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Protein

GBC19890.1

Length

416 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
15 - 344
Protein kinase-like domain (IPR011009)
Protein kinase domain (IPR000719)

1 50 100 150 200 250 300 350 416

Detailed signature matches

IPR011009

Protein kinase-like domain

SSF56112 (Protein k...)

15 - 344

SUPERFAMILY
SSF56112 (Protein kinase-like (PK-like))

IPR000719

Protein kinase domain

SM00220 (serkin_6)

20 - 338

SMART
SM00220 (serkin_6)
PS50011 (PROTEIN_KI...)

20 - 338

PROSITE profiles
PS50011 (PROTEIN_KINASE_DOM)
PF00069 (Pkinase)

20 - 338

Pfam
PF00069 (Pkinase)

IPR008271

Serine/threonine-protein kinase, active site

PS00108 (PROTEIN_KI...)

156 - 168

PROSITE patterns
PS00108 (PROTEIN_KINASE_ST)

no IPR

Unintegrated signatures

cd07842 (STKc_CDK8_...)

19 - 338

CDD
cd07842 (STKc_CDK8_like)
mobidb-lite (disord...)

362 - 416

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

ATP binding site c...

26I

ATP binding site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 94I, 110F, 111E, 112Y, 113A, 116D, 119Q, 164A, 165N, 167L, 178D
CDD
cd07842 (STKc_CDK8_like)

27S

ATP binding site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 94I, 110F, 111E, 112Y, 113A, 116D, 119Q, 164A, 165N, 167L, 178D
CDD
cd07842 (STKc_CDK8_like)

28S

ATP binding site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 94I, 110F, 111E, 112Y, 113A, 116D, 119Q, 164A, 165N, 167L, 178D
CDD
cd07842 (STKc_CDK8_like)

29G

ATP binding site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 94I, 110F, 111E, 112Y, 113A, 116D, 119Q, 164A, 165N, 167L, 178D
CDD
cd07842 (STKc_CDK8_like)

34V

ATP binding site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 94I, 110F, 111E, 112Y, 113A, 116D, 119Q, 164A, 165N, 167L, 178D
CDD
cd07842 (STKc_CDK8_like)

56A

ATP binding site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 94I, 110F, 111E, 112Y, 113A, 116D, 119Q, 164A, 165N, 167L, 178D
CDD
cd07842 (STKc_CDK8_like)

58K

ATP binding site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 94I, 110F, 111E, 112Y, 113A, 116D, 119Q, 164A, 165N, 167L, 178D
CDD
cd07842 (STKc_CDK8_like)

94I

ATP binding site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 94I, 110F, 111E, 112Y, 113A, 116D, 119Q, 164A, 165N, 167L, 178D
CDD
cd07842 (STKc_CDK8_like)

110F

ATP binding site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 94I, 110F, 111E, 112Y, 113A, 116D, 119Q, 164A, 165N, 167L, 178D
CDD
cd07842 (STKc_CDK8_like)

111E

ATP binding site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 94I, 110F, 111E, 112Y, 113A, 116D, 119Q, 164A, 165N, 167L, 178D
CDD
cd07842 (STKc_CDK8_like)

112Y

ATP binding site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 94I, 110F, 111E, 112Y, 113A, 116D, 119Q, 164A, 165N, 167L, 178D
CDD
cd07842 (STKc_CDK8_like)

113A

ATP binding site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 94I, 110F, 111E, 112Y, 113A, 116D, 119Q, 164A, 165N, 167L, 178D
CDD
cd07842 (STKc_CDK8_like)

116D

ATP binding site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 94I, 110F, 111E, 112Y, 113A, 116D, 119Q, 164A, 165N, 167L, 178D
CDD
cd07842 (STKc_CDK8_like)

119Q

ATP binding site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 94I, 110F, 111E, 112Y, 113A, 116D, 119Q, 164A, 165N, 167L, 178D
CDD
cd07842 (STKc_CDK8_like)

164A

ATP binding site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 94I, 110F, 111E, 112Y, 113A, 116D, 119Q, 164A, 165N, 167L, 178D
CDD
cd07842 (STKc_CDK8_like)

165N

ATP binding site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 94I, 110F, 111E, 112Y, 113A, 116D, 119Q, 164A, 165N, 167L, 178D
CDD
cd07842 (STKc_CDK8_like)

167L

ATP binding site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 94I, 110F, 111E, 112Y, 113A, 116D, 119Q, 164A, 165N, 167L, 178D
CDD
cd07842 (STKc_CDK8_like)

178D

ATP binding site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 94I, 110F, 111E, 112Y, 113A, 116D, 119Q, 164A, 165N, 167L, 178D
CDD
cd07842 (STKc_CDK8_like)
active site cd07842

26I

active site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 80R, 94I, 110F, 111E, 112Y, 113A, 116D, 118L, 119Q, 160D, 162K, 164A, 165N, 167L, 178D, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

27S

active site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 80R, 94I, 110F, 111E, 112Y, 113A, 116D, 118L, 119Q, 160D, 162K, 164A, 165N, 167L, 178D, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

28S

active site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 80R, 94I, 110F, 111E, 112Y, 113A, 116D, 118L, 119Q, 160D, 162K, 164A, 165N, 167L, 178D, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

29G

active site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 80R, 94I, 110F, 111E, 112Y, 113A, 116D, 118L, 119Q, 160D, 162K, 164A, 165N, 167L, 178D, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

34V

active site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 80R, 94I, 110F, 111E, 112Y, 113A, 116D, 118L, 119Q, 160D, 162K, 164A, 165N, 167L, 178D, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

56A

active site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 80R, 94I, 110F, 111E, 112Y, 113A, 116D, 118L, 119Q, 160D, 162K, 164A, 165N, 167L, 178D, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

58K

active site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 80R, 94I, 110F, 111E, 112Y, 113A, 116D, 118L, 119Q, 160D, 162K, 164A, 165N, 167L, 178D, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

80R

active site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 80R, 94I, 110F, 111E, 112Y, 113A, 116D, 118L, 119Q, 160D, 162K, 164A, 165N, 167L, 178D, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

94I

active site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 80R, 94I, 110F, 111E, 112Y, 113A, 116D, 118L, 119Q, 160D, 162K, 164A, 165N, 167L, 178D, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

110F

active site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 80R, 94I, 110F, 111E, 112Y, 113A, 116D, 118L, 119Q, 160D, 162K, 164A, 165N, 167L, 178D, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

111E

active site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 80R, 94I, 110F, 111E, 112Y, 113A, 116D, 118L, 119Q, 160D, 162K, 164A, 165N, 167L, 178D, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

112Y

active site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 80R, 94I, 110F, 111E, 112Y, 113A, 116D, 118L, 119Q, 160D, 162K, 164A, 165N, 167L, 178D, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

113A

active site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 80R, 94I, 110F, 111E, 112Y, 113A, 116D, 118L, 119Q, 160D, 162K, 164A, 165N, 167L, 178D, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

116D

active site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 80R, 94I, 110F, 111E, 112Y, 113A, 116D, 118L, 119Q, 160D, 162K, 164A, 165N, 167L, 178D, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

118L

active site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 80R, 94I, 110F, 111E, 112Y, 113A, 116D, 118L, 119Q, 160D, 162K, 164A, 165N, 167L, 178D, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

119Q

active site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 80R, 94I, 110F, 111E, 112Y, 113A, 116D, 118L, 119Q, 160D, 162K, 164A, 165N, 167L, 178D, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

160D

active site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 80R, 94I, 110F, 111E, 112Y, 113A, 116D, 118L, 119Q, 160D, 162K, 164A, 165N, 167L, 178D, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

162K

active site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 80R, 94I, 110F, 111E, 112Y, 113A, 116D, 118L, 119Q, 160D, 162K, 164A, 165N, 167L, 178D, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

164A

active site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 80R, 94I, 110F, 111E, 112Y, 113A, 116D, 118L, 119Q, 160D, 162K, 164A, 165N, 167L, 178D, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

165N

active site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 80R, 94I, 110F, 111E, 112Y, 113A, 116D, 118L, 119Q, 160D, 162K, 164A, 165N, 167L, 178D, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

167L

active site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 80R, 94I, 110F, 111E, 112Y, 113A, 116D, 118L, 119Q, 160D, 162K, 164A, 165N, 167L, 178D, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

178D

active site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 80R, 94I, 110F, 111E, 112Y, 113A, 116D, 118L, 119Q, 160D, 162K, 164A, 165N, 167L, 178D, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

181L

active site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 80R, 94I, 110F, 111E, 112Y, 113A, 116D, 118L, 119Q, 160D, 162K, 164A, 165N, 167L, 178D, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

196D

active site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 80R, 94I, 110F, 111E, 112Y, 113A, 116D, 118L, 119Q, 160D, 162K, 164A, 165N, 167L, 178D, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

198V

active site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 80R, 94I, 110F, 111E, 112Y, 113A, 116D, 118L, 119Q, 160D, 162K, 164A, 165N, 167L, 178D, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

199V

active site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 80R, 94I, 110F, 111E, 112Y, 113A, 116D, 118L, 119Q, 160D, 162K, 164A, 165N, 167L, 178D, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

200V

active site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 80R, 94I, 110F, 111E, 112Y, 113A, 116D, 118L, 119Q, 160D, 162K, 164A, 165N, 167L, 178D, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

201T

active site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 80R, 94I, 110F, 111E, 112Y, 113A, 116D, 118L, 119Q, 160D, 162K, 164A, 165N, 167L, 178D, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

203W

active site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 80R, 94I, 110F, 111E, 112Y, 113A, 116D, 118L, 119Q, 160D, 162K, 164A, 165N, 167L, 178D, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

241G

active site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 80R, 94I, 110F, 111E, 112Y, 113A, 116D, 118L, 119Q, 160D, 162K, 164A, 165N, 167L, 178D, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

242E

active site
26I, 27S, 28S, 29G, 34V, 56A, 58K, 80R, 94I, 110F, 111E, 112Y, 113A, 116D, 118L, 119Q, 160D, 162K, 164A, 165N, 167L, 178D, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)
CDK/cyclin interfa...

73G

CDK/cyclin interface
73G, 74I, 76Q, 79C, 80R, 82I, 83S, 84L, 86R, 87E, 88L, 99V, 101L, 104N, 105S, 106I, 154N, 155W, 156V
CDD
cd07842 (STKc_CDK8_like)

74I

CDK/cyclin interface
73G, 74I, 76Q, 79C, 80R, 82I, 83S, 84L, 86R, 87E, 88L, 99V, 101L, 104N, 105S, 106I, 154N, 155W, 156V
CDD
cd07842 (STKc_CDK8_like)

76Q

CDK/cyclin interface
73G, 74I, 76Q, 79C, 80R, 82I, 83S, 84L, 86R, 87E, 88L, 99V, 101L, 104N, 105S, 106I, 154N, 155W, 156V
CDD
cd07842 (STKc_CDK8_like)

79C

CDK/cyclin interface
73G, 74I, 76Q, 79C, 80R, 82I, 83S, 84L, 86R, 87E, 88L, 99V, 101L, 104N, 105S, 106I, 154N, 155W, 156V
CDD
cd07842 (STKc_CDK8_like)

80R

CDK/cyclin interface
73G, 74I, 76Q, 79C, 80R, 82I, 83S, 84L, 86R, 87E, 88L, 99V, 101L, 104N, 105S, 106I, 154N, 155W, 156V
CDD
cd07842 (STKc_CDK8_like)

82I

CDK/cyclin interface
73G, 74I, 76Q, 79C, 80R, 82I, 83S, 84L, 86R, 87E, 88L, 99V, 101L, 104N, 105S, 106I, 154N, 155W, 156V
CDD
cd07842 (STKc_CDK8_like)

83S

CDK/cyclin interface
73G, 74I, 76Q, 79C, 80R, 82I, 83S, 84L, 86R, 87E, 88L, 99V, 101L, 104N, 105S, 106I, 154N, 155W, 156V
CDD
cd07842 (STKc_CDK8_like)

84L

CDK/cyclin interface
73G, 74I, 76Q, 79C, 80R, 82I, 83S, 84L, 86R, 87E, 88L, 99V, 101L, 104N, 105S, 106I, 154N, 155W, 156V
CDD
cd07842 (STKc_CDK8_like)

86R

CDK/cyclin interface
73G, 74I, 76Q, 79C, 80R, 82I, 83S, 84L, 86R, 87E, 88L, 99V, 101L, 104N, 105S, 106I, 154N, 155W, 156V
CDD
cd07842 (STKc_CDK8_like)

87E

CDK/cyclin interface
73G, 74I, 76Q, 79C, 80R, 82I, 83S, 84L, 86R, 87E, 88L, 99V, 101L, 104N, 105S, 106I, 154N, 155W, 156V
CDD
cd07842 (STKc_CDK8_like)

88L

CDK/cyclin interface
73G, 74I, 76Q, 79C, 80R, 82I, 83S, 84L, 86R, 87E, 88L, 99V, 101L, 104N, 105S, 106I, 154N, 155W, 156V
CDD
cd07842 (STKc_CDK8_like)

99V

CDK/cyclin interface
73G, 74I, 76Q, 79C, 80R, 82I, 83S, 84L, 86R, 87E, 88L, 99V, 101L, 104N, 105S, 106I, 154N, 155W, 156V
CDD
cd07842 (STKc_CDK8_like)

101L

CDK/cyclin interface
73G, 74I, 76Q, 79C, 80R, 82I, 83S, 84L, 86R, 87E, 88L, 99V, 101L, 104N, 105S, 106I, 154N, 155W, 156V
CDD
cd07842 (STKc_CDK8_like)

104N

CDK/cyclin interface
73G, 74I, 76Q, 79C, 80R, 82I, 83S, 84L, 86R, 87E, 88L, 99V, 101L, 104N, 105S, 106I, 154N, 155W, 156V
CDD
cd07842 (STKc_CDK8_like)

105S

CDK/cyclin interface
73G, 74I, 76Q, 79C, 80R, 82I, 83S, 84L, 86R, 87E, 88L, 99V, 101L, 104N, 105S, 106I, 154N, 155W, 156V
CDD
cd07842 (STKc_CDK8_like)

106I

CDK/cyclin interface
73G, 74I, 76Q, 79C, 80R, 82I, 83S, 84L, 86R, 87E, 88L, 99V, 101L, 104N, 105S, 106I, 154N, 155W, 156V
CDD
cd07842 (STKc_CDK8_like)

154N

CDK/cyclin interface
73G, 74I, 76Q, 79C, 80R, 82I, 83S, 84L, 86R, 87E, 88L, 99V, 101L, 104N, 105S, 106I, 154N, 155W, 156V
CDD
cd07842 (STKc_CDK8_like)

155W

CDK/cyclin interface
73G, 74I, 76Q, 79C, 80R, 82I, 83S, 84L, 86R, 87E, 88L, 99V, 101L, 104N, 105S, 106I, 154N, 155W, 156V
CDD
cd07842 (STKc_CDK8_like)

156V

CDK/cyclin interface
73G, 74I, 76Q, 79C, 80R, 82I, 83S, 84L, 86R, 87E, 88L, 99V, 101L, 104N, 105S, 106I, 154N, 155W, 156V
CDD
cd07842 (STKc_CDK8_like)
polypeptide substr...

80R

polypeptide substrate binding site
80R, 118L, 160D, 162K, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

118L

polypeptide substrate binding site
80R, 118L, 160D, 162K, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

160D

polypeptide substrate binding site
80R, 118L, 160D, 162K, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

162K

polypeptide substrate binding site
80R, 118L, 160D, 162K, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

181L

polypeptide substrate binding site
80R, 118L, 160D, 162K, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

196D

polypeptide substrate binding site
80R, 118L, 160D, 162K, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

198V

polypeptide substrate binding site
80R, 118L, 160D, 162K, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

199V

polypeptide substrate binding site
80R, 118L, 160D, 162K, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

200V

polypeptide substrate binding site
80R, 118L, 160D, 162K, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

201T

polypeptide substrate binding site
80R, 118L, 160D, 162K, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

203W

polypeptide substrate binding site
80R, 118L, 160D, 162K, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

241G

polypeptide substrate binding site
80R, 118L, 160D, 162K, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)

242E

polypeptide substrate binding site
80R, 118L, 160D, 162K, 181L, 196D, 198V, 199V, 200V, 201T, 203W, 241G, 242E
CDD
cd07842 (STKc_CDK8_like)
activation loop (A...

177G

activation loop (A-loop)
177G, 178D, 179L, 180G, 181L, 182A, 183R, 184I, 185Y, 186E, 187R, 188P, 189L, 190Q, 192L, 193F, 194N, 195G, 196D, 197K, 198V, 199V, 200V, 201T, 202I, 203W
CDD
cd07842 (STKc_CDK8_like)

178D

activation loop (A-loop)
177G, 178D, 179L, 180G, 181L, 182A, 183R, 184I, 185Y, 186E, 187R, 188P, 189L, 190Q, 192L, 193F, 194N, 195G, 196D, 197K, 198V, 199V, 200V, 201T, 202I, 203W
CDD
cd07842 (STKc_CDK8_like)

179L

activation loop (A-loop)
177G, 178D, 179L, 180G, 181L, 182A, 183R, 184I, 185Y, 186E, 187R, 188P, 189L, 190Q, 192L, 193F, 194N, 195G, 196D, 197K, 198V, 199V, 200V, 201T, 202I, 203W
CDD
cd07842 (STKc_CDK8_like)

180G

activation loop (A-loop)
177G, 178D, 179L, 180G, 181L, 182A, 183R, 184I, 185Y, 186E, 187R, 188P, 189L, 190Q, 192L, 193F, 194N, 195G, 196D, 197K, 198V, 199V, 200V, 201T, 202I, 203W
CDD
cd07842 (STKc_CDK8_like)

181L

activation loop (A-loop)
177G, 178D, 179L, 180G, 181L, 182A, 183R, 184I, 185Y, 186E, 187R, 188P, 189L, 190Q, 192L, 193F, 194N, 195G, 196D, 197K, 198V, 199V, 200V, 201T, 202I, 203W
CDD
cd07842 (STKc_CDK8_like)

182A

activation loop (A-loop)
177G, 178D, 179L, 180G, 181L, 182A, 183R, 184I, 185Y, 186E, 187R, 188P, 189L, 190Q, 192L, 193F, 194N, 195G, 196D, 197K, 198V, 199V, 200V, 201T, 202I, 203W
CDD
cd07842 (STKc_CDK8_like)

183R

activation loop (A-loop)
177G, 178D, 179L, 180G, 181L, 182A, 183R, 184I, 185Y, 186E, 187R, 188P, 189L, 190Q, 192L, 193F, 194N, 195G, 196D, 197K, 198V, 199V, 200V, 201T, 202I, 203W
CDD
cd07842 (STKc_CDK8_like)

184I

activation loop (A-loop)
177G, 178D, 179L, 180G, 181L, 182A, 183R, 184I, 185Y, 186E, 187R, 188P, 189L, 190Q, 192L, 193F, 194N, 195G, 196D, 197K, 198V, 199V, 200V, 201T, 202I, 203W
CDD
cd07842 (STKc_CDK8_like)

185Y

activation loop (A-loop)
177G, 178D, 179L, 180G, 181L, 182A, 183R, 184I, 185Y, 186E, 187R, 188P, 189L, 190Q, 192L, 193F, 194N, 195G, 196D, 197K, 198V, 199V, 200V, 201T, 202I, 203W
CDD
cd07842 (STKc_CDK8_like)

186E

activation loop (A-loop)
177G, 178D, 179L, 180G, 181L, 182A, 183R, 184I, 185Y, 186E, 187R, 188P, 189L, 190Q, 192L, 193F, 194N, 195G, 196D, 197K, 198V, 199V, 200V, 201T, 202I, 203W
CDD
cd07842 (STKc_CDK8_like)

187R

activation loop (A-loop)
177G, 178D, 179L, 180G, 181L, 182A, 183R, 184I, 185Y, 186E, 187R, 188P, 189L, 190Q, 192L, 193F, 194N, 195G, 196D, 197K, 198V, 199V, 200V, 201T, 202I, 203W
CDD
cd07842 (STKc_CDK8_like)

188P

activation loop (A-loop)
177G, 178D, 179L, 180G, 181L, 182A, 183R, 184I, 185Y, 186E, 187R, 188P, 189L, 190Q, 192L, 193F, 194N, 195G, 196D, 197K, 198V, 199V, 200V, 201T, 202I, 203W
CDD
cd07842 (STKc_CDK8_like)

189L

activation loop (A-loop)
177G, 178D, 179L, 180G, 181L, 182A, 183R, 184I, 185Y, 186E, 187R, 188P, 189L, 190Q, 192L, 193F, 194N, 195G, 196D, 197K, 198V, 199V, 200V, 201T, 202I, 203W
CDD
cd07842 (STKc_CDK8_like)

190Q

activation loop (A-loop)
177G, 178D, 179L, 180G, 181L, 182A, 183R, 184I, 185Y, 186E, 187R, 188P, 189L, 190Q, 192L, 193F, 194N, 195G, 196D, 197K, 198V, 199V, 200V, 201T, 202I, 203W
CDD
cd07842 (STKc_CDK8_like)

192L

activation loop (A-loop)
177G, 178D, 179L, 180G, 181L, 182A, 183R, 184I, 185Y, 186E, 187R, 188P, 189L, 190Q, 192L, 193F, 194N, 195G, 196D, 197K, 198V, 199V, 200V, 201T, 202I, 203W
CDD
cd07842 (STKc_CDK8_like)

193F

activation loop (A-loop)
177G, 178D, 179L, 180G, 181L, 182A, 183R, 184I, 185Y, 186E, 187R, 188P, 189L, 190Q, 192L, 193F, 194N, 195G, 196D, 197K, 198V, 199V, 200V, 201T, 202I, 203W
CDD
cd07842 (STKc_CDK8_like)

194N

activation loop (A-loop)
177G, 178D, 179L, 180G, 181L, 182A, 183R, 184I, 185Y, 186E, 187R, 188P, 189L, 190Q, 192L, 193F, 194N, 195G, 196D, 197K, 198V, 199V, 200V, 201T, 202I, 203W
CDD
cd07842 (STKc_CDK8_like)

195G

activation loop (A-loop)
177G, 178D, 179L, 180G, 181L, 182A, 183R, 184I, 185Y, 186E, 187R, 188P, 189L, 190Q, 192L, 193F, 194N, 195G, 196D, 197K, 198V, 199V, 200V, 201T, 202I, 203W
CDD
cd07842 (STKc_CDK8_like)

196D

activation loop (A-loop)
177G, 178D, 179L, 180G, 181L, 182A, 183R, 184I, 185Y, 186E, 187R, 188P, 189L, 190Q, 192L, 193F, 194N, 195G, 196D, 197K, 198V, 199V, 200V, 201T, 202I, 203W
CDD
cd07842 (STKc_CDK8_like)

197K

activation loop (A-loop)
177G, 178D, 179L, 180G, 181L, 182A, 183R, 184I, 185Y, 186E, 187R, 188P, 189L, 190Q, 192L, 193F, 194N, 195G, 196D, 197K, 198V, 199V, 200V, 201T, 202I, 203W
CDD
cd07842 (STKc_CDK8_like)

198V

activation loop (A-loop)
177G, 178D, 179L, 180G, 181L, 182A, 183R, 184I, 185Y, 186E, 187R, 188P, 189L, 190Q, 192L, 193F, 194N, 195G, 196D, 197K, 198V, 199V, 200V, 201T, 202I, 203W
CDD
cd07842 (STKc_CDK8_like)

199V

activation loop (A-loop)
177G, 178D, 179L, 180G, 181L, 182A, 183R, 184I, 185Y, 186E, 187R, 188P, 189L, 190Q, 192L, 193F, 194N, 195G, 196D, 197K, 198V, 199V, 200V, 201T, 202I, 203W
CDD
cd07842 (STKc_CDK8_like)

200V

activation loop (A-loop)
177G, 178D, 179L, 180G, 181L, 182A, 183R, 184I, 185Y, 186E, 187R, 188P, 189L, 190Q, 192L, 193F, 194N, 195G, 196D, 197K, 198V, 199V, 200V, 201T, 202I, 203W
CDD
cd07842 (STKc_CDK8_like)

201T

activation loop (A-loop)
177G, 178D, 179L, 180G, 181L, 182A, 183R, 184I, 185Y, 186E, 187R, 188P, 189L, 190Q, 192L, 193F, 194N, 195G, 196D, 197K, 198V, 199V, 200V, 201T, 202I, 203W
CDD
cd07842 (STKc_CDK8_like)

202I

activation loop (A-loop)
177G, 178D, 179L, 180G, 181L, 182A, 183R, 184I, 185Y, 186E, 187R, 188P, 189L, 190Q, 192L, 193F, 194N, 195G, 196D, 197K, 198V, 199V, 200V, 201T, 202I, 203W
CDD
cd07842 (STKc_CDK8_like)

203W

activation loop (A-loop)
177G, 178D, 179L, 180G, 181L, 182A, 183R, 184I, 185Y, 186E, 187R, 188P, 189L, 190Q, 192L, 193F, 194N, 195G, 196D, 197K, 198V, 199V, 200V, 201T, 202I, 203W
CDD
cd07842 (STKc_CDK8_like)

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0005524 ATP binding

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

GBC19890.1

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component