GBC51109.1

Protein

Length

1,187 amino acids

Protein family membership

Citrate synthase (IPR002020)

Domains and repeats

Domain
67 - 240
ATP-grasp fold, succinyl-CoA synthetase-type (IPR013650)
309 - 486
Succinyl-CoA synthetase-like (IPR016102)
ATP-citrate synthase, citrate-binding domain (IPR032263)
561 - 693
NAD(P)-binding domain (IPR016040)
CoA-binding (IPR003781)
730 - 855
ATP-citrate lyase/succinyl-CoA ligase (IPR005811)

1 200 400 600 800 1000 1187

Detailed signature matches

IPR002020

Citrate synthase
1. PF00285 (Citrate_synt)
  
  951 - 1,150
  
  Pfam
  PF00285 (Citrate_synt)
2. SSF48256 (Citrate s...)
  
  689 - 809
  
  SUPERFAMILY
  SSF48256 (Citrate synthase)
  
  854 - 1,164
  
  SUPERFAMILY
  SSF48256 (Citrate synthase)
IPR013650

ATP-grasp fold, succinyl-CoA synthetase-type
1. PF08442 (ATP-grasp_2)
  
  67 - 240
  
  Pfam
  PF08442 (ATP-grasp_2)
IPR016102

Succinyl-CoA synthetase-like
1. SSF52210 (Succinyl-...)
  
  327 - 463
  
  SUPERFAMILY
  SSF52210 (Succinyl-CoA synthetase domains)
IPR032263

ATP-citrate synthase, citrate-binding domain
1. PF16114 (Citrate_bind)
  
  309 - 486
  
  Pfam
  PF16114 (Citrate_bind)
IPR016040

NAD(P)-binding domain
1. SSF51735 (NAD(P)-bi...)
  
  561 - 693
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
IPR003781

CoA-binding
1. PF02629 (CoA_binding)
  
  564 - 670
  
  Pfam
  PF02629 (CoA_binding)
IPR005811

ATP-citrate lyase/succinyl-CoA ligase
1. PF00549 (Ligase_CoA)
  
  730 - 855
  
  Pfam
  PF00549 (Ligase_CoA)
IPR017866

Succinyl-CoA synthetase, beta subunit, conserved site
1. PS01217 (SUCCINYL_C...)
  
  725 - 750
  
  PROSITE patterns
  PS01217 (SUCCINYL_COA_LIG_3)
IPR033847

ATP-citrate lyase/succinyl-CoA ligase, conserved site
1. PS01216 (SUCCINYL_C...)
  
  731 - 760
  
  PROSITE patterns
  PS01216 (SUCCINYL_COA_LIG_1)
IPR017440

ATP-citrate lyase/succinyl-CoA ligase, active site
1. PS00399 (SUCCINYL_C...)
  
  816 - 832
  
  PROSITE patterns
  PS00399 (SUCCINYL_COA_LIG_2)

no IPR

Unintegrated signatures

PR01798 (SCOASYNTHASE)

787 - 800

PRINTS
PR01798 (SCOASYNTHASE)

756 - 774

PRINTS
PR01798 (SCOASYNTHASE)

823 - 840

PRINTS
PR01798 (SCOASYNTHASE)
SSF56059 (Glutathio...)

69 - 275

SUPERFAMILY
SSF56059 (Glutathione synthetase ATP-binding domain-like)
cd06100 (CCL_ACL-C)

926 - 1,163

CDD
cd06100 (CCL_ACL-C)
mobidb-lite (disord...)

498 - 543

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

citrylCoA binding ...

970H

citrylCoA binding site
970H, 974V, 1,004R, 1,005F, 1,039L, 1,040I, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,094N, 1,135R
CDD
cd06100 (CCL_ACL-C)

974V

citrylCoA binding site
970H, 974V, 1,004R, 1,005F, 1,039L, 1,040I, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,094N, 1,135R
CDD
cd06100 (CCL_ACL-C)

1,004R

citrylCoA binding site
970H, 974V, 1,004R, 1,005F, 1,039L, 1,040I, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,094N, 1,135R
CDD
cd06100 (CCL_ACL-C)

1,005F

citrylCoA binding site
970H, 974V, 1,004R, 1,005F, 1,039L, 1,040I, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,094N, 1,135R
CDD
cd06100 (CCL_ACL-C)

1,039L

citrylCoA binding site
970H, 974V, 1,004R, 1,005F, 1,039L, 1,040I, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,094N, 1,135R
CDD
cd06100 (CCL_ACL-C)

1,040I

citrylCoA binding site
970H, 974V, 1,004R, 1,005F, 1,039L, 1,040I, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,094N, 1,135R
CDD
cd06100 (CCL_ACL-C)

1,042G

citrylCoA binding site
970H, 974V, 1,004R, 1,005F, 1,039L, 1,040I, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,094N, 1,135R
CDD
cd06100 (CCL_ACL-C)

1,043I

citrylCoA binding site
970H, 974V, 1,004R, 1,005F, 1,039L, 1,040I, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,094N, 1,135R
CDD
cd06100 (CCL_ACL-C)

1,044G

citrylCoA binding site
970H, 974V, 1,004R, 1,005F, 1,039L, 1,040I, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,094N, 1,135R
CDD
cd06100 (CCL_ACL-C)

1,045H

citrylCoA binding site
970H, 974V, 1,004R, 1,005F, 1,039L, 1,040I, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,094N, 1,135R
CDD
cd06100 (CCL_ACL-C)

1,046K

citrylCoA binding site
970H, 974V, 1,004R, 1,005F, 1,039L, 1,040I, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,094N, 1,135R
CDD
cd06100 (CCL_ACL-C)

1,056R

citrylCoA binding site
970H, 974V, 1,004R, 1,005F, 1,039L, 1,040I, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,094N, 1,135R
CDD
cd06100 (CCL_ACL-C)

1,094N

citrylCoA binding site
970H, 974V, 1,004R, 1,005F, 1,039L, 1,040I, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,094N, 1,135R
CDD
cd06100 (CCL_ACL-C)

1,135R

citrylCoA binding site
970H, 974V, 1,004R, 1,005F, 1,039L, 1,040I, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,094N, 1,135R
CDD
cd06100 (CCL_ACL-C)
oxalacetate bindin...

970H

oxalacetate binding site
970H, 974V, 1,005F, 1,045H, 1,046K, 1,056R, 1,135R, 1,158W
CDD
cd06100 (CCL_ACL-C)

974V

oxalacetate binding site
970H, 974V, 1,005F, 1,045H, 1,046K, 1,056R, 1,135R, 1,158W
CDD
cd06100 (CCL_ACL-C)

1,005F

oxalacetate binding site
970H, 974V, 1,005F, 1,045H, 1,046K, 1,056R, 1,135R, 1,158W
CDD
cd06100 (CCL_ACL-C)

1,045H

oxalacetate binding site
970H, 974V, 1,005F, 1,045H, 1,046K, 1,056R, 1,135R, 1,158W
CDD
cd06100 (CCL_ACL-C)

1,046K

oxalacetate binding site
970H, 974V, 1,005F, 1,045H, 1,046K, 1,056R, 1,135R, 1,158W
CDD
cd06100 (CCL_ACL-C)

1,056R

oxalacetate binding site
970H, 974V, 1,005F, 1,045H, 1,046K, 1,056R, 1,135R, 1,158W
CDD
cd06100 (CCL_ACL-C)

1,135R

oxalacetate binding site
970H, 974V, 1,005F, 1,045H, 1,046K, 1,056R, 1,135R, 1,158W
CDD
cd06100 (CCL_ACL-C)

1,158W

oxalacetate binding site
970H, 974V, 1,005F, 1,045H, 1,046K, 1,056R, 1,135R, 1,158W
CDD
cd06100 (CCL_ACL-C)
active site cd06100

970H

active site
970H, 974V, 1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,091L, 1,094N, 1,096D, 1,135R, 1,155R, 1,158W
CDD
cd06100 (CCL_ACL-C)

974V

active site
970H, 974V, 1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,091L, 1,094N, 1,096D, 1,135R, 1,155R, 1,158W
CDD
cd06100 (CCL_ACL-C)

1,003D

active site
970H, 974V, 1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,091L, 1,094N, 1,096D, 1,135R, 1,155R, 1,158W
CDD
cd06100 (CCL_ACL-C)

1,004R

active site
970H, 974V, 1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,091L, 1,094N, 1,096D, 1,135R, 1,155R, 1,158W
CDD
cd06100 (CCL_ACL-C)

1,005F

active site
970H, 974V, 1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,091L, 1,094N, 1,096D, 1,135R, 1,155R, 1,158W
CDD
cd06100 (CCL_ACL-C)

1,008A

active site
970H, 974V, 1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,091L, 1,094N, 1,096D, 1,135R, 1,155R, 1,158W
CDD
cd06100 (CCL_ACL-C)

1,011G

active site
970H, 974V, 1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,091L, 1,094N, 1,096D, 1,135R, 1,155R, 1,158W
CDD
cd06100 (CCL_ACL-C)

1,039L

active site
970H, 974V, 1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,091L, 1,094N, 1,096D, 1,135R, 1,155R, 1,158W
CDD
cd06100 (CCL_ACL-C)

1,040I

active site
970H, 974V, 1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,091L, 1,094N, 1,096D, 1,135R, 1,155R, 1,158W
CDD
cd06100 (CCL_ACL-C)

1,041L

active site
970H, 974V, 1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,091L, 1,094N, 1,096D, 1,135R, 1,155R, 1,158W
CDD
cd06100 (CCL_ACL-C)

1,042G

active site
970H, 974V, 1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,091L, 1,094N, 1,096D, 1,135R, 1,155R, 1,158W
CDD
cd06100 (CCL_ACL-C)

1,043I

active site
970H, 974V, 1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,091L, 1,094N, 1,096D, 1,135R, 1,155R, 1,158W
CDD
cd06100 (CCL_ACL-C)

1,044G

active site
970H, 974V, 1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,091L, 1,094N, 1,096D, 1,135R, 1,155R, 1,158W
CDD
cd06100 (CCL_ACL-C)

1,045H

active site
970H, 974V, 1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,091L, 1,094N, 1,096D, 1,135R, 1,155R, 1,158W
CDD
cd06100 (CCL_ACL-C)

1,046K

active site
970H, 974V, 1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,091L, 1,094N, 1,096D, 1,135R, 1,155R, 1,158W
CDD
cd06100 (CCL_ACL-C)

1,056R

active site
970H, 974V, 1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,091L, 1,094N, 1,096D, 1,135R, 1,155R, 1,158W
CDD
cd06100 (CCL_ACL-C)

1,091L

active site
970H, 974V, 1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,091L, 1,094N, 1,096D, 1,135R, 1,155R, 1,158W
CDD
cd06100 (CCL_ACL-C)

1,094N

active site
970H, 974V, 1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,091L, 1,094N, 1,096D, 1,135R, 1,155R, 1,158W
CDD
cd06100 (CCL_ACL-C)

1,096D

active site
970H, 974V, 1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,091L, 1,094N, 1,096D, 1,135R, 1,155R, 1,158W
CDD
cd06100 (CCL_ACL-C)

1,135R

active site
970H, 974V, 1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,091L, 1,094N, 1,096D, 1,135R, 1,155R, 1,158W
CDD
cd06100 (CCL_ACL-C)

1,155R

active site
970H, 974V, 1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,091L, 1,094N, 1,096D, 1,135R, 1,155R, 1,158W
CDD
cd06100 (CCL_ACL-C)

1,158W

active site
970H, 974V, 1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,056R, 1,091L, 1,094N, 1,096D, 1,135R, 1,155R, 1,158W
CDD
cd06100 (CCL_ACL-C)
coenzyme A binding...

1,003D

coenzyme A binding site
1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,091L, 1,094N, 1,096D, 1,155R
CDD
cd06100 (CCL_ACL-C)

1,004R

coenzyme A binding site
1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,091L, 1,094N, 1,096D, 1,155R
CDD
cd06100 (CCL_ACL-C)

1,005F

coenzyme A binding site
1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,091L, 1,094N, 1,096D, 1,155R
CDD
cd06100 (CCL_ACL-C)

1,008A

coenzyme A binding site
1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,091L, 1,094N, 1,096D, 1,155R
CDD
cd06100 (CCL_ACL-C)

1,011G

coenzyme A binding site
1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,091L, 1,094N, 1,096D, 1,155R
CDD
cd06100 (CCL_ACL-C)

1,039L

coenzyme A binding site
1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,091L, 1,094N, 1,096D, 1,155R
CDD
cd06100 (CCL_ACL-C)

1,040I

coenzyme A binding site
1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,091L, 1,094N, 1,096D, 1,155R
CDD
cd06100 (CCL_ACL-C)

1,041L

coenzyme A binding site
1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,091L, 1,094N, 1,096D, 1,155R
CDD
cd06100 (CCL_ACL-C)

1,042G

coenzyme A binding site
1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,091L, 1,094N, 1,096D, 1,155R
CDD
cd06100 (CCL_ACL-C)

1,043I

coenzyme A binding site
1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,091L, 1,094N, 1,096D, 1,155R
CDD
cd06100 (CCL_ACL-C)

1,044G

coenzyme A binding site
1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,091L, 1,094N, 1,096D, 1,155R
CDD
cd06100 (CCL_ACL-C)

1,045H

coenzyme A binding site
1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,091L, 1,094N, 1,096D, 1,155R
CDD
cd06100 (CCL_ACL-C)

1,046K

coenzyme A binding site
1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,091L, 1,094N, 1,096D, 1,155R
CDD
cd06100 (CCL_ACL-C)

1,091L

coenzyme A binding site
1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,091L, 1,094N, 1,096D, 1,155R
CDD
cd06100 (CCL_ACL-C)

1,094N

coenzyme A binding site
1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,091L, 1,094N, 1,096D, 1,155R
CDD
cd06100 (CCL_ACL-C)

1,096D

coenzyme A binding site
1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,091L, 1,094N, 1,096D, 1,155R
CDD
cd06100 (CCL_ACL-C)

1,155R

coenzyme A binding site
1,003D, 1,004R, 1,005F, 1,008A, 1,011G, 1,039L, 1,040I, 1,041L, 1,042G, 1,043I, 1,044G, 1,045H, 1,046K, 1,091L, 1,094N, 1,096D, 1,155R
CDD
cd06100 (CCL_ACL-C)
catalytic triad cd...

1,005F

catalytic triad
1,005F, 1,045H, 1,096D
CDD
cd06100 (CCL_ACL-C)

1,045H

catalytic triad
1,005F, 1,045H, 1,096D
CDD
cd06100 (CCL_ACL-C)

1,096D

catalytic triad
1,005F, 1,045H, 1,096D
CDD
cd06100 (CCL_ACL-C)

GO term prediction

Biological Process

GO:0008152 metabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
GO:0048037 cofactor binding

Cellular Component

None predicted.

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Status

Per-residue features