GBC51086.1

Protein

Length

301 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
8 - 51
DNA-directed RNA polymerase, RBP11-like dimerisation domain (IPR009025)
178 - 263
DNA-directed RNA polymerase, RBP11-like dimerisation domain (IPR009025)
Domain
21 - 261
DNA-directed RNA polymerase, RpoA/D/Rpb3-type (IPR011263)
Domain
47 - 172
DNA-directed RNA polymerase, insert domain (IPR011262)

1 50 100 150 200 250 301

Detailed signature matches

IPR009025

DNA-directed RNA polymerase, RBP11-like dimerisation domain
1. SSF55257 (RBP11-lik...)
  
  178 - 263
  
  SUPERFAMILY
  SSF55257 (RBP11-like subunits of RNA polymerase)
  
  8 - 51
  
  SUPERFAMILY
  SSF55257 (RBP11-like subunits of RNA polymerase)
IPR011263

DNA-directed RNA polymerase, RpoA/D/Rpb3-type
1. PF01193 (RNA_pol_L)
  
  23 - 254
  
  Pfam
  PF01193 (RNA_pol_L)
2. SM00662 (rpoldneu2)
  
  21 - 261
  
  SMART
  SM00662 (rpoldneu2)
IPR011262

DNA-directed RNA polymerase, insert domain
1. SSF56553 (Insert su...)
  
  47 - 172
  
  SUPERFAMILY
  SSF56553 (Insert subdomain of RNA polymerase alpha subunit)
2. PF01000 (RNA_pol_A_bac)
  
  53 - 171
  
  Pfam
  PF01000 (RNA_pol_A_bac)
IPR001514

DNA-directed RNA polymerase, 30-40kDa subunit, conserved site
1. PS00446 (RNA_POL_D_...)
  
  35 - 75
  
  PROSITE patterns
  PS00446 (RNA_POL_D_30KD)

no IPR

Unintegrated signatures

cd07031 (RNAP_II_RPB3)

10 - 262

CDD
cd07031 (RNAP_II_RPB3)

Residue annotation

RPB3 - RPB11 heter...

10P

RPB3 - RPB11 heterodimer interface
10P, 11E, 12I, 17L, 18T, 26L, 30D, 32S, 33M, 36A, 39R, 165K, 166E, 241E, 245M, 248F, 249K, 252L, 258I, 259Q, 262L
CDD
cd07031 (RNAP_II_RPB3)

11E

RPB3 - RPB11 heterodimer interface
10P, 11E, 12I, 17L, 18T, 26L, 30D, 32S, 33M, 36A, 39R, 165K, 166E, 241E, 245M, 248F, 249K, 252L, 258I, 259Q, 262L
CDD
cd07031 (RNAP_II_RPB3)

12I

RPB3 - RPB11 heterodimer interface
10P, 11E, 12I, 17L, 18T, 26L, 30D, 32S, 33M, 36A, 39R, 165K, 166E, 241E, 245M, 248F, 249K, 252L, 258I, 259Q, 262L
CDD
cd07031 (RNAP_II_RPB3)

17L

RPB3 - RPB11 heterodimer interface
10P, 11E, 12I, 17L, 18T, 26L, 30D, 32S, 33M, 36A, 39R, 165K, 166E, 241E, 245M, 248F, 249K, 252L, 258I, 259Q, 262L
CDD
cd07031 (RNAP_II_RPB3)

18T

RPB3 - RPB11 heterodimer interface
10P, 11E, 12I, 17L, 18T, 26L, 30D, 32S, 33M, 36A, 39R, 165K, 166E, 241E, 245M, 248F, 249K, 252L, 258I, 259Q, 262L
CDD
cd07031 (RNAP_II_RPB3)

26L

RPB3 - RPB11 heterodimer interface
10P, 11E, 12I, 17L, 18T, 26L, 30D, 32S, 33M, 36A, 39R, 165K, 166E, 241E, 245M, 248F, 249K, 252L, 258I, 259Q, 262L
CDD
cd07031 (RNAP_II_RPB3)

30D

RPB3 - RPB11 heterodimer interface
10P, 11E, 12I, 17L, 18T, 26L, 30D, 32S, 33M, 36A, 39R, 165K, 166E, 241E, 245M, 248F, 249K, 252L, 258I, 259Q, 262L
CDD
cd07031 (RNAP_II_RPB3)

32S

RPB3 - RPB11 heterodimer interface
10P, 11E, 12I, 17L, 18T, 26L, 30D, 32S, 33M, 36A, 39R, 165K, 166E, 241E, 245M, 248F, 249K, 252L, 258I, 259Q, 262L
CDD
cd07031 (RNAP_II_RPB3)

33M

RPB3 - RPB11 heterodimer interface
10P, 11E, 12I, 17L, 18T, 26L, 30D, 32S, 33M, 36A, 39R, 165K, 166E, 241E, 245M, 248F, 249K, 252L, 258I, 259Q, 262L
CDD
cd07031 (RNAP_II_RPB3)

36A

RPB3 - RPB11 heterodimer interface
10P, 11E, 12I, 17L, 18T, 26L, 30D, 32S, 33M, 36A, 39R, 165K, 166E, 241E, 245M, 248F, 249K, 252L, 258I, 259Q, 262L
CDD
cd07031 (RNAP_II_RPB3)

39R

RPB3 - RPB11 heterodimer interface
10P, 11E, 12I, 17L, 18T, 26L, 30D, 32S, 33M, 36A, 39R, 165K, 166E, 241E, 245M, 248F, 249K, 252L, 258I, 259Q, 262L
CDD
cd07031 (RNAP_II_RPB3)

165K

RPB3 - RPB11 heterodimer interface
10P, 11E, 12I, 17L, 18T, 26L, 30D, 32S, 33M, 36A, 39R, 165K, 166E, 241E, 245M, 248F, 249K, 252L, 258I, 259Q, 262L
CDD
cd07031 (RNAP_II_RPB3)

166E

RPB3 - RPB11 heterodimer interface
10P, 11E, 12I, 17L, 18T, 26L, 30D, 32S, 33M, 36A, 39R, 165K, 166E, 241E, 245M, 248F, 249K, 252L, 258I, 259Q, 262L
CDD
cd07031 (RNAP_II_RPB3)

241E

RPB3 - RPB11 heterodimer interface
10P, 11E, 12I, 17L, 18T, 26L, 30D, 32S, 33M, 36A, 39R, 165K, 166E, 241E, 245M, 248F, 249K, 252L, 258I, 259Q, 262L
CDD
cd07031 (RNAP_II_RPB3)

245M

RPB3 - RPB11 heterodimer interface
10P, 11E, 12I, 17L, 18T, 26L, 30D, 32S, 33M, 36A, 39R, 165K, 166E, 241E, 245M, 248F, 249K, 252L, 258I, 259Q, 262L
CDD
cd07031 (RNAP_II_RPB3)

248F

RPB3 - RPB11 heterodimer interface
10P, 11E, 12I, 17L, 18T, 26L, 30D, 32S, 33M, 36A, 39R, 165K, 166E, 241E, 245M, 248F, 249K, 252L, 258I, 259Q, 262L
CDD
cd07031 (RNAP_II_RPB3)

249K

RPB3 - RPB11 heterodimer interface
10P, 11E, 12I, 17L, 18T, 26L, 30D, 32S, 33M, 36A, 39R, 165K, 166E, 241E, 245M, 248F, 249K, 252L, 258I, 259Q, 262L
CDD
cd07031 (RNAP_II_RPB3)

252L

RPB3 - RPB11 heterodimer interface
10P, 11E, 12I, 17L, 18T, 26L, 30D, 32S, 33M, 36A, 39R, 165K, 166E, 241E, 245M, 248F, 249K, 252L, 258I, 259Q, 262L
CDD
cd07031 (RNAP_II_RPB3)

258I

RPB3 - RPB11 heterodimer interface
10P, 11E, 12I, 17L, 18T, 26L, 30D, 32S, 33M, 36A, 39R, 165K, 166E, 241E, 245M, 248F, 249K, 252L, 258I, 259Q, 262L
CDD
cd07031 (RNAP_II_RPB3)

259Q

RPB3 - RPB11 heterodimer interface
10P, 11E, 12I, 17L, 18T, 26L, 30D, 32S, 33M, 36A, 39R, 165K, 166E, 241E, 245M, 248F, 249K, 252L, 258I, 259Q, 262L
CDD
cd07031 (RNAP_II_RPB3)

262L

RPB3 - RPB11 heterodimer interface
10P, 11E, 12I, 17L, 18T, 26L, 30D, 32S, 33M, 36A, 39R, 165K, 166E, 241E, 245M, 248F, 249K, 252L, 258I, 259Q, 262L
CDD
cd07031 (RNAP_II_RPB3)
RPB3 - RPB2 intera...

35N

RPB3 - RPB2 interaction site
35N, 38R, 39R, 43S, 63A, 65E, 66F, 69H, 70R, 167H, 168A, 173C, 174A, 175A, 177A, 178F, 180Y, 181D, 188H, 189T, 190H, 192W, 194E, 201W, 202P
CDD
cd07031 (RNAP_II_RPB3)

38R

RPB3 - RPB2 interaction site
35N, 38R, 39R, 43S, 63A, 65E, 66F, 69H, 70R, 167H, 168A, 173C, 174A, 175A, 177A, 178F, 180Y, 181D, 188H, 189T, 190H, 192W, 194E, 201W, 202P
CDD
cd07031 (RNAP_II_RPB3)

39R

RPB3 - RPB2 interaction site
35N, 38R, 39R, 43S, 63A, 65E, 66F, 69H, 70R, 167H, 168A, 173C, 174A, 175A, 177A, 178F, 180Y, 181D, 188H, 189T, 190H, 192W, 194E, 201W, 202P
CDD
cd07031 (RNAP_II_RPB3)

43S

RPB3 - RPB2 interaction site
35N, 38R, 39R, 43S, 63A, 65E, 66F, 69H, 70R, 167H, 168A, 173C, 174A, 175A, 177A, 178F, 180Y, 181D, 188H, 189T, 190H, 192W, 194E, 201W, 202P
CDD
cd07031 (RNAP_II_RPB3)

63A

RPB3 - RPB2 interaction site
35N, 38R, 39R, 43S, 63A, 65E, 66F, 69H, 70R, 167H, 168A, 173C, 174A, 175A, 177A, 178F, 180Y, 181D, 188H, 189T, 190H, 192W, 194E, 201W, 202P
CDD
cd07031 (RNAP_II_RPB3)

65E

RPB3 - RPB2 interaction site
35N, 38R, 39R, 43S, 63A, 65E, 66F, 69H, 70R, 167H, 168A, 173C, 174A, 175A, 177A, 178F, 180Y, 181D, 188H, 189T, 190H, 192W, 194E, 201W, 202P
CDD
cd07031 (RNAP_II_RPB3)

66F

RPB3 - RPB2 interaction site
35N, 38R, 39R, 43S, 63A, 65E, 66F, 69H, 70R, 167H, 168A, 173C, 174A, 175A, 177A, 178F, 180Y, 181D, 188H, 189T, 190H, 192W, 194E, 201W, 202P
CDD
cd07031 (RNAP_II_RPB3)

69H

RPB3 - RPB2 interaction site
35N, 38R, 39R, 43S, 63A, 65E, 66F, 69H, 70R, 167H, 168A, 173C, 174A, 175A, 177A, 178F, 180Y, 181D, 188H, 189T, 190H, 192W, 194E, 201W, 202P
CDD
cd07031 (RNAP_II_RPB3)

70R

RPB3 - RPB2 interaction site
35N, 38R, 39R, 43S, 63A, 65E, 66F, 69H, 70R, 167H, 168A, 173C, 174A, 175A, 177A, 178F, 180Y, 181D, 188H, 189T, 190H, 192W, 194E, 201W, 202P
CDD
cd07031 (RNAP_II_RPB3)

167H

RPB3 - RPB2 interaction site
35N, 38R, 39R, 43S, 63A, 65E, 66F, 69H, 70R, 167H, 168A, 173C, 174A, 175A, 177A, 178F, 180Y, 181D, 188H, 189T, 190H, 192W, 194E, 201W, 202P
CDD
cd07031 (RNAP_II_RPB3)

168A

RPB3 - RPB2 interaction site
35N, 38R, 39R, 43S, 63A, 65E, 66F, 69H, 70R, 167H, 168A, 173C, 174A, 175A, 177A, 178F, 180Y, 181D, 188H, 189T, 190H, 192W, 194E, 201W, 202P
CDD
cd07031 (RNAP_II_RPB3)

173C

RPB3 - RPB2 interaction site
35N, 38R, 39R, 43S, 63A, 65E, 66F, 69H, 70R, 167H, 168A, 173C, 174A, 175A, 177A, 178F, 180Y, 181D, 188H, 189T, 190H, 192W, 194E, 201W, 202P
CDD
cd07031 (RNAP_II_RPB3)

174A

RPB3 - RPB2 interaction site
35N, 38R, 39R, 43S, 63A, 65E, 66F, 69H, 70R, 167H, 168A, 173C, 174A, 175A, 177A, 178F, 180Y, 181D, 188H, 189T, 190H, 192W, 194E, 201W, 202P
CDD
cd07031 (RNAP_II_RPB3)

175A

RPB3 - RPB2 interaction site
35N, 38R, 39R, 43S, 63A, 65E, 66F, 69H, 70R, 167H, 168A, 173C, 174A, 175A, 177A, 178F, 180Y, 181D, 188H, 189T, 190H, 192W, 194E, 201W, 202P
CDD
cd07031 (RNAP_II_RPB3)

177A

RPB3 - RPB2 interaction site
35N, 38R, 39R, 43S, 63A, 65E, 66F, 69H, 70R, 167H, 168A, 173C, 174A, 175A, 177A, 178F, 180Y, 181D, 188H, 189T, 190H, 192W, 194E, 201W, 202P
CDD
cd07031 (RNAP_II_RPB3)

178F

RPB3 - RPB2 interaction site
35N, 38R, 39R, 43S, 63A, 65E, 66F, 69H, 70R, 167H, 168A, 173C, 174A, 175A, 177A, 178F, 180Y, 181D, 188H, 189T, 190H, 192W, 194E, 201W, 202P
CDD
cd07031 (RNAP_II_RPB3)

180Y

RPB3 - RPB2 interaction site
35N, 38R, 39R, 43S, 63A, 65E, 66F, 69H, 70R, 167H, 168A, 173C, 174A, 175A, 177A, 178F, 180Y, 181D, 188H, 189T, 190H, 192W, 194E, 201W, 202P
CDD
cd07031 (RNAP_II_RPB3)

181D

RPB3 - RPB2 interaction site
35N, 38R, 39R, 43S, 63A, 65E, 66F, 69H, 70R, 167H, 168A, 173C, 174A, 175A, 177A, 178F, 180Y, 181D, 188H, 189T, 190H, 192W, 194E, 201W, 202P
CDD
cd07031 (RNAP_II_RPB3)

188H

RPB3 - RPB2 interaction site
35N, 38R, 39R, 43S, 63A, 65E, 66F, 69H, 70R, 167H, 168A, 173C, 174A, 175A, 177A, 178F, 180Y, 181D, 188H, 189T, 190H, 192W, 194E, 201W, 202P
CDD
cd07031 (RNAP_II_RPB3)

189T

RPB3 - RPB2 interaction site
35N, 38R, 39R, 43S, 63A, 65E, 66F, 69H, 70R, 167H, 168A, 173C, 174A, 175A, 177A, 178F, 180Y, 181D, 188H, 189T, 190H, 192W, 194E, 201W, 202P
CDD
cd07031 (RNAP_II_RPB3)

190H

RPB3 - RPB2 interaction site
35N, 38R, 39R, 43S, 63A, 65E, 66F, 69H, 70R, 167H, 168A, 173C, 174A, 175A, 177A, 178F, 180Y, 181D, 188H, 189T, 190H, 192W, 194E, 201W, 202P
CDD
cd07031 (RNAP_II_RPB3)

192W

RPB3 - RPB2 interaction site
35N, 38R, 39R, 43S, 63A, 65E, 66F, 69H, 70R, 167H, 168A, 173C, 174A, 175A, 177A, 178F, 180Y, 181D, 188H, 189T, 190H, 192W, 194E, 201W, 202P
CDD
cd07031 (RNAP_II_RPB3)

194E

RPB3 - RPB2 interaction site
35N, 38R, 39R, 43S, 63A, 65E, 66F, 69H, 70R, 167H, 168A, 173C, 174A, 175A, 177A, 178F, 180Y, 181D, 188H, 189T, 190H, 192W, 194E, 201W, 202P
CDD
cd07031 (RNAP_II_RPB3)

201W

RPB3 - RPB2 interaction site
35N, 38R, 39R, 43S, 63A, 65E, 66F, 69H, 70R, 167H, 168A, 173C, 174A, 175A, 177A, 178F, 180Y, 181D, 188H, 189T, 190H, 192W, 194E, 201W, 202P
CDD
cd07031 (RNAP_II_RPB3)

202P

RPB3 - RPB2 interaction site
35N, 38R, 39R, 43S, 63A, 65E, 66F, 69H, 70R, 167H, 168A, 173C, 174A, 175A, 177A, 178F, 180Y, 181D, 188H, 189T, 190H, 192W, 194E, 201W, 202P
CDD
cd07031 (RNAP_II_RPB3)
RPB3 - RPB12 inter...

50I

RPB3 - RPB12 interaction site
50I, 51D, 52M, 53V, 54Q, 55F, 56D, 64D, 69H, 166E, 167H, 169K
CDD
cd07031 (RNAP_II_RPB3)

51D

RPB3 - RPB12 interaction site
50I, 51D, 52M, 53V, 54Q, 55F, 56D, 64D, 69H, 166E, 167H, 169K
CDD
cd07031 (RNAP_II_RPB3)

52M

RPB3 - RPB12 interaction site
50I, 51D, 52M, 53V, 54Q, 55F, 56D, 64D, 69H, 166E, 167H, 169K
CDD
cd07031 (RNAP_II_RPB3)

53V

RPB3 - RPB12 interaction site
50I, 51D, 52M, 53V, 54Q, 55F, 56D, 64D, 69H, 166E, 167H, 169K
CDD
cd07031 (RNAP_II_RPB3)

54Q

RPB3 - RPB12 interaction site
50I, 51D, 52M, 53V, 54Q, 55F, 56D, 64D, 69H, 166E, 167H, 169K
CDD
cd07031 (RNAP_II_RPB3)

55F

RPB3 - RPB12 interaction site
50I, 51D, 52M, 53V, 54Q, 55F, 56D, 64D, 69H, 166E, 167H, 169K
CDD
cd07031 (RNAP_II_RPB3)

56D

RPB3 - RPB12 interaction site
50I, 51D, 52M, 53V, 54Q, 55F, 56D, 64D, 69H, 166E, 167H, 169K
CDD
cd07031 (RNAP_II_RPB3)

64D

RPB3 - RPB12 interaction site
50I, 51D, 52M, 53V, 54Q, 55F, 56D, 64D, 69H, 166E, 167H, 169K
CDD
cd07031 (RNAP_II_RPB3)

69H

RPB3 - RPB12 interaction site
50I, 51D, 52M, 53V, 54Q, 55F, 56D, 64D, 69H, 166E, 167H, 169K
CDD
cd07031 (RNAP_II_RPB3)

166E

RPB3 - RPB12 interaction site
50I, 51D, 52M, 53V, 54Q, 55F, 56D, 64D, 69H, 166E, 167H, 169K
CDD
cd07031 (RNAP_II_RPB3)

167H

RPB3 - RPB12 interaction site
50I, 51D, 52M, 53V, 54Q, 55F, 56D, 64D, 69H, 166E, 167H, 169K
CDD
cd07031 (RNAP_II_RPB3)

169K

RPB3 - RPB12 interaction site
50I, 51D, 52M, 53V, 54Q, 55F, 56D, 64D, 69H, 166E, 167H, 169K
CDD
cd07031 (RNAP_II_RPB3)
RPB3 - RPB10 inter...

61V

RPB3 - RPB10 interaction site
61V, 70R, 73L, 117D, 119T, 141G, 142I, 143L, 146K, 148R, 169K, 174A, 175A, 233E, 235I
CDD
cd07031 (RNAP_II_RPB3)

70R

RPB3 - RPB10 interaction site
61V, 70R, 73L, 117D, 119T, 141G, 142I, 143L, 146K, 148R, 169K, 174A, 175A, 233E, 235I
CDD
cd07031 (RNAP_II_RPB3)

73L

RPB3 - RPB10 interaction site
61V, 70R, 73L, 117D, 119T, 141G, 142I, 143L, 146K, 148R, 169K, 174A, 175A, 233E, 235I
CDD
cd07031 (RNAP_II_RPB3)

117D

RPB3 - RPB10 interaction site
61V, 70R, 73L, 117D, 119T, 141G, 142I, 143L, 146K, 148R, 169K, 174A, 175A, 233E, 235I
CDD
cd07031 (RNAP_II_RPB3)

119T

RPB3 - RPB10 interaction site
61V, 70R, 73L, 117D, 119T, 141G, 142I, 143L, 146K, 148R, 169K, 174A, 175A, 233E, 235I
CDD
cd07031 (RNAP_II_RPB3)

141G

RPB3 - RPB10 interaction site
61V, 70R, 73L, 117D, 119T, 141G, 142I, 143L, 146K, 148R, 169K, 174A, 175A, 233E, 235I
CDD
cd07031 (RNAP_II_RPB3)

142I

RPB3 - RPB10 interaction site
61V, 70R, 73L, 117D, 119T, 141G, 142I, 143L, 146K, 148R, 169K, 174A, 175A, 233E, 235I
CDD
cd07031 (RNAP_II_RPB3)

143L

RPB3 - RPB10 interaction site
61V, 70R, 73L, 117D, 119T, 141G, 142I, 143L, 146K, 148R, 169K, 174A, 175A, 233E, 235I
CDD
cd07031 (RNAP_II_RPB3)

146K

RPB3 - RPB10 interaction site
61V, 70R, 73L, 117D, 119T, 141G, 142I, 143L, 146K, 148R, 169K, 174A, 175A, 233E, 235I
CDD
cd07031 (RNAP_II_RPB3)

148R

RPB3 - RPB10 interaction site
61V, 70R, 73L, 117D, 119T, 141G, 142I, 143L, 146K, 148R, 169K, 174A, 175A, 233E, 235I
CDD
cd07031 (RNAP_II_RPB3)

169K

RPB3 - RPB10 interaction site
61V, 70R, 73L, 117D, 119T, 141G, 142I, 143L, 146K, 148R, 169K, 174A, 175A, 233E, 235I
CDD
cd07031 (RNAP_II_RPB3)

174A

RPB3 - RPB10 interaction site
61V, 70R, 73L, 117D, 119T, 141G, 142I, 143L, 146K, 148R, 169K, 174A, 175A, 233E, 235I
CDD
cd07031 (RNAP_II_RPB3)

175A

RPB3 - RPB10 interaction site
61V, 70R, 73L, 117D, 119T, 141G, 142I, 143L, 146K, 148R, 169K, 174A, 175A, 233E, 235I
CDD
cd07031 (RNAP_II_RPB3)

233E

RPB3 - RPB10 interaction site
61V, 70R, 73L, 117D, 119T, 141G, 142I, 143L, 146K, 148R, 169K, 174A, 175A, 233E, 235I
CDD
cd07031 (RNAP_II_RPB3)

235I

RPB3 - RPB10 interaction site
61V, 70R, 73L, 117D, 119T, 141G, 142I, 143L, 146K, 148R, 169K, 174A, 175A, 233E, 235I
CDD
cd07031 (RNAP_II_RPB3)
RPB3 - RPB8 intera...

187R

RPB3 - RPB8 interaction site
187R, 221F
CDD
cd07031 (RNAP_II_RPB3)

221F

RPB3 - RPB8 interaction site
187R, 221F
CDD
cd07031 (RNAP_II_RPB3)
RPB3 - RPB1 intera...

192W

RPB3 - RPB1 interaction site
192W, 193I, 194E, 221F
CDD
cd07031 (RNAP_II_RPB3)

193I

RPB3 - RPB1 interaction site
192W, 193I, 194E, 221F
CDD
cd07031 (RNAP_II_RPB3)

194E

RPB3 - RPB1 interaction site
192W, 193I, 194E, 221F
CDD
cd07031 (RNAP_II_RPB3)

221F

RPB3 - RPB1 interaction site
192W, 193I, 194E, 221F
CDD
cd07031 (RNAP_II_RPB3)

GO term prediction

Biological Process

GO:0006351 transcription, DNA-templated

Molecular Function

GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0046983 protein dimerization activity

Cellular Component