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Entry type
Status
Per-residue features
Colour by
Protein
GBC16164.1
Length
1,527 amino acids
Protein family membership
- Pentafunctional AroM protein (IPR008289)
- 3-phosphoshikimate 1-carboxyvinyltransferase (IPR006264)
- Shikimate kinase/gluconokinase (IPR031322)
- Shikimate kinase/Threonine synthase-like 1 (IPR000623)
- 3-dehydroquinate dehydratase type I (IPR001381)
Domains and repeats
-
Domain
-
Domain
1
200
400
600
800
1000
1200
1400
1527
Detailed signature matches
no IPR
Residue annotation
-
active site cd08195174Eactive site
19D, 94G, 95G, 96V, 99D, 102G, 119T, 120T, 122I, 141K, 144I, 159F, 167E, 174E, 178S, 258H, 262H, 274H
CDD
cd08195 (DHQS)178Sactive site
19D, 94G, 95G, 96V, 99D, 102G, 119T, 120T, 122I, 141K, 144I, 159F, 167E, 174E, 178S, 258H, 262H, 274H
CDD
cd08195 (DHQS)258Hactive site
19D, 94G, 95G, 96V, 99D, 102G, 119T, 120T, 122I, 141K, 144I, 159F, 167E, 174E, 178S, 258H, 262H, 274H
CDD
cd08195 (DHQS)262Hactive site
19D, 94G, 95G, 96V, 99D, 102G, 119T, 120T, 122I, 141K, 144I, 159F, 167E, 174E, 178S, 258H, 262H, 274H
CDD
cd08195 (DHQS)274Hactive site
19D, 94G, 95G, 96V, 99D, 102G, 119T, 120T, 122I, 141K, 144I, 159F, 167E, 174E, 178S, 258H, 262H, 274H
CDD
cd08195 (DHQS) -
dimer interface cd...68Rdimer interface
68R, 75E, 76D, 103F, 106A, 108F, 109M, 110R, 132K, 133T, 142N, 143L, 144I, 145G, 146S, 147F
CDD
cd08195 (DHQS)75Edimer interface
68R, 75E, 76D, 103F, 106A, 108F, 109M, 110R, 132K, 133T, 142N, 143L, 144I, 145G, 146S, 147F
CDD
cd08195 (DHQS)76Ddimer interface
68R, 75E, 76D, 103F, 106A, 108F, 109M, 110R, 132K, 133T, 142N, 143L, 144I, 145G, 146S, 147F
CDD
cd08195 (DHQS)103Fdimer interface
68R, 75E, 76D, 103F, 106A, 108F, 109M, 110R, 132K, 133T, 142N, 143L, 144I, 145G, 146S, 147F
CDD
cd08195 (DHQS)106Adimer interface
68R, 75E, 76D, 103F, 106A, 108F, 109M, 110R, 132K, 133T, 142N, 143L, 144I, 145G, 146S, 147F
CDD
cd08195 (DHQS)108Fdimer interface
68R, 75E, 76D, 103F, 106A, 108F, 109M, 110R, 132K, 133T, 142N, 143L, 144I, 145G, 146S, 147F
CDD
cd08195 (DHQS)109Mdimer interface
68R, 75E, 76D, 103F, 106A, 108F, 109M, 110R, 132K, 133T, 142N, 143L, 144I, 145G, 146S, 147F
CDD
cd08195 (DHQS)110Rdimer interface
68R, 75E, 76D, 103F, 106A, 108F, 109M, 110R, 132K, 133T, 142N, 143L, 144I, 145G, 146S, 147F
CDD
cd08195 (DHQS)132Kdimer interface
68R, 75E, 76D, 103F, 106A, 108F, 109M, 110R, 132K, 133T, 142N, 143L, 144I, 145G, 146S, 147F
CDD
cd08195 (DHQS)133Tdimer interface
68R, 75E, 76D, 103F, 106A, 108F, 109M, 110R, 132K, 133T, 142N, 143L, 144I, 145G, 146S, 147F
CDD
cd08195 (DHQS)142Ndimer interface
68R, 75E, 76D, 103F, 106A, 108F, 109M, 110R, 132K, 133T, 142N, 143L, 144I, 145G, 146S, 147F
CDD
cd08195 (DHQS)143Ldimer interface
68R, 75E, 76D, 103F, 106A, 108F, 109M, 110R, 132K, 133T, 142N, 143L, 144I, 145G, 146S, 147F
CDD
cd08195 (DHQS)144Idimer interface
68R, 75E, 76D, 103F, 106A, 108F, 109M, 110R, 132K, 133T, 142N, 143L, 144I, 145G, 146S, 147F
CDD
cd08195 (DHQS)145Gdimer interface
68R, 75E, 76D, 103F, 106A, 108F, 109M, 110R, 132K, 133T, 142N, 143L, 144I, 145G, 146S, 147F
CDD
cd08195 (DHQS)146Sdimer interface
68R, 75E, 76D, 103F, 106A, 108F, 109M, 110R, 132K, 133T, 142N, 143L, 144I, 145G, 146S, 147F
CDD
cd08195 (DHQS)147Fdimer interface
68R, 75E, 76D, 103F, 106A, 108F, 109M, 110R, 132K, 133T, 142N, 143L, 144I, 145G, 146S, 147F
CDD
cd08195 (DHQS) -
metal binding site...
-
hinge cd01556402T403P404G405S633I634E635S636D
-
active site cd01556406Kactive site
406K, 407S, 411R, 478N, 480G, 481T, 515R, 563S, 564S, 565Q, 592S, 595Y, 712D, 740N, 744K, 745E, 748R, 793H, 794R, 820K
CDD
cd01556 (EPSP_synthase)407Sactive site
406K, 407S, 411R, 478N, 480G, 481T, 515R, 563S, 564S, 565Q, 592S, 595Y, 712D, 740N, 744K, 745E, 748R, 793H, 794R, 820K
CDD
cd01556 (EPSP_synthase)411Ractive site
406K, 407S, 411R, 478N, 480G, 481T, 515R, 563S, 564S, 565Q, 592S, 595Y, 712D, 740N, 744K, 745E, 748R, 793H, 794R, 820K
CDD
cd01556 (EPSP_synthase)478Nactive site
406K, 407S, 411R, 478N, 480G, 481T, 515R, 563S, 564S, 565Q, 592S, 595Y, 712D, 740N, 744K, 745E, 748R, 793H, 794R, 820K
CDD
cd01556 (EPSP_synthase)480Gactive site
406K, 407S, 411R, 478N, 480G, 481T, 515R, 563S, 564S, 565Q, 592S, 595Y, 712D, 740N, 744K, 745E, 748R, 793H, 794R, 820K
CDD
cd01556 (EPSP_synthase)481Tactive site
406K, 407S, 411R, 478N, 480G, 481T, 515R, 563S, 564S, 565Q, 592S, 595Y, 712D, 740N, 744K, 745E, 748R, 793H, 794R, 820K
CDD
cd01556 (EPSP_synthase)515Ractive site
406K, 407S, 411R, 478N, 480G, 481T, 515R, 563S, 564S, 565Q, 592S, 595Y, 712D, 740N, 744K, 745E, 748R, 793H, 794R, 820K
CDD
cd01556 (EPSP_synthase)563Sactive site
406K, 407S, 411R, 478N, 480G, 481T, 515R, 563S, 564S, 565Q, 592S, 595Y, 712D, 740N, 744K, 745E, 748R, 793H, 794R, 820K
CDD
cd01556 (EPSP_synthase)564Sactive site
406K, 407S, 411R, 478N, 480G, 481T, 515R, 563S, 564S, 565Q, 592S, 595Y, 712D, 740N, 744K, 745E, 748R, 793H, 794R, 820K
CDD
cd01556 (EPSP_synthase)565Qactive site
406K, 407S, 411R, 478N, 480G, 481T, 515R, 563S, 564S, 565Q, 592S, 595Y, 712D, 740N, 744K, 745E, 748R, 793H, 794R, 820K
CDD
cd01556 (EPSP_synthase)592Sactive site
406K, 407S, 411R, 478N, 480G, 481T, 515R, 563S, 564S, 565Q, 592S, 595Y, 712D, 740N, 744K, 745E, 748R, 793H, 794R, 820K
CDD
cd01556 (EPSP_synthase)595Yactive site
406K, 407S, 411R, 478N, 480G, 481T, 515R, 563S, 564S, 565Q, 592S, 595Y, 712D, 740N, 744K, 745E, 748R, 793H, 794R, 820K
CDD
cd01556 (EPSP_synthase)712Dactive site
406K, 407S, 411R, 478N, 480G, 481T, 515R, 563S, 564S, 565Q, 592S, 595Y, 712D, 740N, 744K, 745E, 748R, 793H, 794R, 820K
CDD
cd01556 (EPSP_synthase)740Nactive site
406K, 407S, 411R, 478N, 480G, 481T, 515R, 563S, 564S, 565Q, 592S, 595Y, 712D, 740N, 744K, 745E, 748R, 793H, 794R, 820K
CDD
cd01556 (EPSP_synthase)744Kactive site
406K, 407S, 411R, 478N, 480G, 481T, 515R, 563S, 564S, 565Q, 592S, 595Y, 712D, 740N, 744K, 745E, 748R, 793H, 794R, 820K
CDD
cd01556 (EPSP_synthase)745Eactive site
406K, 407S, 411R, 478N, 480G, 481T, 515R, 563S, 564S, 565Q, 592S, 595Y, 712D, 740N, 744K, 745E, 748R, 793H, 794R, 820K
CDD
cd01556 (EPSP_synthase)748Ractive site
406K, 407S, 411R, 478N, 480G, 481T, 515R, 563S, 564S, 565Q, 592S, 595Y, 712D, 740N, 744K, 745E, 748R, 793H, 794R, 820K
CDD
cd01556 (EPSP_synthase)793Hactive site
406K, 407S, 411R, 478N, 480G, 481T, 515R, 563S, 564S, 565Q, 592S, 595Y, 712D, 740N, 744K, 745E, 748R, 793H, 794R, 820K
CDD
cd01556 (EPSP_synthase)794Ractive site
406K, 407S, 411R, 478N, 480G, 481T, 515R, 563S, 564S, 565Q, 592S, 595Y, 712D, 740N, 744K, 745E, 748R, 793H, 794R, 820K
CDD
cd01556 (EPSP_synthase)820Kactive site
406K, 407S, 411R, 478N, 480G, 481T, 515R, 563S, 564S, 565Q, 592S, 595Y, 712D, 740N, 744K, 745E, 748R, 793H, 794R, 820K
CDD
cd01556 (EPSP_synthase) -
ADP binding site c...856G857V858G859K860T861T961Y968R
-
magnesium binding ...
-
putative shikimate...878D902R905E925G926G927G982R
-
active site cd005021,022Sactive site
1,022S, 1,046E, 1,048R, 1,084R, 1,143H, 1,171K, 1,213R, 1,231A, 1,232A, 1,235Q
CDD
cd00502 (DHQase_I)1,046Eactive site
1,022S, 1,046E, 1,048R, 1,084R, 1,143H, 1,171K, 1,213R, 1,231A, 1,232A, 1,235Q
CDD
cd00502 (DHQase_I)1,048Ractive site
1,022S, 1,046E, 1,048R, 1,084R, 1,143H, 1,171K, 1,213R, 1,231A, 1,232A, 1,235Q
CDD
cd00502 (DHQase_I)1,084Ractive site
1,022S, 1,046E, 1,048R, 1,084R, 1,143H, 1,171K, 1,213R, 1,231A, 1,232A, 1,235Q
CDD
cd00502 (DHQase_I)1,143Hactive site
1,022S, 1,046E, 1,048R, 1,084R, 1,143H, 1,171K, 1,213R, 1,231A, 1,232A, 1,235Q
CDD
cd00502 (DHQase_I)1,171Kactive site
1,022S, 1,046E, 1,048R, 1,084R, 1,143H, 1,171K, 1,213R, 1,231A, 1,232A, 1,235Q
CDD
cd00502 (DHQase_I)1,213Ractive site
1,022S, 1,046E, 1,048R, 1,084R, 1,143H, 1,171K, 1,213R, 1,231A, 1,232A, 1,235Q
CDD
cd00502 (DHQase_I)1,231Aactive site
1,022S, 1,046E, 1,048R, 1,084R, 1,143H, 1,171K, 1,213R, 1,231A, 1,232A, 1,235Q
CDD
cd00502 (DHQase_I)1,232Aactive site
1,022S, 1,046E, 1,048R, 1,084R, 1,143H, 1,171K, 1,213R, 1,231A, 1,232A, 1,235Q
CDD
cd00502 (DHQase_I)1,235Qactive site
1,022S, 1,046E, 1,048R, 1,084R, 1,143H, 1,171K, 1,213R, 1,231A, 1,232A, 1,235Q
CDD
cd00502 (DHQase_I) -
catalytic residue ...1,171K
-
dimer interface cd...1,183Fdimer interface
1,183F, 1,187E, 1,190E, 1,214L, 1,215L, 1,218T, 1,240E, 1,244G, 1,247L
CDD
cd00502 (DHQase_I)1,187Edimer interface
1,183F, 1,187E, 1,190E, 1,214L, 1,215L, 1,218T, 1,240E, 1,244G, 1,247L
CDD
cd00502 (DHQase_I)1,190Edimer interface
1,183F, 1,187E, 1,190E, 1,214L, 1,215L, 1,218T, 1,240E, 1,244G, 1,247L
CDD
cd00502 (DHQase_I)1,214Ldimer interface
1,183F, 1,187E, 1,190E, 1,214L, 1,215L, 1,218T, 1,240E, 1,244G, 1,247L
CDD
cd00502 (DHQase_I)1,215Ldimer interface
1,183F, 1,187E, 1,190E, 1,214L, 1,215L, 1,218T, 1,240E, 1,244G, 1,247L
CDD
cd00502 (DHQase_I)1,218Tdimer interface
1,183F, 1,187E, 1,190E, 1,214L, 1,215L, 1,218T, 1,240E, 1,244G, 1,247L
CDD
cd00502 (DHQase_I)1,240Edimer interface
1,183F, 1,187E, 1,190E, 1,214L, 1,215L, 1,218T, 1,240E, 1,244G, 1,247L
CDD
cd00502 (DHQase_I)1,244Gdimer interface
1,183F, 1,187E, 1,190E, 1,214L, 1,215L, 1,218T, 1,240E, 1,244G, 1,247L
CDD
cd00502 (DHQase_I)1,247Ldimer interface
1,183F, 1,187E, 1,190E, 1,214L, 1,215L, 1,218T, 1,240E, 1,244G, 1,247L
CDD
cd00502 (DHQase_I) -
shikimate binding ...1,355D1,470Y1,495L1,498Q
-
NAD(P) binding sit...1,380GNAD(P) binding site
1,380G, 1,383T, 1,403N, 1,404R, 1,443T, 1,444I, 1,445P, 1,468M, 1,491G, 1,494V, 1,495L
CDD
cd01065 (NAD_bind_Shikimate_DH)1,383TNAD(P) binding site
1,380G, 1,383T, 1,403N, 1,404R, 1,443T, 1,444I, 1,445P, 1,468M, 1,491G, 1,494V, 1,495L
CDD
cd01065 (NAD_bind_Shikimate_DH)1,403NNAD(P) binding site
1,380G, 1,383T, 1,403N, 1,404R, 1,443T, 1,444I, 1,445P, 1,468M, 1,491G, 1,494V, 1,495L
CDD
cd01065 (NAD_bind_Shikimate_DH)1,404RNAD(P) binding site
1,380G, 1,383T, 1,403N, 1,404R, 1,443T, 1,444I, 1,445P, 1,468M, 1,491G, 1,494V, 1,495L
CDD
cd01065 (NAD_bind_Shikimate_DH)1,443TNAD(P) binding site
1,380G, 1,383T, 1,403N, 1,404R, 1,443T, 1,444I, 1,445P, 1,468M, 1,491G, 1,494V, 1,495L
CDD
cd01065 (NAD_bind_Shikimate_DH)1,444INAD(P) binding site
1,380G, 1,383T, 1,403N, 1,404R, 1,443T, 1,444I, 1,445P, 1,468M, 1,491G, 1,494V, 1,495L
CDD
cd01065 (NAD_bind_Shikimate_DH)1,445PNAD(P) binding site
1,380G, 1,383T, 1,403N, 1,404R, 1,443T, 1,444I, 1,445P, 1,468M, 1,491G, 1,494V, 1,495L
CDD
cd01065 (NAD_bind_Shikimate_DH)1,468MNAD(P) binding site
1,380G, 1,383T, 1,403N, 1,404R, 1,443T, 1,444I, 1,445P, 1,468M, 1,491G, 1,494V, 1,495L
CDD
cd01065 (NAD_bind_Shikimate_DH)1,491GNAD(P) binding site
1,380G, 1,383T, 1,403N, 1,404R, 1,443T, 1,444I, 1,445P, 1,468M, 1,491G, 1,494V, 1,495L
CDD
cd01065 (NAD_bind_Shikimate_DH)1,494VNAD(P) binding site
1,380G, 1,383T, 1,403N, 1,404R, 1,443T, 1,444I, 1,445P, 1,468M, 1,491G, 1,494V, 1,495L
CDD
cd01065 (NAD_bind_Shikimate_DH)1,495LNAD(P) binding site
1,380G, 1,383T, 1,403N, 1,404R, 1,443T, 1,444I, 1,445P, 1,468M, 1,491G, 1,494V, 1,495L
CDD
cd01065 (NAD_bind_Shikimate_DH)
GO term prediction
Biological Process
GO:0009073 aromatic amino acid family biosynthetic process
GO:0055114 oxidation-reduction process
Molecular Function
GO:0003824 catalytic activity
GO:0003855 3-dehydroquinate dehydratase activity
GO:0003856 3-dehydroquinate synthase activity
GO:0003866 3-phosphoshikimate 1-carboxyvinyltransferase activity
GO:0004764 shikimate 3-dehydrogenase (NADP+) activity
GO:0004765 shikimate kinase activity
GO:0005524 ATP binding
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
Cellular Component
GO:0005737 cytoplasm