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Protein

GBC13755.1

Length

1,445 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
234 - 334
Retrotransposon gag domain (IPR005162)
446 - 480
Zinc finger, CCHC-type (IPR001878)
673 - 770
Aspartic peptidase domain (IPR021109)
978 - 1,157
Reverse transcriptase domain (IPR000477)

1 200 400 600 800 1000 1200 1445

Detailed signature matches

IPR005162

Retrotransposon gag domain

PF03732 (Retrotrans...)

234 - 334

Pfam
PF03732 (Retrotrans_gag)

IPR001878

Zinc finger, CCHC-type

PS50158 (ZF_CCHC)

462 - 475

PROSITE profiles
PS50158 (ZF_CCHC)
PF00098 (zf-CCHC)

461 - 476

Pfam
PF00098 (zf-CCHC)
SM00343 (c2hcfinal6)

461 - 477

SMART
SM00343 (c2hcfinal6)
SSF57756 (Retroviru...)

446 - 480

SUPERFAMILY
SSF57756 (Retrovirus zinc finger-like domains)

IPR021109

Aspartic peptidase domain

SSF50630 (Acid prot...)

673 - 770

SUPERFAMILY
SSF50630 (Acid proteases)

IPR000477

Reverse transcriptase domain

PF00078 (RVT_1)

998 - 1,156

Pfam
PF00078 (RVT_1)
PS50878 (RT_POL)

978 - 1,157

PROSITE profiles
PS50878 (RT_POL)

IPR001969

Aspartic peptidase, active site

PS00141 (ASP_PROTEASE)

683 - 694

PROSITE patterns
PS00141 (ASP_PROTEASE)

no IPR

Unintegrated signatures

Coil

397 - 417

COILS
Coil (Coil)
PF13975 (gag-asp_pr...)

673 - 763

Pfam
PF13975 (gag-asp_proteas)
SSF56672 (DNA/RNA p...)

923 - 1,356

SUPERFAMILY
SSF56672 (DNA/RNA polymerases)
cd00303 (retropepsi...)

674 - 762

CDD
cd00303 (retropepsin_like)
cd01647 (RT_LTR)

981 - 1,157

CDD
cd01647 (RT_LTR)
cd09274 (RNase_HI_R...)

1,251 - 1,370

CDD
cd09274 (RNase_HI_RT_Ty3)
mobidb-lite (disord...)

525 - 596

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

Catalytic residue ...

686D

Catalytic residue
686D
CDD
cd00303 (retropepsin_like)
catalytic motif cd...

686D

catalytic motif
686D, 687S, 688G
CDD
cd00303 (retropepsin_like)

687S

catalytic motif
686D, 687S, 688G
CDD
cd00303 (retropepsin_like)

688G

catalytic motif
686D, 687S, 688G
CDD
cd00303 (retropepsin_like)
inhibitor binding ...

686D

inhibitor binding site
686D, 688G, 690A, 714V, 715V, 716T, 755L
CDD
cd00303 (retropepsin_like)

688G

inhibitor binding site
686D, 688G, 690A, 714V, 715V, 716T, 755L
CDD
cd00303 (retropepsin_like)

690A

inhibitor binding site
686D, 688G, 690A, 714V, 715V, 716T, 755L
CDD
cd00303 (retropepsin_like)

714V

inhibitor binding site
686D, 688G, 690A, 714V, 715V, 716T, 755L
CDD
cd00303 (retropepsin_like)

715V

inhibitor binding site
686D, 688G, 690A, 714V, 715V, 716T, 755L
CDD
cd00303 (retropepsin_like)

716T

inhibitor binding site
686D, 688G, 690A, 714V, 715V, 716T, 755L
CDD
cd00303 (retropepsin_like)

755L

inhibitor binding site
686D, 688G, 690A, 714V, 715V, 716T, 755L
CDD
cd00303 (retropepsin_like)
Active site flap c...

714V

Active site flap
714V, 715V, 716T, 717A, 721R, 722N, 723R, 724A
CDD
cd00303 (retropepsin_like)

715V

Active site flap
714V, 715V, 716T, 717A, 721R, 722N, 723R, 724A
CDD
cd00303 (retropepsin_like)

716T

Active site flap
714V, 715V, 716T, 717A, 721R, 722N, 723R, 724A
CDD
cd00303 (retropepsin_like)

717A

Active site flap
714V, 715V, 716T, 717A, 721R, 722N, 723R, 724A
CDD
cd00303 (retropepsin_like)

721R

Active site flap
714V, 715V, 716T, 717A, 721R, 722N, 723R, 724A
CDD
cd00303 (retropepsin_like)

722N

Active site flap
714V, 715V, 716T, 717A, 721R, 722N, 723R, 724A
CDD
cd00303 (retropepsin_like)

723R

Active site flap
714V, 715V, 716T, 717A, 721R, 722N, 723R, 724A
CDD
cd00303 (retropepsin_like)

724A

Active site flap
714V, 715V, 716T, 717A, 721R, 722N, 723R, 724A
CDD
cd00303 (retropepsin_like)
putative NTP bindi...

1,044D

putative NTP binding site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,108D
CDD
cd01647 (RT_LTR)

1,045L

putative NTP binding site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,108D
CDD
cd01647 (RT_LTR)

1,046A

putative NTP binding site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,108D
CDD
cd01647 (RT_LTR)

1,047S

putative NTP binding site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,108D
CDD
cd01647 (RT_LTR)

1,048G

putative NTP binding site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,108D
CDD
cd01647 (RT_LTR)

1,049F

putative NTP binding site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,108D
CDD
cd01647 (RT_LTR)

1,078F

putative NTP binding site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,108D
CDD
cd01647 (RT_LTR)

1,108D

putative NTP binding site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,108D
CDD
cd01647 (RT_LTR)
putative active si...

1,044D

putative active site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,079G, 1,106Y, 1,108D, 1,109D, 1,153L, 1,154G
CDD
cd01647 (RT_LTR)

1,045L

putative active site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,079G, 1,106Y, 1,108D, 1,109D, 1,153L, 1,154G
CDD
cd01647 (RT_LTR)

1,046A

putative active site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,079G, 1,106Y, 1,108D, 1,109D, 1,153L, 1,154G
CDD
cd01647 (RT_LTR)

1,047S

putative active site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,079G, 1,106Y, 1,108D, 1,109D, 1,153L, 1,154G
CDD
cd01647 (RT_LTR)

1,048G

putative active site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,079G, 1,106Y, 1,108D, 1,109D, 1,153L, 1,154G
CDD
cd01647 (RT_LTR)

1,049F

putative active site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,079G, 1,106Y, 1,108D, 1,109D, 1,153L, 1,154G
CDD
cd01647 (RT_LTR)

1,078F

putative active site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,079G, 1,106Y, 1,108D, 1,109D, 1,153L, 1,154G
CDD
cd01647 (RT_LTR)

1,079G

putative active site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,079G, 1,106Y, 1,108D, 1,109D, 1,153L, 1,154G
CDD
cd01647 (RT_LTR)

1,106Y

putative active site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,079G, 1,106Y, 1,108D, 1,109D, 1,153L, 1,154G
CDD
cd01647 (RT_LTR)

1,108D

putative active site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,079G, 1,106Y, 1,108D, 1,109D, 1,153L, 1,154G
CDD
cd01647 (RT_LTR)

1,109D

putative active site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,079G, 1,106Y, 1,108D, 1,109D, 1,153L, 1,154G
CDD
cd01647 (RT_LTR)

1,153L

putative active site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,079G, 1,106Y, 1,108D, 1,109D, 1,153L, 1,154G
CDD
cd01647 (RT_LTR)

1,154G

putative active site
1,044D, 1,045L, 1,046A, 1,047S, 1,048G, 1,049F, 1,078F, 1,079G, 1,106Y, 1,108D, 1,109D, 1,153L, 1,154G
CDD
cd01647 (RT_LTR)
putative nucleic a...

1,079G

putative nucleic acid binding site
1,079G
CDD
cd01647 (RT_LTR)
active site cd09274

1,255D

active site
1,255D, 1,297E, 1,322D, 1,365D
CDD
cd09274 (RNase_HI_RT_Ty3)

1,297E

active site
1,255D, 1,297E, 1,322D, 1,365D
CDD
cd09274 (RNase_HI_RT_Ty3)

1,322D

active site
1,255D, 1,297E, 1,322D, 1,365D
CDD
cd09274 (RNase_HI_RT_Ty3)

1,365D

active site
1,255D, 1,297E, 1,322D, 1,365D
CDD
cd09274 (RNase_HI_RT_Ty3)
RNA/DNA hybrid bin...

1,255D

RNA/DNA hybrid binding site
1,255D, 1,256A, 1,257S, 1,258G, 1,292A, 1,293V, 1,294T, 1,297E, 1,322D, 1,355H, 1,369R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,256A

RNA/DNA hybrid binding site
1,255D, 1,256A, 1,257S, 1,258G, 1,292A, 1,293V, 1,294T, 1,297E, 1,322D, 1,355H, 1,369R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,257S

RNA/DNA hybrid binding site
1,255D, 1,256A, 1,257S, 1,258G, 1,292A, 1,293V, 1,294T, 1,297E, 1,322D, 1,355H, 1,369R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,258G

RNA/DNA hybrid binding site
1,255D, 1,256A, 1,257S, 1,258G, 1,292A, 1,293V, 1,294T, 1,297E, 1,322D, 1,355H, 1,369R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,292A

RNA/DNA hybrid binding site
1,255D, 1,256A, 1,257S, 1,258G, 1,292A, 1,293V, 1,294T, 1,297E, 1,322D, 1,355H, 1,369R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,293V

RNA/DNA hybrid binding site
1,255D, 1,256A, 1,257S, 1,258G, 1,292A, 1,293V, 1,294T, 1,297E, 1,322D, 1,355H, 1,369R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,294T

RNA/DNA hybrid binding site
1,255D, 1,256A, 1,257S, 1,258G, 1,292A, 1,293V, 1,294T, 1,297E, 1,322D, 1,355H, 1,369R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,297E

RNA/DNA hybrid binding site
1,255D, 1,256A, 1,257S, 1,258G, 1,292A, 1,293V, 1,294T, 1,297E, 1,322D, 1,355H, 1,369R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,322D

RNA/DNA hybrid binding site
1,255D, 1,256A, 1,257S, 1,258G, 1,292A, 1,293V, 1,294T, 1,297E, 1,322D, 1,355H, 1,369R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,355H

RNA/DNA hybrid binding site
1,255D, 1,256A, 1,257S, 1,258G, 1,292A, 1,293V, 1,294T, 1,297E, 1,322D, 1,355H, 1,369R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,369R

RNA/DNA hybrid binding site
1,255D, 1,256A, 1,257S, 1,258G, 1,292A, 1,293V, 1,294T, 1,297E, 1,322D, 1,355H, 1,369R
CDD
cd09274 (RNase_HI_RT_Ty3)

GO term prediction

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0003676 nucleic acid binding
GO:0004190 aspartic-type endopeptidase activity
GO:0008270 zinc ion binding

Cellular Component