GBC47533.1

Protein

Length

572 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
8 - 263
Protein kinase-like domain (IPR011009)
Protein kinase domain (IPR000719)
284 - 329
Carbon catabolite-derepressing protein kinase, ubiquitin-associated domain (IPR013896)
394 - 490
KA1 domain/Ssp2, C-terminal (IPR028375)
AMPK, C-terminal adenylate sensor domain (IPR032270)
536 - 570
KA1 domain/Ssp2, C-terminal (IPR028375)
Domain
283 - 325
Ubiquitin-associated domain (IPR015940)

1 100 200 300 400 500 572

Detailed signature matches

IPR011009

Protein kinase-like domain
1. SSF56112 (Protein k...)
  
  8 - 263
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
IPR000719

Protein kinase domain
1. SM00220 (serkin_6)
  
  11 - 262
  
  SMART
  SM00220 (serkin_6)
2. PS50011 (PROTEIN_KI...)
  
  11 - 262
  
  PROSITE profiles
  PS50011 (PROTEIN_KINASE_DOM)
3. PF00069 (Pkinase)
  
  11 - 262
  
  Pfam
  PF00069 (Pkinase)
IPR015940

Ubiquitin-associated domain
1. PS50030 (UBA)
  
  283 - 325
  
  PROSITE profiles
  PS50030 (UBA)
IPR013896

Carbon catabolite-derepressing protein kinase, ubiquitin-associated domain
1. PF08587 (UBA_2)
  
  284 - 325
  
  Pfam
  PF08587 (UBA_2)
2. cd14334 (UBA_SNF1_f...)
  
  284 - 329
  
  CDD
  cd14334 (UBA_SNF1_fungi)
IPR028375

KA1 domain/Ssp2, C-terminal
1. SSF103243 (KA1-like)
  
  536 - 570
  
  SUPERFAMILY
  SSF103243 (KA1-like)
  
  394 - 483
  
  SUPERFAMILY
  SSF103243 (KA1-like)
IPR032270

AMPK, C-terminal adenylate sensor domain
1. PF16579 (AdenylateS...)
  
  407 - 490
  
  Pfam
  PF16579 (AdenylateSensor)
IPR017441

Protein kinase, ATP binding site
1. PS00107 (PROTEIN_KI...)
  
  17 - 40
  
  PROSITE patterns
  PS00107 (PROTEIN_KINASE_ATP)
IPR008271

Serine/threonine-protein kinase, active site
1. PS00108 (PROTEIN_KI...)
  
  129 - 141
  
  PROSITE patterns
  PS00108 (PROTEIN_KINASE_ST)

no IPR

Unintegrated signatures

cd12122 (AMPKA_C)

408 - 568

CDD
cd12122 (AMPKA_C)
cd14079 (STKc_AMPK_...)

8 - 262

CDD
cd14079 (STKc_AMPK_alpha)
mobidb-lite (disord...)

490 - 527

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

ATP binding site c...

17L

ATP binding site
17L, 18G, 19V, 20G, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 137E, 138N, 140L, 150A, 151D
CDD
cd14079 (STKc_AMPK_alpha)

18G

ATP binding site
17L, 18G, 19V, 20G, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 137E, 138N, 140L, 150A, 151D
CDD
cd14079 (STKc_AMPK_alpha)

19V

ATP binding site
17L, 18G, 19V, 20G, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 137E, 138N, 140L, 150A, 151D
CDD
cd14079 (STKc_AMPK_alpha)

20G

ATP binding site
17L, 18G, 19V, 20G, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 137E, 138N, 140L, 150A, 151D
CDD
cd14079 (STKc_AMPK_alpha)

25V

ATP binding site
17L, 18G, 19V, 20G, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 137E, 138N, 140L, 150A, 151D
CDD
cd14079 (STKc_AMPK_alpha)

38A

ATP binding site
17L, 18G, 19V, 20G, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 137E, 138N, 140L, 150A, 151D
CDD
cd14079 (STKc_AMPK_alpha)

40K

ATP binding site
17L, 18G, 19V, 20G, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 137E, 138N, 140L, 150A, 151D
CDD
cd14079 (STKc_AMPK_alpha)

72I

ATP binding site
17L, 18G, 19V, 20G, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 137E, 138N, 140L, 150A, 151D
CDD
cd14079 (STKc_AMPK_alpha)

88M

ATP binding site
17L, 18G, 19V, 20G, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 137E, 138N, 140L, 150A, 151D
CDD
cd14079 (STKc_AMPK_alpha)

89E

ATP binding site
17L, 18G, 19V, 20G, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 137E, 138N, 140L, 150A, 151D
CDD
cd14079 (STKc_AMPK_alpha)

90Y

ATP binding site
17L, 18G, 19V, 20G, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 137E, 138N, 140L, 150A, 151D
CDD
cd14079 (STKc_AMPK_alpha)

91A

ATP binding site
17L, 18G, 19V, 20G, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 137E, 138N, 140L, 150A, 151D
CDD
cd14079 (STKc_AMPK_alpha)

94E

ATP binding site
17L, 18G, 19V, 20G, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 137E, 138N, 140L, 150A, 151D
CDD
cd14079 (STKc_AMPK_alpha)

137E

ATP binding site
17L, 18G, 19V, 20G, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 137E, 138N, 140L, 150A, 151D
CDD
cd14079 (STKc_AMPK_alpha)

138N

ATP binding site
17L, 18G, 19V, 20G, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 137E, 138N, 140L, 150A, 151D
CDD
cd14079 (STKc_AMPK_alpha)

140L

ATP binding site
17L, 18G, 19V, 20G, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 137E, 138N, 140L, 150A, 151D
CDD
cd14079 (STKc_AMPK_alpha)

150A

ATP binding site
17L, 18G, 19V, 20G, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 137E, 138N, 140L, 150A, 151D
CDD
cd14079 (STKc_AMPK_alpha)

151D

ATP binding site
17L, 18G, 19V, 20G, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 137E, 138N, 140L, 150A, 151D
CDD
cd14079 (STKc_AMPK_alpha)
active site cd14079

17L

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

18G

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

19V

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

20G

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

21S

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

25V

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

38A

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

40K

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

72I

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

88M

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

89E

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

90Y

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

91A

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

94E

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

96F

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

97N

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

99I

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

132R

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

133D

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

135K

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

137E

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

138N

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

140L

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

150A

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

151D

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

154L

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

168C

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

169G

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

170S

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

171P

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

172N

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

174A

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

204G

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

205R

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

206L

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

207P

active site
17L, 18G, 19V, 20G, 21S, 25V, 38A, 40K, 72I, 88M, 89E, 90Y, 91A, 94E, 96F, 97N, 99I, 132R, 133D, 135K, 137E, 138N, 140L, 150A, 151D, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)
polypeptide substr...

94E

polypeptide substrate binding site
94E, 96F, 97N, 99I, 133D, 135K, 137E, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

96F

polypeptide substrate binding site
94E, 96F, 97N, 99I, 133D, 135K, 137E, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

97N

polypeptide substrate binding site
94E, 96F, 97N, 99I, 133D, 135K, 137E, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

99I

polypeptide substrate binding site
94E, 96F, 97N, 99I, 133D, 135K, 137E, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

133D

polypeptide substrate binding site
94E, 96F, 97N, 99I, 133D, 135K, 137E, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

135K

polypeptide substrate binding site
94E, 96F, 97N, 99I, 133D, 135K, 137E, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

137E

polypeptide substrate binding site
94E, 96F, 97N, 99I, 133D, 135K, 137E, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

154L

polypeptide substrate binding site
94E, 96F, 97N, 99I, 133D, 135K, 137E, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

168C

polypeptide substrate binding site
94E, 96F, 97N, 99I, 133D, 135K, 137E, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

169G

polypeptide substrate binding site
94E, 96F, 97N, 99I, 133D, 135K, 137E, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

170S

polypeptide substrate binding site
94E, 96F, 97N, 99I, 133D, 135K, 137E, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

171P

polypeptide substrate binding site
94E, 96F, 97N, 99I, 133D, 135K, 137E, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

172N

polypeptide substrate binding site
94E, 96F, 97N, 99I, 133D, 135K, 137E, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

174A

polypeptide substrate binding site
94E, 96F, 97N, 99I, 133D, 135K, 137E, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

204G

polypeptide substrate binding site
94E, 96F, 97N, 99I, 133D, 135K, 137E, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

205R

polypeptide substrate binding site
94E, 96F, 97N, 99I, 133D, 135K, 137E, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

206L

polypeptide substrate binding site
94E, 96F, 97N, 99I, 133D, 135K, 137E, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)

207P

polypeptide substrate binding site
94E, 96F, 97N, 99I, 133D, 135K, 137E, 154L, 168C, 169G, 170S, 171P, 172N, 174A, 204G, 205R, 206L, 207P
CDD
cd14079 (STKc_AMPK_alpha)
activation loop (A...

150A

activation loop (A-loop)
150A, 151D, 152F, 153G, 154L, 155S, 156N, 157I, 158M, 159T, 160D, 161G, 162E, 163F, 164L, 165K, 166T, 167S, 168C, 169G, 170S, 171P, 172N
CDD
cd14079 (STKc_AMPK_alpha)

151D

activation loop (A-loop)
150A, 151D, 152F, 153G, 154L, 155S, 156N, 157I, 158M, 159T, 160D, 161G, 162E, 163F, 164L, 165K, 166T, 167S, 168C, 169G, 170S, 171P, 172N
CDD
cd14079 (STKc_AMPK_alpha)

152F

activation loop (A-loop)
150A, 151D, 152F, 153G, 154L, 155S, 156N, 157I, 158M, 159T, 160D, 161G, 162E, 163F, 164L, 165K, 166T, 167S, 168C, 169G, 170S, 171P, 172N
CDD
cd14079 (STKc_AMPK_alpha)

153G

activation loop (A-loop)
150A, 151D, 152F, 153G, 154L, 155S, 156N, 157I, 158M, 159T, 160D, 161G, 162E, 163F, 164L, 165K, 166T, 167S, 168C, 169G, 170S, 171P, 172N
CDD
cd14079 (STKc_AMPK_alpha)

154L

activation loop (A-loop)
150A, 151D, 152F, 153G, 154L, 155S, 156N, 157I, 158M, 159T, 160D, 161G, 162E, 163F, 164L, 165K, 166T, 167S, 168C, 169G, 170S, 171P, 172N
CDD
cd14079 (STKc_AMPK_alpha)

155S

activation loop (A-loop)
150A, 151D, 152F, 153G, 154L, 155S, 156N, 157I, 158M, 159T, 160D, 161G, 162E, 163F, 164L, 165K, 166T, 167S, 168C, 169G, 170S, 171P, 172N
CDD
cd14079 (STKc_AMPK_alpha)

156N

activation loop (A-loop)
150A, 151D, 152F, 153G, 154L, 155S, 156N, 157I, 158M, 159T, 160D, 161G, 162E, 163F, 164L, 165K, 166T, 167S, 168C, 169G, 170S, 171P, 172N
CDD
cd14079 (STKc_AMPK_alpha)

157I

activation loop (A-loop)
150A, 151D, 152F, 153G, 154L, 155S, 156N, 157I, 158M, 159T, 160D, 161G, 162E, 163F, 164L, 165K, 166T, 167S, 168C, 169G, 170S, 171P, 172N
CDD
cd14079 (STKc_AMPK_alpha)

158M

activation loop (A-loop)
150A, 151D, 152F, 153G, 154L, 155S, 156N, 157I, 158M, 159T, 160D, 161G, 162E, 163F, 164L, 165K, 166T, 167S, 168C, 169G, 170S, 171P, 172N
CDD
cd14079 (STKc_AMPK_alpha)

159T

activation loop (A-loop)
150A, 151D, 152F, 153G, 154L, 155S, 156N, 157I, 158M, 159T, 160D, 161G, 162E, 163F, 164L, 165K, 166T, 167S, 168C, 169G, 170S, 171P, 172N
CDD
cd14079 (STKc_AMPK_alpha)

160D

activation loop (A-loop)
150A, 151D, 152F, 153G, 154L, 155S, 156N, 157I, 158M, 159T, 160D, 161G, 162E, 163F, 164L, 165K, 166T, 167S, 168C, 169G, 170S, 171P, 172N
CDD
cd14079 (STKc_AMPK_alpha)

161G

activation loop (A-loop)
150A, 151D, 152F, 153G, 154L, 155S, 156N, 157I, 158M, 159T, 160D, 161G, 162E, 163F, 164L, 165K, 166T, 167S, 168C, 169G, 170S, 171P, 172N
CDD
cd14079 (STKc_AMPK_alpha)

162E

activation loop (A-loop)
150A, 151D, 152F, 153G, 154L, 155S, 156N, 157I, 158M, 159T, 160D, 161G, 162E, 163F, 164L, 165K, 166T, 167S, 168C, 169G, 170S, 171P, 172N
CDD
cd14079 (STKc_AMPK_alpha)

163F

activation loop (A-loop)
150A, 151D, 152F, 153G, 154L, 155S, 156N, 157I, 158M, 159T, 160D, 161G, 162E, 163F, 164L, 165K, 166T, 167S, 168C, 169G, 170S, 171P, 172N
CDD
cd14079 (STKc_AMPK_alpha)

164L

activation loop (A-loop)
150A, 151D, 152F, 153G, 154L, 155S, 156N, 157I, 158M, 159T, 160D, 161G, 162E, 163F, 164L, 165K, 166T, 167S, 168C, 169G, 170S, 171P, 172N
CDD
cd14079 (STKc_AMPK_alpha)

165K

activation loop (A-loop)
150A, 151D, 152F, 153G, 154L, 155S, 156N, 157I, 158M, 159T, 160D, 161G, 162E, 163F, 164L, 165K, 166T, 167S, 168C, 169G, 170S, 171P, 172N
CDD
cd14079 (STKc_AMPK_alpha)

166T

activation loop (A-loop)
150A, 151D, 152F, 153G, 154L, 155S, 156N, 157I, 158M, 159T, 160D, 161G, 162E, 163F, 164L, 165K, 166T, 167S, 168C, 169G, 170S, 171P, 172N
CDD
cd14079 (STKc_AMPK_alpha)

167S

activation loop (A-loop)
150A, 151D, 152F, 153G, 154L, 155S, 156N, 157I, 158M, 159T, 160D, 161G, 162E, 163F, 164L, 165K, 166T, 167S, 168C, 169G, 170S, 171P, 172N
CDD
cd14079 (STKc_AMPK_alpha)

168C

activation loop (A-loop)
150A, 151D, 152F, 153G, 154L, 155S, 156N, 157I, 158M, 159T, 160D, 161G, 162E, 163F, 164L, 165K, 166T, 167S, 168C, 169G, 170S, 171P, 172N
CDD
cd14079 (STKc_AMPK_alpha)

169G

activation loop (A-loop)
150A, 151D, 152F, 153G, 154L, 155S, 156N, 157I, 158M, 159T, 160D, 161G, 162E, 163F, 164L, 165K, 166T, 167S, 168C, 169G, 170S, 171P, 172N
CDD
cd14079 (STKc_AMPK_alpha)

170S

activation loop (A-loop)
150A, 151D, 152F, 153G, 154L, 155S, 156N, 157I, 158M, 159T, 160D, 161G, 162E, 163F, 164L, 165K, 166T, 167S, 168C, 169G, 170S, 171P, 172N
CDD
cd14079 (STKc_AMPK_alpha)

171P

activation loop (A-loop)
150A, 151D, 152F, 153G, 154L, 155S, 156N, 157I, 158M, 159T, 160D, 161G, 162E, 163F, 164L, 165K, 166T, 167S, 168C, 169G, 170S, 171P, 172N
CDD
cd14079 (STKc_AMPK_alpha)

172N

activation loop (A-loop)
150A, 151D, 152F, 153G, 154L, 155S, 156N, 157I, 158M, 159T, 160D, 161G, 162E, 163F, 164L, 165K, 166T, 167S, 168C, 169G, 170S, 171P, 172N
CDD
cd14079 (STKc_AMPK_alpha)
heterotrimer inter...

158M

heterotrimer interface
158M, 159T, 160D, 161G, 162E, 163F, 182R, 183L, 185A, 188E, 248M
CDD
cd14079 (STKc_AMPK_alpha)

159T

heterotrimer interface
158M, 159T, 160D, 161G, 162E, 163F, 182R, 183L, 185A, 188E, 248M
CDD
cd14079 (STKc_AMPK_alpha)

160D

heterotrimer interface
158M, 159T, 160D, 161G, 162E, 163F, 182R, 183L, 185A, 188E, 248M
CDD
cd14079 (STKc_AMPK_alpha)

161G

heterotrimer interface
158M, 159T, 160D, 161G, 162E, 163F, 182R, 183L, 185A, 188E, 248M
CDD
cd14079 (STKc_AMPK_alpha)

162E

heterotrimer interface
158M, 159T, 160D, 161G, 162E, 163F, 182R, 183L, 185A, 188E, 248M
CDD
cd14079 (STKc_AMPK_alpha)

163F

heterotrimer interface
158M, 159T, 160D, 161G, 162E, 163F, 182R, 183L, 185A, 188E, 248M
CDD
cd14079 (STKc_AMPK_alpha)

182R

heterotrimer interface
158M, 159T, 160D, 161G, 162E, 163F, 182R, 183L, 185A, 188E, 248M
CDD
cd14079 (STKc_AMPK_alpha)

183L

heterotrimer interface
158M, 159T, 160D, 161G, 162E, 163F, 182R, 183L, 185A, 188E, 248M
CDD
cd14079 (STKc_AMPK_alpha)

185A

heterotrimer interface
158M, 159T, 160D, 161G, 162E, 163F, 182R, 183L, 185A, 188E, 248M
CDD
cd14079 (STKc_AMPK_alpha)

188E

heterotrimer interface
158M, 159T, 160D, 161G, 162E, 163F, 182R, 183L, 185A, 188E, 248M
CDD
cd14079 (STKc_AMPK_alpha)

248M

heterotrimer interface
158M, 159T, 160D, 161G, 162E, 163F, 182R, 183L, 185A, 188E, 248M
CDD
cd14079 (STKc_AMPK_alpha)
beta subunit inter...

408W

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

409H

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

410F

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

411G

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

418P

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

419L

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

423L

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

426Y

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

427R

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

430K

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

434M

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

435E

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

436W

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

438T

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

439M

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

440D

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

441P

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

442F

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

445R

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

446C

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

447R

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

457K

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

461Q

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

462L

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

463Y

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

464R

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

465L

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

470Y

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

471L

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

473D

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

474F

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

475K

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

476N

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

552T

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

554M

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

555Y

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

557F

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

558F

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

559D

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

561C

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

562T

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

565I

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)

566T

beta subunit interface
408W, 409H, 410F, 411G, 418P, 419L, 423L, 426Y, 427R, 430K, 434M, 435E, 436W, 438T, 439M, 440D, 441P, 442F, 445R, 446C, 447R, 457K, 461Q, 462L, 463Y, 464R, 465L, 470Y, 471L, 473D, 474F, 475K, 476N, 552T, 554M, 555Y, 557F, 558F, 559D, 561C, 562T, 565I, 566T
CDD
cd12122 (AMPKA_C)
gamma subunit inte...

450Y

gamma subunit interface
450Y, 552T, 553S, 555Y, 556P, 559D
CDD
cd12122 (AMPKA_C)

552T

gamma subunit interface
450Y, 552T, 553S, 555Y, 556P, 559D
CDD
cd12122 (AMPKA_C)

553S

gamma subunit interface
450Y, 552T, 553S, 555Y, 556P, 559D
CDD
cd12122 (AMPKA_C)

555Y

gamma subunit interface
450Y, 552T, 553S, 555Y, 556P, 559D
CDD
cd12122 (AMPKA_C)

556P

gamma subunit interface
450Y, 552T, 553S, 555Y, 556P, 559D
CDD
cd12122 (AMPKA_C)

559D

gamma subunit interface
450Y, 552T, 553S, 555Y, 556P, 559D
CDD
cd12122 (AMPKA_C)

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding

Cellular Component