GBC53124.1

Protein

Length

1,202 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
85 - 241
Calponin homology domain (IPR001715)
482 - 857
Rho GTPase activation protein (IPR008936)
Ras GTPase-activating protein (IPR001936)
987 - 1,126
RasGAP protein, C-terminal (IPR000593)

1 200 400 600 800 1000 1202

Detailed signature matches

IPR001715

Calponin homology domain
1. SM00033 (ch_5)
  
  95 - 195
  
  SMART
  SM00033 (ch_5)
2. PF00307 (CH)
  
  98 - 198
  
  Pfam
  PF00307 (CH)
3. PS50021 (CH)
  
  93 - 199
  
  PROSITE profiles
  PS50021 (CH)
4. cd00014 (CH)
  
  94 - 199
  
  CDD
  cd00014 (CH)
5. SSF47576 (Calponin-...)
  
  85 - 241
  
  SUPERFAMILY
  SSF47576 (Calponin-homology domain, CH-domain)
IPR008936

Rho GTPase activation protein
1. SSF48350 (GTPase ac...)
  
  482 - 612
  
  SUPERFAMILY
  SSF48350 (GTPase activation domain, GAP)
  
  644 - 845
  
  SUPERFAMILY
  SSF48350 (GTPase activation domain, GAP)
IPR001936

Ras GTPase-activating protein
1. PF00616 (RasGAP)
  
  541 - 747
  
  Pfam
  PF00616 (RasGAP)
2. PS50018 (RAS_GTPASE...)
  
  520 - 748
  
  PROSITE profiles
  PS50018 (RAS_GTPASE_ACTIV_2)
3. SM00323 (RasGAP_2)
  
  508 - 857
  
  SMART
  SM00323 (RasGAP_2)
IPR000593

RasGAP protein, C-terminal
1. PF03836 (RasGAP_C)
  
  987 - 1,126
  
  Pfam
  PF03836 (RasGAP_C)
IPR000048

IQ motif, EF-hand binding site
1. PF00612 (IQ)
  
  284 - 301
  
  Pfam
  PF00612 (IQ)
  
  327 - 341
  
  Pfam
  PF00612 (IQ)
2. PS50096 (IQ)
  
  324 - 349
  
  PROSITE profiles
  PS50096 (IQ)
  
  281 - 309
  
  PROSITE profiles
  PS50096 (IQ)

no IPR

Unintegrated signatures

Coil

1,029 - 1,056

COILS
Coil (Coil)
SSF143885 (RGC doma...)

1,105 - 1,201

SUPERFAMILY
SSF143885 (RGC domain-like)
cd05127 (RasGAP_IQG...)

529 - 851

CDD
cd05127 (RasGAP_IQGAP_like)
mobidb-lite (disord...)

1 - 27

MobiDB Lite
mobidb-lite (disorder_prediction)

951 - 972

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative actin bin...

94C

putative actin binding surface
94C, 95H, 97G, 98E, 99A, 102W, 105A, 160F, 161A, 164Q, 167G, 169P, 186P, 187K, 190Y, 191C, 193H, 194A, 197H, 198L
CDD
cd00014 (CH)

95H

putative actin binding surface
94C, 95H, 97G, 98E, 99A, 102W, 105A, 160F, 161A, 164Q, 167G, 169P, 186P, 187K, 190Y, 191C, 193H, 194A, 197H, 198L
CDD
cd00014 (CH)

97G

putative actin binding surface
94C, 95H, 97G, 98E, 99A, 102W, 105A, 160F, 161A, 164Q, 167G, 169P, 186P, 187K, 190Y, 191C, 193H, 194A, 197H, 198L
CDD
cd00014 (CH)

98E

putative actin binding surface
94C, 95H, 97G, 98E, 99A, 102W, 105A, 160F, 161A, 164Q, 167G, 169P, 186P, 187K, 190Y, 191C, 193H, 194A, 197H, 198L
CDD
cd00014 (CH)

99A

putative actin binding surface
94C, 95H, 97G, 98E, 99A, 102W, 105A, 160F, 161A, 164Q, 167G, 169P, 186P, 187K, 190Y, 191C, 193H, 194A, 197H, 198L
CDD
cd00014 (CH)

102W

putative actin binding surface
94C, 95H, 97G, 98E, 99A, 102W, 105A, 160F, 161A, 164Q, 167G, 169P, 186P, 187K, 190Y, 191C, 193H, 194A, 197H, 198L
CDD
cd00014 (CH)

105A

putative actin binding surface
94C, 95H, 97G, 98E, 99A, 102W, 105A, 160F, 161A, 164Q, 167G, 169P, 186P, 187K, 190Y, 191C, 193H, 194A, 197H, 198L
CDD
cd00014 (CH)

160F

putative actin binding surface
94C, 95H, 97G, 98E, 99A, 102W, 105A, 160F, 161A, 164Q, 167G, 169P, 186P, 187K, 190Y, 191C, 193H, 194A, 197H, 198L
CDD
cd00014 (CH)

161A

putative actin binding surface
94C, 95H, 97G, 98E, 99A, 102W, 105A, 160F, 161A, 164Q, 167G, 169P, 186P, 187K, 190Y, 191C, 193H, 194A, 197H, 198L
CDD
cd00014 (CH)

164Q

putative actin binding surface
94C, 95H, 97G, 98E, 99A, 102W, 105A, 160F, 161A, 164Q, 167G, 169P, 186P, 187K, 190Y, 191C, 193H, 194A, 197H, 198L
CDD
cd00014 (CH)

167G

putative actin binding surface
94C, 95H, 97G, 98E, 99A, 102W, 105A, 160F, 161A, 164Q, 167G, 169P, 186P, 187K, 190Y, 191C, 193H, 194A, 197H, 198L
CDD
cd00014 (CH)

169P

putative actin binding surface
94C, 95H, 97G, 98E, 99A, 102W, 105A, 160F, 161A, 164Q, 167G, 169P, 186P, 187K, 190Y, 191C, 193H, 194A, 197H, 198L
CDD
cd00014 (CH)

186P

putative actin binding surface
94C, 95H, 97G, 98E, 99A, 102W, 105A, 160F, 161A, 164Q, 167G, 169P, 186P, 187K, 190Y, 191C, 193H, 194A, 197H, 198L
CDD
cd00014 (CH)

187K

putative actin binding surface
94C, 95H, 97G, 98E, 99A, 102W, 105A, 160F, 161A, 164Q, 167G, 169P, 186P, 187K, 190Y, 191C, 193H, 194A, 197H, 198L
CDD
cd00014 (CH)

190Y

putative actin binding surface
94C, 95H, 97G, 98E, 99A, 102W, 105A, 160F, 161A, 164Q, 167G, 169P, 186P, 187K, 190Y, 191C, 193H, 194A, 197H, 198L
CDD
cd00014 (CH)

191C

putative actin binding surface
94C, 95H, 97G, 98E, 99A, 102W, 105A, 160F, 161A, 164Q, 167G, 169P, 186P, 187K, 190Y, 191C, 193H, 194A, 197H, 198L
CDD
cd00014 (CH)

193H

putative actin binding surface
94C, 95H, 97G, 98E, 99A, 102W, 105A, 160F, 161A, 164Q, 167G, 169P, 186P, 187K, 190Y, 191C, 193H, 194A, 197H, 198L
CDD
cd00014 (CH)

194A

putative actin binding surface
94C, 95H, 97G, 98E, 99A, 102W, 105A, 160F, 161A, 164Q, 167G, 169P, 186P, 187K, 190Y, 191C, 193H, 194A, 197H, 198L
CDD
cd00014 (CH)

197H

putative actin binding surface
94C, 95H, 97G, 98E, 99A, 102W, 105A, 160F, 161A, 164Q, 167G, 169P, 186P, 187K, 190Y, 191C, 193H, 194A, 197H, 198L
CDD
cd00014 (CH)

198L

putative actin binding surface
94C, 95H, 97G, 98E, 99A, 102W, 105A, 160F, 161A, 164Q, 167G, 169P, 186P, 187K, 190Y, 191C, 193H, 194A, 197H, 198L
CDD
cd00014 (CH)
putative RAS inter...

562G

putative RAS interface
562G, 593Q, 595M, 597D, 598E, 601D, 604S, 608I, 700K, 708Y, 709R, 712N, 713P, 716V, 737A, 740S, 741K, 744N, 748V, 750K, 755D, 756N
CDD
cd05127 (RasGAP_IQGAP_like)

593Q

putative RAS interface
562G, 593Q, 595M, 597D, 598E, 601D, 604S, 608I, 700K, 708Y, 709R, 712N, 713P, 716V, 737A, 740S, 741K, 744N, 748V, 750K, 755D, 756N
CDD
cd05127 (RasGAP_IQGAP_like)

595M

putative RAS interface
562G, 593Q, 595M, 597D, 598E, 601D, 604S, 608I, 700K, 708Y, 709R, 712N, 713P, 716V, 737A, 740S, 741K, 744N, 748V, 750K, 755D, 756N
CDD
cd05127 (RasGAP_IQGAP_like)

597D

putative RAS interface
562G, 593Q, 595M, 597D, 598E, 601D, 604S, 608I, 700K, 708Y, 709R, 712N, 713P, 716V, 737A, 740S, 741K, 744N, 748V, 750K, 755D, 756N
CDD
cd05127 (RasGAP_IQGAP_like)

598E

putative RAS interface
562G, 593Q, 595M, 597D, 598E, 601D, 604S, 608I, 700K, 708Y, 709R, 712N, 713P, 716V, 737A, 740S, 741K, 744N, 748V, 750K, 755D, 756N
CDD
cd05127 (RasGAP_IQGAP_like)

601D

putative RAS interface
562G, 593Q, 595M, 597D, 598E, 601D, 604S, 608I, 700K, 708Y, 709R, 712N, 713P, 716V, 737A, 740S, 741K, 744N, 748V, 750K, 755D, 756N
CDD
cd05127 (RasGAP_IQGAP_like)

604S

putative RAS interface
562G, 593Q, 595M, 597D, 598E, 601D, 604S, 608I, 700K, 708Y, 709R, 712N, 713P, 716V, 737A, 740S, 741K, 744N, 748V, 750K, 755D, 756N
CDD
cd05127 (RasGAP_IQGAP_like)

608I

putative RAS interface
562G, 593Q, 595M, 597D, 598E, 601D, 604S, 608I, 700K, 708Y, 709R, 712N, 713P, 716V, 737A, 740S, 741K, 744N, 748V, 750K, 755D, 756N
CDD
cd05127 (RasGAP_IQGAP_like)

700K

putative RAS interface
562G, 593Q, 595M, 597D, 598E, 601D, 604S, 608I, 700K, 708Y, 709R, 712N, 713P, 716V, 737A, 740S, 741K, 744N, 748V, 750K, 755D, 756N
CDD
cd05127 (RasGAP_IQGAP_like)

708Y

putative RAS interface
562G, 593Q, 595M, 597D, 598E, 601D, 604S, 608I, 700K, 708Y, 709R, 712N, 713P, 716V, 737A, 740S, 741K, 744N, 748V, 750K, 755D, 756N
CDD
cd05127 (RasGAP_IQGAP_like)

709R

putative RAS interface
562G, 593Q, 595M, 597D, 598E, 601D, 604S, 608I, 700K, 708Y, 709R, 712N, 713P, 716V, 737A, 740S, 741K, 744N, 748V, 750K, 755D, 756N
CDD
cd05127 (RasGAP_IQGAP_like)

712N

putative RAS interface
562G, 593Q, 595M, 597D, 598E, 601D, 604S, 608I, 700K, 708Y, 709R, 712N, 713P, 716V, 737A, 740S, 741K, 744N, 748V, 750K, 755D, 756N
CDD
cd05127 (RasGAP_IQGAP_like)

713P

putative RAS interface
562G, 593Q, 595M, 597D, 598E, 601D, 604S, 608I, 700K, 708Y, 709R, 712N, 713P, 716V, 737A, 740S, 741K, 744N, 748V, 750K, 755D, 756N
CDD
cd05127 (RasGAP_IQGAP_like)

716V

putative RAS interface
562G, 593Q, 595M, 597D, 598E, 601D, 604S, 608I, 700K, 708Y, 709R, 712N, 713P, 716V, 737A, 740S, 741K, 744N, 748V, 750K, 755D, 756N
CDD
cd05127 (RasGAP_IQGAP_like)

737A

putative RAS interface
562G, 593Q, 595M, 597D, 598E, 601D, 604S, 608I, 700K, 708Y, 709R, 712N, 713P, 716V, 737A, 740S, 741K, 744N, 748V, 750K, 755D, 756N
CDD
cd05127 (RasGAP_IQGAP_like)

740S

putative RAS interface
562G, 593Q, 595M, 597D, 598E, 601D, 604S, 608I, 700K, 708Y, 709R, 712N, 713P, 716V, 737A, 740S, 741K, 744N, 748V, 750K, 755D, 756N
CDD
cd05127 (RasGAP_IQGAP_like)

741K

putative RAS interface
562G, 593Q, 595M, 597D, 598E, 601D, 604S, 608I, 700K, 708Y, 709R, 712N, 713P, 716V, 737A, 740S, 741K, 744N, 748V, 750K, 755D, 756N
CDD
cd05127 (RasGAP_IQGAP_like)

744N

putative RAS interface
562G, 593Q, 595M, 597D, 598E, 601D, 604S, 608I, 700K, 708Y, 709R, 712N, 713P, 716V, 737A, 740S, 741K, 744N, 748V, 750K, 755D, 756N
CDD
cd05127 (RasGAP_IQGAP_like)

748V

putative RAS interface
562G, 593Q, 595M, 597D, 598E, 601D, 604S, 608I, 700K, 708Y, 709R, 712N, 713P, 716V, 737A, 740S, 741K, 744N, 748V, 750K, 755D, 756N
CDD
cd05127 (RasGAP_IQGAP_like)

750K

putative RAS interface
562G, 593Q, 595M, 597D, 598E, 601D, 604S, 608I, 700K, 708Y, 709R, 712N, 713P, 716V, 737A, 740S, 741K, 744N, 748V, 750K, 755D, 756N
CDD
cd05127 (RasGAP_IQGAP_like)

755D

putative RAS interface
562G, 593Q, 595M, 597D, 598E, 601D, 604S, 608I, 700K, 708Y, 709R, 712N, 713P, 716V, 737A, 740S, 741K, 744N, 748V, 750K, 755D, 756N
CDD
cd05127 (RasGAP_IQGAP_like)

756N

putative RAS interface
562G, 593Q, 595M, 597D, 598E, 601D, 604S, 608I, 700K, 708Y, 709R, 712N, 713P, 716V, 737A, 740S, 741K, 744N, 748V, 750K, 755D, 756N
CDD
cd05127 (RasGAP_IQGAP_like)

GO term prediction

Biological Process

GO:0007165 signal transduction
GO:0043087 regulation of GTPase activity

Molecular Function

GO:0005515 protein binding

Cellular Component