GBC48765.1

Protein

Length

527 amino acids

Protein family membership

Hydroxymethylglutaryl-CoA reductase, class I/II (IPR002202)
- Hydroxymethylglutaryl-CoA reductase, bacterial-type (IPR004553)

Domains and repeats

Domain
19 - 140
Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain (IPR009029)
266 - 484
Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain (IPR009029)
Domain
137 - 255
Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain (IPR009023)

1 50 100 150 200 250 300 350 400 450 500 527

Detailed signature matches

IPR002202

Hydroxymethylglutaryl-CoA reductase, class I/II
1. PS50065 (HMG_COA_RE...)
  
  58 - 446
  
  PROSITE profiles
  PS50065 (HMG_COA_REDUCTASE_4)
2. PF00368 (HMG-CoA_red)
  
  54 - 447
  
  Pfam
  PF00368 (HMG-CoA_red)
IPR004553

Hydroxymethylglutaryl-CoA reductase, bacterial-type
1. TIGR00532
  
  18 - 447
  
  TIGRFAMs
  TIGR00532 (TIGR00532)
2. cd00644 (HMG-CoA_re...)
  
  19 - 484
  
  CDD
  cd00644 (HMG-CoA_reductase_classII)
IPR009029

Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain
1. SSF56542 (Substrate...)
  
  19 - 140
  
  SUPERFAMILY
  SSF56542 (Substrate-binding domain of HMG-CoA reductase)
  
  266 - 484
  
  SUPERFAMILY
  SSF56542 (Substrate-binding domain of HMG-CoA reductase)
IPR009023

Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain
1. SSF55035 (NAD-bindi...)
  
  137 - 255
  
  SUPERFAMILY
  SSF55035 (NAD-binding domain of HMG-CoA reductase)
IPR023076

Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site
1. PS01192 (HMG_COA_RE...)
  
  432 - 445
  
  PROSITE patterns
  PS01192 (HMG_COA_REDUCTASE_3)

Residue annotation

homodimer interfac...

21F

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

26L

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

29R

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

30Q

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

52L

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

65E

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

68A

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

69D

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

71M

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

72I

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

73E

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

74N

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

75C

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

76I

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

77G

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

78T

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

79I

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

80G

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

81L

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

82P

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

83V

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

84G

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

85L

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

101A

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

102I

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

103E

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

104E

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

105P

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

106S

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

107V

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

108I

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

109A

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

134I

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

137Q

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

139C

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

188I

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

211V

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

213H

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

247G

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

248L

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

249R

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

250I

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

251V

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

252S

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

253N

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

283A

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

286I

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

287E

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

288A

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

290E

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

291W

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

294V

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

295D

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

297Y

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

298R

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

300T

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

301T

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

304K

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

307M

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

308N

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

311D

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

315L

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

316A

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

320D

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

321W

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

322R

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

335G

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

337R

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

338T

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

341D

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

345S

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

347G

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

349Y

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

392V

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

396N

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

398V

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

399Y

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

433L

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

436E

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

437G

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

438I

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

439Q

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

443M

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

445L

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

446H

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

448K

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

449N

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

452I

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

453A

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)

477S

homodimer interface
21F, 26L, 29R, 30Q, 52L, 65E, 68A, 69D, 71M, 72I, 73E, 74N, 75C, 76I, 77G, 78T, 79I, 80G, 81L, 82P, 83V, 84G, 85L, 101A, 102I, 103E, 104E, 105P, 106S, 107V, 108I, 109A, 134I, 137Q, 139C, 188I, 211V, 213H, 247G, 248L, 249R, 250I, 251V, 252S, 253N, 283A, 286I, 287E, 288A, 290E, 291W, 294V, 295D, 297Y, 298R, 300T, 301T, 304K, 307M, 308N, 311D, 315L, 316A, 320D, 321W, 322R, 335G, 337R, 338T, 341D, 345S, 347G, 349Y, 392V, 396N, 398V, 399Y, 433L, 436E, 437G, 438I, 439Q, 443M, 445L, 446H, 448K, 449N, 452I, 453A, 477S
CDD
cd00644 (HMG-CoA_reductase_classII)
substrate binding ...

104E

substrate binding pocket
104E, 298R, 301T, 302H, 304K, 305G, 308N, 429A, 433L, 438I
CDD
cd00644 (HMG-CoA_reductase_classII)

298R

substrate binding pocket
104E, 298R, 301T, 302H, 304K, 305G, 308N, 429A, 433L, 438I
CDD
cd00644 (HMG-CoA_reductase_classII)

301T

substrate binding pocket
104E, 298R, 301T, 302H, 304K, 305G, 308N, 429A, 433L, 438I
CDD
cd00644 (HMG-CoA_reductase_classII)

302H

substrate binding pocket
104E, 298R, 301T, 302H, 304K, 305G, 308N, 429A, 433L, 438I
CDD
cd00644 (HMG-CoA_reductase_classII)

304K

substrate binding pocket
104E, 298R, 301T, 302H, 304K, 305G, 308N, 429A, 433L, 438I
CDD
cd00644 (HMG-CoA_reductase_classII)

305G

substrate binding pocket
104E, 298R, 301T, 302H, 304K, 305G, 308N, 429A, 433L, 438I
CDD
cd00644 (HMG-CoA_reductase_classII)

308N

substrate binding pocket
104E, 298R, 301T, 302H, 304K, 305G, 308N, 429A, 433L, 438I
CDD
cd00644 (HMG-CoA_reductase_classII)

429A

substrate binding pocket
104E, 298R, 301T, 302H, 304K, 305G, 308N, 429A, 433L, 438I
CDD
cd00644 (HMG-CoA_reductase_classII)

433L

substrate binding pocket
104E, 298R, 301T, 302H, 304K, 305G, 308N, 429A, 433L, 438I
CDD
cd00644 (HMG-CoA_reductase_classII)

438I

substrate binding pocket
104E, 298R, 301T, 302H, 304K, 305G, 308N, 429A, 433L, 438I
CDD
cd00644 (HMG-CoA_reductase_classII)
NAD binding site c...

104E

NAD binding site
104E, 173M, 176R, 219C, 220N, 221A, 222M, 223G, 224A, 225N, 226C, 228S, 251V, 253N, 301T, 304K, 320D, 335G, 389A, 390G, 391G, 442H
CDD
cd00644 (HMG-CoA_reductase_classII)

173M

NAD binding site
104E, 173M, 176R, 219C, 220N, 221A, 222M, 223G, 224A, 225N, 226C, 228S, 251V, 253N, 301T, 304K, 320D, 335G, 389A, 390G, 391G, 442H
CDD
cd00644 (HMG-CoA_reductase_classII)

176R

NAD binding site
104E, 173M, 176R, 219C, 220N, 221A, 222M, 223G, 224A, 225N, 226C, 228S, 251V, 253N, 301T, 304K, 320D, 335G, 389A, 390G, 391G, 442H
CDD
cd00644 (HMG-CoA_reductase_classII)

219C

NAD binding site
104E, 173M, 176R, 219C, 220N, 221A, 222M, 223G, 224A, 225N, 226C, 228S, 251V, 253N, 301T, 304K, 320D, 335G, 389A, 390G, 391G, 442H
CDD
cd00644 (HMG-CoA_reductase_classII)

220N

NAD binding site
104E, 173M, 176R, 219C, 220N, 221A, 222M, 223G, 224A, 225N, 226C, 228S, 251V, 253N, 301T, 304K, 320D, 335G, 389A, 390G, 391G, 442H
CDD
cd00644 (HMG-CoA_reductase_classII)

221A

NAD binding site
104E, 173M, 176R, 219C, 220N, 221A, 222M, 223G, 224A, 225N, 226C, 228S, 251V, 253N, 301T, 304K, 320D, 335G, 389A, 390G, 391G, 442H
CDD
cd00644 (HMG-CoA_reductase_classII)

222M

NAD binding site
104E, 173M, 176R, 219C, 220N, 221A, 222M, 223G, 224A, 225N, 226C, 228S, 251V, 253N, 301T, 304K, 320D, 335G, 389A, 390G, 391G, 442H
CDD
cd00644 (HMG-CoA_reductase_classII)

223G

NAD binding site
104E, 173M, 176R, 219C, 220N, 221A, 222M, 223G, 224A, 225N, 226C, 228S, 251V, 253N, 301T, 304K, 320D, 335G, 389A, 390G, 391G, 442H
CDD
cd00644 (HMG-CoA_reductase_classII)

224A

NAD binding site
104E, 173M, 176R, 219C, 220N, 221A, 222M, 223G, 224A, 225N, 226C, 228S, 251V, 253N, 301T, 304K, 320D, 335G, 389A, 390G, 391G, 442H
CDD
cd00644 (HMG-CoA_reductase_classII)

225N

NAD binding site
104E, 173M, 176R, 219C, 220N, 221A, 222M, 223G, 224A, 225N, 226C, 228S, 251V, 253N, 301T, 304K, 320D, 335G, 389A, 390G, 391G, 442H
CDD
cd00644 (HMG-CoA_reductase_classII)

226C

NAD binding site
104E, 173M, 176R, 219C, 220N, 221A, 222M, 223G, 224A, 225N, 226C, 228S, 251V, 253N, 301T, 304K, 320D, 335G, 389A, 390G, 391G, 442H
CDD
cd00644 (HMG-CoA_reductase_classII)

228S

NAD binding site
104E, 173M, 176R, 219C, 220N, 221A, 222M, 223G, 224A, 225N, 226C, 228S, 251V, 253N, 301T, 304K, 320D, 335G, 389A, 390G, 391G, 442H
CDD
cd00644 (HMG-CoA_reductase_classII)

251V

NAD binding site
104E, 173M, 176R, 219C, 220N, 221A, 222M, 223G, 224A, 225N, 226C, 228S, 251V, 253N, 301T, 304K, 320D, 335G, 389A, 390G, 391G, 442H
CDD
cd00644 (HMG-CoA_reductase_classII)

253N

NAD binding site
104E, 173M, 176R, 219C, 220N, 221A, 222M, 223G, 224A, 225N, 226C, 228S, 251V, 253N, 301T, 304K, 320D, 335G, 389A, 390G, 391G, 442H
CDD
cd00644 (HMG-CoA_reductase_classII)

301T

NAD binding site
104E, 173M, 176R, 219C, 220N, 221A, 222M, 223G, 224A, 225N, 226C, 228S, 251V, 253N, 301T, 304K, 320D, 335G, 389A, 390G, 391G, 442H
CDD
cd00644 (HMG-CoA_reductase_classII)

304K

NAD binding site
104E, 173M, 176R, 219C, 220N, 221A, 222M, 223G, 224A, 225N, 226C, 228S, 251V, 253N, 301T, 304K, 320D, 335G, 389A, 390G, 391G, 442H
CDD
cd00644 (HMG-CoA_reductase_classII)

320D

NAD binding site
104E, 173M, 176R, 219C, 220N, 221A, 222M, 223G, 224A, 225N, 226C, 228S, 251V, 253N, 301T, 304K, 320D, 335G, 389A, 390G, 391G, 442H
CDD
cd00644 (HMG-CoA_reductase_classII)

335G

NAD binding site
104E, 173M, 176R, 219C, 220N, 221A, 222M, 223G, 224A, 225N, 226C, 228S, 251V, 253N, 301T, 304K, 320D, 335G, 389A, 390G, 391G, 442H
CDD
cd00644 (HMG-CoA_reductase_classII)

389A

NAD binding site
104E, 173M, 176R, 219C, 220N, 221A, 222M, 223G, 224A, 225N, 226C, 228S, 251V, 253N, 301T, 304K, 320D, 335G, 389A, 390G, 391G, 442H
CDD
cd00644 (HMG-CoA_reductase_classII)

390G

NAD binding site
104E, 173M, 176R, 219C, 220N, 221A, 222M, 223G, 224A, 225N, 226C, 228S, 251V, 253N, 301T, 304K, 320D, 335G, 389A, 390G, 391G, 442H
CDD
cd00644 (HMG-CoA_reductase_classII)

391G

NAD binding site
104E, 173M, 176R, 219C, 220N, 221A, 222M, 223G, 224A, 225N, 226C, 228S, 251V, 253N, 301T, 304K, 320D, 335G, 389A, 390G, 391G, 442H
CDD
cd00644 (HMG-CoA_reductase_classII)

442H

NAD binding site
104E, 173M, 176R, 219C, 220N, 221A, 222M, 223G, 224A, 225N, 226C, 228S, 251V, 253N, 301T, 304K, 320D, 335G, 389A, 390G, 391G, 442H
CDD
cd00644 (HMG-CoA_reductase_classII)
catalytic residues...

104E

catalytic residues
104E, 304K, 320D, 442H
CDD
cd00644 (HMG-CoA_reductase_classII)

304K

catalytic residues
104E, 304K, 320D, 442H
CDD
cd00644 (HMG-CoA_reductase_classII)

320D

catalytic residues
104E, 304K, 320D, 442H
CDD
cd00644 (HMG-CoA_reductase_classII)

442H

catalytic residues
104E, 304K, 320D, 442H
CDD
cd00644 (HMG-CoA_reductase_classII)
flexible flap cd00...

439Q

flexible flap
439Q, 440R, 441G, 442H, 443M, 444S, 445L, 446H, 447A, 448K, 449N, 450V, 451A, 452I, 453A, 454A
CDD
cd00644 (HMG-CoA_reductase_classII)

440R

flexible flap
439Q, 440R, 441G, 442H, 443M, 444S, 445L, 446H, 447A, 448K, 449N, 450V, 451A, 452I, 453A, 454A
CDD
cd00644 (HMG-CoA_reductase_classII)

441G

flexible flap
439Q, 440R, 441G, 442H, 443M, 444S, 445L, 446H, 447A, 448K, 449N, 450V, 451A, 452I, 453A, 454A
CDD
cd00644 (HMG-CoA_reductase_classII)

442H

flexible flap
439Q, 440R, 441G, 442H, 443M, 444S, 445L, 446H, 447A, 448K, 449N, 450V, 451A, 452I, 453A, 454A
CDD
cd00644 (HMG-CoA_reductase_classII)

443M

flexible flap
439Q, 440R, 441G, 442H, 443M, 444S, 445L, 446H, 447A, 448K, 449N, 450V, 451A, 452I, 453A, 454A
CDD
cd00644 (HMG-CoA_reductase_classII)

444S

flexible flap
439Q, 440R, 441G, 442H, 443M, 444S, 445L, 446H, 447A, 448K, 449N, 450V, 451A, 452I, 453A, 454A
CDD
cd00644 (HMG-CoA_reductase_classII)

445L

flexible flap
439Q, 440R, 441G, 442H, 443M, 444S, 445L, 446H, 447A, 448K, 449N, 450V, 451A, 452I, 453A, 454A
CDD
cd00644 (HMG-CoA_reductase_classII)

446H

flexible flap
439Q, 440R, 441G, 442H, 443M, 444S, 445L, 446H, 447A, 448K, 449N, 450V, 451A, 452I, 453A, 454A
CDD
cd00644 (HMG-CoA_reductase_classII)

447A

flexible flap
439Q, 440R, 441G, 442H, 443M, 444S, 445L, 446H, 447A, 448K, 449N, 450V, 451A, 452I, 453A, 454A
CDD
cd00644 (HMG-CoA_reductase_classII)

448K

flexible flap
439Q, 440R, 441G, 442H, 443M, 444S, 445L, 446H, 447A, 448K, 449N, 450V, 451A, 452I, 453A, 454A
CDD
cd00644 (HMG-CoA_reductase_classII)

449N

flexible flap
439Q, 440R, 441G, 442H, 443M, 444S, 445L, 446H, 447A, 448K, 449N, 450V, 451A, 452I, 453A, 454A
CDD
cd00644 (HMG-CoA_reductase_classII)

450V

flexible flap
439Q, 440R, 441G, 442H, 443M, 444S, 445L, 446H, 447A, 448K, 449N, 450V, 451A, 452I, 453A, 454A
CDD
cd00644 (HMG-CoA_reductase_classII)

451A

flexible flap
439Q, 440R, 441G, 442H, 443M, 444S, 445L, 446H, 447A, 448K, 449N, 450V, 451A, 452I, 453A, 454A
CDD
cd00644 (HMG-CoA_reductase_classII)

452I

flexible flap
439Q, 440R, 441G, 442H, 443M, 444S, 445L, 446H, 447A, 448K, 449N, 450V, 451A, 452I, 453A, 454A
CDD
cd00644 (HMG-CoA_reductase_classII)

453A

flexible flap
439Q, 440R, 441G, 442H, 443M, 444S, 445L, 446H, 447A, 448K, 449N, 450V, 451A, 452I, 453A, 454A
CDD
cd00644 (HMG-CoA_reductase_classII)

454A

flexible flap
439Q, 440R, 441G, 442H, 443M, 444S, 445L, 446H, 447A, 448K, 449N, 450V, 451A, 452I, 453A, 454A
CDD
cd00644 (HMG-CoA_reductase_classII)

GO term prediction

Biological Process

GO:0015936 coenzyme A metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0050662 coenzyme binding

Cellular Component

None predicted.

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Status

Per-residue features