases/Protein prenyltransferases)

IPR001330

PFTB repeat

PF00432 (Prenyltrans)

205 - 246

Pfam
PF00432 (Prenyltrans)

251 - 295

Pfam
PF00432 (Prenyltrans)

155 - 197

Pfam
PF00432 (Prenyltrans)

60 - 98

Pfam
PF00432 (Prenyltrans)

107 - 149

Pfam
PF00432 (Prenyltrans)

Residue annotation

active site cavity...

33L

active site cavity
33L, 36H, 37L, 40S, 44W, 86H, 88T, 89Y, 91L, 92Y, 137R, 140Y, 141C, 183H, 185G, 189C, 231D, 233C, 234Y, 237W, 273D, 282F, 283H
CDD
cd02894 (GGTase-II)

36H

active site cavity
33L, 36H, 37L, 40S, 44W, 86H, 88T, 89Y, 91L, 92Y, 137R, 140Y, 141C, 183H, 185G, 189C, 231D, 233C, 234Y, 237W, 273D, 282F, 283H
CDD
cd02894 (GGTase-II)

37L

active site cavity
33L, 36H, 37L, 40S, 44W, 86H, 88T, 89Y, 91L, 92Y, 137R, 140Y, 141C, 183H, 185G, 189C, 231D, 233C, 234Y, 237W, 273D, 282F, 283H
CDD
cd02894 (GGTase-II)

40S

active site cavity
33L, 36H, 37L, 40S, 44W, 86H, 88T, 89Y, 91L, 92Y, 137R, 140Y, 141C, 183H, 185G, 189C, 231D, 233C, 234Y, 237W, 273D, 282F, 283H
CDD
cd02894 (GGTase-II)

44W

active site cavity
33L, 36H, 37L, 40S, 44W, 86H, 88T, 89Y, 91L, 92Y, 137R, 140Y, 141C, 183H, 185G, 189C, 231D, 233C, 234Y, 237W, 273D, 282F, 283H
CDD
cd02894 (GGTase-II)

86H

active site cavity
33L, 36H, 37L, 40S, 44W, 86H, 88T, 89Y, 91L, 92Y, 137R, 140Y, 141C, 183H, 185G, 189C, 231D, 233C, 234Y, 237W, 273D, 282F, 283H
CDD
cd02894 (GGTase-II)

88T

active site cavity
33L, 36H, 37L, 40S, 44W, 86H, 88T, 89Y, 91L, 92Y, 137R, 140Y, 141C, 183H, 185G, 189C, 231D, 233C, 234Y, 237W, 273D, 282F, 283H
CDD
cd02894 (GGTase-II)

89Y

active site cavity
33L, 36H, 37L, 40S, 44W, 86H, 88T, 89Y, 91L, 92Y, 137R, 140Y, 141C, 183H, 185G, 189C, 231D, 233C, 234Y, 237W, 273D, 282F, 283H
CDD
cd02894 (GGTase-II)

91L

active site cavity
33L, 36H, 37L, 40S, 44W, 86H, 88T, 89Y, 91L, 92Y, 137R, 140Y, 141C, 183H, 185G, 189C, 231D, 233C, 234Y, 237W, 273D, 282F, 283H
CDD
cd02894 (GGTase-II)

92Y

active site cavity
33L, 36H, 37L, 40S, 44W, 86H, 88T, 89Y, 91L, 92Y, 137R, 140Y, 141C, 183H, 185G, 189C, 231D, 233C, 234Y, 237W, 273D, 282F, 283H
CDD
cd02894 (GGTase-II)

137R

active site cavity
33L, 36H, 37L, 40S, 44W, 86H, 88T, 89Y, 91L, 92Y, 137R, 140Y, 141C, 183H, 185G, 189C, 231D, 233C, 234Y, 237W, 273D, 282F, 283H
CDD
cd02894 (GGTase-II)

140Y

active site cavity
33L, 36H, 37L, 40S, 44W, 86H, 88T, 89Y, 91L, 92Y, 137R, 140Y, 141C, 183H, 185G, 189C, 231D, 233C, 234Y, 237W, 273D, 282F, 283H
CDD
cd02894 (GGTase-II)

141C

active site cavity
33L, 36H, 37L, 40S, 44W, 86H, 88T, 89Y, 91L, 92Y, 137R, 140Y, 141C, 183H, 185G, 189C, 231D, 233C, 234Y, 237W, 273D, 282F, 283H
CDD
cd02894 (GGTase-II)

183H

active site cavity
33L, 36H, 37L, 40S, 44W, 86H, 88T, 89Y, 91L, 92Y, 137R, 140Y, 141C, 183H, 185G, 189C, 231D, 233C, 234Y, 237W, 273D, 282F, 283H
CDD
cd02894 (GGTase-II)

185G

active site cavity
33L, 36H, 37L, 40S, 44W, 86H, 88T, 89Y, 91L, 92Y, 137R, 140Y, 141C, 183H, 185G, 189C, 231D, 233C, 234Y, 237W, 273D, 282F, 283H
CDD
cd02894 (GGTase-II)

189C

active site cavity
33L, 36H, 37L, 40S, 44W, 86H, 88T, 89Y, 91L, 92Y, 137R, 140Y, 141C, 183H, 185G, 189C, 231D, 233C, 234Y, 237W, 273D, 282F, 283H
CDD
cd02894 (GGTase-II)

231D

active site cavity
33L, 36H, 37L, 40S, 44W, 86H, 88T, 89Y, 91L, 92Y, 137R, 140Y, 141C, 183H, 185G, 189C, 231D, 233C, 234Y, 237W, 273D, 282F, 283H
CDD
cd02894 (GGTase-II)

233C

active site cavity
33L, 36H, 37L, 40S, 44W, 86H, 88T, 89Y, 91L, 92Y, 137R, 140Y, 141C, 183H, 185G, 189C, 231D, 233C, 234Y, 237W, 273D, 282F, 283H
CDD
cd02894 (GGTase-II)

234Y

active site cavity
33L, 36H, 37L, 40S, 44W, 86H, 88T, 89Y, 91L, 92Y, 137R, 140Y, 141C, 183H, 185G, 189C, 231D, 233C, 234Y, 237W, 273D, 282F, 283H
CDD
cd02894 (GGTase-II)

237W

active site cavity
33L, 36H, 37L, 40S, 44W, 86H, 88T, 89Y, 91L, 92Y, 137R, 140Y, 141C, 183H, 185G, 189C, 231D, 233C, 234Y, 237W, 273D, 282F, 283H
CDD
cd02894 (GGTase-II)

273D

active site cavity
33L, 36H, 37L, 40S, 44W, 86H, 88T, 89Y, 91L, 92Y, 137R, 140Y, 141C, 183H, 185G, 189C, 231D, 233C, 234Y, 237W, 273D, 282F, 283H
CDD
cd02894 (GGTase-II)

282F

active site cavity
33L, 36H, 37L, 40S, 44W, 86H, 88T, 89Y, 91L, 92Y, 137R, 140Y, 141C, 183H, 185G, 189C, 231D, 233C, 234Y, 237W, 273D, 282F, 283H
CDD
cd02894 (GGTase-II)

283H

active site cavity
33L, 36H, 37L, 40S, 44W, 86H, 88T, 89Y, 91L, 92Y, 137R, 140Y, 141C, 183H, 185G, 189C, 231D, 233C, 234Y, 237W, 273D, 282F, 283H
CDD
cd02894 (GGTase-II)
peptide binding po...

36H

peptide binding pocket
36H, 37L, 40S, 88T, 89Y, 137R, 231D, 273D
CDD
cd02894 (GGTase-II)

37L

peptide binding pocket
36H, 37L, 40S, 88T, 89Y, 137R, 231D, 273D
CDD
cd02894 (GGTase-II)

40S

peptide binding pocket
36H, 37L, 40S, 88T, 89Y, 137R, 231D, 273D
CDD
cd02894 (GGTase-II)

88T

peptide binding pocket
36H, 37L, 40S, 88T, 89Y, 137R, 231D, 273D
CDD
cd02894 (GGTase-II)

89Y

peptide binding pocket
36H, 37L, 40S, 88T, 89Y, 137R, 231D, 273D
CDD
cd02894 (GGTase-II)

137R

peptide binding pocket
36H, 37L, 40S, 88T, 89Y, 137R, 231D, 273D
CDD
cd02894 (GGTase-II)

231D

peptide binding pocket
36H, 37L, 40S, 88T, 89Y, 137R, 231D, 273D
CDD
cd02894 (GGTase-II)

273D

peptide binding pocket
36H, 37L, 40S, 88T, 89Y, 137R, 231D, 273D
CDD
cd02894 (GGTase-II)
lipid binding pock...

40S

lipid binding pocket
40S, 43Y, 137R, 140Y, 183H, 185G, 189C, 225R, 228K, 234Y, 237W, 282F
CDD
cd02894 (GGTase-II)

43Y

lipid binding pocket
40S, 43Y, 137R, 140Y, 183H, 185G, 189C, 225R, 228K, 234Y, 237W, 282F
CDD
cd02894 (GGTase-II)

137R

lipid binding pocket
40S, 43Y, 137R, 140Y, 183H, 185G, 189C, 225R, 228K, 234Y, 237W, 282F
CDD
cd02894 (GGTase-II)

140Y

lipid binding pocket
40S, 43Y, 137R, 140Y, 183H, 185G, 189C, 225R, 228K, 234Y, 237W, 282F
CDD
cd02894 (GGTase-II)

183H

lipid binding pocket
40S, 43Y, 137R, 140Y, 183H, 185G, 189C, 225R, 228K, 234Y, 237W, 282F
CDD
cd02894 (GGTase-II)

185G

lipid binding pocket
40S, 43Y, 137R, 140Y, 183H, 185G, 189C, 225R, 228K, 234Y, 237W, 282F
CDD
cd02894 (GGTase-II)

189C

lipid binding pocket
40S, 43Y, 137R, 140Y, 183H, 185G, 189C, 225R, 228K, 234Y, 237W, 282F
CDD
cd02894 (GGTase-II)

225R

lipid binding pocket
40S, 43Y, 137R, 140Y, 183H, 185G, 189C, 225R, 228K, 234Y, 237W, 282F
CDD
cd02894 (GGTase-II)

228K

lipid binding pocket
40S, 43Y, 137R, 140Y, 183H, 185G, 189C, 225R, 228K, 234Y, 237W, 282F
CDD
cd02894 (GGTase-II)

234Y

lipid binding pocket
40S, 43Y, 137R, 140Y, 183H, 185G, 189C, 225R, 228K, 234Y, 237W, 282F
CDD
cd02894 (GGTase-II)

237W

lipid binding pocket
40S, 43Y, 137R, 140Y, 183H, 185G, 189C, 225R, 228K, 234Y, 237W, 282F
CDD
cd02894 (GGTase-II)

282F

lipid binding pocket
40S, 43Y, 137R, 140Y, 183H, 185G, 189C, 225R, 228K, 234Y, 237W, 282F
CDD
cd02894 (GGTase-II)
heterodimer interf...

132G

heterodimer interface
132G, 170F, 180A, 181E, 186Q, 210W, 213C, 215R, 216Q, 225R, 226P, 227E
CDD
cd02894 (GGTase-II)

170F

heterodimer interface
132G, 170F, 180A, 181E, 186Q, 210W, 213C, 215R, 216Q, 225R, 226P, 227E
CDD
cd02894 (GGTase-II)

180A

heterodimer interface
132G, 170F, 180A, 181E, 186Q, 210W, 213C, 215R, 216Q, 225R, 226P, 227E
CDD
cd02894 (GGTase-II)

181E

heterodimer interface
132G, 170F, 180A, 181E, 186Q, 210W, 213C, 215R, 216Q, 225R, 226P, 227E
CDD
cd02894 (GGTase-II)

186Q

heterodimer interface
132G, 170F, 180A, 181E, 186Q, 210W, 213C, 215R, 216Q, 225R, 226P, 227E
CDD
cd02894 (GGTase-II)

210W

heterodimer interface
132G, 170F, 180A, 181E, 186Q, 210W, 213C, 215R, 216Q, 225R, 226P, 227E
CDD
cd02894 (GGTase-II)

213C

heterodimer interface
132G, 170F, 180A, 181E, 186Q, 210W, 213C, 215R, 216Q, 225R, 226P, 227E
CDD
cd02894 (GGTase-II)

215R

heterodimer interface
132G, 170F, 180A, 181E, 186Q, 210W, 213C, 215R, 216Q, 225R, 226P, 227E
CDD
cd02894 (GGTase-II)

216Q

heterodimer interface
132G, 170F, 180A, 181E, 186Q, 210W, 213C, 215R, 216Q, 225R, 226P, 227E
CDD
cd02894 (GGTase-II)

225R

heterodimer interface
132G, 170F, 180A, 181E, 186Q, 210W, 213C, 215R, 216Q, 225R, 226P, 227E
CDD
cd02894 (GGTase-II)

226P

heterodimer interface
132G, 170F, 180A, 181E, 186Q, 210W, 213C, 215R, 216Q, 225R, 226P, 227E
CDD
cd02894 (GGTase-II)

227E

heterodimer interface
132G, 170F, 180A, 181E, 186Q, 210W, 213C, 215R, 216Q, 225R, 226P, 227E
CDD
cd02894 (GGTase-II)
Zn2+ binding site ...

231D

Zn2+ binding site
231D, 233C, 283H
CDD
cd02894 (GGTase-II)

233C

Zn2+ binding site
231D, 233C, 283H
CDD
cd02894 (GGTase-II)

283H

Zn2+ binding site
231D, 233C, 283H
CDD
cd02894 (GGTase-II)

GO term prediction

Biological Process

GO:0018344 protein geranylgeranylation

Molecular Function

GO:0003824 catalytic activity
GO:0004663 Rab geranylgeranyltransferase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

GBC20949.1

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component