GBC18369.1

Protein

Length

2,180 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
32 - 133
EF-hand domain pair (IPR011992)
EF-hand domain (IPR002048)
EH domain (IPR000261)
239 - 339
EF-hand domain pair (IPR011992)
EF-hand domain (IPR002048)
EH domain (IPR000261)
1,110 - 1,224
Formin Homology 1 (IPR009408)
1,237 - 1,263
WH2 domain (IPR003124)
1,397 - 1,463
SH3 domain (IPR001452)
1,465 - 1,525
SH3 domain (IPR001452)
1,700 - 1,918
Dbl homology (DH) domain (IPR000219)
2,050 - 2,179
C2 domain (IPR000008)
Domain
1,918 - 2,047
PH domain-like (IPR011993)
Pleckstrin homology domain (IPR001849)

1 200 400 600 800 1000 1200 1400 1600 1800 2000 2180

Detailed signature matches

IPR011992

EF-hand domain pair
1. SSF47473 (EF-hand)
  
  239 - 337
  
  SUPERFAMILY
  SSF47473 (EF-hand)
  
  32 - 133
  
  SUPERFAMILY
  SSF47473 (EF-hand)
IPR000261

EH domain
1. PF12763 (EF-hand_4)
  
  62 - 127
  
  Pfam
  PF12763 (EF-hand_4)
  
  248 - 339
  
  Pfam
  PF12763 (EF-hand_4)
2. PS50031 (EH)
  
  46 - 127
  
  PROSITE profiles
  PS50031 (EH)
  
  249 - 338
  
  PROSITE profiles
  PS50031 (EH)
3. SM00027 (eh_3)
  
  242 - 337
  
  SMART
  SM00027 (eh_3)
  
  39 - 133
  
  SMART
  SM00027 (eh_3)
IPR002048

EF-hand domain
1. SM00054 (efh_1)
  
  286 - 314
  
  SMART
  SM00054 (efh_1)
  
  82 - 110
  
  SMART
  SM00054 (efh_1)
2. PS50222 (EF_HAND_2)
  
  282 - 317
  
  PROSITE profiles
  PS50222 (EF_HAND_2)
  
  78 - 113
  
  PROSITE profiles
  PS50222 (EF_HAND_2)
IPR009408

Formin Homology 1
1. PF06346 (Drf_FH1)
  
  1,110 - 1,224
  
  Pfam
  PF06346 (Drf_FH1)
IPR003124

WH2 domain
1. PS51082 (WH2)
  
  1,240 - 1,257
  
  PROSITE profiles
  PS51082 (WH2)
2. PF02205 (WH2)
  
  1,237 - 1,263
  
  Pfam
  PF02205 (WH2)
3. SM00246 (wh2_8)
  
  1,240 - 1,257
  
  SMART
  SM00246 (wh2_8)
IPR001452

SH3 domain
1. PF00018 (SH3_1)
  
  1,471 - 1,516
  
  Pfam
  PF00018 (SH3_1)
2. PS50002 (SH3)
  
  1,398 - 1,463
  
  PROSITE profiles
  PS50002 (SH3)
  
  1,465 - 1,524
  
  PROSITE profiles
  PS50002 (SH3)
3. SSF50044 (SH3-domain)
  
  1,467 - 1,525
  
  SUPERFAMILY
  SSF50044 (SH3-domain)
  
  1,397 - 1,462
  
  SUPERFAMILY
  SSF50044 (SH3-domain)
4. PR00452 (SH3DOMAIN)
  
  1,468 - 1,478
  
  PRINTS
  PR00452 (SH3DOMAIN)
  
  1,510 - 1,522
  
  PRINTS
  PR00452 (SH3DOMAIN)
  
  1,482 - 1,497
  
  PRINTS
  PR00452 (SH3DOMAIN)
5. SM00326 (SH3_2)
  
  1,401 - 1,462
  
  SMART
  SM00326 (SH3_2)
  
  1,468 - 1,523
  
  SMART
  SM00326 (SH3_2)
IPR000219

Dbl homology (DH) domain
1. SSF48065 (DBL homol...)
  
  1,700 - 1,918
  
  SUPERFAMILY
  SSF48065 (DBL homology domain (DH-domain))
2. PS50010 (DH_2)
  
  1,719 - 1,901
  
  PROSITE profiles
  PS50010 (DH_2)
3. SM00325 (RhoGEF_3)
  
  1,723 - 1,900
  
  SMART
  SM00325 (RhoGEF_3)
4. PF00621 (RhoGEF)
  
  1,724 - 1,899
  
  Pfam
  PF00621 (RhoGEF)
IPR011993

PH domain-like
1. SSF50729 (PH domain...)
  
  1,934 - 2,042
  
  SUPERFAMILY
  SSF50729 (PH domain-like)
IPR001849

Pleckstrin homology domain
1. PS50003 (PH_DOMAIN)
  
  1,940 - 2,034
  
  PROSITE profiles
  PS50003 (PH_DOMAIN)
2. PF16652 (PH_13)
  
  1,918 - 2,047
  
  Pfam
  PF16652 (PH_13)
3. SM00233 (PH_update)
  
  1,941 - 2,036
  
  SMART
  SM00233 (PH_update)
IPR000008

C2 domain
1. PS50004 (C2)
  
  2,057 - 2,138
  
  PROSITE profiles
  PS50004 (C2)
2. SSF49562 (C2 domain...)
  
  2,050 - 2,179
  
  SUPERFAMILY
  SSF49562 (C2 domain (Calcium/lipid-binding domain, CaLB))
3. SM00239 (C2_3c)
  
  2,057 - 2,156
  
  SMART
  SM00239 (C2_3c)
4. PF00168 (C2)
  
  2,056 - 2,143
  
  Pfam
  PF00168 (C2)
IPR018247

EF-Hand 1, calcium-binding site
1. PS00018 (EF_HAND_1)
  
  295 - 307
  
  PROSITE patterns
  PS00018 (EF_HAND_1)
IPR001331

Guanine-nucleotide dissociation stimulator, CDC24, conserved site
1. PS00741 (DH_1)
  
  1,849 - 1,874
  
  PROSITE patterns
  PS00741 (DH_1)

no IPR

Unintegrated signatures

Coil

1,888 - 1,915

COILS
Coil (Coil)

809 - 980

COILS
Coil (Coil)

481 - 508

COILS
Coil (Coil)

644 - 685

COILS
Coil (Coil)

131 - 158

COILS
Coil (Coil)
cd00030 (C2)

2,058 - 2,157

CDD
cd00030 (C2)
cd00052 (EH)

253 - 319

CDD
cd00052 (EH)

63 - 115

CDD
cd00052 (EH)
cd00160 (RhoGEF)

1,720 - 1,899

CDD
cd00160 (RhoGEF)
mobidb-lite (disord...)

1,039 - 1,390

MobiDB Lite
mobidb-lite (disorder_prediction)

1,662 - 1,698

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 32

MobiDB Lite
mobidb-lite (disorder_prediction)

1,529 - 1,570

MobiDB Lite
mobidb-lite (disorder_prediction)

403 - 442

MobiDB Lite
mobidb-lite (disorder_prediction)

708 - 1,008

MobiDB Lite
mobidb-lite (disorder_prediction)

1,015 - 1,034

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

pseudo EF-hand loo...

64L

pseudo EF-hand loop
64L, 65T, 66G, 67E, 68G
CDD
cd00052 (EH)

65T

pseudo EF-hand loop
64L, 65T, 66G, 67E, 68G
CDD
cd00052 (EH)

66G

pseudo EF-hand loop
64L, 65T, 66G, 67E, 68G
CDD
cd00052 (EH)

67E

pseudo EF-hand loop
64L, 65T, 66G, 67E, 68G
CDD
cd00052 (EH)

68G

pseudo EF-hand loop
64L, 65T, 66G, 67E, 68G
CDD
cd00052 (EH)
peptide binding po...

73L

peptide binding pocket
73L, 83L, 87W
CDD
cd00052 (EH)

83L

peptide binding pocket
73L, 83L, 87W
CDD
cd00052 (EH)

87W

peptide binding pocket
73L, 83L, 87W
CDD
cd00052 (EH)
Ca2+ binding site ...

91N

Ca2+ binding site
91N, 93T, 95N, 102E
CDD
cd00052 (EH)

93T

Ca2+ binding site
91N, 93T, 95N, 102E
CDD
cd00052 (EH)

95N

Ca2+ binding site
91N, 93T, 95N, 102E
CDD
cd00052 (EH)

102E

Ca2+ binding site
91N, 93T, 95N, 102E
CDD
cd00052 (EH)
pseudo EF-hand loo...

259Q

pseudo EF-hand loop
259Q, 260W, 261D, 268L, 269T, 270G, 271E, 272K
CDD
cd00052 (EH)

260W

pseudo EF-hand loop
259Q, 260W, 261D, 268L, 269T, 270G, 271E, 272K
CDD
cd00052 (EH)

261D

pseudo EF-hand loop
259Q, 260W, 261D, 268L, 269T, 270G, 271E, 272K
CDD
cd00052 (EH)

268L

pseudo EF-hand loop
259Q, 260W, 261D, 268L, 269T, 270G, 271E, 272K
CDD
cd00052 (EH)

269T

pseudo EF-hand loop
259Q, 260W, 261D, 268L, 269T, 270G, 271E, 272K
CDD
cd00052 (EH)

270G

pseudo EF-hand loop
259Q, 260W, 261D, 268L, 269T, 270G, 271E, 272K
CDD
cd00052 (EH)

271E

pseudo EF-hand loop
259Q, 260W, 261D, 268L, 269T, 270G, 271E, 272K
CDD
cd00052 (EH)

272K

pseudo EF-hand loop
259Q, 260W, 261D, 268L, 269T, 270G, 271E, 272K
CDD
cd00052 (EH)
peptide binding po...

277L

peptide binding pocket
277L, 287L, 291W
CDD
cd00052 (EH)

287L

peptide binding pocket
277L, 287L, 291W
CDD
cd00052 (EH)

291W

peptide binding pocket
277L, 287L, 291W
CDD
cd00052 (EH)
Ca2+ binding site ...

295D

Ca2+ binding site
295D, 297N, 299N, 306E
CDD
cd00052 (EH)

297N

Ca2+ binding site
295D, 297N, 299N, 306E
CDD
cd00052 (EH)

299N

Ca2+ binding site
295D, 297N, 299N, 306E
CDD
cd00052 (EH)

306E

Ca2+ binding site
295D, 297N, 299N, 306E
CDD
cd00052 (EH)
GTPase interaction...

1,726E

GTPase interaction site
1,726E, 1,730T, 1,822Q, 1,850S, 1,851S, 1,854L, 1,855K, 1,857M, 1,858Q, 1,861T, 1,862R, 1,865L, 1,866L, 1,869Q, 1,895L, 1,899N
CDD
cd00160 (RhoGEF)

1,730T

GTPase interaction site
1,726E, 1,730T, 1,822Q, 1,850S, 1,851S, 1,854L, 1,855K, 1,857M, 1,858Q, 1,861T, 1,862R, 1,865L, 1,866L, 1,869Q, 1,895L, 1,899N
CDD
cd00160 (RhoGEF)

1,822Q

GTPase interaction site
1,726E, 1,730T, 1,822Q, 1,850S, 1,851S, 1,854L, 1,855K, 1,857M, 1,858Q, 1,861T, 1,862R, 1,865L, 1,866L, 1,869Q, 1,895L, 1,899N
CDD
cd00160 (RhoGEF)

1,850S

GTPase interaction site
1,726E, 1,730T, 1,822Q, 1,850S, 1,851S, 1,854L, 1,855K, 1,857M, 1,858Q, 1,861T, 1,862R, 1,865L, 1,866L, 1,869Q, 1,895L, 1,899N
CDD
cd00160 (RhoGEF)

1,851S

GTPase interaction site
1,726E, 1,730T, 1,822Q, 1,850S, 1,851S, 1,854L, 1,855K, 1,857M, 1,858Q, 1,861T, 1,862R, 1,865L, 1,866L, 1,869Q, 1,895L, 1,899N
CDD
cd00160 (RhoGEF)

1,854L

GTPase interaction site
1,726E, 1,730T, 1,822Q, 1,850S, 1,851S, 1,854L, 1,855K, 1,857M, 1,858Q, 1,861T, 1,862R, 1,865L, 1,866L, 1,869Q, 1,895L, 1,899N
CDD
cd00160 (RhoGEF)

1,855K

GTPase interaction site
1,726E, 1,730T, 1,822Q, 1,850S, 1,851S, 1,854L, 1,855K, 1,857M, 1,858Q, 1,861T, 1,862R, 1,865L, 1,866L, 1,869Q, 1,895L, 1,899N
CDD
cd00160 (RhoGEF)

1,857M

GTPase interaction site
1,726E, 1,730T, 1,822Q, 1,850S, 1,851S, 1,854L, 1,855K, 1,857M, 1,858Q, 1,861T, 1,862R, 1,865L, 1,866L, 1,869Q, 1,895L, 1,899N
CDD
cd00160 (RhoGEF)

1,858Q

GTPase interaction site
1,726E, 1,730T, 1,822Q, 1,850S, 1,851S, 1,854L, 1,855K, 1,857M, 1,858Q, 1,861T, 1,862R, 1,865L, 1,866L, 1,869Q, 1,895L, 1,899N
CDD
cd00160 (RhoGEF)

1,861T

GTPase interaction site
1,726E, 1,730T, 1,822Q, 1,850S, 1,851S, 1,854L, 1,855K, 1,857M, 1,858Q, 1,861T, 1,862R, 1,865L, 1,866L, 1,869Q, 1,895L, 1,899N
CDD
cd00160 (RhoGEF)

1,862R

GTPase interaction site
1,726E, 1,730T, 1,822Q, 1,850S, 1,851S, 1,854L, 1,855K, 1,857M, 1,858Q, 1,861T, 1,862R, 1,865L, 1,866L, 1,869Q, 1,895L, 1,899N
CDD
cd00160 (RhoGEF)

1,865L

GTPase interaction site
1,726E, 1,730T, 1,822Q, 1,850S, 1,851S, 1,854L, 1,855K, 1,857M, 1,858Q, 1,861T, 1,862R, 1,865L, 1,866L, 1,869Q, 1,895L, 1,899N
CDD
cd00160 (RhoGEF)

1,866L

GTPase interaction site
1,726E, 1,730T, 1,822Q, 1,850S, 1,851S, 1,854L, 1,855K, 1,857M, 1,858Q, 1,861T, 1,862R, 1,865L, 1,866L, 1,869Q, 1,895L, 1,899N
CDD
cd00160 (RhoGEF)

1,869Q

GTPase interaction site
1,726E, 1,730T, 1,822Q, 1,850S, 1,851S, 1,854L, 1,855K, 1,857M, 1,858Q, 1,861T, 1,862R, 1,865L, 1,866L, 1,869Q, 1,895L, 1,899N
CDD
cd00160 (RhoGEF)

1,895L

GTPase interaction site
1,726E, 1,730T, 1,822Q, 1,850S, 1,851S, 1,854L, 1,855K, 1,857M, 1,858Q, 1,861T, 1,862R, 1,865L, 1,866L, 1,869Q, 1,895L, 1,899N
CDD
cd00160 (RhoGEF)

1,899N

GTPase interaction site
1,726E, 1,730T, 1,822Q, 1,850S, 1,851S, 1,854L, 1,855K, 1,857M, 1,858Q, 1,861T, 1,862R, 1,865L, 1,866L, 1,869Q, 1,895L, 1,899N
CDD
cd00160 (RhoGEF)

GO term prediction

Biological Process

GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction

Molecular Function

GO:0003779 actin binding
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding

Cellular Component